LOCUS       NM_013262               3072 bp    mRNA    linear   PRI 18-MAR-2025
DEFINITION  Homo sapiens myosin regulatory light chain interacting protein
            (MYLIP), transcript variant 1, mRNA.
ACCESSION   NM_013262
VERSION     NM_013262.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Lam,S., Lui,D.T.W., Shiu,S.W.M., Wong,Y. and Tan,K.C.B.
  TITLE     Effect of type 2 diabetes on the inducible degrader of LDL receptor
  JOURNAL   J Lipid Res 64 (6), 100380 (2023)
   PUBMED   37094639
  REMARK    GeneRIF: Effect of type 2 diabetes on the inducible degrader of LDL
            receptor.
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Martins,I., Neves-Silva,D., Ascensao-Ferreira,M., Dias,A.F.,
            Ribeiro,D., Isidro,A.F., Quiteria,R., Paramos-de-Carvalho,D.,
            Barbosa-Morais,N.L. and Saude,L.
  TITLE     Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9
            and MYLIP as Injury-Induced Players
  JOURNAL   Int J Mol Sci 24 (7), 6433 (2023)
   PUBMED   37047406
  REMARK    GeneRIF: Mouse Spinal Cord Vascular Transcriptome Analysis
            Identifies CD9 and MYLIP as Injury-Induced Players.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Adi,D., Abuzhalihan,J., Tao,J., Wu,Y., Wang,Y.H., Liu,F.,
            Yang,Y.N., Ma,X., Li,X.M., Xie,X., Fu,Z.Y. and Ma,Y.T.
  TITLE     Genetic polymorphism of IDOL gene was associated with the
            susceptibility of coronary artery disease in Han population in
            Xinjiang, China
  JOURNAL   Hereditas 158 (1), 12 (2021)
   PUBMED   33845890
  REMARK    GeneRIF: Genetic polymorphism of IDOL gene was associated with the
            susceptibility of coronary artery disease in Han population in
            Xinjiang, China.
            Erratum:[Hereditas. 2021 Jun 5;158(1):19. doi:
            10.1186/s41065-021-00185-x. PMID: 34090523]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   Wang,H., Ma,L., Pan,X., Du,Z. and Chen,Y.
  TITLE     Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene
            with early-onset-preeclampsia: A case-control candidate genetic
            study
  JOURNAL   Pregnancy Hypertens 23, 185-190 (2021)
   PUBMED   33450693
  REMARK    GeneRIF: Novel associations of SNPs MYLIP rs3757354 and ABCA1
            2230806 gene with early-onset-preeclampsia: A case-control
            candidate genetic study.
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Ni,M., Yan,Q., Xue,H., Du,Y., Zhao,S. and Zhao,Z.
  TITLE     Identification of MYLIP gene and miRNA-802 involved in the growth
            and metastasis of cervical cancer cells
  JOURNAL   Cancer Biomark 30 (3), 287-298 (2021)
   PUBMED   33185588
  REMARK    GeneRIF: Identification of MYLIP gene and miRNA-802 involved in the
            growth and metastasis of cervical cancer cells.
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   7  (bases 1 to 3072)
  AUTHORS   Bornhauser,B.C., Johansson,C. and Lindholm,D.
  TITLE     Functional activities and cellular localization of the ezrin,
            radixin, moesin (ERM) and RING zinc finger domains in MIR
  JOURNAL   FEBS Lett 553 (1-2), 195-199 (2003)
   PUBMED   14550572
REFERENCE   8  (bases 1 to 3072)
  AUTHORS   Bornhauser,B.C., Olsson,P.A. and Lindholm,D.
  TITLE     MSAP is a novel MIR-interacting protein that enhances neurite
            outgrowth and increases myosin regulatory light chain
  JOURNAL   J Biol Chem 278 (37), 35412-35420 (2003)
   PUBMED   12826659
  REMARK    GeneRIF: MSAP interacts with this protein that enhances neurite
            outgrowth and increases myosin regulatory light chain in fetal and
            adult brain.
REFERENCE   9  (bases 1 to 3072)
  AUTHORS   Olsson,P.A., Bornhauser,B.C., Korhonen,L. and Lindholm,D.
  TITLE     Neuronal expression of the ERM-like protein MIR in rat brain and
            its localization to human chromosome 6
  JOURNAL   Biochem Biophys Res Commun 279 (3), 879-883 (2000)
   PUBMED   11162443
REFERENCE   10 (bases 1 to 3072)
  AUTHORS   Olsson,P.A., Korhonen,L., Mercer,E.A. and Lindholm,D.
  TITLE     MIR is a novel ERM-like protein that interacts with myosin
            regulatory light chain and inhibits neurite outgrowth
  JOURNAL   J Biol Chem 274 (51), 36288-36292 (1999)
   PUBMED   10593918
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074391.1, AK026739.1 and
            AF212221.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013262.3.
            
            Summary: The ERM protein family members ezrin, radixin, and moesin
            are cytoskeletal effector proteins linking actin to membrane-bound
            proteins at the cell surface. Myosin regulatory light chain
            interacting protein (MYLIP) is a novel ERM-like protein that
            interacts with myosin regulatory light chain and inhibits neurite
            outgrowth. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074391.1, SRR1803616.246318.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356840.8/ ENSP00000349298.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1705              AK074391.1         1-1705
            1706-2760           AK026739.1         925-1979
            2761-3072           AF212221.1         2488-2799
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..3072
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /note="myosin regulatory light chain interacting protein"
                     /db_xref="GeneID:29116"
                     /db_xref="HGNC:HGNC:21155"
                     /db_xref="MIM:610082"
     exon            1..324
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1575
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin ligase-inducible degrader of the low density
                     lipoprotein receptor; E3 ubiquitin-protein ligase MYLIP;
                     band 4.1 superfamily member BZF1; cellular modulator of
                     immune recognition (c-MIR); inducible degrader of the
                     LDL-receptor; RING-type E3 ubiquitin transferase MYLIP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MYLIP isoform 1"
                     /protein_id="NP_037394.2"
                     /db_xref="CCDS:CCDS4536.1"
                     /db_xref="GeneID:29116"
                     /db_xref="HGNC:HGNC:21155"
                     /db_xref="MIM:610082"
                     /translation="MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGL
                     QFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKE
                     ALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKH
                     KELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSP
                     INRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYR
                     CDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAG
                     VVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCE
                     EEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI"
     exon            325..515
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     exon            516..701
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     exon            702..899
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1064
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1485
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..3072
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /note="hexamer: AATAAA"
     polyA_site      3072
                     /gene="MYLIP"
                     /gene_synonym="IDOL; MIR"
                     /note="major polyA site"
ORIGIN      
        1 agttgggctg ctggagtgcg gcgccaccgc ggaggacagg ggcagctggc gggcagcggg
       61 tgagggggtg gcggggacgc gagtggcggc cgcggggccc cggacaaggg tccgcagagc
      121 tgcagccttc gagggccagc cctctccgag tccggggctg ggtcccacca gtgacaaggc
      181 ggcagccccg cgcacaccaa agagaaggcg gctgtggcgg cagcggcagc cccagccatg
      241 ctgtgttatg tgacgaggcc ggacgcggtg ctgatggagg tggaggtgga ggcgaaagcc
      301 aacggcgagg actgcctcaa ccaggtgtgc aggcgactgg gaatcataga agttgactat
      361 tttggactgc agtttacggg tagcaaaggt gaaagtttat ggctaaacct gagaaaccgg
      421 atctcccagc agatggatgg gctagcccct tacaggctta aacttagagt caagttcttc
      481 gtggagcctc atctcatctt acaggagcag actaggcata tctttttctt gcacatcaag
      541 gaggccctct tggcaggcca cctcttgtgt tccccagagc aggcagtgga actcagtgcc
      601 ctcctggccc agaccaagtt tggagactac aaccagaaca ctgccaagta taactatgag
      661 gagctctgtg ccaaggagct ctcctctgcc accttgaaca gcattgttgc aaaacataag
      721 gagttggagg ggaccagcca ggcttcagct gaataccaag ttttgcagat tgtgtcggca
      781 atggaaaact atggcataga atggcattct gtgcgggata gcgaagggca gaaactgctc
      841 attggggttg gacctgaagg aatctcaatt tgtaaagatg actttagccc aattaatagg
      901 atagcttatc ctgtggtgca gatggccacc cagtcaggaa agaatgtata tttgacggtc
      961 accaaggaat ctgggaacag catcgtgctc ttgtttaaaa tgatcagcac cagggcggcc
     1021 agcgggctct accgagcgat aacagagacg cacgcattct acaggtgtga cacagtgacc
     1081 agcgccgtga tgatgcagta tagccgtgac ttgaagggcc acttggcatc tctgtttctg
     1141 aatgaaaaca ttaaccttgg caagaaatat gtctttgata ttaaaagaac atcaaaggag
     1201 gtgtatgacc atgccaggag ggctctgtac aatgctggcg ttgtggacct cgtttcaaga
     1261 aacaaccaga gcccttcaca ctcgcctctg aagtcctcag aaagcagcat gaactgcagc
     1321 agctgcgagg gcctcagctg ccagcagacc cgggtgctgc aggagaagct acgcaagctg
     1381 aaggaagcca tgctgtgcat ggtgtgctgc gaggaggaga tcaactccac cttctgtccc
     1441 tgtggccaca ctgtgtgctg tgagagctgc gccgcccagc tacagtcatg tcccgtctgc
     1501 aggtcgcgtg tggagcatgt ccagcacgtc tatctgccaa cgcacaccag tcttctcaat
     1561 ctgactgtaa tctaatctgt tgtgcttttg ttggacttgg catgtttcca tgaactgcac
     1621 tattataaac tattaaaatg atagattgtg gagaaagtaa ttattccaac acccatctgc
     1681 catgcgatgt taaaaaaaaa aaaaaggaag aaaaataaca cagctactcc tcactgcaaa
     1741 aacatatcca tgcgtagaat caacaactcc agtcatggga ccaggaggag ctctgggacg
     1801 cagacacatt ccttggatgt tgattttttt tatgatctag taaaggaata ggtaaagtct
     1861 ttgatgtcag tgaagtggca acatagccaa aaagttgggt accttttagg aaatgatgtt
     1921 gtaagtctcc ttaatgtatc ctgaggtaag tttcctactg gcagcagatt ttgtaagaat
     1981 tacttttaag aatttcattc tttttgtatg gtcatggagc tccaaccatt tttaatagga
     2041 aagtcttttg taaattgttg tcgttttaat gtcatttctg tctttataac ttgatcaaga
     2101 atgattggaa ggcaaacagg tttacaaatc aattctgtga cttttaaaaa gttgacaatg
     2161 ttgtcagatt taaaccagtg tggctagtaa aaagcagctc actcaatgtg ggtggctccc
     2221 tattccttta cgctccccct atccctaccc cacaagcctt tcgattataa aatactacca
     2281 atcttgttat aagattactg tggagtagtc aagtactccc cgggccttct gagctggtgg
     2341 aatattttat ttcagactga aaacagagag cactctcctt gggaagggaa agcggagctt
     2401 gctgagtgag agatggagcc tcatggtgta caactgaggg tagttaactc atcacttctc
     2461 ccaagcactc gatcccagct tcacccactg gtgttgcttt gcttgaactg ttcaagcctt
     2521 ttatagcctt accataagta tttagatatg gtgtcctttt ctgtttttgg ggggggagtt
     2581 ttgttgtgtt tttttaaagt aagtgcttaa gtattaactt tgggttgtcc cctctgtatg
     2641 tttcgaaggg gttttggttc tttttgcttc tgttttctta aacatgtttt ccactcccac
     2701 ttgggcattt tggaagctgg tcagctagca ggttttctgg gatgtcggga gacctagatg
     2761 accttatcgg gtgcaatact agctaaggta aagctagaaa cctacactgt cactttactg
     2821 agatttctga gtatactttt catattgcct taatgtagca gtaatgtgtt tatgcatttg
     2881 tttctttgca cagacatttt gtcaaatatt aaaactctac ttttttatgg cacatattag
     2941 catataagcc tttattccaa gaggtattta ttttttcact tgtaaaaaaa taatgtttcc
     3001 acgtaaagaa ctctgttata tcctagagga ctctgtcttt tatattcggg ataataaaga
     3061 ctttaaagca aa
//
