LOCUS       NM_006097               2786 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens myosin light chain 9 (MYL9), transcript variant 1,
            mRNA.
ACCESSION   NM_006097
VERSION     NM_006097.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Chen,X., Fansler,M.M., Janjos,U., Ule,J. and Mayr,C.
  TITLE     The FXR1 network acts as a signaling scaffold for actomyosin
            remodeling
  JOURNAL   Cell 187 (18), 5048-5063 (2024)
   PUBMED   39106863
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Ikeda,H., Ihara,E., Takeya,K., Mukai,K., Onimaru,M., Ouchida,K.,
            Hata,Y., Bai,X., Tanaka,Y., Sasaki,T., Saito,F., Eto,M.,
            Nakayama,J., Oda,Y., Nakamura,M., Inoue,H. and Ogawa,Y.
  TITLE     The interplay between alterations in esophageal microbiota
            associated with Th17 immune response and impaired LC20
            phosphorylation in achalasia
  JOURNAL   J Gastroenterol 59 (5), 361-375 (2024)
   PUBMED   38472375
  REMARK    GeneRIF: The interplay between alterations in esophageal microbiota
            associated with Th17 immune response and impaired LC20
            phosphorylation in achalasia.
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Qin,X., Zeng,B., Sooranna,S.R. and Li,M.
  TITLE     LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in
            Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway
  JOURNAL   Cell Biochem Biophys 82 (1), 127-137 (2024)
   PUBMED   37801199
  REMARK    GeneRIF: LAMB3 Promotes Myofibrogenesis and Cytoskeletal
            Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9
            Pathway.
REFERENCE   4  (bases 1 to 2786)
  AUTHORS   Deng,S., Cheng,D., Wang,J., Gu,J., Xue,Y., Jiang,Z., Qin,L.,
            Mao,F., Cao,Y. and Cai,K.
  TITLE     MYL9 expressed in cancer-associated fibroblasts regulate the immune
            microenvironment of colorectal cancer and promotes tumor
            progression in an autocrine manner
  JOURNAL   J Exp Clin Cancer Res 42 (1), 294 (2023)
   PUBMED   37926835
  REMARK    GeneRIF: MYL9 expressed in cancer-associated fibroblasts regulate
            the immune microenvironment of colorectal cancer and promotes tumor
            progression in an autocrine manner.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2786)
  AUTHORS   Wen,B., Luo,L., Zeng,Z. and Luo,X.
  TITLE     MYL9 promotes squamous cervical cancer migration and invasion by
            enhancing aerobic glycolysis
  JOURNAL   J Int Med Res 51 (11), 3000605231208582 (2023)
   PUBMED   37950670
  REMARK    GeneRIF: MYL9 promotes squamous cervical cancer migration and
            invasion by enhancing aerobic glycolysis.
REFERENCE   6  (bases 1 to 2786)
  AUTHORS   Webb,R.C.
  TITLE     Smooth muscle contraction and relaxation
  JOURNAL   Adv Physiol Educ 27 (1-4), 201-206 (2003)
   PUBMED   14627618
  REMARK    Review article
REFERENCE   7  (bases 1 to 2786)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 2786)
  AUTHORS   Iwasaki,T., Murata-Hori,M., Ishitobi,S. and Hosoya,H.
  TITLE     Diphosphorylated MRLC is required for organization of stress fibers
            in interphase cells and the contractile ring in dividing cells
  JOURNAL   Cell Struct Funct 26 (6), 677-683 (2001)
   PUBMED   11942626
REFERENCE   9  (bases 1 to 2786)
  AUTHORS   Ambartsumyan,L.
  TITLE     Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31070878
REFERENCE   10 (bases 1 to 2786)
  AUTHORS   Kumar,C.C., Mohan,S.R., Zavodny,P.J., Narula,S.K. and
            Leibowitz,P.J.
  TITLE     Characterization and differential expression of human vascular
            smooth muscle myosin light chain 2 isoform in nonmuscle cells
  JOURNAL   Biochemistry 28 (9), 4027-4035 (1989)
   PUBMED   2526655
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK130879.1, BC002648.2 and
            AL050318.13.
            
            On Nov 22, 2018 this sequence version replaced NM_006097.4.
            
            Summary: Myosin, a structural component of muscle, consists of two
            heavy chains and four light chains. The protein encoded by this
            gene is a myosin light chain that may regulate muscle contraction
            by modulating the ATPase activity of myosin heads. The encoded
            protein binds calcium and is activated by myosin light chain
            kinase. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130879.1, D82057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279022.7/ ENSP00000279022.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1160              AK130879.1         1-1160
            1161-1162           BC002648.2         973-974
            1163-2786           AL050318.13        60542-62165
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2786
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /note="myosin light chain 9"
                     /db_xref="GeneID:10398"
                     /db_xref="HGNC:HGNC:15754"
                     /db_xref="MIM:609905"
     exon            1..43
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            44..253
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..588
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /note="isoform a is encoded by transcript variant 1;
                     myosin regulatory light chain 1; myosin RLC; myosin
                     regulatory light polypeptide 9; myosin, light polypeptide
                     9, regulatory; myosin, light chain 9, regulatory; 20 kDa
                     myosin light chain; myosin regulatory light chain 9;
                     myosin regulatory light chain MRLC1; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="myosin regulatory light polypeptide 9 isoform a"
                     /protein_id="NP_006088.2"
                     /db_xref="CCDS:CCDS13276.1"
                     /db_xref="GeneID:10398"
                     /db_xref="HGNC:HGNC:15754"
                     /db_xref="MIM:609905"
                     /translation="MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQN
                     RDGFIDKEDLHDMLASLGKNPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDV
                     IRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFT
                     RILKHGAKDKDD"
     exon            254..415
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..2786
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /note="hexamer: AATAGA"
     polyA_site      1160
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /note="major polyA site"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
                     /note="hexamer: ATTAAA"
     polyA_site      2786
                     /gene="MYL9"
                     /gene_synonym="LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYRL2"
ORIGIN      
        1 agttccacgc acccagcgag cccaagcgcc ttctccgcac cagggaagcc ccacccacca
       61 gaagccaaga tgtccagcaa gcgggccaaa gccaagacca ccaagaagcg gccacagcgg
      121 gccacatcca atgtcttcgc aatgtttgac cagtcccaga tccaggagtt taaggaggct
      181 ttcaacatga ttgaccagaa ccgtgatggc ttcattgaca aggaggacct gcacgacatg
      241 ctggcctcgc tggggaagaa ccccacagac gaatacctgg agggcatgat gagcgaggcc
      301 ccggggccca tcaacttcac catgttcctc accatgtttg gggagaagct gaacggcacg
      361 gaccccgagg atgtgattcg caacgccttt gcctgcttcg acgaggaagc ctcaggtttc
      421 atccatgagg accacctccg ggagctgctc accaccatgg gtgaccgctt cacagatgag
      481 gaagtggacg agatgtaccg ggaggcaccc attgataaga aaggcaactt caactacgtg
      541 gagttcaccc gcatcctcaa acatggcgcc aaggataaag acgactaggc caccccagcc
      601 ccctgacacc ccagcccccg ccagtcaccc ctccccgcac acacccgtcc ataccagctc
      661 cctgcccatg accctcgctc agggatcccc ctttgagggg ttagggtccc agttcccagt
      721 ggaagaaaca ggccaggaga agtgcgtgcc gagctgaggc agatgttccc acagtgaccc
      781 cagagccctg ggctatagtc tctgacccct ccaaggaaag accaccttct ggggacatgg
      841 gctggagggc aggacctaga ggcaccaagg gaaggcccca ttccggggct gttccccgag
      901 gaggaaggga aggggctctg tgtgcccccc aggaggaaga ggccctgagt cctgggatca
      961 gacacccctt cacgtgtatc cccacacaaa tgcaagctca ccaaggtccc ctctcagtcc
     1021 ccttccctac accctgaccg gccactgccg cacacccacc cagagcacgc cacccgccat
     1081 gggagtgtgc tcaggagtcg cgggcagcgt ggacatctgt cccagagggg gcagaatctc
     1141 caatagagga ctgagcactg cttctggtct gtgtgtctgt ggctggggtg aagtaagggg
     1201 accccgggcc tgaaaccctc tcccaccttc tcctgccatc tccagttact gccctgctcc
     1261 tcccaccctg gcccagggaa ggactgggtg tcctccggcc atatggtccc tgaagcctct
     1321 agggaccaga gtccctagta agtgggctct gtgctcagct gagaccagca ggggacaggg
     1381 gacggaggga atgggcctca tggccttctc agggcttgtg ggaaagggag gaccatggga
     1441 atcaccacag ccaatcccgt ggagggttcc aggcctcttg gggggcagag gtcaggccac
     1501 acagccctca ggactaaagc tccgggttcc agaagaacag ggaggctcca acagtgatga
     1561 ggcaggcgtc ccagcagctc agggttggag gtgggaatga ggggtttccc agccccaggc
     1621 aggtggaggg cgagttcagc cccaggacca acagcatggg ggccacagct ttccatgtcc
     1681 ctgtgtacgc agggcaggca gggccgggac ccctgctact ggtggatgat ggggacactg
     1741 atggcagtgc ctggggccta agaggggcag aaagagcgct gaatgactga gcagagagtc
     1801 cagaggggca tggactgcct gggtcaccca ataggcctag ggaagagtga gggccggacc
     1861 caccccacct gaccccagcg agtggaccca gcttggtcct gaggccttct ccagaggtca
     1921 cccagcgcag gcagccgcag cactcagcaa aggtcccaga tcagggccaa gggggagctg
     1981 agcaccaggg gaccctgtgc ctgaccagga ggccctaacc tcctgcaggc ctcaacgcca
     2041 ggccctgctc agagctcggc tgaaactcct catcctggct ccaaacagag gcccaaaagt
     2101 ccctggtatc aactccagaa ggggcgagac ccgaacaagt tccaaaccag gcccaaatag
     2161 tatcccaaac tcagtcccaa acacattctc acccccggca gcaggctgca ggcctccagc
     2221 tacacacacg gccctgggca actctcagtc tggccaccca ttcgatgctg ccagccccaa
     2281 gggtgtggga ggggggtctc agagtgtccc agggtactgg ccacacatgc ccgacaccag
     2341 ggtcataagg tcctctcagc agagccactg cagcaccaaa ggcatttctg gaaggaggca
     2401 aggacgcgtc atctagatgt caagccccag cgtgcgattc tgtcacagtt caccccacct
     2461 tcaccccgag acggaagacg gaagagcttc gcacacaggc gggaagaggt caggaccagt
     2521 ccagcctcac tggcttcaga actggcctgg gggctacctt gacccacagg aagggaagag
     2581 gaacgtgctc tgggcagggc aaggcaggac ctgcagcacc cacagaccag cagtaaagga
     2641 cccccggaac tttccaagtc tagcacaaaa cccagaagcc acaaaggaaa atactggcag
     2701 atttaaatgc atgaagtcaa cattcttttt gtagagctaa agaaaccata agcaaaatta
     2761 aaagccaaat gcattctggg aggaaa
//
