LOCUS       NM_021223                612 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens myosin light chain 7 (MYL7), mRNA.
ACCESSION   NM_021223
VERSION     NM_021223.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 612)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 612)
  AUTHORS   Yang,H.Y., Wang,Z.Y., Cao,L.J., Zhao,X.J., Bai,X. and Ruan,C.G.
  TITLE     [Expression and function of non-muscle myosin-IIA in Fechtner
            syndrome]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 16 (4), 871-874 (2008)
   PUBMED   18718080
  REMARK    GeneRIF: Dominant-negative effect of NMMHC-IIA is involved in the
            formation of inclusion bodies in Fechtner syndrome.
REFERENCE   3  (bases 1 to 612)
  AUTHORS   Grimm,M., Haas,P., Willipinski-Stapelfeldt,B., Zimmermann,W.H.,
            Rau,T., Pantel,K., Weyand,M. and Eschenhagen,T.
  TITLE     Key role of myosin light chain (MLC) kinase-mediated MLC2a
            phosphorylation in the alpha 1-adrenergic positive inotropic effect
            in human atrium
  JOURNAL   Cardiovasc Res 65 (1), 211-220 (2005)
   PUBMED   15621049
REFERENCE   4  (bases 1 to 612)
  AUTHORS   Kovacs,M., Wang,F., Hu,A., Zhang,Y. and Sellers,J.R.
  TITLE     Functional divergence of human cytoplasmic myosin II: kinetic
            characterization of the non-muscle IIA isoform
  JOURNAL   J Biol Chem 278 (40), 38132-38140 (2003)
   PUBMED   12847096
  REMARK    GeneRIF: Nonmuscle Myosin Type IIA has distinct enzymatic
            properties that may be of importance in carrying out its cellular
            functions
REFERENCE   5  (bases 1 to 612)
  AUTHORS   Bird,S.D., Doevendans,P.A., van Rooijen,M.A., Brutel de la
            Riviere,A., Hassink,R.J., Passier,R. and Mummery,C.L.
  TITLE     The human adult cardiomyocyte phenotype
  JOURNAL   Cardiovasc Res 58 (2), 423-434 (2003)
   PUBMED   12757876
REFERENCE   6  (bases 1 to 612)
  AUTHORS   Nishigaki,R., Shinohara,T., Toda,T., Omori,A., Ichinose,S.,
            Itoh,M., Shirayoshi,Y., Kurimasa,A. and Oshimura,M.
  TITLE     An extra human chromosome 21 reduces mlc-2a expression in chimeric
            mice and Down syndrome
  JOURNAL   Biochem Biophys Res Commun 295 (1), 112-118 (2002)
   PUBMED   12083776
REFERENCE   7  (bases 1 to 612)
  AUTHORS   Kubalak,S.W., Miller-Hance,W.C., O'Brien,T.X., Dyson,E. and
            Chien,K.R.
  TITLE     Chamber specification of atrial myosin light chain-2 expression
            precedes septation during murine cardiogenesis
  JOURNAL   J Biol Chem 269 (24), 16961-16970 (1994)
   PUBMED   8207020
REFERENCE   8  (bases 1 to 612)
  AUTHORS   Hailstones,D., Barton,P., Chan-Thomas,P., Sasse,S., Sutherland,C.,
            Hardeman,E. and Gunning,P.
  TITLE     Differential regulation of the atrial isoforms of the myosin light
            chains during striated muscle development
  JOURNAL   J Biol Chem 267 (32), 23295-23300 (1992)
   PUBMED   1429676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006454.4, W17098.1 and BC027915.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021223.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP318217.1, BC027915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150585, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223364.7/ ENSP00000223364.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC006454.4         111268-111282
            16-275              W17098.1           2-261
            276-612             BC027915.1         257-593
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..612
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /note="myosin light chain 7"
                     /db_xref="GeneID:58498"
                     /db_xref="HGNC:HGNC:21719"
                     /db_xref="MIM:613993"
     exon            1..30
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..555
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /note="myosin light chain 2a; myosin, light polypeptide 7,
                     regulatory; MLC2a; MLC-2a; myosin regulatory light chain
                     7; myosin, light chain 7, regulatory"
                     /codon_start=1
                     /product="myosin regulatory light chain 2, atrial isoform"
                     /protein_id="NP_067046.1"
                     /db_xref="CCDS:CCDS5478.1"
                     /db_xref="GeneID:58498"
                     /db_xref="HGNC:HGNC:21719"
                     /db_xref="MIM:613993"
                     /translation="MASRKAGTRGKVAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCI
                     DQNRDGIICKADLRETYSQLGKVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTD
                     PEEAILSAFRMFDPSGKGVVNKDEFKQLLLTQADKFSPAEVEQMFALTPMDLAGNIDY
                     KSLCYIITHGDEKEE"
     exon            31..144
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     exon            145..220
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     exon            221..325
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     exon            326..404
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     exon            405..453
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     exon            454..612
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      588..593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /note="hexamer: AATAAA"
     polyA_site      612
                     /gene="MYL7"
                     /gene_synonym="MYL2A; MYLC2A"
                     /note="major polyA site"
ORIGIN      
        1 gacagcagcc acacctctgc agagagaatg gccagcagga aggcggggac ccggggcaag
       61 gtggcagcca ccaagcaggc ccaacgtggt tcttccaacg tcttttccat gtttgaacaa
      121 gcccagatac aggagttcaa agaagccttc agctgtatcg accagaatcg tgatggcatc
      181 atctgcaagg cagacctgag ggagacctac tcccagctgg ggaaggtgag tgtcccagag
      241 gaggagctgg acgccatgct gcaagagggc aagggcccca tcaacttcac cgtcttcctc
      301 acgctctttg gggagaagct caatgggaca gaccccgagg aagccatcct gagtgccttc
      361 cgcatgtttg accccagcgg caaaggggtg gtgaacaagg atgagttcaa gcagcttctc
      421 ctgacccagg cagacaagtt ctctccagct gaggtggagc agatgttcgc cctgacaccc
      481 atggacctgg cggggaacat cgactacaag tcactgtgct acatcatcac ccatggagac
      541 gagaaagagg aatgaggggc agggccaggc ccacgggggg gcacctcaat aaactctgtt
      601 gcaaaattgg aa
//
