LOCUS       NM_002477                940 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens myosin light chain 5 (MYL5), transcript variant 1,
            mRNA.
ACCESSION   NM_002477
VERSION     NM_002477.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 940)
  AUTHORS   Lv,M.
  TITLE     MYL5 as a Novel Prognostic Marker is Associated with Immune
            Infiltrating in Breast Cancer: A Preliminary Study
  JOURNAL   Breast J 2023, 9508632 (2023)
   PUBMED   36846347
  REMARK    GeneRIF: MYL5 as a Novel Prognostic Marker is Associated with
            Immune Infiltrating in Breast Cancer: A Preliminary Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 940)
  AUTHORS   Joslyn,G., Ravindranathan,A., Brush,G., Schuckit,M. and White,R.L.
  TITLE     Human variation in alcohol response is influenced by variation in
            neuronal signaling genes
  JOURNAL   Alcohol Clin Exp Res 34 (5), 800-812 (2010)
   PUBMED   20201926
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 940)
  AUTHORS   Sellers,J.R.
  TITLE     Myosins: a diverse superfamily
  JOURNAL   Biochim Biophys Acta 1496 (1), 3-22 (2000)
   PUBMED   10722873
  REMARK    Review article
REFERENCE   4  (bases 1 to 940)
  AUTHORS   Collins,C., Schappert,K. and Hayden,M.R.
  TITLE     The genomic organization of a novel regulatory myosin light chain
            gene (MYL5) that maps to chromosome 4p16.3 and shows different
            patterns of expression between primates
  JOURNAL   Hum Mol Genet 1 (9), 727-733 (1992)
   PUBMED   1284596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107464.5.
            
            On Jul 9, 2021 this sequence version replaced NM_002477.1.
            
            Summary: This gene encodes one of the myosin light chains, a
            component of the hexameric ATPase cellular motor protein myosin.
            Myosin is composed of two heavy chains, two nonphosphorylatable
            alkali light chains, and two phosphorylatable regulatory light
            chains. This gene product, one of the regulatory light chains, is
            expressed in fetal muscle and in adult retina, cerebellum, and
            basal ganglia. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2435536.1,
                                           SRR18074968.1225846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400159.7/ ENSP00000383023.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC107464.5         66110-66251
            143-279             AC107464.5         67641-67777
            280-387             AC107464.5         69490-69597
            388-495             AC107464.5         70226-70333
            496-571             AC107464.5         70526-70601
            572-676             AC107464.5         71482-71586
            677-755             AC107464.5         72077-72155
            756-804             AC107464.5         72660-72708
            805-940             AC107464.5         73461-73596
FEATURES             Location/Qualifiers
     source          1..940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..940
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /note="myosin light chain 5"
                     /db_xref="GeneID:4636"
                     /db_xref="HGNC:HGNC:7586"
                     /db_xref="MIM:160782"
     exon            1..142
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..279
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..387
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..906
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin, light polypeptide 5, regulatory; superfast myosin
                     regulatory light chain 2; myosin regulatory light chain 5;
                     myosin, light chain 5, regulatory"
                     /codon_start=1
                     /product="myosin light chain 5 isoform 1"
                     /protein_id="NP_002468.1"
                     /db_xref="CCDS:CCDS43197.1"
                     /db_xref="GeneID:4636"
                     /db_xref="HGNC:HGNC:7586"
                     /db_xref="MIM:160782"
                     /translation="MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQ
                     NRDGFIDKEDLKDTYASLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAE
                     ETILNAFKMLDPDGKGKINKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKA
                     LSYVITHGEEKEE"
     exon            388..495
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..571
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..676
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..755
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..804
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..940
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /note="hexamer: AATAAA"
     polyA_site      940
                     /gene="MYL5"
                     /gene_synonym="MYLC2"
                     /note="major polyA site"
ORIGIN      
        1 ctttccccgc agggctgggg gtccgctgtt tccccgcgct gctgccgagg ccccgccgtc
       61 cgcgtcctgg ccgtgtgtcc acaccccaga ctgcgggccg gggcgcactc tgtcttcttg
      121 cgcggagcgt cggaggcctg agggggccag aagcaaactc cagccctccc cgtgtctact
      181 gctcgctgag gaagccgcag gtgcacactg gatccacaag gcacagaacc atcttggccc
      241 tcggcaagcc cccgcttccg ccagggcaga cggcctcagg gagtggcagc cggagtctga
      301 actgtcctgg gggaccaagc aggagcttaa gatgggcaag acctggggcc ctgggcagac
      361 gcatcaaagc aggcagaagc aggcatggcc agcaggaaga ccaagaagaa ggaagggggt
      421 gccctccggg cccagagagc ctcatccaat gtcttctcca actttgagca gactcagatc
      481 caggagttca aggaggcatt cacactcatg gatcagaacc gagatggctt cattgacaag
      541 gaggacctga aggacaccta tgcctccctg ggcaagacca acgtcaagga cgacgagctg
      601 gacgccatgc tcaaagaggc ctcggggccc atcaacttca ccatgtttct gaacctgttt
      661 ggggagaagc tgagcggtac cgacgccgag gagaccattc ttaacgcctt caagatgctg
      721 gacccggacg ggaaagggaa aatcaacaag gagtacatca agcgtctgct gatgtcccag
      781 gctgacaaga tgacggcgga agaggtggac cagatgttcc agttcgcctc catcgatgtg
      841 gcgggcaacc tggactacaa ggcgctcagc tacgtgatca cccacgggga ggagaaggag
      901 gagtgagacc cagccgggtc aataaacctg gacgcttgga
//
