LOCUS       NM_138403               1004 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myosin light chain 10 (MYL10), mRNA.
ACCESSION   NM_138403
VERSION     NM_138403.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1004)
  AUTHORS   Ji,Y., Schaid,D.J., Desta,Z., Kubo,M., Batzler,A.J., Snyder,K.,
            Mushiroda,T., Kamatani,N., Ogburn,E., Hall-Flavin,D., Flockhart,D.,
            Nakamura,Y., Mrazek,D.A. and Weinshilboum,R.M.
  TITLE     Citalopram and escitalopram plasma drug and metabolite
            concentrations: genome-wide associations
  JOURNAL   Br J Clin Pharmacol 78 (2), 373-383 (2014)
   PUBMED   24528284
REFERENCE   3  (bases 1 to 1004)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1004)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   5  (bases 1 to 1004)
  AUTHORS   Oltz,E.M., Yancopoulos,G.D., Morrow,M.A., Rolink,A., Lee,G.,
            Wong,F., Kaplan,K., Gillis,S., Melchers,F. and Alt,F.W.
  TITLE     A novel regulatory myosin light chain gene distinguishes pre-B cell
            subsets and is IL-7 inducible
  JOURNAL   EMBO J 11 (7), 2759-2767 (1992)
   PUBMED   1628631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC002778.2 and AC004953.2.
            
            On May 17, 2019 this sequence version replaced NM_138403.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002778.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2161674 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223167.5/ ENSP00000223167.4
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BC002778.2         1-111
            112-112             AC004953.2         82847-82847         c
            113-780             BC002778.2         113-780
            781-781             AC004953.2         67215-67215         c
            782-1004            BC002778.2         782-1004
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1004
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /note="myosin light chain 10"
                     /db_xref="GeneID:93408"
                     /db_xref="HGNC:HGNC:29825"
                     /db_xref="MIM:617177"
     exon            1..256
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..859
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /note="myosin light chain 2, precursor
                     lymphocyte-specific; myosin, light chain 10, regulatory;
                     myosin light chain 2, lymphocyte-specific; precursor
                     lymphocyte-specific regulatory light chain"
                     /codon_start=1
                     /product="myosin regulatory light chain 10"
                     /protein_id="NP_612412.2"
                     /db_xref="CCDS:CCDS34713.1"
                     /db_xref="GeneID:93408"
                     /db_xref="HGNC:HGNC:29825"
                     /db_xref="MIM:617177"
                     /translation="MLLRLVSNSWPQVILPPRPPKVLGLQAPRRARKRAEGTASSNVF
                     SMFDQSQIQEFKESLALSPRLERNGMISAHCNLCLTGSSNSPASASQAFTIMDQNRDG
                     FIDKEDLRDTFAALGRINVKNEELEAMVKEAPGPINFTVFLTMFGEKLKGTDPEETIL
                     HAFKVFDTEGKGFVKADVIKEKLMTQADRFSEEEVKQMFAAFPPDVCGNLDYRNLCYV
                     ITHGEEKD"
     exon            257..349
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            350..451
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            452..527
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            528..632
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            633..711
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            712..760
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1004
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /note="hexamer: AATAAA"
     polyA_site      1004
                     /gene="MYL10"
                     /gene_synonym="MYLC2PL; PLRLC"
                     /note="major polyA site"
ORIGIN      
        1 ccatagcctg cctgtctgca tggtccgcct agaggtttga gcagctgggc atggaagaag
       61 cgagccacac ccccatcgca tgccctatga acgggataag ggaacttttt cacttcacca
      121 ctatgcctga ctaatttttt aattaaaaaa aatttttttg tagaaacaga gtttcaccat
      181 gttgcttagg ctggtctcaa actcctggcc tcaagtgatc ctccctcctc ggcctcccaa
      241 agtgctggga ttacaggcac cgagaagagc tcggaaaaga gcagaaggca ccgccagctc
      301 caacgtcttc tccatgtttg atcagtccca gatccaggag tttaaagaga gtctggctct
      361 gtcgcccagg ctggagcgca atggcatgat ctcggctcac tgcaacctct gcctcacggg
      421 ttcaagcaat tctcctgcct cagcctccca agctttcacc atcatggacc agaaccgtga
      481 tggcttcatc gacaaagagg acttgaggga cacctttgcc gcgctgggcc gcatcaatgt
      541 caagaacgag gaactggagg ccatggtgaa ggaggccccc ggacccatca acttcacggt
      601 gttcctgacc atgtttgggg agaagctgaa gggcacggac ccagaggaga ccattctcca
      661 cgccttcaaa gtgttcgaca ctgaagggaa aggtttcgtc aaggccgatg tcatcaaaga
      721 aaaacttatg acccaggcag accgcttcag tgaggaggag gtcaagcaga tgtttgcagc
      781 atttccccca gatgtgtgcg gcaacctgga ctacagaaac ctgtgctacg tcatcactca
      841 cggtgaagag aaggattagg ggatcacaag tctccccgac attcaggggc agcaaacact
      901 gttgtggggt gtgacaggga gctcttgcag ccagaggctg caggaaaaag gcttcccttg
      961 tcctacggtt ggggacaaag caagaataaa taatgctaat gagg
//
