LOCUS       NM_002473               7451 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens myosin heavy chain 9 (MYH9), mRNA.
ACCESSION   NM_002473
VERSION     NM_002473.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7451)
  AUTHORS   Wang,F., Suo,X.G., Wang,J.N., Liu,C.Y., Liu,C.C., Wang,C., Li,J.,
            Duan,Z.H., Zhang,F.S., Xia,Y.M., Jiang,J.J., Hao,Y.W., Li,G.Y.,
            Meng,X.M., Shao,Y.X. and Wang,F.C.
  TITLE     SFN promotes renal fibrosis via binding with MYH9 in chronic kidney
            disease
  JOURNAL   Eur J Pharmacol 979, 176806 (2024)
   PUBMED   38986830
  REMARK    GeneRIF: SFN promotes renal fibrosis via binding with MYH9 in
            chronic kidney disease.
REFERENCE   2  (bases 1 to 7451)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   3  (bases 1 to 7451)
  AUTHORS   Chang,F., Wang,L., Kim,Y., Kim,M., Lee,S. and Lee,S.W.
  TITLE     The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility
            in Acute Myeloid Leukemia Cells through Expressional Regulation of
            Non-Muscle Myosin Heavy Chain IIA
  JOURNAL   Int J Mol Sci 25 (15), 8147 (2024)
   PUBMED   39125717
  REMARK    GeneRIF: The Aryl Hydrocarbon Receptor Regulates Invasiveness and
            Motility in Acute Myeloid Leukemia Cells through Expressional
            Regulation of Non-Muscle Myosin Heavy Chain IIA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7451)
  AUTHORS   Garlapati,C., Joshi,S., Yang,C., Chandrashekar,D.S., Rida,P. and
            Aneja,R.
  TITLE     A novel role for KIFC1-MYH9 interaction in triple-negative breast
            cancer aggressiveness and racial disparity
  JOURNAL   Cell Commun Signal 22 (1), 312 (2024)
   PUBMED   38902769
  REMARK    GeneRIF: A novel role for KIFC1-MYH9 interaction in triple-negative
            breast cancer aggressiveness and racial disparity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7451)
  AUTHORS   Savoia,A. and Pecci,A.
  TITLE     MYH9-Related Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301740
REFERENCE   6  (bases 1 to 7451)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   7  (bases 1 to 7451)
  AUTHORS   Toothaker,L.E., Gonzalez,D.A., Tung,N., Lemons,R.S., Le Beau,M.M.,
            Arnaout,M.A., Clayton,L.K. and Tenen,D.G.
  TITLE     Cellular myosin heavy chain in human leukocytes: isolation of 5'
            cDNA clones, characterization of the protein, chromosomal
            localization, and upregulation during myeloid differentiation
  JOURNAL   Blood 78 (7), 1826-1833 (1991)
   PUBMED   1912569
REFERENCE   8  (bases 1 to 7451)
  AUTHORS   Simons,M., Wang,M., McBride,O.W., Kawamoto,S., Yamakawa,K.,
            Gdula,D., Adelstein,R.S. and Weir,L.
  TITLE     Human nonmuscle myosin heavy chains are encoded by two genes
            located on different chromosomes
  JOURNAL   Circ Res 69 (2), 530-539 (1991)
   PUBMED   1860190
REFERENCE   9  (bases 1 to 7451)
  AUTHORS   Saez,C.G., Myers,J.C., Shows,T.B. and Leinwand,L.A.
  TITLE     Human nonmuscle myosin heavy chain mRNA: generation of diversity
            through alternative polyadenylylation
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1164-1168 (1990)
   PUBMED   1967836
REFERENCE   10 (bases 1 to 7451)
  AUTHORS   Starr,R. and Offer,G.
  TITLE     The interaction of C-protein with heavy meromyosin and
            subfragment-2
  JOURNAL   Biochem J 171 (3), 813-816 (1978)
   PUBMED   352343
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB191263.1, Z82215.1 and
            AA420536.1.
            
            On Dec 4, 2019 this sequence version replaced NM_002473.5.
            
            Summary: This gene encodes a conventional non-muscle myosin; this
            protein should not be confused with the unconventional myosin-9a or
            9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy
            chain that contains an IQ domain and a myosin head-like domain
            which is involved in several important functions, including
            cytokinesis, cell motility and maintenance of cell shape. Defects
            in this gene have been associated with non-syndromic sensorineural
            deafness autosomal dominant type 17, Epstein syndrome, Alport
            syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner
            syndrome and macrothrombocytopenia with progressive sensorineural
            deafness. [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB191263.1, AB290175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216181.11/ ENSP00000216181.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3608              AB191263.1         1-3608
            3609-3609           Z82215.1           63857-63857         c
            3610-6658           AB191263.1         3610-6658
            6659-6659           Z82215.1           50368-50368         c
            6660-7450           AB191263.1         6660-7450
            7451-7451           AA420536.1         484-484
FEATURES             Location/Qualifiers
     source          1..7451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..7451
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /note="myosin heavy chain 9"
                     /db_xref="GeneID:4627"
                     /db_xref="HGNC:HGNC:7579"
                     /db_xref="MIM:160775"
     exon            1..161
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            162..513
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..6063
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /note="nonmuscle myosin heavy chain II-A; cellular myosin
                     heavy chain, type A; non-muscle myosin heavy chain 9;
                     myosin, heavy chain 9, non-muscle; non-muscle myosin heavy
                     polypeptide 9; non-muscle myosin heavy chain A; non-muscle
                     myosin heavy chain IIa; nonmuscle myosin IIA2"
                     /codon_start=1
                     /product="myosin-9"
                     /protein_id="NP_002464.1"
                     /db_xref="CCDS:CCDS13927.1"
                     /db_xref="GeneID:4627"
                     /db_xref="HGNC:HGNC:7579"
                     /db_xref="MIM:160775"
                     /translation="MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPA
                     SLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLK
                     ERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRS
                     MMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPIL
                     EAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHI
                     FYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEE
                     EQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTP
                     RIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGI
                     LDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDL
                     QPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKA
                     DFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQV
                     AGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGK
                     LDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQAC
                     VLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKA
                     FAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVK
                     VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE
                     EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK
                     LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT
                     DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA
                     LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT
                     ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ
                     LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN
                     EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE
                     NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG
                     CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA
                     CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE
                     LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE
                     DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVA
                     ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA
                     KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR
                     LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE
                     RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK
                     KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL
                     EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKP
                     AE"
     exon            514..670
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            671..698
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            699..792
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..885
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            886..949
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1048
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1288
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1407
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1560
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1734
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1908
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2023
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2217
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2339
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2409
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2570
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2679
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2811
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3018
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3156
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3280
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3452
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3665
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3810
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..4017
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4122
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..4275
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4524
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4737
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4950
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4951..5112
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5113..5241
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5242..5330
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5331..5454
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5455..5663
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5772
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5773..5945
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            5946..7451
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7067..7072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /note="hexamer: AATAAA"
     polyA_site      7086
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
     regulatory      7431..7436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /note="hexamer: AATAAA"
     polyA_site      7451
                     /gene="MYH9"
                     /gene_synonym="BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA;
                     NMHC-II-A; NMMHC-IIA; NMMHCA"
                     /note="major polyA site"
ORIGIN      
        1 gcagatcacc gcggttcctg ggcagggcac ggaaggctaa gcaaggctga cctgctgcag
       61 ctcccgcctc gtgcgctcgc cccacccggc cgccgcccga gcgctcgaga aagtcctctc
      121 gggagaagca gcgcctgttc ccggggcaga tccaggttca ggtcctggct ataagtcacc
      181 atggcacagc aagctgccga taagtatctc tatgtggata aaaacttcat caacaatccg
      241 ctggcccagg ccgactgggc tgccaagaag ctggtatggg tgccttccga caagagtggc
      301 tttgagccag ccagcctcaa ggaggaggtg ggcgaagagg ccatcgtgga gctggtggag
      361 aatgggaaga aggtgaaggt gaacaaggat gacatccaga agatgaaccc gcccaagttc
      421 tccaaggtgg aggacatggc agagctcacg tgcctcaacg aagcctcggt gctgcacaac
      481 ctcaaggagc gttactactc agggctcatc tacacctatt caggcctgtt ctgtgtggtc
      541 atcaatcctt acaagaacct gcccatctac tctgaagaga ttgtggaaat gtacaagggc
      601 aagaagaggc acgagatgcc ccctcacatc tatgccatca cagacaccgc ctacaggagt
      661 atgatgcaag accgagaaga tcaatccatc ttgtgcactg gtgaatctgg agctggcaag
      721 acggagaaca ccaagaaggt catccagtat ctggcgtacg tggcgtcctc gcacaagagc
      781 aagaaggacc agggcgagct ggagcggcag ctgctgcagg ccaaccccat cctggaggcc
      841 ttcgggaacg ccaagaccgt gaagaatgac aactcctccc gcttcggcaa attcattcgc
      901 atcaactttg atgtcaatgg ctacattgtt ggagccaaca ttgagactta tcttttggag
      961 aaatctcgtg ctatccgcca agccaaggaa gaacggacct tccacatctt ctattatctc
     1021 ctgtctgggg ctggagagca cctgaagacc gatctcctgt tggagccgta caacaaatac
     1081 cgcttcctgt ccaatggaca cgtcaccatc cccgggcagc aggacaagga catgttccag
     1141 gagaccatgg aggccatgag gattatgggc atcccagaag aggagcaaat gggcctgctg
     1201 cgggtcatct caggggttct tcagctcggc aacatcgtct tcaagaagga gcggaacact
     1261 gaccaggcgt ccatgcccga caacacagct gcccaaaagg tgtcccatct cttgggtatc
     1321 aatgtgaccg atttcaccag aggaatcctc accccgcgca tcaaggtggg acgggattac
     1381 gtccagaagg cgcagactaa agagcaggct gactttgcca tcgaggcctt ggccaaggcg
     1441 acctatgagc ggatgttccg ctggctggtg ctgcgcatca acaaggctct ggacaagacc
     1501 aagaggcagg gcgcctcctt catcgggatc ctggacattg ccggcttcga gatctttgat
     1561 ctgaactcgt ttgagcagct gtgcatcaat tacaccaatg agaagctgca gcagctcttc
     1621 aaccacacca tgttcatcct ggagcaggag gagtaccagc gcgagggcat cgagtggaac
     1681 ttcatcgact ttggcctcga cctgcagccc tgcatcgacc tcattgagaa gccagcaggc
     1741 cccccgggca ttctggccct gctggacgag gagtgctggt tccccaaagc caccgacaag
     1801 agcttcgtgg agaaggtgat gcaggagcag ggcacccacc ccaagttcca gaagcccaag
     1861 cagctgaagg acaaagctga tttctgcatt atccactatg ccggcaaggt ggattacaaa
     1921 gctgacgagt ggctgatgaa gaacatggat cccctgaatg acaacatcgc cacactgctc
     1981 caccagtcct ctgacaagtt tgtctcggag ctgtggaagg atgtggaccg catcatcggc
     2041 ctggaccagg tggccggcat gtcggagacc gcactgcccg gggccttcaa gacgcggaag
     2101 ggcatgttcc gcactgtggg gcagctttac aaggagcagc tggccaagct gatggctacg
     2161 ctgaggaaca cgaaccccaa ctttgtccgc tgcatcatcc ccaaccacga gaagaaggcc
     2221 ggcaagctgg acccgcatct cgtgctggac cagctgcgct gcaacggtgt tctcgagggc
     2281 atccgtatct gccgccaggg cttccccaac agggtggtct tccaggagtt tcggcagaga
     2341 tatgagatcc tgactccaaa ctccattccc aagggtttca tggacgggaa gcaggcgtgc
     2401 gtgctcatga taaaagccct ggagctcgac agcaatctgt accgcattgg ccagagcaaa
     2461 gtcttcttcc gtgccggtgt gctggcccac ctggaggagg agcgagacct gaagatcacc
     2521 gacgtcatca tagggttcca ggcctgctgc aggggctacc tggccaggaa agcatttgcc
     2581 aagcggcagc agcagcttac cgccatgaag gtcctccagc ggaactgcgc tgcctacctg
     2641 aagctgcgga actggcagtg gtggcggctc ttcaccaagg tcaagccgct gctgcaggtg
     2701 agccggcagg aggaggagat gatggccaag gaggaggagc tggtgaaggt cagagagaag
     2761 cagctggctg cggagaacag gctcacggag atggagacgc tgcagtctca gctcatggca
     2821 gagaaattgc agctgcagga gcagctccag gcagaaaccg agctgtgtgc cgaggctgag
     2881 gagctccggg cccgcctgac cgccaagaag caggaattag aagagatctg ccatgaccta
     2941 gaggccaggg tggaggagga ggaggagcgc tgccagcacc tgcaggcgga gaagaagaag
     3001 atgcagcaga acatccagga gcttgaggag cagctggagg aggaggagag cgcccggcag
     3061 aagctgcagc tggagaaggt gaccaccgag gcgaagctga aaaagctgga ggaggagcag
     3121 atcatcctgg aggaccagaa ctgcaagctg gccaaggaaa agaaactgct ggaagacaga
     3181 atagctgagt tcaccaccaa cctcacagaa gaggaggaga aatctaagag cctcgccaag
     3241 ctcaagaaca agcatgaggc aatgatcact gacttggaag agcgcctccg cagggaggag
     3301 aagcagcgac aggagctgga gaagacccgc cggaagctgg agggagactc cacagacctc
     3361 agcgaccaga tcgccgagct ccaggcccag atcgcggagc tcaagatgca gctggccaag
     3421 aaagaggagg agctccaggc cgccctggcc agagtggaag aggaagctgc ccagaagaac
     3481 atggccctca agaagatccg ggagctggaa tctcagatct ctgaactcca ggaagacctg
     3541 gagtctgagc gtgcttccag gaataaagct gagaagcaga aacgggacct tggggaagag
     3601 ctagaggctc tgaaaacaga gttggaggac acgctggatt ccacagctgc ccagcaggag
     3661 ctcaggtcaa aacgtgagca ggaggtgaac atcctgaaga agaccctgga ggaggaggcc
     3721 aagacccacg aggcccagat ccaggagatg aggcagaagc actcacaggc cgtggaggag
     3781 ctggcggagc agctggagca gacgaagcgg gtgaaagcaa acctcgagaa ggcaaagcag
     3841 actctggaga acgagcgggg ggagctggcc aacgaggtga aggtgctgct gcagggcaaa
     3901 ggggactcgg agcacaagcg caagaaagtg gaggcgcagc tgcaggagct gcaggtcaag
     3961 ttcaacgagg gagagcgcgt gcgcacagag ctggccgaca aggtcaccaa gctgcaggtg
     4021 gagctggaca acgtgaccgg gcttctcagc cagtccgaca gcaagtccag caagctcacc
     4081 aaggacttct ccgcgctgga gtcccagctg caggacactc aggagctgct gcaggaggag
     4141 aaccggcaga agctgagcct gagcaccaag ctcaagcagg tggaggacga gaagaattcc
     4201 ttccgggagc agctggagga ggaggaggag gccaagcaca acctggagaa gcagatcgcc
     4261 accctccatg cccaggtggc cgacatgaaa aagaagatgg aggacagtgt ggggtgcctg
     4321 gaaactgctg aggaggtgaa gaggaagctc cagaaggacc tggagggcct gagccagcgg
     4381 cacgaggaga aggtggccgc ctacgacaag ctggagaaga ccaagacgcg gctgcagcag
     4441 gagctggacg acctgctggt ggacctggac caccagcgcc agagcgcgtg caacctggag
     4501 aagaagcaga agaagtttga ccagctcctg gcggaggaga agaccatctc tgccaagtat
     4561 gcagaggagc gcgaccgggc tgaggcggag gcccgagaga aggagaccaa ggctctgtcg
     4621 ctggcccggg ccctggagga agccatggag cagaaggcgg agctggagcg gctcaacaag
     4681 cagttccgca cggagatgga ggaccttatg agctccaagg atgatgtggg caagagtgtc
     4741 cacgagctgg agaagtccaa gcgggcccta gagcagcagg tggaggagat gaagacgcag
     4801 ctggaagagc tggaggacga gctgcaggcc accgaagatg ccaagctgcg gttggaggtc
     4861 aacctgcagg ccatgaaggc ccagttcgag cgggacctgc agggccggga cgagcagagc
     4921 gaggagaaga agaagcagct ggtcagacag gtgcgggaga tggaggcaga gctggaggac
     4981 gagaggaagc agcgctcgat ggcagtggcc gcccggaaga agctggagat ggacctgaag
     5041 gacctggagg cgcacatcga ctcggccaac aagaaccggg acgaagccat caaacagctg
     5101 cggaagctgc aggcccagat gaaggactgc atgcgcgagc tggatgacac ccgcgcctct
     5161 cgtgaggaga tcctggccca ggccaaagag aacgagaaga agctgaagag catggaggcc
     5221 gagatgatcc agttgcagga ggaactggca gccgcggagc gtgccaagcg ccaggcccag
     5281 caggagcggg atgagctggc tgacgagatc gccaacagca gcggcaaagg agccctggcg
     5341 ttagaggaga agcggcgtct ggaggcccgc atcgcccagc tggaggagga gctggaggag
     5401 gagcagggca acacggagct gatcaacgac cggctgaaga aggccaacct gcagatcgac
     5461 cagatcaaca ccgacctgaa cctggagcgc agccacgccc agaagaacga gaatgctcgg
     5521 cagcagctgg aacgccagaa caaggagctt aaggtcaagc tgcaggagat ggagggcact
     5581 gtcaagtcca agtacaaggc ctccatcacc gccctcgagg ccaagattgc acagctggag
     5641 gagcagctgg acaacgagac caaggagcgc caggcagcct gcaaacaggt gcgtcggacc
     5701 gagaagaagc tgaaggatgt gctgctgcag gtggatgacg agcggaggaa cgccgagcag
     5761 tacaaggacc aggccgacaa ggcatctacc cgcctgaagc agctcaagcg gcagctggag
     5821 gaggccgaag aggaggccca gcgggccaac gcctcccgcc ggaaactgca gcgcgagctg
     5881 gaggacgcca ctgagacggc cgatgccatg aaccgcgaag tcagctccct aaagaacaag
     5941 ctcaggcgcg gggacctgcc gtttgtcgtg ccccgccgaa tggcccggaa aggcgccggg
     6001 gatggctccg acgaagaggt agatggcaaa gcggatgggg ctgaggccaa acctgccgaa
     6061 taagcctctt ctcctgcagc ctgagatgga tggacagaca gacaccacag cctccccttc
     6121 ccagaccccg cagcacgcct ctccccacct tcttgggact gctgtgaaca tgcctcctcc
     6181 tgccctccgc cccgtccccc catcccgttt ccctccaggt gttgttgagg gcatttggct
     6241 tcctctgctg catccccttc cagctccctc ccctgctcag aatctgatac caaagagaca
     6301 gggcccgggc ccaggcagag agcgaccagc aggctcctca gccctctctt gccaaaaagc
     6361 acaagatgtt gaggcgagca gggcaggccc ccggggaggg gccagagttt tctatgaatc
     6421 tatttttctt cagactgagg ccttttggta gtcggagccc ccgcagtcgt cagcctccct
     6481 gacgtctgcc accagcgccc ccactcctcc tcctttcttt gctgtttgca atcacacgtg
     6541 gtgacctcac acacctctgc cccttgggcc tcccactccc atggctctgg gcggtccaga
     6601 aggagcaggc cctgggcctc cacctctgtg cagggcacag aaggctgggg tggggggagg
     6661 agtggattcc tccccaccct gtcccaggca gcgccactgt ccgctgtctc cctcctgatt
     6721 ctaaaatgtc tcaagtgcaa tgccccctcc cctcctttac cgaggacagc ctgcctctgc
     6781 cacagcaagg ctgtcggggt caagctggaa aggccagcag ccttccagtg gcttctccca
     6841 acactcttgg ggaccaaata tatttaatgg ttaagggact tgtcccaagt ctgacagcca
     6901 gagcgttaga ggggccagcg gccctcccag gcgatcttgt gtctactcta ggactgggcc
     6961 cgagggtggt ttacctgcac cgttgactca gtatagttta aaaatctgcc acctgcacag
     7021 gtatttttga aagcaaaata aggttttctt ttttcccctt tcttgtaata aatgataaaa
     7081 ttccgagtct ttctcactgc ctttgtttag aagagagtag ctcgtcctca ctggtctaca
     7141 ctggttgccg aatttacttg tattcctaac tgttttgtat atgctgcatt gagacttacg
     7201 gcaagaaggc attttttttt tttaaaggaa acaaactctc aaatcatgaa gtgatataaa
     7261 agctgcatat gcctacaaag ctctgaattc aggtcccagt tgctgtcaca aaggagtgag
     7321 tgaaactccc accctacccc cttttttata taataaaagt gccttagcat gtgttgcagc
     7381 tgtcaccact acagtaagct ggtttacaga tgttttccac tgagcatcac aataaagaga
     7441 accatgtgct a
//
