LOCUS       NM_002472               6041 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myosin heavy chain 8 (MYH8), mRNA.
ACCESSION   NM_002472
VERSION     NM_002472.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6041)
  AUTHORS   Deguchi,H., Shukla,M., Hayat,M., Torkamani,A., Elias,D.J. and
            Griffin,J.H.
  TITLE     Novel exomic rare variants associated with venous thrombosis
  JOURNAL   Br J Haematol 190 (5), 783-786 (2020)
   PUBMED   32232851
  REMARK    GeneRIF: Novel exomic rare variants associated with venous
            thrombosis.
REFERENCE   2  (bases 1 to 6041)
  AUTHORS   Park,H., Kim,D., Kim,D., Park,J., Koh,Y. and Yoon,S.S.
  TITLE     Truncation of MYH8 tail in AML: a novel prognostic marker with
            increase cell migration and epithelial-mesenchymal transition
            utilizing RAF/MAPK pathway
  JOURNAL   Carcinogenesis 41 (6), 817-827 (2020)
   PUBMED   31430364
  REMARK    GeneRIF: Truncation of MYH8 tail in AML: a novel prognostic marker
            with increase cell migration and epithelial-mesenchymal transition
            utilizing RAF/MAPK pathway.
REFERENCE   3  (bases 1 to 6041)
  AUTHORS   Lou,J., Zou,Y., Luo,Y., Zhang,Z.Y., Liu,F.Y., Tan,J., Zeng,X.,
            Wan,L. and Huang,O.P.
  TITLE     Novel MYH8 mutations in 152 Han Chinese samples with ovarian
            endometriosis
  JOURNAL   Gynecol Endocrinol 36 (7), 632-635 (2020)
   PUBMED   32308057
  REMARK    GeneRIF: Novel MYH8 mutations in 152 Han Chinese samples with
            ovarian endometriosis.
REFERENCE   4  (bases 1 to 6041)
  AUTHORS   Andersen,J.L. and Gruschy-Knudsen,T.
  TITLE     Rapid switch-off of the human myosin heavy chain IIX gene after
            heavy load muscle contractions is sustained for at least four days
  JOURNAL   Scand J Med Sci Sports 28 (2), 371-380 (2018)
   PUBMED   28508505
  REMARK    GeneRIF: There was an immediate shutdown of the MHC IIX gene after
            resistance exercise. Silencing of the MHC IIX gene is sustained at
            least 4 days after removal of the stimulus.
REFERENCE   5  (bases 1 to 6041)
  AUTHORS   Jullian,E.H., Kelly,A.M., Pompidou,A.J., Hoffman,R., Schiaffino,S.,
            Stedman,H.H. and Rubinstein,N.A.
  TITLE     Characterization of a human perinatal myosin heavy-chain transcript
  JOURNAL   Eur J Biochem 230 (3), 1001-1006 (1995)
   PUBMED   7601129
REFERENCE   6  (bases 1 to 6041)
  AUTHORS   Soussi-Yanicostas,N., Whalen,R.G. and Petit,C.
  TITLE     Five skeletal myosin heavy chain genes are organized as a multigene
            complex in the human genome
  JOURNAL   Hum Mol Genet 2 (5), 563-569 (1993)
   PUBMED   8518795
REFERENCE   7  (bases 1 to 6041)
  AUTHORS   Bober,E., Lyons,G.E., Braun,T., Cossu,G., Buckingham,M. and
            Arnold,H.H.
  TITLE     The muscle regulatory gene, Myf-6, has a biphasic pattern of
            expression during early mouse development
  JOURNAL   J Cell Biol 113 (6), 1255-1265 (1991)
   PUBMED   2045411
REFERENCE   8  (bases 1 to 6041)
  AUTHORS   Karsch-Mizrachi,I., Feghali,R., Shows,T.B. and Leinwand,L.A.
  TITLE     Generation of a full-length human perinatal myosin
            heavy-chain-encoding cDNA
  JOURNAL   Gene 89 (2), 289-294 (1990)
   PUBMED   2373371
REFERENCE   9  (bases 1 to 6041)
  AUTHORS   Bober,E., Buchberger-Seidl,A., Braun,T., Singh,S., Goedde,H.W. and
            Arnold,H.H.
  TITLE     Identification of three developmentally controlled isoforms of
            human myosin heavy chains
  JOURNAL   Eur J Biochem 189 (1), 55-65 (1990)
   PUBMED   1691980
REFERENCE   10 (bases 1 to 6041)
  AUTHORS   Feghali,R. and Leinwand,L.A.
  TITLE     Molecular genetic characterization of a developmentally regulated
            human perinatal myosin heavy chain
  JOURNAL   J Cell Biol 108 (5), 1791-1797 (1989)
   PUBMED   2715179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB142109.1, M36769.1,
            AC005323.1, Z38133.1 and AC005291.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002472.2.
            
            Summary: Myosins are actin-based motor proteins that function in
            the generation of mechanical force in eukaryotic cells. Muscle
            myosins are heterohexamers composed of 2 myosin heavy chains and 2
            pairs of nonidentical myosin light chains. This gene encodes a
            member of the class II or conventional myosin heavy chains, and
            functions in skeletal muscle contraction. This gene is
            predominantly expressed in fetal skeletal muscle. This gene is
            found in a cluster of myosin heavy chain genes on chromosome 17. A
            mutation in this gene results in trismus-pseudocamptodactyly
            syndrome. [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M36769.1, Z38133.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968968,
                                    SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403437.2/ ENSP00000384330.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               DB142109.1         1-417
            418-808             M36769.1           396-786
            809-809             AC005323.1         7723-7723           c
            810-5834            Z38133.1           788-5812
            5835-6038           M36769.1           5813-6016
            6039-6041           AC005291.1         179308-179310       c
FEATURES             Location/Qualifiers
     source          1..6041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6041
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /note="myosin heavy chain 8"
                     /db_xref="GeneID:4626"
                     /db_xref="HGNC:HGNC:7578"
                     /db_xref="MIM:160741"
     exon            1..21
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            22..65
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            66..305
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..5909
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /note="myosin, heavy polypeptide 8, skeletal muscle,
                     perinatal; fetal-myosin heavy chain; myHC-perinatal;
                     myosin heavy chain, skeletal muscle, perinatal; myosin,
                     heavy chain 8, skeletal muscle, perinatal"
                     /codon_start=1
                     /product="myosin-8"
                     /protein_id="NP_002463.2"
                     /db_xref="CCDS:CCDS11153.1"
                     /db_xref="GeneID:4626"
                     /db_xref="HGNC:HGNC:7578"
                     /db_xref="MIM:160741"
                     /translation="MSASSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAE
                     PKESYVKSTIQSKEGGKVTVKTEGGATLTVREDQVFPMNPPKYDKIEDMAMMTHLHEP
                     GVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSI
                     SDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRV
                     TFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMA
                     TDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQS
                     LNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANF
                     QKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLF
                     STYASAEADSSAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETK
                     TPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFID
                     SKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGF
                     LMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK
                     EEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN
                     KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH
                     ATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKL
                     EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF
                     EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSREL
                     EEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA
                     ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL
                     KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH
                     QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY
                     ETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE
                     RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEES
                     LDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA
                     SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS
                     RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE
                     DLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL
                     INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER
                     MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG
                     LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR
                     KLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE"
     exon            306..449
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            450..606
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            607..634
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            635..743
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            744..836
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            837..900
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            901..999
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1103
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1242
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1361
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1511
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1682
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1992
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2060
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2148
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2266
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2390
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2527
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2783
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3026
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3203
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3349
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3440
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3830
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3957
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4076
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4273
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4457
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4623
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4748
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..5057
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5261
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5387
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5558
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5559..5663
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5759
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     exon            5760..6041
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6011..6016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /note="hexamer: AATAAA"
     regulatory      6023..6028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /note="hexamer: AGTAAA"
     polyA_site      6032
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
     polyA_site      6041
                     /gene="MYH8"
                     /gene_synonym="DA7; gtMHC-F; MyHC-peri; MyHC-pn"
                     /note="major polyA site"
ORIGIN      
        1 atttccacca agaacccaga gagtggaaca cttctgaacc tgcattttta tctggaactc
       61 cagaggcaga atcctttgct aaataaatcg cagccatgag tgcgagctca gacgctgaga
      121 tggctgtttt tggcgaagct gctccctacc ttcgaaaatc agaaaaggag cggattgagg
      181 cccaaaacaa gccgtttgat gctaaaacat ctgtctttgt ggcggagccc aaggaatcct
      241 atgtgaagag cactatacaa agcaaagaag gagggaaagt aaccgtaaag actgaaggtg
      301 gagcaactct aactgtcagg gaagaccaag tcttccctat gaaccctccg aaatatgaca
      361 aaattgagga catggccatg atgactcatc tacacgagcc tggagtgctg tacaacctca
      421 aagagcgcta tgcagcctgg atgatctaca cctactcagg cctcttctgt gtcaccgtca
      481 acccctacaa gtggctgccg gtgtacaagc ccgaggtggt ggctgcctac agaggcaaaa
      541 agcgccagga ggccccgccc cacatcttct ccatctctga caatgcctat cagttcatgt
      601 tgactgatcg agagaatcag tccatcctga tcaccggaga atctggtgcc ggaaagactg
      661 tgaacaccaa gcgtgtcatc caatactttg caacaattgc agttactgga gagaagaaga
      721 aggatgaatc tggcaaaatg caggggactc tggaagatca aatcatcagc gccaatcccc
      781 tactggaggc ctttggcaat gccaaaactg tgaggaatga caactcctct cgctttggta
      841 aattcattag aatccacttt ggtactacag ggaagctggc atctgctgat atagaaacat
      901 atcttttaga aaagtccaga gttactttcc agctaaaggc ggaaagaagc taccatattt
      961 tttatcagat cacttccaat aagaagccag atctaattga aatgctcctg atcaccacca
     1021 acccatatga ctatgccttc gtcagtcagg gggagatcac agttcccagt attgatgacc
     1081 aagaagagtt gatggccact gatagtgcca ttgacatcct gggcttcact cctgaagaga
     1141 aagtgtccat ctataaactc acaggggctg tgatgcatta tgggaacatg aaattcaagc
     1201 aaaagcagcg tgaggagcaa gctgagccag atggcacaga agtcgctgac aaggcagcct
     1261 atctccagag tctgaactct gcagacctac tcaaagccct ctgctaccct agggtcaagg
     1321 ttggcaatga gtatgtcacc aaaggccaga ctgtgcagca ggtgtacaat gcggtgggtg
     1381 ctctggccaa agccgtctac gagaagatgt tcctgtggat ggtcacccgc atcaaccagc
     1441 agctggacac caagcagccc aggcagtact tcatcggggt cttggacatt gctggctttg
     1501 aaatctttga ttttaacagc ctggagcagc tgtgcatcaa cttcaccaac gagaaactgc
     1561 aacagttttt caaccaccac atgtttgtgc tagagcagga ggagtacaag aaggaaggca
     1621 tcgagtggac gttcattgac tttgggatgg acctggctgc ctgcattgag ctcattgaga
     1681 agccactggg catcttctcc atcctggaag aggagtgcat gttccctaag gcaacggaca
     1741 cctccttcaa gaacaagctg tatgaccagc acctgggcaa gtctgccaac ttccagaagc
     1801 ccaaggtggt caaaggcaag gctgaggccc acttctctct gattcactat gctggcactg
     1861 tggactacaa cattactggc tggctggaca aaaataagga ccccctgaat gatactgtgg
     1921 ttgggctgta ccagaagtct gcaatgaaga ctctagccag tctcttttcc acgtatgcta
     1981 gtgctgaagc agatagcagc gcgaagaaag gtgctaagaa aaagggctct tctttccaga
     2041 ctgtgtctgc ccttttcagg gaaaatttaa ataaattgat gacgaatctg aggagcacac
     2101 accctcactt cgtacggtgt atcattccca atgaaaccaa aactcctggg gcaatggaac
     2161 atgaacttgt gttgcaccag ctgaggtgta atggtgtgct ggaaggcatc cgcatctgta
     2221 ggaaaggatt cccaagcaga atcttatatg gtgatttcaa acaaagatac aaggttttaa
     2281 atgcaagtgc tattccagag ggacagttca ttgacagcaa gaaggcttct gagaaacttc
     2341 ttgcatctat tgatattgat catactcaat ataaatttgg acataccaag gttttcttca
     2401 aagctggact tctgggtctt ctggaagaaa tgagagatga aaaattagcc caaattataa
     2461 caagaacaca agctgtctgt aggggattcc taatgagggt agaatatcag aagatgttgc
     2521 aaaggagaga agcacttttc tgcatccagt ataatgtccg tgccttcatg aacgtcaagc
     2581 actggccctg gatgaaactc tttttcaaga ttaagcccct cctcaagagt gcagagaccg
     2641 agaaagagat ggccaccatg aaggaagaat tccagaaaac caaagatgaa ctcgccaagt
     2701 cagaggcaaa acggaaggag ctagaggaaa aaatggtcac tctcttaaaa gagaaaaatg
     2761 acctgcaact ccaggttcaa tctgaagcag atagcttggc tgatgcagag gaaaggtgtg
     2821 agcaactgat taaaaacaaa atccaacttg aggccaaaat caaagaggtg actgaaagag
     2881 ctgaggagga ggaagagatc aatgctgagc tgacagccaa gaagagaaaa ctggaggatg
     2941 aatgttcaga actcaagaaa gacattgatg accttgagct gacactggcc aaggttgaga
     3001 aggagaaaca tgccacggag aacaaggtga aaaatcttac agaagagatg gcaggcctgg
     3061 atgaaaccat tgcaaaactg tccaaggaga agaaggctct ccaagagacc caccagcaga
     3121 ccctggatga cctgcaggca gaggaggaca aagtcaacat cctgaccaaa gctaaaacca
     3181 agctagaaca gcaagtggat gatcttgaag ggtctctgga acaagaaaag aagcttcgaa
     3241 tggatctaga aagagcaaag cggaaactgg agggtgacct caaattggcc caagaatcca
     3301 caatggatat ggaaaatgac aaacagcaac ttgatgaaaa gcttgaaaag aaagaatttg
     3361 aaatcagcaa tttgataagc aaaattgaag atgagcaagc tgtagaaatt caactacaga
     3421 agaagatcaa agagttgcag gcccgcattg aggagctggg ggaagaaatc gaggcagaga
     3481 gggcgtcccg agccaaagcg gagaagcagc gctctgacct ctcccgggaa ctggaggaga
     3541 tcagcgagag gctggaagaa gccggtgggg caacttctgc tcaggtggaa ttgaacaaga
     3601 agcgggaggc tgagtttcag aaactgcgca gggacctgga ggaggccacc ctgcagcatg
     3661 aagctatggt ggctgctctt cggaagaagc acgcagacag tatggctgag cttggggagc
     3721 agattgacaa cttgcagcgg gtcaaacaga agctggagaa ggagaagagt gagctgaaga
     3781 tggagactga tgacctcagc agtaacgcag aggccatttc caaagccaag ggaaaccttg
     3841 aaaagatgtg ccgctctcta gaagatcaag tgagtgagct taagaccaag gaagaggagc
     3901 agcagcggct gatcaatgac ctcacagcac agagagcgcg cctgcagaca gaagcgggtg
     3961 aatattctcg acaattagat gagaaagatg ctttagtctc tcagctttca aggagcaagc
     4021 aagcatctac tcagcagatt gaagagctga aacatcaact agaggaagaa actaaagcca
     4081 agaacgccct ggcacacgcc ctgcagtcct cccgccatga ctgcgacctg ctgcgggaac
     4141 agtatgagga agagcaggaa ggcaaagctg agctgcagag ggcgctgtcc aaggccaaca
     4201 gtgaggttgc ccagtggaga accaaatacg agacggatgc catccagcgc acagaggagc
     4261 tggaggaggc caagaaaaag ttggcccagc gcctgcaaga agctgaggaa catgtagaag
     4321 ctgtgaacgc caaatgtgct tcccttgaga agacgaagca gcggctccag aatgaagttg
     4381 aagacctcat gcttgatgtg gaaaggtcta atgcagcctg tgcagccctt gataagaagc
     4441 aaaggaactt tgacaaggtc ctatcagaat ggaagcagaa gtatgaggaa actcaggctg
     4501 aacttgaggc ctcccagaag gagtcacgtt ctcttagcac tgagctgttc aaggtgaaga
     4561 atgtctatga ggaatccctg gatcaactcg aaacgctaag aagagaaaat aagaacttgc
     4621 aacaggagat ttctgacctc actgagcaga ttgcagaggg aggaaagcaa attcatgaat
     4681 tggagaaaat aaagaagcaa gtagaacaag agaaatgtga aattcaggct gctttagagg
     4741 aagcagaggc atctcttgaa catgaagaag gaaagattct gcgtatccag cttgagttaa
     4801 accaagtcaa gtctgaagtt gatagaaaaa tcgcagaaaa ggatgaggaa attgaccagc
     4861 tgaagagaaa ccacactaga gtcgtggaga caatgcagag cacgctggat gcagagatta
     4921 gaagcagaaa tgatgctctg agagtcaaga agaaaatgga aggagatctg aatgaaatgg
     4981 aaatccagct gaaccatgcc aatcgcttag ctgcagagag tttaaggaac tacaggaaca
     5041 cccaaggaat cctgaaggaa acccagctcc acctggatga tgctctccgg ggccaggagg
     5101 acctcaagga acagctggca attgtggagc gcagagccaa cctgctgcag gctgagatcg
     5161 aggagctgtg ggccactctg gaacagacag agagaagcag gaaaatcgcc gaacaggagc
     5221 tcctggatgc cagtgagcgt gtccagctcc tccacaccca gaataccagt ctcattaaca
     5281 ccaagaagaa attagaaaat gacgtttccc aactccaaag tgaagtggaa gaagtaatcc
     5341 aagaatcacg caatgcagaa gagaaagcca agaaggccat cactgatgct gccatgatgg
     5401 ctgaggagct gaagaaggaa caggacacca gcgcccacct ggagcggatg aagaagaacc
     5461 tggagcagac ggtgaaggac ctgcagcatc gtctagatga ggccgagcag ctggcgctga
     5521 agggtgggaa gaagcagatc cagaaactgg aggccagggt acgtgagctt gaaggagagg
     5581 ttgaaaatga acagaaacgt aatgcagagg ctgttaaagg tttacggaaa catgagcgac
     5641 gagtaaaaga actcacctac cagactgaag aagatcgcaa gaatgttctc aggctgcagg
     5701 acttggtaga taaattacag gcgaaggtga aatcatacaa gagacaagct gaggaggctg
     5761 aggaacaatc caatgctaat ctatctaaat tccgcaaact ccagcatgag ctggaggagg
     5821 ccgaggaacg ggctgacatt gctgagtccc aggtcaacaa attgcgagtg aagagccgag
     5881 aggttcacac aaaaatcagt gcagagtaaa cacacctgcc tgatgctatc aagaggctga
     5941 agaaaggcac aaaatgtgct atttttggtc acttgcttta tgacgtttat tttcctgtta
     6001 aagctgaata aataaaaact acagtaaatg tatacattaa a
//
