LOCUS       NM_020884               6551 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens myosin heavy chain 7B (MYH7B), mRNA.
ACCESSION   NM_020884 XM_005260472 XM_371398
VERSION     NM_020884.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6551)
  AUTHORS   Lee,L.A., Barrick,S.K., Buvoli,A.E., Walklate,J., Stump,W.T.,
            Geeves,M., Greenberg,M.J. and Leinwand,L.A.
  TITLE     Distinct effects of two hearing loss-associated mutations in the
            sarcomeric myosin MYH7b
  JOURNAL   J Biol Chem 299 (5), 104631 (2023)
   PUBMED   36963494
  REMARK    GeneRIF: Distinct effects of two hearing loss-associated mutations
            in the sarcomeric myosin MYH7b.
REFERENCE   2  (bases 1 to 6551)
  AUTHORS   Lee,L.A., Barrick,S.K., Meller,A., Walklate,J., Lotthammer,J.M.,
            Tay,J.W., Stump,W.T., Bowman,G., Geeves,M.A., Greenberg,M.J. and
            Leinwand,L.A.
  TITLE     Functional divergence of the sarcomeric myosin, MYH7b, supports
            species-specific biological roles
  JOURNAL   J Biol Chem 299 (1), 102657 (2023)
   PUBMED   36334627
  REMARK    GeneRIF: Functional divergence of the sarcomeric myosin, MYH7b,
            supports species-specific biological roles.
REFERENCE   3  (bases 1 to 6551)
  AUTHORS   Broadwell,L.J., Smallegan,M.J., Rigby,K.M., Navarro-Arriola,J.S.,
            Montgomery,R.L., Rinn,J.L. and Leinwand,L.A.
  TITLE     Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the
            human heart
  JOURNAL   J Biol Chem 296, 100694 (2021)
   PUBMED   33895132
  REMARK    GeneRIF: Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in
            the human heart.
REFERENCE   4  (bases 1 to 6551)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6551)
  AUTHORS   Weck,M.L., Crawley,S.W., Stone,C.R. and Tyska,M.J.
  TITLE     Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar
            Adhesion Complex
  JOURNAL   Curr Biol 26 (20), 2717-2728 (2016)
   PUBMED   27666969
  REMARK    GeneRIF: The actin-based motor myosin-7b (Myo7b) promotes the
            accumulation of intermicrovillar adhesion complex (IMAC components
            at microvillar tips. Myo7b is highly enriched at the tips of
            microvilli in both kidney and intestinal brush borders, and loss of
            Myo7b in differentiating intestinal epithelial cells disrupts
            intermicrovillar adhesion and, thus, brush border assembly.
REFERENCE   6  (bases 1 to 6551)
  AUTHORS   Rossi,A.C., Mammucari,C., Argentini,C., Reggiani,C. and
            Schiaffino,S.
  TITLE     Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b
            and MYH15 are expressed in extraocular muscles and muscle spindles
  JOURNAL   J Physiol 588 (Pt 2), 353-364 (2010)
   PUBMED   19948655
  REMARK    GeneRIF: MYH7b, the ortholog of slow myosin 2 (SM2) of frogs and
            birds, is detected as mRNA in heart, slow muscles and extraocular
            muscles. MYH7b protein is detected only in a subset of fibers,
            corresponding to slow-tonic fibers, in extraocular muscles.
REFERENCE   7  (bases 1 to 6551)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6551)
  AUTHORS   Hu,Z., Liang,J., Wang,Z., Tian,T., Zhou,X., Chen,J., Miao,R.,
            Wang,Y., Wang,X. and Shen,H.
  TITLE     Common genetic variants in pre-microRNAs were associated with
            increased risk of breast cancer in Chinese women
  JOURNAL   Hum Mutat 30 (1), 79-84 (2009)
   PUBMED   18634034
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6551)
  AUTHORS   McGuigan,K., Phillips,P.C. and Postlethwait,J.H.
  TITLE     Evolution of sarcomeric myosin heavy chain genes: evidence from
            fish
  JOURNAL   Mol Biol Evol 21 (6), 1042-1056 (2004)
   PUBMED   15014174
REFERENCE   10 (bases 1 to 6551)
  AUTHORS   Desjardins,P.R., Burkman,J.M., Shrager,J.B., Allmond,L.A. and
            Stedman,H.H.
  TITLE     Evolutionary implications of three novel members of the human
            sarcomeric myosin heavy chain gene family
  JOURNAL   Mol Biol Evol 19 (4), 375-393 (2002)
   PUBMED   11919279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133324.13, DB484143.2,
            BC151242.1, AL132825.35 and BC007808.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 26, 2021 this sequence version replaced NM_020884.6.
            
            Summary: The myosin II molecule is a multi-subunit complex
            consisting of two heavy chains and four light chains. This gene
            encodes a heavy chain of myosin II, which is a member of the
            motor-domain superfamily. The heavy chain includes a globular motor
            domain, which catalyzes ATP hydrolysis and interacts with actin,
            and a tail domain in which heptad repeat sequences promote
            dimerization by interacting to form a rod-like alpha-helical coiled
            coil. This heavy chain subunit is a slow-twitch myosin.
            Alternatively spliced transcript variants have been found, but the
            full-length nature of these variants is not determined. [provided
            by RefSeq, Mar 2010].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB040945.2, BC151242.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000262873.13/
                                                ENSP00000262873.8
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL133324.13        35316-35348
            34-451              DB484143.2         1-418
            452-2630            BC151242.1         206-2384
            2631-2637           AL132825.35        11539-11545
            2638-2923           BC151242.1         2392-2677
            2924-2930           AL132825.35        14595-14601
            2931-6403           BC151242.1         2685-6157
            6404-6410           AL132825.35        22736-22742
            6411-6547           BC151242.1         6165-6301
            6548-6551           BC007808.1         3268-3271
FEATURES             Location/Qualifiers
     source          1..6551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..6551
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /note="myosin heavy chain 7B"
                     /db_xref="GeneID:57644"
                     /db_xref="HGNC:HGNC:15906"
                     /db_xref="MIM:609928"
     exon            1..140
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            141..255
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            256..355
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            356..404
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            405..567
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..6302
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /note="myosin, heavy polypeptide 7B, cardiac muscle, beta;
                     antigen MLAA-21; U937-associated antigen; slow A MYH14;
                     myosin, heavy chain 7B, cardiac muscle, beta"
                     /codon_start=1
                     /product="myosin-7B"
                     /protein_id="NP_065935.4"
                     /db_xref="CCDS:CCDS42869.2"
                     /db_xref="GeneID:57644"
                     /db_xref="HGNC:HGNC:15906"
                     /db_xref="MIM:609928"
                     /translation="MMDVSELGESARYLRQGYQEMTKVHTIPWDGKKRVWVPDEQDAY
                     VEAEVKSEATGGRVTVETKDQKVLMVREAELQPMNPPRFDLLEDMAMMTHLNEASVLH
                     NLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYAVADNA
                     YNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGT
                     LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRV
                     IFQLPGERSYHVYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVITVDNMNDGEELIA
                     TDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMG
                     VSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTL
                     DTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREG
                     IDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNF
                     QQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATL
                     YENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVP
                     NENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDD
                     TFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQRLAKVLTLLQAR
                     SRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEEL
                     AALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHL
                     LIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAE
                     KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKA
                     KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK
                     KKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEA
                     ARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA
                     EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ
                     LSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLE
                     ELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW
                     RSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT
                     LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHG
                     HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALE
                     EAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA
                     ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ
                     RLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ
                     NTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSA
                     HLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE
                     ALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNL
                     AKYRKAQHELDDAEERADMAETQANKLRARTRDALGPKHKE"
     exon            568..674
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            675..818
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            819..975
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1003
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1100
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1124
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1217
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1281
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1380
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1484
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1623
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1742
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1892
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2063
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2243
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2376
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2453
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2541
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2659
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2783
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2920
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3176
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3419
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3596
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3742
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3833
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..4223
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4350
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4469
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4666
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            4667..5016
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5141
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..5257
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5654
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5655..5780
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5781..5951
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            5952..6056
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            6057..6152
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            6153..6290
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     exon            6291..6551
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6528..6533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /note="hexamer: AATAAA"
     polyA_site      6551
                     /gene="MYH7B"
                     /gene_synonym="lncMYH7b; MHC14; MYH14"
                     /note="major polyA site"
ORIGIN      
        1 acctttggcg ctgagtcgag gccaggaagg ggcggtcgat gagagggcgg ccttagcatt
       61 aggagtgcgt cggctgcacc ctggcggatg gaccttggga aggaggggag gggaccatcg
      121 gggtcggcgg ggagctacgg gttcccctct tccaagacgg gtgccaagtg atgagtatca
      181 ggtgtctatg gtgagatttg gggaggatcc cagaccttaa cagccctttg gttgaaacct
      241 ctcacaatgt ggcagagatg gggttttgat gtgttgccca ggctggtctt gaactcctga
      301 gcttaagtga tgtgtccgcc tgggcctccc aaagtgctgg aattacagac atgagtggca
      361 ataaaagggg tagcagagct tcctgccctc accgtggtgc cgagtgcctg ctgccttggg
      421 ccgccttgaa cctccagggt ttccagctcc tcctccttca ccccagtgcc actgccatga
      481 tggatgtgag tgaacttggg gagtctgccc gctacctccg ccagggctac caggagatga
      541 cgaaggtgca cactatccca tgggacggga agaagcgagt ctgggtgcct gatgaacagg
      601 acgcctacgt ggaggccgag gtcaagtcgg aggctaccgg gggcagagtc accgtggaga
      661 ccaaagacca gaaggtgctg atggtgcgtg aagccgagct gcagcccatg aacccgcctc
      721 gcttcgactt actggaggac atggccatga tgacgcacct gaacgaggcc tctgtgctgc
      781 acaacctgcg ccagcgctat gcccgctgga tgatctatac ctactcaggc ctcttctgtg
      841 tcaccatcaa cccctacaaa tggctcccag tctatacggc ctccgtagtg gctgcttaca
      901 agggaaagcg ccgctcagat tccccgcccc atatatatgc ggtggcggac aacgcctaca
      961 acgacatgct gcgcaaccga gacaaccagt ccatgctgat caccggagag tcgggggccg
     1021 gtaagacggt taacaccaag cgggtcattc agtactttgc catcgtcgct gccctgggag
     1081 acgggccggg caagaaggcc caatttctgg caacaaagac ggggggcacc cttgaggatc
     1141 aaatcatcga ggccaaccct gccatggagg cctttggcaa cgccaagacc ctgaggaatg
     1201 ataactcctc ccgctttggc aagttcatcc gcattcactt tggtccctct gggaagctgg
     1261 catccgcgga tattgacagc tatctcctgg agaagtcgcg ggtgatcttc cagttgcctg
     1321 gtgagcgcag ctaccatgtc tactaccaga tcctctcagg gaggaagcca gagctgcagg
     1381 acatgctgct tctgtctatg aacccctatg actaccactt ctgcagccag ggcgtcatca
     1441 ccgtggacaa catgaatgat ggggaggagc tcatcgccac cgaccatgcc atggacatcc
     1501 taggcttcag cgtggatgag aaatgtgcct gctataagat cgtgggcgcc ctcctgcact
     1561 ttggcaacat gaagttcaag cagaagcagc gggaggagca ggcggaggcc gatggcactg
     1621 agagtgctga caaggctgcc tacctgatgg gggtcagcag tggggacctc ctcaaaggcc
     1681 ttttgcaccc ccgggtgcgt gtagggaacg agtacgtgac caagggccag agtgtggagc
     1741 aggtggtgtt tgctgtgggg gctctggcca aggccaccta tgaccggctg ttcaggtggc
     1801 tggtgtctcg gatcaaccag accctggaca caaagctgcc ccggcagttc ttcatcgggg
     1861 ttctggacat cgctgggttt gagatctttg agttcaacag cttcgaacag ctgtgcatca
     1921 acttcaccaa tgagaaattg cagcagttct tcaaccagca catgtttgtg ctggagcagg
     1981 aggagtacaa gcgggagggc atcgactggg tcttcatcga cttcggcctt gacctgcagc
     2041 cttgcatcga cctcatcgag aagccactgg gcatcctgtc catcctggag gaggaatgca
     2101 tgttccccaa ggcctcagac gccagcttcc gggccaagct ctacgacaac cacgcgggga
     2161 agtcacccaa tttccagcag cctcggcctg acaagaagcg caagtaccag gcccacttcg
     2221 aggtggtcca ctacgcaggc gtggtgcctt acagcattgt gggctggctg gagaaaaaca
     2281 aggatcccct gaatgagacc gtggtcccca tcttccagaa gtcacagaat aggctcctgg
     2341 cgactctcta tgagaattat gcgggctcct gctccactga gccccccaag tctggggtga
     2401 aagagaagcg taagaaggca gcatcgttcc agacggtgtc ccagctgcac aaggagaacc
     2461 tcaacaagct gatgaccaac ctgcgggcca cacagcccca cttcgtccgc tgcattgtcc
     2521 ccaacgagaa caaaacccca ggggtcatgg atgccttctt ggtgctacac cagctgcgct
     2581 gcaatggggt cctggagggg atccggatct gccgccaagg gttccccaac aggttgctct
     2641 acaccgactt ccggcagcgg taccgtatcc tgaaccccag tgccatcccg gatgacacct
     2701 tcatggacag caggaaggcc acagagaaac tgctgggctc gctggacttg gatcacaccc
     2761 agtaccagtt tggccacacc aaggtgttct tcaaggctgg gcttctaggc gtcctggaag
     2821 agctccgtga ccagcgcctg gccaaggtgc tgacgctgct gcaggcgcgg agccgtggcc
     2881 gcctcatgcg ccttgagtac cagcgcctgc tgggaggcag ggatgcgctg ttcaccatcc
     2941 agtggaacat ccgtgccttc aatgccgtca agaactggtc atggatgaag ctctttttca
     3001 agatgaagcc gctgctgcgc tcggcgcagg ctgaggagga gctggcggcc ctgcgggcag
     3061 agctgcgggg gttgcgaggg gcgctggctg cggccgaggc caagcgccag gaactggagg
     3121 agacgcacgt cagcatcacc caggagaaga atgacctggc cctgcagctg caggctgagc
     3181 aggacaacct ggcagatgcc gaggagcgct gccacttgct gatcaagtcc aaggtgcagc
     3241 tggaggggaa ggtgaaggag ctgagtgagc ggctggagga tgaggaggag gtgaacgctg
     3301 acctggccgc ccgccggcgc aagctggagg acgagtgcac ggagctcaag aaggacattg
     3361 atgacctgga gctgacactg gccaaagctg agaaggagaa gcaagccact gagaacaagg
     3421 tgaagaacct gacggaagag atggctgcgc tggacgagtc agtggcccgg ctgaccaagg
     3481 agaagaaggc gttgcaggag gcccaccaac aggccctggg tgacctgcag gccgaggagg
     3541 accgtgtgag cgcgctgacc aaggccaagc tccggctgga gcaacaggtg gaggacctgg
     3601 aatgctccct ggagcaggag aagaagctgc gcatggacac ggagcgggcc aagcgcaagc
     3661 tggagggtga cctgaagctg acgcaggagt cggtggctga tgctgctcaa gacaagcagc
     3721 agctggagga gaagctcaag aagaaggact ccgagctgag ccagctgagc ctgcgggtgg
     3781 aagacgagca gctcttgggg gcccagatgc agaagaagat caaggagctg caggctcggg
     3841 cggaggagct ggaagaggag ctggaggcag agcgggcagc ccgggcccgc gtggagaagc
     3901 agcgtgcaga ggcggcgcgg gagctggagg agctgagcga gcggctggag gaggcaggcg
     3961 gcgcatccgc ggggcagcgc gagggctgcc gcaagcggga ggcggagctg gggaggctgc
     4021 ggcgggagct ggaggaggcg gcgctgcggc acgaggccac agtggcggca ctgcggcgca
     4081 agcaggcgga gggcgcggcg gagctggggg agcaggtgga cagcctgcag cgggtgcggc
     4141 agaagctgga gaaggagaag agtgagctgc gcatggaggt ggacgacctg gctgccaacg
     4201 tggagactct gacccgcgcc aaggccagtg cagagaagct gtgccggacc tatgaggatc
     4261 agctaagcga ggccaagatc aaggtggagg agctgcagcg gcagctggcg gacgcaagca
     4321 cgcagcgtgg gcgactacag acggaaagcg gggagctgag tcgcctgcta gaggagaagg
     4381 agtgtctgat cagtcagctg agccgtggaa aggccctggc cgcccaaagc ctggaagagt
     4441 tgcggcgcca gctagaggag gaaagcaagg ccaagagtgc cctggcccac gccgtgcagg
     4501 ctctgcggca cgactgtgac ctcctgcggg agcaacacga ggaggaggct gaggcccagg
     4561 ctgagctgca gcggctgctg tccaaggcca atgccgaggt ggcccagtgg aggagcaagt
     4621 acgaagcaga tgccatccag aggaccgagg agctggagga ggccaaaaaa aagctggcac
     4681 tgcggctgca ggaggcagag gagggcgtgg aggctgccaa cgccaagtgc tcatcgttgg
     4741 agaaggccaa gctgcggcta cagacagagt cagaggatgt aaccctggag ctggagcggg
     4801 cgacctcagc agctgctgcg ctggacaaga agcagcggca cttggaacgg gcactggagg
     4861 aacggcggcg gcaggaggag gagatgcagc gggagctgga ggcggcacag agggagtccc
     4921 gtggcctggg caccgagctc ttccggctgc ggcacggcca cgaggaggca cttgaagccc
     4981 tggagacgct caagcgggag aacaagaacc tgcaggagga gatcagcgac ctcacagacc
     5041 aggtgagtct cagtgggaag agcatccagg aactggagaa aaccaagaag gcgctggaag
     5101 gcgagaagag tgagatccag gctgcactgg aggaggcaga gggggccctg gagctggagg
     5161 agaccaagac gctgcggatc cagctggagc tctcccaggt caaagcagaa gtggaccgga
     5221 agctggcaga gaaagacgag gagtgcgcta acctgaggcg caaccaccag cgagctgtgg
     5281 agtccctgca ggcctccctg gatgcagaga cacgggcccg caatgaggcg ctgcggctca
     5341 agaagaagat ggagggtgac ctcaacgacc tggagctgca gctgggccat gccacccgtc
     5401 aggccacaga ggcccaggct gccacgcggc tgatgcaggc acagctcaag gaggagcagg
     5461 cagggcggga cgaggagcag cggctggcag ctgagctcca cgagcaggcg caggctctgg
     5521 agcgccgggc ctcgctgctg gctgcggagc tggaggagct gcgggctgcc ctggagcagg
     5581 gcgagcgcag ccggcgactg gcagagcagg agcttttgga ggccaccgag cgcctcaacc
     5641 ttctgcattc gcagaacaca ggcctcctaa accagaagaa gaagctggag gcggacttgg
     5701 cccagctgag cggggaggtg gaggaggctg cacaggagag gcgggaggct gaggagaagg
     5761 ccaaaaaggc catcactgat gcggccatga tggccgagga gctgaagaag gagcaggaca
     5821 caagtgcaca cctggaacgg atgaagaaga cgctggagca gacggtgcgc gagctccagg
     5881 cccgccttga ggaggcagaa caggccgccc tccgtggcgg gaagaagcag gtgcagaagc
     5941 tggaggccaa ggtacgggag ctggaggctg agcttgatgc agagcagaag aagcacgccg
     6001 aggcccttaa gggcgtgcgc aagcatgagc gccgtgtcaa ggagctcgca taccaggccg
     6061 aggaggacag gaagaacctg gctcgcatgc aggacctggt ggacaagctg cagagcaagg
     6121 tcaagagcta caagcgccag tttgaggagg cggagcagca ggccaacacc aacctggcca
     6181 agtatcgcaa ggcccagcac gagctggatg atgcggagga gcgggcagac atggcggaaa
     6241 cccaggccaa caagctgcgg gcacggaccc gggacgccct gggccccaag cacaaggagt
     6301 gacggcctga ccccctgggc tctaaagagg aatgtctgct gttgcacatc tggctgaggc
     6361 cacctgcccc gatcctgcca tctctgcatc gccccctgct gccttcagcc ttccctgggc
     6421 cctgaataaa caccacagcc agtttccttc tcattctttt ctttggggtt caggaggaaa
     6481 aacacagtcc tagggacaaa agccaggtcc acagcagtca tttttaaaat aaagttattt
     6541 aatagtctcc a
//
