LOCUS       NM_000257               6027 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myosin heavy chain 7 (MYH7), transcript variant 1,
            mRNA.
ACCESSION   NM_000257 XM_005267696
VERSION     NM_000257.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6027)
  AUTHORS   Kim,O.H., Kim,J., Kim,Y., Lee,S., Lee,B.H., Kim,B.J., Park,H.Y. and
            Park,M.H.
  TITLE     Exploring novel MYH7 gene variants using in silico analyses in
            Korean patients with cardiomyopathy
  JOURNAL   BMC Med Genomics 17 (1), 225 (2024)
   PUBMED   39237976
  REMARK    GeneRIF: Exploring novel MYH7 gene variants using in silico
            analyses in Korean patients with cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6027)
  AUTHORS   Lee,S., Vander Roest,A.S., Blair,C.A., Kao,K., Bremner,S.B.,
            Childers,M.C., Pathak,D., Heinrich,P., Lee,D., Chirikian,O.,
            Mohran,S.E., Roberts,B., Smith,J.E., Jahng,J.W., Paik,D.T.,
            Wu,J.C., Gunawardane,R.N., Ruppel,K.M., Mack,D.L., Pruitt,B.L.,
            Regnier,M., Wu,S.M., Spudich,J.A. and Bernstein,D.
  TITLE     Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E
            mutation causes hypercontractility and elevated mitochondrial
            respiration
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2318413121 (2024)
   PUBMED   38683993
  REMARK    GeneRIF: Incomplete-penetrant hypertrophic cardiomyopathy MYH7
            G256E mutation causes hypercontractility and elevated mitochondrial
            respiration.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410753121.
            doi: 10.1073/pnas.2410753121.. PMID: 38885393]
REFERENCE   3  (bases 1 to 6027)
  AUTHORS   Golubenko,M.V., Pavlyukova,E.N., Salakhov,R.R., Makeeva,O.A.,
            Puzyrev,K.V., Glotov,O.S., Puzyrev,V.P. and Nazarenko,M.S.
  TITLE     A New Leu714Arg Variant in the Converter Domain of MYH7 is
            Associated with a Severe Form of Familial Hypertrophic
            Cardiomyopathy
  JOURNAL   Front Biosci (Schol Ed) 16 (1), 1 (2024)
   PUBMED   38538344
  REMARK    GeneRIF: A New Leu714Arg Variant in the Converter Domain of MYH7 is
            Associated with a Severe Form of Familial Hypertrophic
            Cardiomyopathy.
REFERENCE   4  (bases 1 to 6027)
  AUTHORS   Oldfors,A.
  TITLE     Hereditary myosin myopathies
  JOURNAL   Neuromuscul Disord 17 (5), 355-367 (2007)
   PUBMED   17434305
  REMARK    Review article
REFERENCE   5  (bases 1 to 6027)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   6  (bases 1 to 6027)
  AUTHORS   Lamont,P. and Laing,N.G.
  TITLE     Laing Distal Myopathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301606
REFERENCE   7  (bases 1 to 6027)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   8  (bases 1 to 6027)
  AUTHORS   DeChene,E.T., Kang,P.B. and Beggs,A.H.
  TITLE     Congenital Fiber-Type Disproportion - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301436
REFERENCE   9  (bases 1 to 6027)
  AUTHORS   Warlick,C.A., Ramachandra,S., Mishra,S. and Donis-Keller,H.
  TITLE     Dinucleotide repeat polymorphism at the human cardiac beta-myosin
            heavy chain gene (HMSYHCO1) locus
  JOURNAL   Hum Mol Genet 1 (2), 136 (1992)
   PUBMED   1301151
REFERENCE   10 (bases 1 to 6027)
  AUTHORS   Fougerousse,F., Dufour,C., Roudaut,C. and Beckmann,J.S.
  TITLE     Dinucleotide repeat polymorphism at the human gene for cardiac
            beta-myosin heavy chain (MYH6)
  JOURNAL   Hum Mol Genet 1 (1), 64 (1992)
   PUBMED   1301139
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU747717.1, M58018.1 and
            BC112173.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000257.3.
            
            Summary: Muscle myosin is a hexameric protein containing 2 heavy
            chain subunits, 2 alkali light chain subunits, and 2 regulatory
            light chain subunits. This gene encodes the beta (or slow) heavy
            chain subunit of cardiac myosin. It is expressed predominantly in
            normal human ventricle. It is also expressed in skeletal muscle
            tissues rich in slow-twitch type I muscle fibers. Changes in the
            relative abundance of this protein and the alpha (or fast) heavy
            subunit of cardiac myosin correlate with the contractile velocity
            of cardiac muscle. Its expression is also altered during thyroid
            hormone depletion and hemodynamic overloading. Mutations in this
            gene are associated with familial hypertrophic cardiomyopathy,
            myosin storage myopathy, dilated cardiomyopathy, and Laing distal
            myopathy. [provided by RefSeq, May 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58018.1, EU747717.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355349.4/ ENSP00000347507.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               EU747717.1         2-295
            295-1805            M58018.1           276-1786
            1806-3475           BC112173.1         1756-3425
            3476-6027           M58018.1           3457-6008
FEATURES             Location/Qualifiers
     source          1..6027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..6027
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /note="myosin heavy chain 7"
                     /db_xref="GeneID:4625"
                     /db_xref="HGNC:HGNC:7577"
                     /db_xref="MIM:160760"
     exon            1..41
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            42..97
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            98..306
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..5913
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /note="myosin, heavy polypeptide 7, cardiac muscle, beta;
                     myhc-slow; cardiac muscle myosin heavy chain 7 beta;
                     rhabdomyosarcoma antigen MU-RMS-40.7A; myHC-beta; myosin
                     7; myosin, heavy chain 7, cardiac muscle, beta; myosin
                     heavy chain beta-subunit"
                     /codon_start=1
                     /product="myosin-7"
                     /protein_id="NP_000248.2"
                     /db_xref="CCDS:CCDS9601.1"
                     /db_xref="GeneID:4625"
                     /db_xref="HGNC:HGNC:7577"
                     /db_xref="MIM:160760"
                     /translation="MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQ
                     EFVKAKIVSREGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVL
                     YNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDN
                     AYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLED
                     QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ
                     LKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDN
                     AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNS
                     ADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETK
                     QPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEW
                     TFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKP
                     RNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY
                     AGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPG
                     VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRK
                     GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLAR
                     MEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEF
                     TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ
                     LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE
                     NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ
                     VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN
                     ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI
                     SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG
                     EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK
                     AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE
                     EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD
                     AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN
                     AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH
                     LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE
                     HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE
                     ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK
                     ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ
                     KKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK
                     NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK
                     SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ
                     HELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE"
     exon            307..450
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            451..607
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            608..635
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            636..744
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            745..837
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            838..901
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1000
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1104
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1243
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1362
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1512
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1683
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1993
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2061
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2149
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2267
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2391
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2528
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2784
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3027
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3204
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3350
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3441
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3831
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3958
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4077
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4274
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4458
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4624
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            4625..4749
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..5058
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5262
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5388
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5389..5664
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5665..5760
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..5895
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..6027
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6002..6007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /note="hexamer: AATAAA"
     polyA_site      6027
                     /gene="MYH7"
                     /gene_synonym="CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A;
                     CMYP7B; MPD1; MYHCB; SPMD; SPMM"
                     /note="major polyA site"
ORIGIN      
        1 acagctctgt cctgctctgt gtctttccct gctgctctca ggtcccctgc aggccttggc
       61 ccctttcctc atctgtagac acacttgagt agcccaggca cagccatggg agattcggag
      121 atggcagtct ttggggctgc cgccccctac ctgcgcaagt cagagaagga gcggctagaa
      181 gcgcagacca ggccttttga cctcaagaag gatgtcttcg tgcctgatga caaacaggag
      241 tttgtcaagg ccaagatcgt gtctcgagag ggtggcaaag tcactgccga gaccgagtat
      301 ggcaagacag tgaccgtgaa ggaggaccag gtgatgcagc agaacccacc caagttcgac
      361 aaaatcgagg acatggccat gctgaccttc ctgcatgagc ccgcggtgct ctacaacctc
      421 aaggatcgct acggctcctg gatgatctac acctactcgg gcctcttctg tgtcaccgtc
      481 aacccttaca agtggctgcc ggtgtacact cctgaggtgg tggctgccta ccggggcaag
      541 aagaggagcg aggccccgcc ccacatcttc tccatctccg acaacgccta tcagtacatg
      601 ctgacagaca gagaaaacca gtccatcctg atcaccggag aatccggagc agggaagaca
      661 gtcaacacca agagggtcat ccagtacttt gctgttattg cagccattgg ggaccgcagc
      721 aagaaggacc agagcccggg caagggcacc ctggaggacc agatcatcca ggccaaccct
      781 gctctggagg cctttggcaa tgccaagacc gtccggaacg acaactcctc ccgcttcggg
      841 aaattcattc gaattcattt tggggcaaca ggaaagttgg catctgcaga catagagacc
      901 tatcttctgg aaaaatccag agttattttc cagctgaaag cagagagaga ttatcacatt
      961 ttctaccaaa tcctgtctaa caaaaagcct gagctgctgg acatgctgct gatcaccaac
     1021 aacccctacg attatgcatt catctcccaa ggagagacca ccgtggcctc cattgatgac
     1081 gctgaggagc tcatggccac tgataacgct tttgatgtgc tgggcttcac ttcagaggag
     1141 aaaaactcca tgtataagct gacaggcgcc atcatgcact ttggaaacat gaagttcaag
     1201 ctgaagcagc gggaggagca ggcggagcca gacggcactg aagaggctga caagtctgcc
     1261 tacctcatgg ggctgaactc agccgacctg ctcaaggggc tgtgccaccc tcgggtgaaa
     1321 gtgggcaatg agtacgtcac caaggggcag aatgtccagc aggtgatata tgccactggg
     1381 gcactggcca aggcagtgta tgagaggatg ttcaactgga tggtgacgcg catcaatgcc
     1441 accctggaga ccaagcagcc acgccagtac ttcataggag tcctggacat cgctggcttc
     1501 gagatcttcg atttcaacag ctttgagcag ctctgcatca acttcaccaa cgagaagctg
     1561 cagcagttct tcaaccacca catgtttgtg ctggagcagg aggagtacaa gaaggagggc
     1621 atcgagtgga cattcattga ctttggcatg gacctgcagg cctgcattga cctcatcgag
     1681 aagcccatgg gcatcatgtc catcctggaa gaggagtgca tgttccccaa ggccaccgac
     1741 atgaccttca aggccaagct gtttgacaac cacctgggca aatccgccaa cttccagaag
     1801 ccacgcaata tcaaggggaa gcctgaagcc cacttctccc tgatccacta tgccggcatc
     1861 gtggactaca acatcattgg ctggctgcag aagaacaagg atcctctcaa tgagactgtc
     1921 gtgggcttgt atcagaagtc ttccctcaag ctgctcagca ccctgtttgc caactatgct
     1981 ggggctgatg cgcctattga gaagggcaaa ggcaaggcca agaaaggctc gtcctttcag
     2041 actgtgtcag ctctgcacag ggaaaatctg aacaagctga tgaccaactt gcgctccacc
     2101 catccccact ttgtacgttg tatcatccct aatgagacaa agtctccagg ggtgatggac
     2161 aaccccctgg tcatgcacca gctgcgctgc aatggtgtgc tggagggcat ccgcatctgc
     2221 aggaaaggct tccccaaccg catcctctac ggggacttcc ggcagaggta tcgcatcctg
     2281 aacccagcgg ccatccctga gggacagttc attgatagca ggaagggggc agagaagctg
     2341 ctcagctccc tggacattga tcacaaccag tacaagtttg gccacaccaa ggtgttcttc
     2401 aaggccgggc tgctggggct gctggaggaa atgagggacg agaggctgag ccgcatcatc
     2461 acgcgtatcc aggcccagtc ccgaggtgtg ctcgccagaa tggagtacaa aaagctgctg
     2521 gaacgtagag actccctgct ggtaatccag tggaacattc gggccttcat gggggtcaag
     2581 aattggccct ggatgaagct ctacttcaag atcaagccgc tgctgaagag tgcagaaaga
     2641 gagaaggaga tggcctccat gaaggaggag ttcacacgcc tcaaagaggc gctagagaag
     2701 tccgaggctc gccgcaagga gctggaggag aagatggtgt ccctgctgca ggagaagaat
     2761 gacctgcagc tccaagtgca ggcggaacaa gacaacctgg cagatgctga ggagcgctgt
     2821 gatcagctga tcaaaaacaa gattcagctg gaggccaagg tgaaggagat gaacgagagg
     2881 ctggaggatg aggaggagat gaatgctgag ctcactgcca agaagcgcaa gctggaagat
     2941 gagtgctcag agctcaaaag ggacatcgat gatctggagc tgacactggc caaagtggag
     3001 aaggagaaac acgcaacaga gaacaaggtg aaaaacctga cagaggagat ggctgggctg
     3061 gatgagatca ttgccaagct gaccaaggag aagaaagctc tgcaagaggc ccaccaacag
     3121 gctctggatg accttcaggc cgaggaggac aaggtcaaca ccctgactaa ggccaaagtc
     3181 aagctggagc agcaagtgga tgatctggaa ggatccctgg agcaagagaa gaaggtgcgc
     3241 atggacctgg agcgagcgaa gcggaagctg gagggcgacc tgaagctgac ccaggagagc
     3301 atcatggacc tggagaatga caagcagcag ctggatgagc ggctgaaaaa aaaagacttt
     3361 gagctgaatg ctctcaacgc aaggattgag gatgaacagg ccctcggcag ccagctgcag
     3421 aagaagctca aggagcttca ggcacgcatc gaggagctgg aggaggagct ggaggccgag
     3481 cgcaccgcca gggctaaggt ggagaagctg cgctcagacc tgtctcggga gctggaggag
     3541 atcagcgagc ggctggaaga ggccggcggg gccacgtccg tgcagatcga gatgaacaag
     3601 aagcgcgagg ccgagttcca gaagatgcgg cgggacctgg aggaggccac gctgcagcac
     3661 gaggccactg ccgcggccct gcgcaagaag cacgccgaca gcgtggccga gctgggcgag
     3721 cagatcgaca acctgcagcg ggtgaagcag aagctggaga aggagaagag cgagttcaag
     3781 ctggagctgg atgacgtcac ctccaacatg gagcagatca tcaaggccaa ggctaacctg
     3841 gagaagatgt gccggacctt ggaagaccag atgaatgagc accggagcaa ggcggaggag
     3901 acccagcgtt ctgtcaacga cctcaccagc cagcgggcca agttgcaaac cgagaatggt
     3961 gagctgtccc ggcagctgga tgagaaggag gcactgatct cccagctgac ccgaggcaag
     4021 ctcacctaca cccagcagct ggaggacctc aagaggcagc tggaggagga ggttaaggcg
     4081 aagaacgccc tggcccacgc actgcagtcg gcccggcatg actgcgacct gctgcgggag
     4141 cagtacgagg aggagacgga ggccaaggcc gagctgcagc gcgtcctttc caaggccaac
     4201 tcggaggtgg cccagtggag gaccaagtat gagacggacg ccattcagcg gactgaggag
     4261 ctcgaggagg ccaagaagaa gctggcccag cggctgcagg aagctgagga ggccgtggag
     4321 gctgttaatg ccaagtgctc ctcgctggag aagaccaagc accggctaca gaatgagatc
     4381 gaggacttga tggtggacgt agagcgctcc aatgctgctg ctgcagccct ggacaagaag
     4441 cagaggaact tcgacaagat cctggccgag tggaagcaga agtatgagga gtcgcagtcg
     4501 gagctggagt cctcgcagaa ggaggctcgc tccctcagca cagagctctt caaactcaag
     4561 aacgcctatg aggagtccct ggaacatctg gagaccttca agcgggagaa caaaaacctg
     4621 caggaggaga tctccgactt gactgagcag ttgggttcca gcggaaagac tatccatgag
     4681 ctggagaagg tccgaaagca gctggaggcc gagaagatgg agctgcagtc agccctggag
     4741 gaggccgagg cctccctgga gcacgaggag ggcaagatcc tccgggccca gctggagttc
     4801 aaccagatca aggcagagat cgagcggaag ctggcagaga aggacgagga gatggaacag
     4861 gccaagcgca accacctgcg ggtggtggac tcgctgcaga cctccctgga cgcagagaca
     4921 cgcagccgca acgaggccct gagggtgaag aagaagatgg aaggagacct caatgagatg
     4981 gagatccagc tcagccacgc caaccgcatg gccgccgagg cccagaagca agtcaagagc
     5041 ctccagagct tgttgaagga cacccagatt cagctggacg atgcagtccg tgccaacgac
     5101 gacctgaagg agaacatcgc catcgtggag cggcgcaaca acctgctgca ggctgagctg
     5161 gaggagttgc gtgccgtggt ggagcagaca gagcggtccc ggaagctggc ggagcaggag
     5221 ctgattgaga ctagtgagcg ggtgcagctg ctgcattccc agaacaccag cctcatcaac
     5281 cagaagaaga agatggatgc tgacctgtcc cagctccaga ctgaagtgga ggaggcagtg
     5341 caggagtgca ggaatgctga ggagaaggcc aagaaggcca tcacggatgc cgccatgatg
     5401 gcagaggagc tgaagaagga gcaggacacc agcgcccacc tggagcgcat gaagaagaac
     5461 atggaacaga ccattaagga cctgcagcac cggctggacg aagccgagca gatcgccctc
     5521 aagggcggca agaagcagct gcagaagctg gaagcgcggg tgcgggagct ggagaatgag
     5581 ctggaggccg agcagaagcg caacgcagag tcggtgaagg gcatgaggaa gagcgagcgg
     5641 cgcatcaagg agctcaccta ccagacggag gaggacagga aaaacctgct gcggctgcag
     5701 gacctggtag acaagctgca gctaaaggtc aaggcctaca agcgccaggc cgaggaggcg
     5761 gaggagcaag ccaacaccaa cctgtccaag ttccgcaagg tgcagcacga gctggatgag
     5821 gcagaggagc gggcggacat cgccgagtcc caggtcaaca agctgcgggc caagagccgt
     5881 gacattggca cgaagggctt gaatgaggag tagctttgcc acatcttgat ctgctcagcc
     5941 ctggaggtgc cagcaaagcc ccatgctgga gcctgtgtaa cagctccttg ggaggaagca
     6001 gaataaagca attttccttg aagccga
//
