LOCUS       NM_002471               5940 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens myosin heavy chain 6 (MYH6), mRNA.
ACCESSION   NM_002471
VERSION     NM_002471.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Wang,F., Shen,H., Li,K., Ding,Y., Wang,J. and Sun,J.
  TITLE     MYH6 suppresses tumor progression by downregulating KIT expression
            in human prostate cancer
  JOURNAL   Sci Rep 14 (1), 19685 (2024)
   PUBMED   39181964
  REMARK    GeneRIF: MYH6 suppresses tumor progression by downregulating KIT
            expression in human prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Song,Z., Bian,W., Lin,J., Guo,Y., Shi,W., Meng,H., Chen,Y.,
            Zhang,M., Liu,Z., Lin,Z., Ma,K. and Li,L.
  TITLE     Heart proteomic profiling discovers MYH6 and COX5B as biomarkers
            for sudden unexplained death
  JOURNAL   Forensic Sci Int 361, 112121 (2024)
   PUBMED   38971138
  REMARK    GeneRIF: Heart proteomic profiling discovers MYH6 and COX5B as
            biomarkers for sudden unexplained death.
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Zuo,J.Y., Chen,H.X., Yang,Q., Liu,Z.G. and He,G.W.
  TITLE     Tetralogy of Fallot: variants of MYH6 gene promoter and cellular
            functional analyses
  JOURNAL   Pediatr Res 96 (2), 338-346 (2024)
   PUBMED   38135727
  REMARK    GeneRIF: Tetralogy of Fallot: variants of MYH6 gene promoter and
            cellular functional analyses.
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Zuo,J.Y., Chen,H.X., Yang,Q. and He,G.W.
  TITLE     Variants of the promoter of MYH6 gene in congenital isolated and
            sporadic patent ductus arteriosus: case-control study and cellular
            functional analyses
  JOURNAL   Hum Mol Genet 33 (10), 884-893 (2024)
   PUBMED   38340456
  REMARK    GeneRIF: Variants of the promoter of MYH6 gene in congenital
            isolated and sporadic patent ductus arteriosus: case-control study
            and cellular functional analyses.
REFERENCE   5  (bases 1 to 5940)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   6  (bases 1 to 5940)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   7  (bases 1 to 5940)
  AUTHORS   Matsuoka,R., Beisel,K.W., Furutani,M., Arai,S. and Takao,A.
  TITLE     Complete sequence of human cardiac alpha-myosin heavy chain gene
            and amino acid comparison to other myosins based on structural and
            functional differences
  JOURNAL   Am J Med Genet 41 (4), 537-547 (1991)
   PUBMED   1776652
REFERENCE   8  (bases 1 to 5940)
  AUTHORS   Brand,N.J., Dabhade,N., Yacoub,M. and Barton,P.J.
  TITLE     Determination of the 5' exon structure of the human cardiac
            alpha-myosin heavy chain gene
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1255-1258 (1991)
   PUBMED   1930170
REFERENCE   9  (bases 1 to 5940)
  AUTHORS   Ehrlich,P.H., Moustafa,Z.A. and Ostberg,L.
  TITLE     Nucleotide sequence of chimpanzee Fc and hinge regions
  JOURNAL   Mol Immunol 28 (4-5), 319-322 (1991)
   PUBMED   2062315
REFERENCE   10 (bases 1 to 5940)
  AUTHORS   Solomon,S.D., Geisterfer-Lowrance,A.A., Vosberg,H.P., Hiller,G.,
            Jarcho,J.A., Morton,C.C., McBride,W.O., Mitchell,A.L., Bale,A.E.,
            McKenna,W.J. et al.
  TITLE     A locus for familial hypertrophic cardiomyopathy is closely linked
            to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on
            chromosome 14 at q11-q12
  JOURNAL   Am J Hum Genet 47 (3), 389-394 (1990)
   PUBMED   1975475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA566231.1, BC132667.1,
            D00943.1, M21664.1 and AL049829.4.
            
            On Feb 27, 2020 this sequence version replaced NM_002471.3.
            
            Summary: Cardiac muscle myosin is a hexamer consisting of two heavy
            chain subunits, two light chain subunits, and two regulatory
            subunits. This gene encodes the alpha heavy chain subunit of
            cardiac myosin. The gene is located approximately 4kb downstream of
            the gene encoding the beta heavy chain subunit of cardiac myosin.
            Mutations in this gene cause familial hypertrophic cardiomyopathy
            and atrial septal defect 3. [provided by RefSeq, Feb 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC132667.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2155550, SAMEA2159607 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405093.9/ ENSP00000386041.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA566231.1         3-39
            38-4980             BC132667.1         1-4943
            4981-5181           D00943.1           4914-5114
            5182-5908           BC132667.1         5145-5871
            5909-5937           M21664.1           1622-1650
            5938-5940           AL049829.4         164045-164047       c
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..5940
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /note="myosin heavy chain 6"
                     /db_xref="GeneID:4624"
                     /db_xref="HGNC:HGNC:7576"
                     /db_xref="MIM:160710"
     exon            1..21
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            22..54
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            55..268
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..5887
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /note="myosin, heavy polypeptide 6, cardiac muscle, alpha
                     (cardiomyopathy, hypertrophic 1); myHC-alpha"
                     /codon_start=1
                     /product="myosin-6"
                     /protein_id="NP_002462.2"
                     /db_xref="CCDS:CCDS9600.1"
                     /db_xref="GeneID:4624"
                     /db_xref="HGNC:HGNC:7576"
                     /db_xref="MIM:160710"
                     /translation="MTDAQMADFGAAAQYLRKSEKERLEAQTRPFDIRTECFVPDDKE
                     EFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVL
                     FNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDN
                     AYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLE
                     DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIF
                     QLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATD
                     SAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLN
                     SADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLET
                     KQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE
                     WTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQK
                     PRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSS
                     YATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKA
                     PGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQFIDS
                     RKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQL
                     MRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKE
                     EFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNK
                     IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA
                     TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE
                     QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD
                     INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE
                     EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE
                     LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR
                     VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ
                     LEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE
                     TDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER
                     SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL
                     EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEAS
                     LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR
                     NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD
                     LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI
                     NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM
                     KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM
                     RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK
                     VQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDEE"
     exon            269..412
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            413..569
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..597
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..709
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..802
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..866
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..965
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1069
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1208
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1477
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1648
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1958
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2029
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2117
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2235
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2359
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2496
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2752
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2995
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3172
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3318
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3409
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3799
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3926
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4045
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4242
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4426
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4427..4592
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4717
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..5026
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5230
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5231..5356
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5357..5632
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5633..5728
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5729..5863
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5864..5940
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5922..5927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /note="hexamer: AATAAA"
     polyA_site      5940
                     /gene="MYH6"
                     /gene_synonym="alpha-MHC; ASD3; CMD1EE; CMH14; MYHC;
                     MYHCA; SSS3"
                     /note="major polyA site"
ORIGIN      
        1 agagagactc ctgcggccca gattcttcag gattctccgt gaagggataa ccaggggaag
       61 caccaagatg accgatgccc agatggctga ctttggggca gcggcccagt acctccgcaa
      121 gtcagagaag gagcgtctag aggcccagac ccggcccttt gacattcgca ctgagtgctt
      181 cgtgcccgat gacaaggaag agtttgtcaa agccaagatt ttgtcccggg agggaggcaa
      241 ggtcattgct gaaaccgaga atgggaagac ggtgactgtg aaggaggacc aggtgttgca
      301 gcagaaccca cccaagttcg acaagattga ggacatggcc atgctgacct tcctgcacga
      361 gcccgcggtg cttttcaacc tcaaggagcg ctacgcggcc tggatgatat atacctactc
      421 gggcctcttc tgtgtcactg tcaaccccta caagtggctg ccggtgtaca atgccgaggt
      481 ggtggccgcc taccggggca agaagaggag tgaggccccg ccccacatct tctccatctc
      541 cgacaacgcc tatcagtaca tgctgacaga tcgggagaac cagtccatcc tcatcacggg
      601 agaatccggg gcggggaaga ctgtgaacac caagcgtgtc atccagtact ttgccagcat
      661 tgcagccata ggtgaccgtg gcaagaagga caatgccaat gcgaacaagg gcaccctgga
      721 ggaccagatc atccaggcca accccgctct ggaggccttc ggcaatgcca agactgtccg
      781 gaacgacaac tcctcccgct ttgggaaatt cattaggatc cactttgggg ccactggaaa
      841 gctggcttct gcagacatag agacctacct gctggagaag tcccgggtga tcttccagct
      901 gaaagctgag agaaactacc acatcttcta ccagattctg tccaacaaga agccggagtt
      961 gctggacatg ctgctggtca ccaacaatcc ctacgactac gccttcgtgt ctcagggaga
     1021 ggtgtccgtg gcctccattg atgactccga ggagctcatg gccaccgata gtgcctttga
     1081 cgtgctgggc ttcacttcag aggagaaagc tggcgtctac aagctgacgg gagccatcat
     1141 gcactacggg aacatgaagt tcaagcagaa gcagcgggag gagcaggcgg agccagacgg
     1201 caccgaagat gctgacaagt cggcctacct catggggctg aactcagctg acctgctcaa
     1261 ggggctgtgc caccctcggg tgaaagtggg caacgagtat gtcaccaagg ggcagagcgt
     1321 gcagcaggtg tactactcca tcggggctct ggccaaggca gtgtatgaga agatgttcaa
     1381 ctggatggtg acgcgcatca acgccaccct ggagaccaag cagccacgcc agtacttcat
     1441 aggagtcctg gacatcgctg gcttcgagat cttcgacttc aacagctttg agcagctctg
     1501 catcaacttc accaacgaga agctgcagca gttcttcaac caccacatgt tcgtgctgga
     1561 gcaggaggag tacaagaagg agggcattga gtggacattc attgactttg gcatggacct
     1621 gcaggcctgc attgacctca tcgagaagcc catgggcatc atgtccatcc tggaggagga
     1681 gtgcatgttc cccaaggcca ctgacatgac cttcaaggcc aagctgtacg acaaccacct
     1741 gggcaagtcc aacaatttcc agaagccacg caacatcaag gggaagcagg aagcccactt
     1801 ctccctgatc cactacgccg gcactgtgga ctacaacatc ctgggctggc tggaaaaaaa
     1861 caaggatcct ctcaacgaga ctgttgtggc cctgtaccag aagtcctccc tcaagctcat
     1921 ggccactctc ttctcctcct acgcaactgc cgatactggg gacagtggta aaagcaaagg
     1981 aggcaagaaa aagggctcat ccttccagac ggtgtcggct ctccaccggg aaaatctcaa
     2041 caagctaatg accaacctga ggaccaccca tcctcacttt gtgcgttgca tcatccccaa
     2101 tgagcggaag gctccagggg tgatggacaa ccccctggtc atgcaccagc tgcgctgcaa
     2161 tggcgtgctg gagggcatcc gcatctgcag gaagggcttc cccaaccgca tcctctacgg
     2221 ggacttccgg cagaggtatc gcatcctgaa cccagtggcc atccctgagg gacagttcat
     2281 tgatagcagg aaggggacag agaagctgct cagctctctg gacattgatc acaaccagta
     2341 caagtttggc cacaccaagg tgttcttcaa ggcagggctg cttgggctgc tggaggagat
     2401 gcgggatgag aggctgagcc gcatcatcac gcgcatgcag gcccaagccc ggggccagct
     2461 catgcgcatt gagttcaaga agatagtgga acgcagggat gccctgctgg taatccagtg
     2521 gaacattcgg gccttcatgg gggtcaagaa ttggccctgg atgaagctct acttcaagat
     2581 caagccgctg ctgaagagcg cagagacgga gaaggagatg gccaccatga aggaagagtt
     2641 cgggcgcatc aaagagacgc tggagaagtc cgaggctcgc cgcaaggagc tggaggagaa
     2701 gatggtgtcc ctgctgcagg agaagaatga cctgcagctc caagtgcagg cggaacaaga
     2761 caacctcaat gatgctgagg agcgctgcga ccagctgatc aaaaacaaga ttcagctgga
     2821 ggccaaagta aaggagatga atgagaggct ggaggatgag gaggagatga acgcggagct
     2881 cactgccaag aagcgcaagc tggaagacga gtgctcagag ctcaagaagg acattgatga
     2941 cctggagctg acactggcca aggtggagaa ggagaagcat gcaacagaga acaaggtgaa
     3001 gaacctaaca gaggagatgg ctgggctgga tgaaatcatc gctaagctga ccaaggagaa
     3061 gaaagctcta caagaggccc atcagcaggc cctggatgac cttcaggttg aggaagacaa
     3121 ggtcaacagc ctgtccaagt ctaaggtcaa gctggagcag caggtggatg atctggaggg
     3181 atccctagag caagagaaga aggtgcgcat ggacctggag cgagcaaagc ggaaactgga
     3241 gggcgacctg aagctgaccc aggagagcat catggacctg gaaaatgata aactgcagct
     3301 ggaagaaaag cttaagaaga aggagtttga cattaatcag cagaacagta agattgagga
     3361 tgagcaggtg ctggcccttc aactacagaa gaaactgaag gaaaaccagg cacgcatcga
     3421 ggagctggag gaggagctgg aggccgagcg caccgccagg gctaaggtgg agaagctgcg
     3481 ctcagacctg tctcgggagc tggaggagat cagcgagcgg ctggaagagg ccggcggggc
     3541 cacgtccgtg cagatcgaga tgaacaagaa gcgcgaggcc gagttccaga agatgcggcg
     3601 ggacctggag gaggccacgc tgcagcacga ggccactgcc gcggccctgc gcaagaagca
     3661 cgccgacagc gtggccgagc tgggcgagca gatcgacaac ctgcagcggg tgaagcagaa
     3721 gctggagaag gagaagagcg agttcaagct ggagctggat gacgtcacct ccaacatgga
     3781 gcagatcatc aaggccaagg caaacctgga gaaagtgtct cggacgctgg aggaccaggc
     3841 caatgagtac cgcgtgaagc tagaagaggc ccaacgctcc ctcaatgatt tcaccaccca
     3901 gcgagccaag ctgcagaccg agaatggaga gttggcccgg cagctagagg aaaaggaggc
     3961 gctaatctcg cagctgaccc gggggaagct ctcttatacc cagcaaatgg aggacctcaa
     4021 aaggcagctg gaggaggagg gcaaggcgaa gaacgccctg gcccatgcac tgcagtcggc
     4081 ccggcatgac tgcgacctgc tgcgggagca gtacgaggag gagacagagg ccaaggccga
     4141 gctgcagcgc gtcctgtcca aggccaactc ggaggtggcc cagtggagga ccaagtatga
     4201 gacggacgcc attcagcgga ctgaggagct cgaagaggcc aaaaagaagc tggcccagcg
     4261 gctgcaggat gccgaggagg ccgtggaggc tgttaatgcc aagtgctcct cactggagaa
     4321 gaccaagcac cggctacaga atgagataga ggacttgatg gtggacgtag agcgctccaa
     4381 tgctgctgct gcagccctgg acaagaagca gagaaacttt gacaagatcc tggccgagtg
     4441 gaagcagaag tatgaggagt cgcagtctga gctggagtcc tcacagaagg aggctcgctc
     4501 cctcagcaca gagctcttca agctcaagaa cgcctacgag gagtccctgg agcacctaga
     4561 gaccttcaag cgggagaaca agaaccttca ggaggaaatc tcggacctta ctgagcagct
     4621 aggagaagga ggaaagaatg tgcatgagct ggagaaggtc cgcaaacagc tggaggtgga
     4681 gaagctggag ctgcagtcag ccctggagga ggcagaggcc tccctggagc acgaggaggg
     4741 caagatcctc cgggcccagc tagagttcaa ccagatcaag gcagagatcg agcggaagct
     4801 ggcagagaag gacgaggaga tggaacaggc caagcgcaac caccagcggg tggtggactc
     4861 gctgcagacc tccctggatg cagagacacg cagccgcaac gaggtcctga gggtgaagaa
     4921 gaagatggaa ggagacctca atgagatgga gatccagctc agccacgcca accgcatggc
     4981 tgccgaggcc cagaagcaag tcaagagcct ccagagcttg ctgaaggaca cccagatcca
     5041 gctggacgat gcggtccgtg ccaacgacga cctgaaggag aacatcgcca tcgtggagcg
     5101 gcgcaacaac ctgctgcagg ctgagctgga ggagctgcgt gccgtggtgg agcagacaga
     5161 gcggtcccgg aagctggcgg agcaggagct gattgagacc agcgagcggg tgcagctgct
     5221 gcattcccag aacaccagcc tcatcaacca gaagaagaag atggagtcgg atctgaccca
     5281 gctccagtcg gaagtggagg aggcagtgca ggagtgcaga aacgccgagg agaaggccaa
     5341 gaaggccatc acggatgccg ccatgatggc agaggagctg aagaaggagc aggacaccag
     5401 cgcccacctg gagcgcatga agaagaacat ggagcagacc attaaggacc tgcagcaccg
     5461 gctggacgag gccgagcaga tcgccctcaa gggaggcaag aagcagctgc agaagctgga
     5521 agcgcgggtg cgggagctgg agggtgagct ggaggccgag cagaagcgca acgcagagtc
     5581 ggtgaagggc atgaggaaga gcgagcggcg catcaaggag ctcacctacc agacagagga
     5641 agacaaaaag aacctgctgc ggctacagga cctggtggac aagctgcaac tgaaggtcaa
     5701 ggcctacaag cgccaggccg aggaggcgga ggagcaagcc aacaccaacc tgtccaagtt
     5761 ccgcaaggtg cagcatgagc tggatgaggc agaggagcgg gcggacatcg ctgagtccca
     5821 ggtcaacaag cttcgagcca agagccgtga cattggtgcc aagcaaaaaa tgcacgatga
     5881 ggagtgacac tgcctcggga acctcactct tgccaacctg taataaatat gagtgccaaa
//
