LOCUS       NM_002470               6032 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens myosin heavy chain 3 (MYH3), mRNA.
ACCESSION   NM_002470
VERSION     NM_002470.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6032)
  AUTHORS   Morali,B., Miranda,V., Raelson,J., Grimard,G., Glavas,P.,
            Audibert,F., Dumont,N.A., Barone,J., Bamshad,M., Lemyre,E. and
            Campeau,P.M.
  TITLE     Bi-allelic variants in MYH3 cause recessively-inherited
            arthrogryposis
  JOURNAL   Clin Genet 106 (4), 483-487 (2024)
   PUBMED   38856159
  REMARK    GeneRIF: Bi-allelic variants in MYH3 cause recessively-inherited
            arthrogryposis.
REFERENCE   2  (bases 1 to 6032)
  AUTHORS   He,Q.B., Wu,C.H., Sun,D.L., Yuan,J.Y., Hu,H.Y., Yang,K., Chen,W.Q.,
            Yan,Y.S., Yin,G.Y., Zhang,J. and Li,Y.Z.
  TITLE     Functional assessment of a novel biallelic MYH3 variation causing
            CPSKF1B (contractures, pterygia, and spondylocarpotarsal fusion
            syndrome1B)
  JOURNAL   Mol Genet Genomic Med 12 (3), e2401 (2024)
   PUBMED   38444278
  REMARK    GeneRIF: Functional assessment of a novel biallelic MYH3 variation
            causing CPSKF1B (contractures, pterygia, and spondylocarpotarsal
            fusion syndrome1B).
REFERENCE   3  (bases 1 to 6032)
  AUTHORS   Gong,C., Wu,J., Li,H., Luo,C., Ji,G., Guan,X., Liu,J. and Wang,M.
  TITLE     METTL3 achieves lipopolysaccharide-induced myocardial injury via
            m6A-dependent stabilization of Myh3 mRNA
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119503 (2023)
   PUBMED   37245538
  REMARK    GeneRIF: METTL3 achieves lipopolysaccharide-induced myocardial
            injury via m[6]A-dependent stabilization of Myh3 mRNA.
REFERENCE   4  (bases 1 to 6032)
  AUTHORS   Hakonen,A.H., Lehtonen,J., Kivirikko,S., Keski-Filppula,R.,
            Moilanen,J., Kivisaari,R., Almusa,H., Jakkula,E., Saarela,J.,
            Avela,K. and Aittomaki,K.
  TITLE     Recessive MYH3 variants cause 'Contractures, pterygia, and variable
            skeletal fusions syndrome 1B' mimicking Escobar variant multiple
            pterygium syndrome
  JOURNAL   Am J Med Genet A 182 (11), 2605-2610 (2020)
   PUBMED   32902138
  REMARK    GeneRIF: Recessive MYH3 variants cause ''Contractures, pterygia,
            and variable skeletal fusions syndrome 1B'' mimicking Escobar
            variant multiple pterygium syndrome.
REFERENCE   5  (bases 1 to 6032)
  AUTHORS   Zhang,J., Chen,W.Q., Wang,S.W., Wang,S.X., Yu,M., Guo,Q. and
            Yu,Y.D.
  TITLE     Identification of a novel pathogenic variant in the MYH3 gene in a
            five-generation family with CPSFS1A (Contractures, Pterygia, and
            Spondylocarpotarsal Fusion Syndrome 1A)
  JOURNAL   Mol Genet Genomic Med 8 (10), e1440 (2020)
   PUBMED   32767732
  REMARK    GeneRIF: Identification of a novel pathogenic variant in the MYH3
            gene in a five-generation family with CPSFS1A (Contractures,
            Pterygia, and Spondylocarpotarsal Fusion Syndrome 1A).
REFERENCE   6  (bases 1 to 6032)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   7  (bases 1 to 6032)
  AUTHORS   Bober,E., Buchberger-Seidl,A., Braun,T., Singh,S., Goedde,H.W. and
            Arnold,H.H.
  TITLE     Identification of three developmentally controlled isoforms of
            human myosin heavy chains
  JOURNAL   Eur J Biochem 189 (1), 55-65 (1990)
   PUBMED   1691980
REFERENCE   8  (bases 1 to 6032)
  AUTHORS   Eller,M., Stedman,H.H., Sylvester,J.E., Fertels,S.H., Wu,Q.L.,
            Raychowdhury,M.K., Rubinstein,N.A., Kelly,A.M. and Sarkar,S.
  TITLE     Human embryonic myosin heavy chain cDNA. Interspecies sequence
            conservation of the myosin rod, chromosomal locus and isoform
            specific transcription of the gene
  JOURNAL   FEBS Lett 256 (1-2), 21-28 (1989)
   PUBMED   2806546
REFERENCE   9  (bases 1 to 6032)
  AUTHORS   Karsch-Mizrachi,I., Travis,M., Blau,H. and Leinwand,L.A.
  TITLE     Expression and DNA sequence analysis of a human embryonic skeletal
            muscle myosin heavy chain gene
  JOURNAL   Nucleic Acids Res 17 (15), 6167-6179 (1989)
   PUBMED   2771643
REFERENCE   10 (bases 1 to 6032)
  AUTHORS   Eller,M., Stedman,H.H., Sylvester,J.E., Fertels,S.H.,
            Rubinstein,N.A., Kelly,A.M. and Sarkar,S.
  TITLE     Nucleotide sequence of full length human embryonic myosin heavy
            chain cDNA
  JOURNAL   Nucleic Acids Res 17 (9), 3591-3592 (1989)
   PUBMED   2726495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP233220.1, BQ956249.1,
            X13988.1, AC002347.3, BX500019.1, BY796597.2, BP232269.1,
            BP232093.1, AY517555.1, CD614924.1 and BP370003.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002470.3.
            
            Summary: Myosin is a major contractile protein which converts
            chemical energy into mechanical energy through the hydrolysis of
            ATP. Myosin is a hexameric protein composed of a pair of myosin
            heavy chains (MYH) and two pairs of nonidentical light chains. This
            gene is a member of the MYH family and encodes a protein with an IQ
            domain and a myosin head-like domain. Mutations in this gene have
            been associated with two congenital contracture (arthrogryposis)
            syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X13988.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583535.6/ ENSP00000464317.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               BP233220.1         1-449
            450-706             BQ956249.1         442-698
            707-1066            X13988.1           703-1062
            1067-1090           AC002347.3         98432-98455
            1091-1809           X13988.1           1087-1805
            1810-2103           BX500019.1         93-386
            2104-2238           X13988.1           2100-2234
            2239-2253           AC002347.3         103285-103299
            2254-2282           X13988.1           2250-2278
            2283-2377           AC002347.3         103727-103821
            2378-2619           X13988.1           2374-2615
            2620-3016           BY796597.2         89-485
            3017-3039           X13988.1           3013-3035
            3040-3136           BY796597.2         509-605
            3137-3225           X13988.1           3133-3221
            3226-3603           BP232269.1         168-545
            3604-3929           BP232093.1         256-581
            3930-4818           AY517555.1         846-1734
            4819-5046           CD614924.1         355-582
            5047-6030           AY517555.1         1963-2946
            6031-6032           BP370003.1         452-453
FEATURES             Location/Qualifiers
     source          1..6032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6032
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="myosin heavy chain 3"
                     /db_xref="GeneID:4621"
                     /db_xref="HGNC:HGNC:7573"
                     /db_xref="MIM:160720"
     exon            1..21
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            22..80
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            81..292
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..5911
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="myosin, heavy polypeptide 3, skeletal muscle,
                     embryonic; myosin, skeletal, heavy chain, embryonic 1;
                     myosin heavy chain, fast skeletal muscle, embryonic;
                     myosin, heavy chain 3, skeletal muscle, embryonic"
                     /codon_start=1
                     /product="myosin-3"
                     /protein_id="NP_002461.2"
                     /db_xref="CCDS:CCDS11157.1"
                     /db_xref="GeneID:4621"
                     /db_xref="HGNC:HGNC:7573"
                     /db_xref="MIM:160720"
                     /translation="MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSK
                     EEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAV
                     LYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISD
                     NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLE
                     DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTF
                     QLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATD
                     SAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLN
                     SSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDT
                     KLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE
                     WTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQK
                     PKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYAT
                     FATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTP
                     GAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSK
                     KACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLM
                     RVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEE
                     FQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF
                     QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT
                     ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ
                     QVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEY
                     CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE
                     LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAEL
                     GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG
                     KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL
                     EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET
                     DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERA
                     NSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD
                     QLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL
                     EHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN
                     EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDL
                     KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIH
                     TKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK
                     KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLR
                     KYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA
                     QHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE"
     exon            293..436
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            437..593
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            594..621
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            622..730
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            731..823
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            824..887
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            888..986
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1090
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1229
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1348
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1498
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1669
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1976
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2047
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2135
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2253
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2377
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2514
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2770
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..3013
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3190
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3336
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3427
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3817
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3944
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4063
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4260
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4444
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4445..4610
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4611..4735
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4736..5044
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5248
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5374
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5545
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5546..5650
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5651..5746
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..5884
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5885..6032
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6011..6016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="hexamer: AATAAA"
     polyA_site      6032
                     /gene="MYH3"
                     /gene_synonym="CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A;
                     DA2B; DA2B3; DA8; HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="major polyA site"
ORIGIN      
        1 gtggctcgct tgtgggcgga ggtctgggat ctcctggctg ttgctgtctt ctgctctcat
       61 cctgcaggtg ggactctcag ctgacaccat gagtagtgac actgaaatgg aagtgttcgg
      121 catagctgct cctttcctcc ggaagtcaga aaaggagagg atcgaggctc agaaccagcc
      181 ctttgatgcc aagacgtatt gcttcgtggt ggactcaaag gaagaatatg ccaaggggaa
      241 aatcaagagt tctcaggatg ggaaggtcac tgtggaaact gaggacaaca ggaccctggt
      301 ggtcaaacca gaggatgtgt acgccatgaa cccccccaag ttcgacagga tcgaagacat
      361 ggccatgctg acgcacctga atgagccagc cgtgctgtac aacctgaagg accgttacac
      421 atcttggatg atctatacct actcaggcct cttctgtgtc actgtcaacc cctacaagtg
      481 gctgccggtg tacaaccccg aggtggtgga aggctaccga ggcaaaaagc gccaggaggc
      541 cccaccccac atcttctcca tctctgacaa cgcctatcag ttcatgctga ctgatcgtga
      601 aaaccagtcc attctgatca ccggagaatc cggggcagga aagactgtga acaccaaacg
      661 ggtcatccag tactttgcaa caattgcagc tactggggac ctggccaaga agaaggactc
      721 caaaatgaag gggactctgg aagatcaaat catcagtgcc aatcccctgc tggaggcctt
      781 tgggaacgcc aagactgtga ggaatgacaa ctcctcccgt tttggcaagt tcatccgaat
      841 ccattttgga accactggga agctggcctc tgcagatatt gaaacttatc ttctggaaaa
      901 atcaagagtc actttccagc tgaaggctga aagaagctac cacatcttct accagattct
      961 ttctaacaag aagcctgagc tcatagagct gctgcttatt acgaccaacc cttacgacta
     1021 cccgttcatt agccaggggg agatcctggt ggccagcata gatgatgcag aggagctgct
     1081 ggctacagac agcgccattg acatcctggg cttcacccca gaagagaaat ctgggctcta
     1141 caagctgacg ggagccgtga tgcactacgg gaacatgaag ttcaagcaga agcagcgaga
     1201 ggagcaggcc gagccggatg gcacagaagt ggctgacaaa acagcctatc tgatgggcct
     1261 gaactcttcg gacctcctaa aagctttgtg ctttcctaga gtgaaagttg ggaatgagta
     1321 cgttaccaaa ggtcaaactg tggatcaggt tcaccatgct gtgaatgctc tttcaaaatc
     1381 agtttatgaa aagttgttct tgtggatggt cactcgcatt aaccagcaac tggatacgaa
     1441 gcttccaaga caacacttca ttggtgtttt ggacattgca ggctttgaaa tctttgagta
     1501 taacagcctg gagcagctgt gcatcaactt caccaatgag aaactgcaac agtttttcaa
     1561 ccaccacatg ttcgtgctgg agcaggagga gtacaagaag gaaggcatcg agtggacgtt
     1621 cattgacttc gggatggacc tggctgcctg catcgagctc atcgagaagc ctatgggcat
     1681 cttctccatc ctggaagagg agtgcatgtt ccccaaggca acagacacct ccttcaagaa
     1741 caagctgtat gaccagcatc ttggaaagtc caacaacttc cagaagccca aggtggtcaa
     1801 aggcagggcc gaggctcact tctcactgat ccactatgcg ggcaccgtgg actacagtgt
     1861 ctcaggttgg ctggagaaga acaaggaccc tctgaacgag actgtggttg ggctgtacca
     1921 gaagtcttcc aacaggctcc tggcacacct ctatgccacg tttgccacgg cggatgctga
     1981 cagtggaaag aagaaagttg ccaagaagaa gggttcttcc ttccaaactg tctctgccct
     2041 tttcagggaa aacctgaaca agctgatgtc aaatttaaga actactcacc ctcattttgt
     2101 gcgttgtata attcccaatg aaaccaaaac tccaggggct atggaacaca gccttgttct
     2161 gcaccagctg cggtgtaacg gtgtcctgga gggcatccgc atctgcagga aagggttccc
     2221 aaacaggatt ctctatggcg attttaaaca aagataccga gtgctgaatg ccagtgcaat
     2281 ccctgaggga caattcattg acagcaagaa agcctgtgaa aagcttctgg catccattga
     2341 tattgaccac actcagtaca aatttggaca taccaaggtg ttcttcaagg ctggcttgct
     2401 gggaaccctg gaagagatgc gggatgaccg cctggccaaa ctaatcaccc ggacacaagc
     2461 tgtgtgcaga gggttcctca tgcgtgtgga attccagaag atggtgcaga ggagggagtc
     2521 catcttctgc atccagtaca acattcgctc attcatgaac gtcaagcact ggccctggat
     2581 gaaactcttc ttcaagatca agcccctcct caagagtgca gagactgaga aagagatggc
     2641 caccatgaag gaagaattcc agaaaaccaa agatgaactc gccaagtcgg aggcaaaaag
     2701 gaaggagcta gaggaaaaac tggtgactct ggtccaagag aagaatgacc tgcagctcca
     2761 agtacaagct gaaagcgaaa atttgttgga tgctgaggaa agatgcgatc agctgatcaa
     2821 agccaaattc cagctcgagg ccaagatcaa ggaggtgaca gagagagctg aagatgagga
     2881 ggagatcaat gctgagctga cggccaagaa gaggaaactg gaggatgaat gctcagagct
     2941 caagaaagac attgatgacc ttgagttgac cctggccaag gttgagaagg agaagcatgc
     3001 cacagagaac aaggttaaaa accttactga ggaactctct gggttagatg aaacaattgc
     3061 aaagttaacc agagagaaga aggccctcca agaggcgcac cagcaggcct tggatgacct
     3121 ccaagctgaa gaagacaaag tcaattcttt gaacaaaacc aagagcaaac tggaacagca
     3181 agtggaagac ctggaaagct ccctagaaca agaaaagaag ctccgagtag acctggaaag
     3241 gaacaaaagg aaattggaag gagacttgaa gcttgctcaa gagtccatat tagatctgga
     3301 gaatgacaag caacagctgg acgaaaggct caagaagaaa gattttgaat attgtcaact
     3361 tcaaagcaaa gtggaagatg agcagacact gggcctccag tttcagaaga aaatcaaaga
     3421 gttgcaggct cgaattgagg agctggaaga ggagatagag gcggagaggg ccacccgcgc
     3481 gaagacagag aaacagcgca gcgactatgc ccgggagctg gaggagctga gcgagcggct
     3541 ggaggaggcg ggaggcgtca cctccacgca gatagagctc aacaagaagc gggaggcgga
     3601 gttcctgaag ctgcgcaggg acctggagga ggccacactg cagcacgaag ccatggtggc
     3661 cgcgctgagg aagaagcatg cggatagtgt ggccgagctt ggggagcaga ttgacaacct
     3721 gcagcgggtc aagcagaagc tggagaagga gaagagcgag ttcaagctgg agatcgatga
     3781 cctctccagc agcatggaga gtgtgtcgaa atctaaggca aatctggaaa aaatctgccg
     3841 aaccctggag gatcagttaa gtgaggccag gggcaagaat gaggaaattc agaggagcct
     3901 gagcgagctg accacacaga agtctcgttt gcagaccgag gctggtgagc tgagtcgtca
     3961 gctggaagaa aaagaaagca tagtatccca actttccagg agcaagcaag cctttaccca
     4021 gcaaacagaa gagctcaaga ggcagctgga ggaagagaac aaggccaaga acgccctggc
     4081 gcacgccctg cagtcctccc gccacgactg tgacctgctg cgggaacagt atgaggagga
     4141 gcaggaaggc aaagctgagc tgcagagggc gctgtccaag gccaatagtg aggttgccca
     4201 gtggagaacc aaatacgaga cggacgccat ccagcgcaca gaagagctgg aggaggccaa
     4261 gaaaaaactt gctcagcgcc ttcaagattc cgaggaacag gttgaggcag tgaatgctaa
     4321 atgtgcttca ctggagaaga ccaagcagag gctgcaagga gaggtggagg atctgatggt
     4381 tgatgttgaa agagccaatt ccttggccgc cgctctggac aagaagcaga ggaactttga
     4441 caaggtgttg gcagagtgga agacaaagtg tgaggagagc caagcagagc tggaggcatc
     4501 cctgaaggag tcccgctcct tgagcactga gctcttcaaa ctgaaaaatg cctacgagga
     4561 agccttagat caacttgaaa ctgtgaaacg ggaaaataag aacttagagc aggagatagc
     4621 agatctcaca gaacaaattg ctgaaaatgg caaaaccatc catgaactgg agaaatcaag
     4681 aaagcagatt gagctggaaa aggctgatat ccagctggct ctcgaggaag cagaggctgc
     4741 tcttgagcat gaagaagcca agatcctccg aatccagctt gaattgacac aagtgaaatc
     4801 agaaattgat agaaagatcg ccgagaagga tgaagagatc gagcagctga agaggaacta
     4861 ccagagaaca gtggaaacca tgcagagcgc cctggacgcc gaggtgcgga gcaggaatga
     4921 agccatccgg ctcaagaaga agatggaggg ggacctgaat gaaatcgaga tccagctgag
     4981 ccacgccaac cgccaggcgg cggagaccct caaacacctc aggagtgtcc agggacagct
     5041 gaaggatacg cagctccacc tggatgatgc cctccggggc caggaggacc tgaaggagca
     5101 gctggcgatt gtggagcgca gagccaacct gctgcaggcc gaggtggagg agctgcgggc
     5161 tactctggag cagacggaga gggcccggaa actggcggaa caggagctcc tggactccaa
     5221 cgagagggtg cagctgctgc atacccagaa caccagcctc atccacacca agaagaagct
     5281 ggagacagac ctcatgcagc tccagagtga ggtagaagat gccagcaggg atgcaaggaa
     5341 cgctgaggag aaggccaaga aggccatcac ggacgctgcc atgatggcgg aggagctgaa
     5401 gaaggagcag gacaccagcg cccaccttga gcggatgaag aagaacctgg aacagacggt
     5461 gaaggacctg cagcatcgtc tagatgaggc cgagcagctg gcgctgaagg gcgggaagaa
     5521 gcagatccag aaactggaga ccaggatccg agagctggag tttgaacttg agggagagca
     5581 gaagaagaac acagagtctg ttaagggcct gaggaagtat gagcggaggg tcaaggagct
     5641 gacgtaccag agtgaagagg acaggaagaa tgtgctgaga ttgcaggatc tggtggataa
     5701 actgcaagtg aaagtcaagt cctacaagag gcaggcggag gaggctgatg aacaagccaa
     5761 tgctcatctc accaaattcc gaaaggctca gcatgagctg gaggaggccg aggaacgtgc
     5821 ggatatcgca gaatctcaag tcaacaagct ccgcgctaag actcgagact tcacctccag
     5881 caggatggtg gtccacgaga gtgaagagtg agccagccct tctggagcag gacagaagat
     5941 atgcaaaatg tatattttct tgattcctga ccattgatac ttaatgtcca tgtgactctt
     6001 tttcacatgc aataaacttt gctttgtttc aa
//
