LOCUS       NM_017534               6044 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens myosin heavy chain 2 (MYH2), transcript variant 1,
            mRNA.
ACCESSION   NM_017534
VERSION     NM_017534.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6044)
  AUTHORS   Jo,S., Lee,S.H., Jeon,C., Jo,H.R., You,Y.J., Lee,J.K., Sung,I.H.,
            Kim,T.H. and Lee,C.H.
  TITLE     Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes
            of soft callus provokes endochondral bone formation in fracture
  JOURNAL   Life Sci 334, 122204 (2023)
   PUBMED   37871676
  REMARK    GeneRIF: Myosin heavy chain 2 (MYH2) expression in hypertrophic
            chondrocytes of soft callus provokes endochondral bone formation in
            fracture.
REFERENCE   2  (bases 1 to 6044)
  AUTHORS   Vitriol,E.A., Quintanilla,M.A., Tidei,J.J., Troughton,L.D.,
            Cody,A., Cisterna,B.A., Jane,M.L., Oakes,P.W. and Beach,J.R.
  TITLE     Nonmuscle myosin 2 filaments are processive in cells
  JOURNAL   Biophys J 122 (18), 3678-3689 (2023)
   PUBMED   37218133
  REMARK    GeneRIF: Nonmuscle myosin 2 filaments are processive in cells.
REFERENCE   3  (bases 1 to 6044)
  AUTHORS   Baskar,D., Vengalil,S., Nashi,S., Bardhan,M., Srivastava,K.,
            Sanka,S.B., Polavarapu,K., Menon,D., Preethish-Kumar,V.,
            Padmanabha,H., Arunachal,G. and Nalini,A.
  TITLE     MYH2-related Myopathy: Expanding the Clinical Spectrum of Chronic
            Progressive External Ophthalmoplegia (CPEO)
  JOURNAL   J Neuromuscul Dis 10 (4), 727-730 (2023)
   PUBMED   37154181
  REMARK    GeneRIF: MYH2-related Myopathy: Expanding the Clinical Spectrum of
            Chronic Progressive External Ophthalmoplegia (CPEO).
REFERENCE   4  (bases 1 to 6044)
  AUTHORS   Tajsharghi,H., Darin,N., Rekabdar,E., Kyllerman,M., Wahlstrom,J.,
            Martinsson,T. and Oldfors,A.
  TITLE     Mutations and sequence variation in the human myosin heavy chain
            IIa gene (MYH2)
  JOURNAL   Eur J Hum Genet 13 (5), 617-622 (2005)
   PUBMED   15741996
  REMARK    GeneRIF: analysis of normal variation indicates that there is
            strong selective pressure against mutations in MYH2; On the basis
            of these results, we suggest that MyHC genes should be regarded as
            candidate genes in hereditary myopathies of unknown etiology.
REFERENCE   5  (bases 1 to 6044)
  AUTHORS   Martinsson,T., Oldfors,A., Darin,N., Berg,K., Tajsharghi,H.,
            Kyllerman,M. and Wahlstrom,J.
  TITLE     Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in
            the myosin heavy chain IIa gene
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14614-14619 (2000)
   PUBMED   11114175
REFERENCE   6  (bases 1 to 6044)
  AUTHORS   Weiss,A., Schiaffino,S. and Leinwand,L.A.
  TITLE     Comparative sequence analysis of the complete human sarcomeric
            myosin heavy chain family: implications for functional diversity
  JOURNAL   J Mol Biol 290 (1), 61-75 (1999)
   PUBMED   10388558
REFERENCE   7  (bases 1 to 6044)
  AUTHORS   Weiss,A., McDonough,D., Wertman,B., Acakpo-Satchivi,L.,
            Montgomery,K., Kucherlapati,R., Leinwand,L. and Krauter,K.
  TITLE     Organization of human and mouse skeletal myosin heavy chain gene
            clusters is highly conserved
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2958-2963 (1999)
   PUBMED   10077619
REFERENCE   8  (bases 1 to 6044)
  AUTHORS   Smerdu,V., Karsch-Mizrachi,I., Campione,M., Leinwand,L. and
            Schiaffino,S.
  TITLE     Type IIx myosin heavy chain transcripts are expressed in type IIb
            fibers of human skeletal muscle
  JOURNAL   Am J Physiol 267 (6 Pt 1), C1723-C1728 (1994)
   PUBMED   7545970
REFERENCE   9  (bases 1 to 6044)
  AUTHORS   Schwartz,C.E., McNally,E., Leinwand,L. and Skolnick,M.H.
  TITLE     A polymorphic human myosin heavy chain locus is linked to an
            anonymous single copy locus (D17S1) at 17p13
  JOURNAL   Cytogenet Cell Genet 43 (1-2), 117-120 (1986)
   PUBMED   2877813
REFERENCE   10 (bases 1 to 6044)
  AUTHORS   Barton,P.J. and Buckingham,M.E.
  TITLE     The myosin alkali light chain proteins and their genes
  JOURNAL   Biochem J 231 (2), 249-261 (1985)
   PUBMED   3904738
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC379233.1, BC126409.1 and
            BC093082.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017534.5.
            
            Summary: Myosins are actin-based motor proteins that function in
            the generation of mechanical force in eukaryotic cells. Muscle
            myosins are heterohexamers composed of 2 myosin heavy chains and 2
            pairs of nonidentical myosin light chains. This gene encodes a
            member of the class II or conventional myosin heavy chains, and
            functions in skeletal muscle contraction. This gene is found in a
            cluster of myosin heavy chain genes on chromosome 17. A mutation in
            this gene results in inclusion body myopathy-3. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX510904.2, BC126409.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245503.10/ ENSP00000245503.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               DC379233.1         43-524
            483-5935            BC126409.1         468-5920
            5936-6044           BC093082.1         2224-2332
FEATURES             Location/Qualifiers
     source          1..6044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6044
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /note="myosin heavy chain 2"
                     /db_xref="GeneID:4620"
                     /db_xref="HGNC:HGNC:7572"
                     /db_xref="MIM:160740"
     exon            1..23
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            24..66
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            67..290
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..5912
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /note="myosin, heavy polypeptide 2, skeletal muscle,
                     adult; type IIA myosin heavy chain; fast 2a myosin heavy
                     chain; myosin heavy chain 2a; myosin heavy chain IIa;
                     myosin heavy chain, skeletal muscle, adult 2; inclusion
                     body myopathy 3, autosomal dominant; myosin, heavy chain
                     2, skeletal muscle, adult"
                     /codon_start=1
                     /product="myosin-2"
                     /protein_id="NP_060004.3"
                     /db_xref="CCDS:CCDS11156.1"
                     /db_xref="GeneID:4620"
                     /db_xref="HGNC:HGNC:7572"
                     /db_xref="MIM:160740"
                     /translation="MSSDSELAVFGEAAPFLRKSERERIEAQNRPFDAKTSVFVAEPK
                     ESFVKGTIQSREGGKVTVKTEGGATLTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAV
                     LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISD
                     NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRV
                     VFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMA
                     TDSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQS
                     LNSADLLKALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANF
                     QKPKVVKGKAEAHFALIHYAGVVDYNITGWLEKNKDPLNETVVGLYQKSAMKTLAQLF
                     SGAQTAEGEGAGGGAKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPN
                     ETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQ
                     FIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARC
                     RGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMA
                     TMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQL
                     IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK
                     EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK
                     IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK
                     KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS
                     RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD
                     SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL
                     SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE
                     LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR
                     TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML
                     DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY
                     EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE
                     AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE
                     IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR
                     SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQN
                     TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH
                     LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA
                     VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA
                     KFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE"
     exon            291..434
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            435..591
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..619
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            620..734
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            735..827
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..891
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            892..990
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1094
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1233
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1352
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1502
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1673
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1983
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2060
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2148
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2266
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2390
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2527
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2783
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3026
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3203
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3349
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3440
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3830
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3957
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4076
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4273
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4457
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4623
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4748
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..5057
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5261
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5387
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5558
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5559..5663
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5759
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     exon            5760..6044
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6015..6020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /note="hexamer: AATAAA"
     polyA_site      6044
                     /gene="MYH2"
                     /gene_synonym="CMYO6; CMYP6; IBM3; MYH2A; MYHas8; MyHC-2A;
                     MyHC-IIa; MYHSA2; MYPOP"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgcttt aaaaagctcc aagaactgtc tcactcccag gctacatctt ctcacttgct
       61 aacaaggacc tctgagttca gcagccatga gttcagactc agaattggct gtttttgggg
      121 aggctgctcc tttcctccga aagtctgaaa gggagcgcat tgaggcccag aataggccct
      181 ttgatgccaa aacatctgtc tttgtggcgg agcccaaaga atcctttgtc aaagggacca
      241 tccagagcag agaaggagga aaagtgacgg tgaagactga gggaggagcg actctgacag
      301 tgaaggatga tcaggtcttc cccatgaacc ctcccaaata tgacaagatc gaggatatgg
      361 ccatgatgac tcatctgcat gagcctgctg tgctgtacaa cctcaaagaa cgttatgcag
      421 cctggatgat ctacacctat tcaggtctct tctgtgtcac tgtcaacccc tacaagtggc
      481 tgcctgtgta taagcccgag gtggtgacag cctaccgagg caaaaagcgc caggaggccc
      541 cgccccacat cttctccatc tctgacaacg cctatcagtt catgctgact gaccgagaga
      601 atcagtcaat cctgatcact ggagaatctg gtgcagggaa gactgtgaac accaagcgtg
      661 tcatccagta ctttgcaaca attgcagtta ctggtgagaa gaagaaggaa gaaattactt
      721 ctggcaaaat acaggggact ctggaagatc aaatcatcag tgccaacccc ctactggagg
      781 cctttggcaa cgccaagacc gtgaggaatg acaactcctc tcgctttggt aaattcatca
      841 gaatccactt tggcactact ggaaaactgg catctgctga tattgaaaca tatctgctag
      901 agaagtctag agttgttttc cagcttaagg ctgagagaag ttatcatatt ttttaccaga
      961 ttacatcgaa taagaaacca gaacttattg aaatgcttct gattaccacg aacccatatg
     1021 attacccatt tgtcagtcaa ggggagatca gtgtggccag catcgatgat caggaagaac
     1081 tgatggccac agatagtgct attgatattt tgggctttac taatgaagaa aaggtctcca
     1141 tttacaagct cacgggggct gtgatgcatt atgggaacct aaaatttaag caaaagcagc
     1201 gtgaggagca agcagagcca gatggcacag aagttgctga caaggcggcc tacctccaga
     1261 gtctgaactc tgcagatctg ctcaaagctc tctgctaccc cagggtcaag gtcggcaatg
     1321 agtatgtcac caaaggccag actgtagaac aggtgtccaa cgcagtaggt gctctggcca
     1381 aagccgtcta cgagaagatg ttcctgtgga tggttgcccg catcaaccag cagctggaca
     1441 ccaagcagcc caggcagtac ttcatcgggg tcttggacat tgctggtttt gagatttttg
     1501 atttcaacag cctggagcag ctgtgcatca acttcaccaa tgagaaactg caacagtttt
     1561 tcaaccacca catgttcgtg ctggagcagg aggagtacaa gaaggaaggc atcgagtgga
     1621 cgttcatcga cttcgggatg gacctggctg cctgcatcga gctcatcgag aagcctatgg
     1681 gcatcttctc catcctggaa gaggagtgca tgttccctaa ggcaacagac acctccttca
     1741 agaacaagct gtatgaccag cacctgggca agtctgccaa cttccagaag cccaaggtgg
     1801 tcaaaggcaa ggccgaggcc cacttcgctc tgattcacta tgctggtgtt gtggactaca
     1861 acattactgg ctggctggag aagaacaagg accccctgaa tgagaccgtg gttggactgt
     1921 accagaagtc tgcaatgaaa actctagctc agctcttctc tggggctcaa actgctgaag
     1981 gagagggagc tggtggaggg gccaagaaag gtggtaagaa gaagggctct tctttccaga
     2041 cagtgtctgc ccttttcaga gagaatttga acaagctgat gaccaacctc aggagtaccc
     2101 atcctcactt tgtgaggtgt atcatcccca atgagacaaa aactcctggt gccatggagc
     2161 atgagcttgt cctccaccag ctgaggtgta acggtgtgct ggaaggcatc cgcatctgta
     2221 ggaaaggatt tccaagcaga atcctttatg cagacttcaa acagagatac aaggtattaa
     2281 atgcaagtgc aatccctgaa gggcaattca ttgatagcaa gaaggcctct gagaagctcc
     2341 ttgcatccat cgacattgac cacacccagt ataaatttgg gcacaccaag gtctttttca
     2401 aagctggtct tctggggctc ctagaggaga tgcgagatga caagctggcc cagctgatta
     2461 cccgaaccca ggccaggtgc agagggttct tggcaagagt ggagtaccag aggatggtgg
     2521 agagaaggga ggccatcttc tgtatccagt acaatatcag atccttcatg aatgtcaagc
     2581 actggccctg gatgaaactc ttcttcaaga tcaagcctct gttgaagagt gcagaaactg
     2641 agaaggagat ggccaccatg aaggaagaat ttcagaaaat taaagacgaa cttgccaagt
     2701 cagaggcaaa aaggaaggaa ctggaagaaa agatggtgac gctgttgaaa gaaaaaaatg
     2761 acttgcagct ccaagttcag gctgaagccg aaggcttggc tgatgcagag gaaaggtgtg
     2821 accagctaat caaaaccaaa atccagctag aagccaaaat caaagaggtg actgagagag
     2881 ctgaggatga ggaagagatc aatgctgagc tgacagccaa gaagaggaaa ctggaggatg
     2941 aatgttcaga actcaagaaa gacattgatg accttgagct gacactggcc aaggttgaga
     3001 aggagaaaca tgccacagaa aacaaggtga aaaacctcac agaagagatg gcaggtctgg
     3061 atgaaaccat tgctaagctg accaaggaga agaaggctct ccaggaggcc caccagcaga
     3121 ccctggatga cctgcaggca gaggaggaca aagtcaacac cctgaccaaa gctaaaatca
     3181 aacttgaaca acaagtggat gatcttgaag ggtccttgga gcaagaaaag aaacttcgca
     3241 tggacctaga aagggctaag aggaaacttg agggtgactt gaagttggcc caagaatcca
     3301 taatggacat tgaaaatgag aaacagcaac ttgatgaaaa gctcaaaaag aaagagtttg
     3361 aaatcagcaa tctgcaaagc aagattgaag atgaacaggc acttggcatt caattgcaga
     3421 agaaaattaa agaattgcaa gcccgcattg aggagctgga ggaggaaatc gaggcagagc
     3481 gggcctcccg ggccaaagca gagaagcagc gctctgacct ctcccgggag ctggaggaga
     3541 tcagcgagag gctggaagaa gccggtgggg ccacttcagc ccagattgag atgaacaaga
     3601 agcgggaggc tgagttccag aaaatgcgca gggacctgga ggaggccacc ctacagcatg
     3661 aagccacagc ggccaccctg aggaagaagc atgcagatag tgtggccgag cttggggagc
     3721 agattgacaa cctgcagcga gtgaagcaga agctggagaa ggagaagagt gagatgaaga
     3781 tggagattga tgaccttgct agtaatgtag aaacggtctc caaagccaag ggaaacctag
     3841 agaaaatgtg ccggactcta gaggaccaac tgagtgaact gaaatcaaag gaagaggagc
     3901 agcagcggct gatcaatgac ctgactgcgc agagggggcg cctgcagact gaatctggtg
     3961 agttttcacg ccagcttgat gaaaaggaag ctctggtgtc tcagttatca agaggcaaac
     4021 aagcctttac tcaacagatt gaagaattaa agaggcaact tgaagaggag ataaaagcca
     4081 agaacgccct ggcgcatgcc ctgcagtctt cccgccacga ctgtgacctg ctgcgggaac
     4141 agtatgagga ggagcaggaa tccaaggccg agctgcagag agcactgtcc aaggccaaca
     4201 ccgaggttgc ccaatggagg accaaatacg agacggacgc catccagcgc acagaggagc
     4261 tggaggaggc caagaagaag ctggcccagc ggctgcaggc agctgaggaa catgtagaag
     4321 ctgtgaacgc caaatgtgct tccctcgaaa agacgaagca gcggctgcag aatgaggtcg
     4381 aggacctcat gcttgatgtg gagaggacaa atgccgcctg tgccgccctt gacaaaaagc
     4441 aaaggaactt cgataagatc ctggcagaat ggaaacagaa atgtgaggaa acgcatgctg
     4501 agcttgaggc ctcccagaag gaggcccgtt cccttggcac tgagctgttc aagataaaga
     4561 atgcctatga ggaatctttg gatcagctag aaaccctgaa gcgagagaac aaaaacttac
     4621 agcaggagat ttctgacctc acggaacaga ttgcagaagg agggaaacgt atccatgaac
     4681 tggagaaaat aaagaaacaa gtggaacaag aaaagtgtga acttcaggct gctttagaag
     4741 aagcagaggc atctcttgaa catgaagagg gaaagatcct gcgcatccag cttgagttga
     4801 accaagtcaa gtctgaggtt gataggaaaa ttgctgaaaa agatgaggaa attgaccagc
     4861 tgaagagaaa ccacattaga atcgtggagt ccatgcagag cacgctggat gctgagatca
     4921 ggagtaggaa tgatgccatt aggctcaaga agaagatgga gggagacctc aatgaaatgg
     4981 aaatccagct gaaccatgcc aaccgcatgg ctgctgaggc cctgaggaac tacaggaaca
     5041 cccaaggcat cctcaaggat acccagatcc acctggatga tgctctccgg agccaggagg
     5101 acctgaagga acagctggcc atggtggagc gcagagccaa cctgctgcag gctgagatcg
     5161 aggagctgcg ggccactctg gaacagacag agaggagcag aaaaatcgca gaacaggagc
     5221 tcctggatgc cagtgagcgt gttcagctac tgcacaccca gaacaccagc ctgatcaaca
     5281 ccaagaagaa gctggagaca gatatttccc aaatgcaagg agagatggag gacattctcc
     5341 aggaagcccg caatgcagaa gaaaaggcca agaaggccat cactgatgcc gccatgatgg
     5401 ctgaggagct gaagaaggag caggacacca gcgcccacct ggagcggatg aagaagaaca
     5461 tggagcagac cgtgaaggat ctgcagctcc gtctggatga ggctgagcag ctggccctga
     5521 agggtgggaa gaagcagatc cagaaactgg aggccagggt acgggagctg gaaggagagg
     5581 ttgagagtga gcaaaagcgt aatgctgagg ctgtcaaagg tctgcgcaaa catgagaggc
     5641 gagtgaagga actcacttac cagacggaag aagatagaaa gaatattctc aggcttcaag
     5701 atttggtaga taaacttcag gcaaaagtga aatcttataa gagacaagct gaggaggctg
     5761 aggaacaatc caacaccaat ctagctaaat tccgcaagct ccagcatgag ctggaggagg
     5821 ccgaggaacg ggctgacatt gctgagtccc aggtgaacaa actgcgggtg aagagccggg
     5881 aggttcacac aaaagtcata agtgaagagt gatcatgtcc tgatgccatg gaatgactga
     5941 agacaggcac aaaatgtgac atctttggtc atttccctct gtaattattg tgtattctac
     6001 cctgttgcaa aggaaataaa gcatagggta gtttgcaaac aata
//
