LOCUS       NM_014981               7024 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myosin heavy chain 15 (MYH15), mRNA.
ACCESSION   NM_014981 XM_036988 XM_938225
VERSION     NM_014981.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7024)
  AUTHORS   Kim,H., Lim,J., Bao,H., Jiao,B., Canon,S.M., Epstein,M.P., Xu,K.,
            Jiang,J., Parameswaran,J., Li,Y., Moberg,K.H., Landers,J.E.,
            Fournier,C., Allen,E.G., Glass,J.D., Wingo,T.S. and Jin,P.
  TITLE     Rare variants in MYH15 modify amyotrophic lateral sclerosis risk
  JOURNAL   Hum Mol Genet 28 (14), 2309-2318 (2019)
   PUBMED   30985904
  REMARK    GeneRIF: Rare variants in MYH15 represent a likely genetic risk
            factor for amyotrophic lateral sclerosis. Furthermore, MYH15 could
            modulate the toxicity of dipeptides produced from expanded G4C2
            repeat.
REFERENCE   2  (bases 1 to 7024)
  AUTHORS   Chen,G., Luo,L., Zhang,M.M., Wu,S.Q., Wang,Y., Sandford,A.J. and
            He,J.Q.
  TITLE     Association Study of Myosin Heavy Chain 15 Polymorphisms with
            Asthma Susceptibility in Chinese Han
  JOURNAL   Biomed Res Int 2019, 3805405 (2019)
   PUBMED   30906771
  REMARK    GeneRIF: This is the first study to report the association of MYH15
            gene polymorphisms with asthma. Polymorphisms of rs9288876,
            rs7635009, and rs1454197 altered transcriptional regulation of
            MYH15 and may be functional variants conferring susceptibility to
            asthma
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7024)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: MYH15 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   4  (bases 1 to 7024)
  AUTHORS   Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
            Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
  TITLE     Proteomic analysis identifies dysfunction in cellular transport,
            energy, and protein metabolism in different brain regions of
            atypical frontotemporal lobar degeneration
  JOURNAL   J Proteome Res 11 (4), 2533-2543 (2012)
   PUBMED   22360420
  REMARK    GeneRIF: A protein encoded by this locus was found to be
            differentially expressed in postmortem brains from patients with
            atypical frontotemporal lobar degeneration.
REFERENCE   5  (bases 1 to 7024)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   6  (bases 1 to 7024)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7024)
  AUTHORS   Bare,L.A., Morrison,A.C., Rowland,C.M., Shiffman,D., Luke,M.M.,
            Iakoubova,O.A., Kane,J.P., Malloy,M.J., Ellis,S.G., Pankow,J.S.,
            Willerson,J.T., Devlin,J.J. and Boerwinkle,E.
  TITLE     Five common gene variants identify elevated genetic risk for
            coronary heart disease
  JOURNAL   Genet Med 9 (10), 682-689 (2007)
   PUBMED   18073581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 7024)
  AUTHORS   McGuigan,K., Phillips,P.C. and Postlethwait,J.H.
  TITLE     Evolution of sarcomeric myosin heavy chain genes: evidence from
            fish
  JOURNAL   Mol Biol Evol 21 (6), 1042-1056 (2004)
   PUBMED   15014174
REFERENCE   9  (bases 1 to 7024)
  AUTHORS   Stedman,H.H., Kozyak,B.W., Nelson,A., Thesier,D.M., Su,L.T.,
            Low,D.W., Bridges,C.R., Shrager,J.B., Minugh-Purvis,N. and
            Mitchell,M.A.
  TITLE     Myosin gene mutation correlates with anatomical changes in the
            human lineage
  JOURNAL   Nature 428 (6981), 415-418 (2004)
   PUBMED   15042088
REFERENCE   10 (bases 1 to 7024)
  AUTHORS   Desjardins,P.R., Burkman,J.M., Shrager,J.B., Allmond,L.A. and
            Stedman,H.H.
  TITLE     Evolutionary implications of three novel members of the human
            sarcomeric myosin heavy chain gene family
  JOURNAL   Mol Biol Evol 19 (4), 375-393 (2002)
   PUBMED   11919279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069499.17 and AC135308.2.
            
            On Feb 9, 2021 this sequence version replaced NM_014981.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000693548.1/ ENSP00000508967.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC069499.17        76130-76283
            155-261             AC069499.17        80897-81003
            262-405             AC069499.17        84871-85014
            406-562             AC069499.17        86452-86608
            563-590             AC069499.17        87244-87271
            591-684             AC069499.17        88581-88674
            685-777             AC069499.17        90854-90946
            778-841             AC069499.17        93549-93612
            842-937             AC069499.17        94131-94226
            938-1041            AC069499.17        100200-100303
            1042-1180           AC069499.17        101497-101635
            1181-1299           AC069499.17        110211-110329
            1300-1449           AC069499.17        115879-116028
            1450-1620           AC069499.17        116514-116684
            1621-1797           AC069499.17        121912-122088
            1798-1930           AC069499.17        123483-123615
            1931-1998           AC069499.17        126359-126426
            1999-2086           AC069499.17        127277-127364
            2087-2204           AC069499.17        129843-129960
            2205-2328           AC069499.17        130867-130990
            2329-2465           AC069499.17        132584-132720
            2466-2721           AC069499.17        141831-142086
            2722-2964           AC069499.17        145466-145708
            2965-3141           AC069499.17        146813-146989
            3142-3287           AC069499.17        149027-149172
            3288-3378           AC069499.17        155804-155894
            3379-3768           AC069499.17        157845-158234
            3769-3895           AC069499.17        165512-165638
            3896-4014           AC069499.17        169796-169914
            4015-4211           AC069499.17        172298-172494
            4212-4561           AC069499.17        175794-176143
            4562-4686           AC069499.17        178322-178446
            4687-4802           AC069499.17        181273-181388
            4803-4995           AC069499.17        187459-187651
            4996-5199           AC069499.17        187886-188089
            5200-5325           AC069499.17        192570-192695
            5326-5496           AC069499.17        194796-194966
            5497-5601           AC069499.17        197652-197756
            5602-5697           AC069499.17        201944-202039
            5698-5832           AC069499.17        202997-203131
            5833-6604           AC069499.17        205167-205938
            6605-7024           AC135308.2         1-420
FEATURES             Location/Qualifiers
     source          1..7024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..7024
                     /gene="MYH15"
                     /note="myosin heavy chain 15"
                     /db_xref="GeneID:22989"
                     /db_xref="HGNC:HGNC:31073"
                     /db_xref="MIM:609929"
     exon            1..154
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..5847
                     /gene="MYH15"
                     /note="myosin, heavy polypeptide 15"
                     /codon_start=1
                     /product="myosin-15"
                     /protein_id="NP_055796.2"
                     /db_xref="CCDS:CCDS43127.2"
                     /db_xref="GeneID:22989"
                     /db_xref="HGNC:HGNC:31073"
                     /db_xref="MIM:609929"
                     /translation="MDLSDLGEAAAFLRRSEAELLLLQATALDGKKKCWIPDGENAYI
                     EAEVKGSEDDGTVIVETADGESLSIKEDKIQQMNPPEFEMIEDMAMLTHLNEASVLHT
                     LKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAF
                     QDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANT
                     ILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNY
                     HIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFL
                     PDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLI
                     HPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIG
                     ILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLD
                     LQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFE
                     AHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIP
                     FGEKKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVL
                     QQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGS
                     LEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILE
                     ERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALE
                     KSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKEL
                     SERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTE
                     EVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGAL
                     EQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVEN
                     EKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVG
                     GSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQ
                     VKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLA
                     NDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSA
                     LAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDL
                     EDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQ
                     KQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRREN
                     KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILH
                     FQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKM
                     EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAER
                     RNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADV
                     ARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITD
                     LQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKEL
                     TYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE
                     RAEVAESQVNKLKIKAREFGKKVQEE"
     exon            155..261
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            262..405
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            406..562
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            563..590
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            591..684
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            685..777
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            778..841
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            842..937
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1041
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1180
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1299
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1449
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1620
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1797
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1930
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1998
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2086
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2204
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2328
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2465
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2721
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2964
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3141
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3287
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3378
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3768
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3895
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4014
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4211
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4561
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4686
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4802
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4803..4995
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            4996..5199
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5325
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5326..5496
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5497..5601
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5697
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5698..5832
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     exon            5833..7024
                     /gene="MYH15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6087..6092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH15"
                     /note="hexamer: AATAAA"
     polyA_site      6126
                     /gene="MYH15"
     regulatory      7005..7010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH15"
                     /note="hexamer: AATAAA"
     polyA_site      7024
                     /gene="MYH15"
                     /note="major polyA site"
ORIGIN      
        1 ttttttcagg ttgaatcttg cctactcacg tttagggcct ttttttggtg gattgcttta
       61 ataaagatgg atctgtcaga ccttggagaa gccgcagcct tcctcagaag aagtgaagct
      121 gagctgcttc tactacaggc cacagccttg gatgggaaga agaaatgctg gattcctgat
      181 ggtgagaatg cttatatcga ggctgaggta aaagggagtg aagatgatgg aacagtaatt
      241 gttgagacag cagatggaga gagtctgagc ataaaggagg acaaaatcca gcagatgaat
      301 cctccagagt ttgaaatgat tgaagacatg gcaatgctga ctcacctcaa tgaggcatcc
      361 gtgctgcata ccctgaagcg gcgctatggc cagtggatga tctatacata ttcaggtctc
      421 ttctgtgtga ccataaaccc ttacaaatgg cttcccgtgt atcagaaaga agtcatggcc
      481 gcctacaaag ggaagaggcg atcagaggct ccccctcaca tctttgctgt tgccaataac
      541 gcctttcagg acatgcttca caatcgagaa aatcagtcta tactcttcac aggagaatct
      601 ggtgctggaa agactgtgaa cagcaaacat attatccagt attttgccac catagcagcc
      661 atgattgaat ccaggaaaaa gcagggggcg ttagaagatc aaatcatgca agcgaatact
      721 atcttggaag catttggaaa tgctaaaacc ctgagaaatg acaactcctc tcgttttggc
      781 aaattcatca ggatgcactt tggtgccaga ggcatgctgt catctgtgga cattgatatc
      841 tatttgcttg aaaagtccag ggtgattttc cagcaggctg gagagaggaa ctaccacata
      901 ttctatcaaa ttctatctgg acaaaaagag cttcatgacc tgctcctggt atctgcaaat
      961 ccctcagact tccacttttg ctcctgtgga gcagttactg tggagagctt ggatgatgct
     1021 gaagaattgc tggccacaga acaagccatg gacatcttgg gctttcttcc tgatgagaag
     1081 tatggatgct ataaactcac tggagccatc atgcactttg gaaatatgaa atttaaacag
     1141 aaacctagag aagagcaact ggaagcagat ggcacagaaa atgctgacaa agctgctttc
     1201 ctcatgggca ttaactcctc tgagttggta aagtgcttga tccatcctag aatcaaagtt
     1261 ggtaacgaat atgttaccag aggtcaaact atagaacagg taacctgtgc tgtcggtgcc
     1321 ctgtccaagt caatgtatga aaggatgttt aagtggctag tggcacggat caacagggcc
     1381 ctggatgcca agctgtcaag gcagttcttc attggcattc ttgacatcac tggttttgaa
     1441 atccttgagt ataatagcct tgagcaactt tgcattaatt ttaccaatga aaaattacaa
     1501 caattcttca attggcacat gtttgttctg gagcaagagg aatataagaa agaaagcatt
     1561 gaatgggtgt ctattggctt tggtctggat ttgcaagctt gcatagatct cattgagaag
     1621 ccaatgggca tcctttccat ccttgaagaa gagtgtatgt ttcctaaggc tacagacctg
     1681 actttcaaga ccaaactctt tgacaaccat tttggaaagt cggttcatct ccagaagccc
     1741 aagcctgata agaagaaatt tgaagctcat tttgaacttg tccattatgc aggagtggta
     1801 ccttataata tcagtggttg gctggaaaag aacaaagacc tccttaatga aacagtggta
     1861 gctgtatttc agaagtcttc caacagactc ctggcgagcc tttttgaaaa ttacatgagt
     1921 actgacagtg ctataccatt tggggagaag aaacgaaaga aaggagcttc attccaaacg
     1981 gttgcatctc tgcataaaga aaacctgaat aaattgatga ctaatctgaa atcaacagca
     2041 cctcattttg tgagatgcat aaatcccaat gtgaacaaaa taccaggtat actggaccct
     2101 tacttggttc tacagcagtt gcgctgtaat ggtgtcttgg aagggactag gatatgccgt
     2161 gaaggttttc caaaccgact gcagtatgct gattttaaac aaaggtactg cattctgaat
     2221 ccaaggacct ttccaaagag caagtttgtg agcagcagaa aagcagctga agaattactt
     2281 ggctccttgg agatagacca tacccagtac cgatttggaa tcactaaggt gttttttaaa
     2341 gctgggtttc tgggccaact ggaagcaata agagatgaga gactatctaa agtcttcaca
     2401 ttgttccaag ccagagcaca gggcaaactg atgcgaatca aattccagaa gattctggaa
     2461 gaaagggatg cacttatttt gatccaatgg aacataagag ctttcatggc tgtgaagaac
     2521 tggccctgga tgaggctctt cttcaagatc aagcctcttg ttaaatcttc agaagtagga
     2581 gaagaagtag ctggactgaa ggaagagtgt gcacaattac agaaagcctt ggagaaatca
     2641 gagtttcaga gggaggaact gaaagcaaag caagtatccc tcactcagga aaaaaatgac
     2701 ctgattcttc agcttcaggc tgagcaagag acactggcaa atgttgaaga gcagtgcgag
     2761 tggctgatta aatccaagat ccagctggag gccagagtaa aggagctgtc ggagagggtg
     2821 gaggaagaag aggagataaa ttctgagctg actgccaggg ggcggaaact cgaagatgaa
     2881 tgttttgagt tgaagaaaga aatcgatgac ctggaaacaa tgttggtgaa gtcagagaag
     2941 gagaagcgta ctacagagca caaggtcaag aacttgactg aggaagtaga gtttctaaat
     3001 gaggatatca gcaaacttaa cagagcagcc aaggttgtgc aggaggccca tcagcagacc
     3061 ctggatgacc tgcacatgga ggaggagaag ctcagcagcc tgagcaaagc aaatctgaag
     3121 ctggaacagc aagttgatga gcttgagggt gcccttgagc aggagagaaa agcgagaatg
     3181 aactgtgaaa gggaactgca caaactggag ggcaatttaa agctgaatcg ggaaagtatg
     3241 gagaacctgg aaagcagcca gcgacacctg gcagaagagc tgaggaaaaa agaattagaa
     3301 ttgagtcaga tgaattcaaa agtggagaat gagaaaggcc tggtagctca gcttcagaag
     3361 acggttaaag agcttcagac tcaaataaag gatttgaaag agaaactaga agctgaaagg
     3421 accactcgag ccaagatgga aagggagaga gctgacctca cccaagacct ggctgacttg
     3481 aatgagaggc tggaggaggt aggaggatcc agtttggctc agctggaaat aactaagaaa
     3541 caggaaacca aattccagaa gctgcaccga gacatggaag aggccactct gcactttgag
     3601 acaacttctg catctttgaa gaagagacat gcagacagcc tggctgagct cgagggccag
     3661 gtagaaaatc tacagcaggt caagcagaaa ctggaaaaag acaagagtga cttgcagcta
     3721 gaagtagatg acctcctgac ccgtgttgag cagatgacaa gagctaaggc aaatgctgag
     3781 aaactctgta ctctatatga agagcgcttg catgaagcaa ctgcaaagct agataaggtg
     3841 actcagttgg caaatgacct ggcagcacaa aagacaaagc tgtggagtga gagtggcgag
     3901 ttcctacgga ggcttgaaga gaaggaggct ctgataaacc aactttccag ggaaaagagc
     3961 aacttcactc ggcagattga agacctgaga gggcagctgg aaaaggagac caaatcccag
     4021 agtgccctgg cccatgccct gcagaaggct cagcgtgact gtgaccttct acgagagcag
     4081 tatgaggaag aacaagaggt caaggctgag ctgcaccgga ccttatccaa agtcaatgct
     4141 gaaatggtgc aatggagaat gaagtatgaa aacaatgtca tccagagaac agaagacttg
     4201 gaggatgcca agaaggaact ggcaattaga ttgcaggagg cagccgaagc catgggggtg
     4261 gccaatgcca gaaatgcctc cttggagaga gccaggcacc agctgcagct ggagctcggg
     4321 gacgccctgt ctgacctcgg gaaggtccgc tctgcagcag ccaggctgga ccagaagcag
     4381 ctgcagtctg gcaaggccct tgccgactgg aagcagaagc acgaggagtc ccaggcgttg
     4441 ctggatgcct ctcagaagga agttcaggct ctcagtacag agctcctcaa gctcaagaac
     4501 acctatgagg agagcatcgt gggccaggag acactcagga gggagaacaa gaacctccaa
     4561 gaagagattt ctaatctgac aaaccaggtt agagaaggga ccaagaactt aactgaaatg
     4621 gaaaaggtca agaaactaat tgaagaagag aagacagaag tccaggtgac actggaagaa
     4681 acagagggag ccctggaacg taatgaaagc aagattcttc atttccagct tgaactcttg
     4741 gaagctaaag cagaacttga aagaaagctt tcagagaaag atgaagaaat agaaaatttt
     4801 aggaggaagc agcagtgtac cattgactcc ctgcagtcta gtctggattc tgaagctaag
     4861 agcagaattg aggttacccg gctgaagaag aagatggaag aggacctcaa tgagatggaa
     4921 ctccagctta gctgtgccaa ccggcaggtg tcagaagcaa ccaaatccct gggccagctt
     4981 cagattcaaa tcaaggacct tcaaatgcag ctggatgaca gcacacaact gaacagtgat
     5041 ctgaaggagc aggtggctgt ggctgagcgg cgcaactctc ttcttcagtc tgaactagag
     5101 gatctaaggt ccctgcaaga gcagacagag cgtggccgca ggctgtcaga agaagagctc
     5161 ctggaagcaa cagaaagaat caatcttttc tatacccaga acacaagcct cctcagccag
     5221 aagaagaaac tggaggctga tgttgcccgg atgcagaaag aagctgaaga ggtggtgcag
     5281 gagtgtcaaa atgcagaaga gaaggccaag aaggcagcca ttgaggcagc aaacttgtca
     5341 gaagaactga agaagaagca agacaccatt gcccacttgg aaaggacaag agaaaatatg
     5401 gagcagacaa ttacagactt acagaaaagg ctggctgaag ctgaacagat ggccctgatg
     5461 gggagtagaa agcaaatcca gaaactagaa tccagggttc gtgaactgga aggtgaactg
     5521 gagggtgaaa tccgtcgcag tgcagaggcc cagaggggag cccgcagact tgagcgatgc
     5581 atcaaagagc tgacctatca ggcagaggaa gacaagaaga atctgagcag gatgcaaact
     5641 cagatggata aacttcagct aaaagtgcaa aattacaagc agcaagtcga ggtggcggaa
     5701 acacaagcca atcaatacct ttccaagtat aagaaacagc aacatgagtt gaatgaagtg
     5761 aaggaaaggg cagaggtggc agaatctcaa gtcaataaac tcaaaattaa agcaagagag
     5821 tttgggaaaa aggttcaaga agaatagcat cccctgcttt gaaaggacaa cagctggaga
     5881 agtacaagga aggtgctgtt tcatggccaa aaacttaggt tgcatggaaa catttttaaa
     5941 aacatgttta aattgctttt cacaccatat aaacaaggca attagaaaaa taattaaagg
     6001 gaatatcatt gcttccacag ttaatgggga ttttttgatc ctcaaatgca agtaaactac
     6061 cttctaatgc ttcacatgac agattaaata aatggaagaa ccttttcaat tctgatgttt
     6121 aaaaaatgaa taaatacttg atcctttgtc catatttcct cttaatgggt aggactcata
     6181 gaagatgtcc ttagaccagt cacgcttcat ggggactagg gcatgttggt gaatggtttt
     6241 tactaaagtt aggcaacttt ggcttgattc acccctaaat ctatgaatgt atattgtgag
     6301 ccagcagtgg tagaatggaa gtcataagat ctcctcagca ttgtgatata aatatagcta
     6361 tagttaggca atttgaacat gtaggcaaaa ctctcctaat caacacacat gtaggctata
     6421 tgctggtaca tgctttaaac atggaggtaa ccccacacga gacattcagt gacaggtaat
     6481 atgctggatt tgtgcagtac cgatttggct cagctggagg aacatgtccc ggaattcctc
     6541 tctctcatgg ttctggattg gagtaggtca taaagaaatt tgcattaatt tgatcagcag
     6601 ctattttata ctcataaggt cagtgtacag acccaagcat ggtgacagct tgaaaatatg
     6661 actccaggcc aaaaagggga gctagaagag accagagaca gctccctgga cccagagctc
     6721 ttccagctcc tgccagcctc ctccttcagc tttgcaaagt actggccagg tgtgtgtgca
     6781 gctccatggc aaccagcatc agcttttcct gagatcacac acagcattgc agtggaggcc
     6841 gtgagacaga catgggttct gtttgttctt atggacttcc cttcatcctt gctgcattca
     6901 cagtcgacct acagtgactt caggcccaga accagatgca gagggaacag cctggcctag
     6961 acttctccac cagcacccac aattgtgtaa ggctgaagct ctataataaa tctttattct
     7021 gtca
//
