LOCUS       NM_001145809            6914 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens myosin heavy chain 14 (MYH14), transcript variant 3,
            mRNA.
ACCESSION   NM_001145809
VERSION     NM_001145809.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6914)
  AUTHORS   Duman,D., Ramzan,M., Subasioglu,A., Mutlu,A., Peart,L., Seyhan,S.,
            Guo,S., Ila,K., Balta,B., Kalcioglu,M.T., Bademci,G. and Tekin,M.
  TITLE     Identification of novel MYH14 variants in families with autosomal
            dominant sensorineural hearing loss
  JOURNAL   Am J Med Genet A 194 (6), e63563 (2024)
   PUBMED   38352997
  REMARK    GeneRIF: Identification of novel MYH14 variants in families with
            autosomal dominant sensorineural hearing loss.
REFERENCE   2  (bases 1 to 6914)
  AUTHORS   Hiramatsu,K., Nishio,S.Y., Kitajiri,S.I., Kitano,T., Moteki,H.,
            Usami,S.I. and On Behalf Of The Deafness Gene Study,Consortium.
  TITLE     Prevalence and Clinical Characteristics of Hearing Loss Caused by
            MYH14 Variants
  JOURNAL   Genes (Basel) 12 (10), 1623 (2021)
   PUBMED   34681017
  REMARK    GeneRIF: Prevalence and Clinical Characteristics of Hearing Loss
            Caused by MYH14 Variants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6914)
  AUTHORS   Weissenbruch,K., Grewe,J., Hippler,M., Fladung,M., Tremmel,M.,
            Stricker,K., Schwarz,U.S. and Bastmeyer,M.
  TITLE     Distinct roles of nonmuscle myosin II isoforms for establishing
            tension and elasticity during cell morphodynamics
  JOURNAL   Elife 10, e71888 (2021)
   PUBMED   34374341
  REMARK    GeneRIF: Distinct roles of nonmuscle myosin II isoforms for
            establishing tension and elasticity during cell morphodynamics.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6914)
  AUTHORS   Singh,R.R., McNamara,J.W. and Sadayappan,S.
  TITLE     Mutations in myosin S2 alter cardiac myosin-binding protein-C
            interaction in hypertrophic cardiomyopathy in a
            phosphorylation-dependent manner
  JOURNAL   J Biol Chem 297 (1), 100836 (2021)
   PUBMED   34051236
  REMARK    GeneRIF: Mutations in myosin S2 alter cardiac myosin-binding
            protein-C interaction in hypertrophic cardiomyopathy in a
            phosphorylation-dependent manner.
REFERENCE   5  (bases 1 to 6914)
  AUTHORS   Wang,M., Zhou,Y., Zhang,F., Fan,Z., Bai,X. and Wang,H.
  TITLE     A novel MYH14 mutation in a Chinese family with autosomal dominant
            nonsyndromic hearing loss
  JOURNAL   BMC Med Genet 21 (1), 154 (2020)
   PUBMED   32711451
  REMARK    GeneRIF: A novel MYH14 mutation in a Chinese family with autosomal
            dominant nonsyndromic hearing loss.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6914)
  AUTHORS   Golomb,E., Ma,X., Jana,S.S., Preston,Y.A., Kawamoto,S.,
            Shoham,N.G., Goldin,E., Conti,M.A., Sellers,J.R. and Adelstein,R.S.
  TITLE     Identification and characterization of nonmuscle myosin II-C, a new
            member of the myosin II family
  JOURNAL   J Biol Chem 279 (4), 2800-2808 (2004)
   PUBMED   14594953
REFERENCE   7  (bases 1 to 6914)
  AUTHORS   Leal,A., Endele,S., Stengel,C., Huehne,K., Loetterle,J.,
            Barrantes,R., Winterpacht,A. and Rautenstrauss,B.
  TITLE     A novel myosin heavy chain gene in human chromosome 19q13.3
  JOURNAL   Gene 312, 165-171 (2003)
   PUBMED   12909352
REFERENCE   8  (bases 1 to 6914)
  AUTHORS   Desjardins,P.R., Burkman,J.M., Shrager,J.B., Allmond,L.A. and
            Stedman,H.H.
  TITLE     Evolutionary implications of three novel members of the human
            sarcomeric myosin heavy chain gene family
  JOURNAL   Mol Biol Evol 19 (4), 375-393 (2002)
   PUBMED   11919279
REFERENCE   9  (bases 1 to 6914)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c. PMID: 7972138]
REFERENCE   10 (bases 1 to 6914)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020906.6, BC129803.1,
            AB290169.1, BC018933.2, AK125082.1, DB110776.1 and BC007877.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001145809.1.
            
            Summary: This gene encodes a member of the myosin superfamily. The
            protein represents a conventional non-muscle myosin; it should not
            be confused with the unconventional myosin-14 (MYO14). Myosins are
            actin-dependent motor proteins with diverse functions including
            regulation of cytokinesis, cell motility, and cell polarity.
            Mutations in this gene result in one form of autosomal dominant
            hearing impairment. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642316.2/ ENSP00000493594.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC020906.6         55456-55461         c
            7-36                BC129803.1         1-30
            37-709              AB290169.1         1-673
            710-710             BC018933.2         456-456
            711-2302            AB290169.1         675-2266
            2303-3071           AK125082.1         2277-3045
            3072-5482           AB290169.1         3036-5446
            5483-5483           DB110776.1         427-427
            5484-6285           AB290169.1         5448-6249
            6286-6914           BC007877.2         895-1523
FEATURES             Location/Qualifiers
     source          1..6914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..6914
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /note="myosin heavy chain 14"
                     /db_xref="GeneID:79784"
                     /db_xref="HGNC:HGNC:23212"
                     /db_xref="MIM:608568"
     exon            1..50
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            51..458
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            459..615
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            616..643
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            644..746
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            747..770
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            771..863
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            864..927
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1026
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1167
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1263
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1382
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1535
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1709
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1883
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1998
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2097
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2285
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2407
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2477
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2638
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2747
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2879
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3086
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3224
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3348
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3520
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3733
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3878
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            3879..4085
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4190
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4343
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4592
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4805
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            4806..5018
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5019..5180
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5181..5309
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5310..5398
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..5522
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5731
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5732..5840
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            5841..6013
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     exon            6014..6914
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6893..6898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /note="hexamer: AATAAA"
     polyA_site      6914
                     /gene="MYH14"
                     /gene_synonym="DFNA4; DFNA4A; FP17425; MHC16; MYH17;
                     myosin; NMHC II-C; NMHC-II-C; PNMHH"
                     /note="major polyA site"
ORIGIN      
        1 acgcccctct ttctccccag gccgaagcct cgggacggcc ctggaagccg accatggcag
       61 ccgtgaccat gtcggtgccc gggcggaagg cgccccccag gccgggccca gtgcccgagg
      121 cggcccagcc gttcctgttc acgccccgcg ggcccagcgc gggtggcggg cctggctcgg
      181 gcacctcccc gcaggtggag tggacggccc ggcgtctcgt gtgggtgcct tcggagcttc
      241 acgggttcga ggcggcggcg ctgcgggacg aaggcgagga ggaggcggag gtggagctgg
      301 cggagagcgg gaggcggctg cgactgccgc gggaccagat ccagcgcatg aacccgccca
      361 agttcagcaa ggccgaggac atggccgagc tgacctgcct caacgaggcc tcggtcctgc
      421 acaacctccg ggagcggtac tactccggcc tcatctacac gtactccggc cttttctgtg
      481 tggtcatcaa cccgtacaag cagcttccca tctacacaga agccattgtg gagatgtacc
      541 ggggcaagaa gcgccacgag gtgccacccc acgtgtacgc agtgaccgag ggggcctatc
      601 ggagcatgct gcaggatcgt gaggaccagt ccattctctg cactggagag tctggagctg
      661 ggaagacgga aaacaccaag aaggtcatcc agtacctcgc ccacgtggcg tcgtctccaa
      721 agggcaggaa ggagccgggt gtccccgcct ccgtcagcac cgtgtcttat ggtgagctgg
      781 agcggcagct gcttcaggcc aaccccatcc tagaggcctt tggcaatgcc aagacagtga
      841 agaatgacaa ctcctcccga ttcggcaaat tcatccgcat caactttgat gttgccgggt
      901 acatcgtggg cgccaacatt gagacctacc tgctggagaa gtcgcgggcc atccgccagg
      961 ccaaggacga gtgcagcttc cacatcttct accagctgct ggggggcgct ggagagcagc
     1021 tcaaagccga cctcctcctc gagccctgct cccactaccg gttcctgacc aacgggccgt
     1081 catcctctcc cggccaggag cgggaactct tccaggagac gctggagtcg ctgcgggtcc
     1141 tgggattcag ccacgaggaa atcatctcca tgctgcggat ggtctcagca gttctccagt
     1201 ttggcaacat tgccttgaag agagaacgga acaccgatca agccaccatg cctgacaaca
     1261 cagctgcaca gaagctctgc cgcctcttgg gactgggggt gacggatttc tcccgagcct
     1321 tgctcacccc tcgcatcaaa gttggccgag actatgtgca gaaagcccag actaaggaac
     1381 aggctgactt cgcgctggag gccctggcca aggccaccta cgagcgcctc ttccgctggc
     1441 tggttctgcg cctcaaccgg gccttggacc gcagcccccg ccaaggcgcc tccttcctgg
     1501 gcatcctgga catcgcgggc tttgagatct tccagctgaa ctccttcgag cagctctgca
     1561 tcaactacac caacgagaag ctgcagcagc tcttcaacca caccatgttc gtgctggagc
     1621 aggaggagta ccagcgtgag ggcatcccct ggaccttcct cgactttggc ctcgacctgc
     1681 agccctgcat cgacctcatc gagcggccgg ccaacccccc tggactcctg gccctgctgg
     1741 atgaggagtg ctggttcccg aaggccacag acaagtcgtt tgtggagaag gtagcccagg
     1801 agcagggcgg ccaccccaag ttccagcggc cgaggcacct gcgggatcag gccgacttca
     1861 gtgttctcca ctacgcgggc aaggtcgact acaaggccaa cgagtggctg atgaaaaaca
     1921 tggaccctct gaatgacaac gtcgcagcct tgctccacca gagcacagac cggctgacgg
     1981 cagagatctg gaaagacgaa catgggggct tccagcagtt ctctttcctt ggctccttcc
     2041 caccgtcgcc cccaggatct gcagagaggt gcagctctgc tatttctccg ccaggggtgg
     2101 agggcatcgt ggggctggaa caggtgagca gcctgggcga cggcccacca ggtggccgcc
     2161 cccgtcgggg tatgttccgg acagtgggac agctctacaa ggagtccctg agccgcctca
     2221 tggccacact cagcaacacc aaccccagtt ttgtccgctg cattgtcccc aaccacgaga
     2281 agagggccgg gaagctggag ccacggctgg tgctggacca gcttcgctgc aacggggtcc
     2341 tggagggcat ccgcatctgt cgccagggct tccccaaccg catcctcttc caggagttcc
     2401 ggcagcgata cgagatcctg acacccaatg ccatccccaa gggcttcatg gatgggaagc
     2461 aggcctgtga aaagatgatc caggcgctgg aactggaccc caacctctac cgcgtgggac
     2521 agagcaagat cttcttccgg gctggggtcc tggcccagct ggaagaggag cgagacctga
     2581 aggtcaccga catcatcgtc tccttccagg cagctgcccg gggatacctg gctcgcaggg
     2641 ccttccagaa gcgccagcag cagcagagcg ccctgagggt gatgcagcgg aactgcgcgg
     2701 cctacctcaa gctgagacac tggcagtggt ggcggctgtt taccaaggtg aagccactgc
     2761 tgcaggtgac gcggcaggat gaggtgctgc aggcacgggc ccaggagctg cagaaagtgc
     2821 aggagctaca gcagcagagc gcccgcgaag ttggggagct ccagggccga gtggcacagc
     2881 tggaagagga gcgcgcccgc ctggcagagc aattgcgagc agaggcagaa ctgtgtgcag
     2941 aggccgagga gacgcggggg aggctggcag cccgcaagca ggagctggag ctggtggtgt
     3001 cagagctgga ggctcgcgtg ggcgaggagg aggagtgcag ccgtcaaatg caaaccgaga
     3061 agaagaggct gcagcagcac atacaggagc tagaggccca ccttgaggct gaggagggtg
     3121 cgcggcagaa gctgcagctg gagaaggtga cgacagaggc aaaaatgaag aaatttgaag
     3181 aggacctgct gctcctggaa gaccagaatt ccaagctgag caaggagcgg aagctgctgg
     3241 aagatcgtct ggccgagttc tcatcccagg cagctgagga ggaggagaag gtcaagagcc
     3301 tcaataagct acggctcaaa tatgaggcca caatcgcaga catggaggac cgcctacgga
     3361 aggaggagaa gggtcgccag gagctggaga agctgaagcg gaggctggat ggggagagct
     3421 cagagctgca ggagcagatg gtggagcagc aacagcgggc agaggagctg cgggcccagc
     3481 tgggccggaa ggaggaggag ctgcaggctg ccctggccag ggcagaagac gagggtgggg
     3541 cccgggccca gctgctgaaa tccctgcggg aggctcaagc agccctggcc gaggcccagg
     3601 aggacctgga gtctgagcgt gtggccagga ccaaggcgga gaagcagcgc cgggacctgg
     3661 gcgaggagct ggaggcgctg cggggcgagc tggaggacac gctggactcc accaacgcac
     3721 agcaggagct ccggtccaag agggaacagg aggtgacgga gctgaagaag actctggagg
     3781 aggagactcg catccacgag gcggcagtgc aggagctgag gcagcgccac ggccaggccc
     3841 tgggggagct ggcggagcag ctggagcagg cccggagggg caaaggtgca tgggagaaga
     3901 cccggctggc cctggaggcc gaggtgtccg agctgcgggc agaactgagc agcctgcaga
     3961 ctgcacgtca ggagggtgag cagcggaggc gccgcctgga gttacagctg caggaggtgc
     4021 agggccgggc tggtgatggg gagagggcac gagcggaggc tgctgagaag ctgcagcgag
     4081 cccaggctga actggagaat gtgtctgggg cgctgaacga ggctgagtcc aaaaccatcc
     4141 gtcttagcaa ggagctgagc agcacagaag cccagctgca cgatgcccag gagctgctgc
     4201 aggaggagac cagggcgaaa ttggccttgg ggtcccgggt gcgagccatg gaggctgagg
     4261 cagccgggct gcgtgagcag ctggaggagg aggcagctgc cagggaacgg gcgggccgtg
     4321 aactgcagac tgcccaggcc cagctttccg agtggcggcg gcgccaggag gaggaggcag
     4381 gggcactgga ggcaggggag gaggcacggc gccgggcagc ccgggaggcc gaggccctga
     4441 cccagcgcct ggcagaaaag acagagaccg tggatcggct ggagcggggc cgccgccggc
     4501 tgcagcagga gctggacgac gccaccatgg acctggagca gcagcggcag cttgtgagca
     4561 ccctggagaa gaagcagcgc aagtttgacc agcttctggc agaggagaag gcagctgtac
     4621 ttcgggcagt ggaggaacgt gagcgggccg aggcagaggg ccgggagcgt gaggctcggg
     4681 ccctgtcact gacacgggca ctggaggagg agcaggaggc acgtgaggag ctggagcggc
     4741 agaaccgggc cctgcgggct gagctggagg cactgctgag cagcaaggat gacgtcggca
     4801 agagcgtgca tgagctggaa cgagcctgcc gggtagcaga acaggcagcc aatgatctgc
     4861 gagcacaggt gacagaactg gaggatgagc tgacagcggc cgaggatgcc aagctgcgtc
     4921 tggaggtgac tgtgcaggct ctcaagactc agcatgagcg tgacctgcag ggccgtgatg
     4981 aggctggtga agagaggcgg aggcagctgg ccaagcagct gagagatgca gaggtggagc
     5041 gggatgagga gcggaagcag cgcactctgg ccgtggctgc ccgcaagaag ctggagggag
     5101 agctggagga gctgaaggct cagatggcct ctgccggcca gggcaaggag gaggcggtga
     5161 agcagcttcg caagatgcag gcccagatga aggagctatg gcgggaggtg gaggagacac
     5221 gcacctcccg ggaggagatc ttctcccaga atcgggaaag tgaaaagcgc ctcaagggcc
     5281 tggaggctga ggtgctgcgg ctgcaggagg aactggccgc ctcggaccgt gctcggcggc
     5341 aggcccagca ggaccgggat gagatggcag atgaggtggc caatggtaac cttagcaagg
     5401 cagccattct ggaggagaag cgtcagctgg aggggcgcct ggggcagttg gaggaagagc
     5461 tggaggagga gcagagcaac tcggagctgc tcaatgaccg ctaccgcaag ctgctcctgc
     5521 aggtagagtc actgaccaca gagctgtcag ctgagcgcag tttctcagcc aaggcagaga
     5581 gcgggcggca gcagctggaa cggcagatcc aggagctacg gggacgcctg ggtgaggagg
     5641 atgctggggc ccgtgcccgc cacaagatga ccattgctgc ccttgagtct aagttggccc
     5701 aggctgagga gcagctagag caagagacca gagagcgcat cctctctgga aagctggtgc
     5761 gcagagctga gaagcggctt aaagaggtgg tgctccaggt ggaggaggag cggagggtgg
     5821 ctgaccagct ccgggaccag ctggagaagg gaaaccttcg agtcaagcag ctgaagcggc
     5881 agctggagga ggccgaggag gaggcatccc gggctcaggc cggccgccgg aggctgcagc
     5941 gtgagctgga agatgtcaca gagtcggccg agtccatgaa ccgtgaagtg accacactga
     6001 ggaaccggct tcgacgcggc cccctcacct tcaccacccg cacggtgcgc caggtcttcc
     6061 gactagagga gggcgtggca tccgacgagg aggcagagga agcacagcct gggtctgggc
     6121 catccccgga gcctgagggg tccccaccag cccaccccca gtgaccctac cctgtcccca
     6181 gatgcactaa cagatggggc ccagccccct tcctccctgg accccacggg cccctgtccc
     6241 aggaaccccg ccctctgact tcttgccctt tggaaatggt gcagcactct ggcatttatc
     6301 acccccacct gggtcccctg caacctccca tcaaaggatg acccctaaac acagaggagc
     6361 ggggcaggca gggaggcaat gactggagct accttgcttg ttgggggact gggtacagtt
     6421 ggcaagctgt gtttccatca gctccctgtc ctcctttctt ccctcgttat tgatctatag
     6481 acattaggaa gggagtgaga cggctcctcc accatcctca gccagtgcaa cccattccct
     6541 ctgcttctct ctctctctct ctctctccct ccctctcctt ccctaccctc tcaccatctt
     6601 tcttggcctc tctgagggtc tctctgtgca tctttttagg aatctcgctc tcactctcta
     6661 cgtagccact ctccttcccc catttctgcg tccacccctg aactcctgag cgacagaagc
     6721 cccaggcctc caccagcctt gaacccttgc aaaggggcag gacaagggga cccctctcac
     6781 tcctgctgct gcccatgctc tgccctccct tctggttgct ctgagggttc ggagcttccc
     6841 tctgggacta aaggagtgtc ctttaccctc ccagcctcca ggctctggca gaaataaact
     6901 ccaacccgac tgga
//
