LOCUS       NM_003802               5994 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myosin heavy chain 13 (MYH13), mRNA.
ACCESSION   NM_003802
VERSION     NM_003802.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Schiaffino,S., Hughes,S.M., Murgia,M. and Reggiani,C.
  TITLE     MYH13, a superfast myosin expressed in extraocular, laryngeal and
            syringeal muscles
  JOURNAL   J Physiol 602 (3), 427-443 (2024)
   PUBMED   38160435
  REMARK    GeneRIF: MYH13, a superfast myosin expressed in extraocular,
            laryngeal and syringeal muscles.
REFERENCE   2  (bases 1 to 5994)
  AUTHORS   Chen,Z., Zhao,T.J., Li,J., Gao,Y.S., Meng,F.G., Yan,Y.B. and
            Zhou,H.M.
  TITLE     Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates
            recruitment of muscle-type creatine kinase (CK) to myosin
  JOURNAL   Biochem J 436 (2), 437-445 (2011)
   PUBMED   21426302
  REMARK    GeneRIF: Domain-mapping experiments indicated that muscle-type
            creatine kinase binds to the C-terminal domains of MyBPC1, which is
            also the binding site of myosin.
REFERENCE   3  (bases 1 to 5994)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 5994)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 5994)
  AUTHORS   Schjeide,B.M., McQueen,M.B., Mullin,K., DiVito,J., Hogan,M.F.,
            Parkinson,M., Hooli,B., Lange,C., Blacker,D., Tanzi,R.E. and
            Bertram,L.
  TITLE     Assessment of Alzheimer's disease case-control associations using
            family-based methods
  JOURNAL   Neurogenetics 10 (1), 19-25 (2009)
   PUBMED   18830724
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5994)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   7  (bases 1 to 5994)
  AUTHORS   Schachat,F. and Briggs,M.M.
  TITLE     Phylogenetic implications of the superfast myosin in extraocular
            muscles
  JOURNAL   J Exp Biol 205 (Pt 15), 2189-2201 (2002)
   PUBMED   12110653
  REMARK    GeneRIF: phylogenic imlications in extraocular muscles (REVIEW)
REFERENCE   8  (bases 1 to 5994)
  AUTHORS   Weiss,A., Schiaffino,S. and Leinwand,L.A.
  TITLE     Comparative sequence analysis of the complete human sarcomeric
            myosin heavy chain family: implications for functional diversity
  JOURNAL   J Mol Biol 290 (1), 61-75 (1999)
   PUBMED   10388558
REFERENCE   9  (bases 1 to 5994)
  AUTHORS   Weiss,A., McDonough,D., Wertman,B., Acakpo-Satchivi,L.,
            Montgomery,K., Kucherlapati,R., Leinwand,L. and Krauter,K.
  TITLE     Organization of human and mouse skeletal myosin heavy chain gene
            clusters is highly conserved
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2958-2963 (1999)
   PUBMED   10077619
REFERENCE   10 (bases 2 to 91)
  AUTHORS   Weiss,A.
  TITLE     Sequences and Genomic Organization of the Human Myosin Heavy Chain
            Gene Family
  JOURNAL   Thesis (1999) Albert Einstein College of Medicine, Bronx, NY, USA
REFERENCE   11 (bases 1 to 5994)
  AUTHORS   Winters,L.M., Briggs,M.M. and Schachat,F.
  TITLE     The human extraocular muscle myosin heavy chain gene (MYH13) maps
            to the cluster of fast and developmental myosin genes on chromosome
            17
  JOURNAL   Genomics 54 (1), 188-189 (1998)
   PUBMED   9806854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005291.1 and AF111782.2.
            
            On Nov 23, 2018 this sequence version replaced NM_003802.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF111782.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252172.9/ ENSP00000252172.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC005291.1         161992-161992       c
            2-1435              AF111782.2         1-1434
            1436-1504           AC005291.1         134453-134521       c
            1505-1675           AC005291.1         134188-134358       c
            1676-1985           AC005291.1         132786-133095       c
            1986-2059           AC005291.1         129314-129387       c
            2060-2147           AC005291.1         129136-129223       c
            2148-2265           AC005291.1         122060-122177       c
            2266-2389           AC005291.1         121085-121208       c
            2390-2526           AC005291.1         119373-119509       c
            2527-2782           AC005291.1         116852-117107       c
            2783-3025           AC005291.1         113008-113250       c
            3026-3202           AC005291.1         110518-110694       c
            3203-3348           AC005291.1         109337-109482       c
            3349-3439           AC005291.1         109139-109229       c
            3440-3829           AC005291.1         107776-108165       c
            3830-3956           AC005291.1         104885-105011       c
            3957-4075           AC005291.1         104679-104797       c
            4076-4272           AC005291.1         102144-102340       c
            4273-4456           AC005291.1         101560-101743       c
            4457-4622           AC005291.1         100897-101062       c
            4623-4747           AC005291.1         100089-100213       c
            4748-5056           AC005291.1         98508-98816         c
            5057-5260           AC005291.1         98220-98423         c
            5261-5386           AC005291.1         95925-96050         c
            5387-5557           AC005291.1         95445-95615         c
            5558-5662           AC005291.1         92380-92484         c
            5663-5677           AC005291.1         92263-92277         c
            5678-5993           AF111782.2         5677-5992
            5994-5994           AC005291.1         89851-89851         c
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..5994
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /note="myosin heavy chain 13"
                     /db_xref="GeneID:8735"
                     /db_xref="HGNC:HGNC:7571"
                     /db_xref="MIM:603487"
     exon            1..28
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            29..79
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            80..295
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..5908
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /note="myosin, heavy polypeptide 13, skeletal muscle;
                     extraocular muscle myosin heavy chain; extraocular myosin
                     heavy chain; myosin heavy chain, skeletal muscle,
                     extraocular; superfast myosin; myosin heavy chain,
                     skeletal muscle, laryngeal; myosin, heavy chain 13,
                     skeletal muscle"
                     /codon_start=1
                     /product="myosin-13"
                     /protein_id="NP_003793.2"
                     /db_xref="CCDS:CCDS45613.1"
                     /db_xref="GeneID:8735"
                     /db_xref="HGNC:HGNC:7571"
                     /db_xref="MIM:603487"
                     /translation="MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNK
                     EMYVKGMIQTRENDKVIVKTLDDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAV
                     LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISD
                     NAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKETQPGKMQGTL
                     EDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVT
                     FQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLAT
                     DNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGL
                     NSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLD
                     TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI
                     EWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ
                     KPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFS
                     NYAGAETGDSGGSKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNET
                     KTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQFI
                     DSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVCRG
                     YLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATM
                     KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIK
                     SKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEK
                     HATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK
                     LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE
                     FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE
                     LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV
                     AELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE
                     IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK
                     RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK
                     YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL
                     ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEE
                     VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE
                     GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR
                     SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN
                     EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS
                     LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE
                     RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALK
                     GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRC
                     RRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE"
     exon            296..439
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            440..596
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            597..624
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            625..736
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            737..829
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            830..893
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            894..992
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1096
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1235
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1354
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1504
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1675
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1985
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2059
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2147
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2265
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2389
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2526
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2782
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..3025
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3202
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3348
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3439
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3829
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3956
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4075
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4272
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4456
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4622
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4747
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            4748..5056
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5057..5260
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5386
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5557
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5558..5662
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5663..5758
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5759..5893
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     exon            5894..5994
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5971..5976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /note="hexamer: AATAAA"
     polyA_site      5994
                     /gene="MYH13"
                     /gene_synonym="MyHC-eo; MyHC-IIL"
                     /note="major polyA site"
ORIGIN      
        1 gaaattgctg tgaccgcagc atctctagga agacgcttta ttcctgaagg acactgactg
       61 tcacttggga accaagaagc cctctgcagt catgagctct gacgcagaaa tggccatttt
      121 tggagaagca gctccctacc tccggaaacc agagaaggag agaatcgagg ctcaaaatcg
      181 tccattcgat tccaagaaag cctgctttgt agcggataat aaggaaatgt atgtgaaagg
      241 catgatccag actagggaaa atgacaaagt catagtcaag accctcgatg accggatgct
      301 cactctgaac aatgaccagg tcttccccat gaaccctccc aaatttgaca agatcgagga
      361 catggccatg atgactcacc tgcatgaacc tgctgttctg tacaacctca aagagcgcta
      421 tgcagcctgg atgatctaca cctactcagg cctcttctgt gtcaccgtca acccctacaa
      481 gtggctgccg gtgtacaagc ccgaggtggt ggctgcctac agaggcaaaa agcgccagga
      541 ggccccgccc cacatcttct ccatctctga caatgcctat cagttcatgc tgactgatcg
      601 agacaaccag tctatcctca tcaccggaga atccggggct gggaagactg tgaacaccaa
      661 gcgtgtcatc cagtattttg caacaattgc agttaccggg gacaagaaga aggagacaca
      721 gccaggcaaa atgcagggaa ccctagagga tcagatcatc caggccaacc cactgctgga
      781 ggcctttgga aatgccaaga ctgtgaggaa tgacaactcc tcaagatttg ggaagttcat
      841 tcggattcat tttggagcca caggaaagct ggcatcggca gacatcgaaa cttatctgtt
      901 agaaaaatcc agagtgacgt ttcaattatc cagtgagaga agctatcata ttttctacca
      961 aattatgtca aacaagaagc cagaactaat tgacctgctt ctgatctcca ccaacccctt
     1021 cgacttcccc ttcgtgagcc aaggagaggt cacggtagcc agtatcgatg acagtgaaga
     1081 actgctggcg acagataatg ccattgacat cctgggcttc agctcagagg agaaagtcgg
     1141 gatctacaaa ctgacgggag ccgtgatgca ttatgggaac atgaagttca agcagaagca
     1201 gcgtgaggag caggcggagc cagacggcac cgaagtggct gacaaagccg gatacctgat
     1261 gggactgaat tctgcagaaa tgctgaaggg cctgtgctgt ccaagggtga aggttggcaa
     1321 tgaatatgtc actaaagggc aaaatgtcca gcaggtgacc aattcggtgg gtgctctggc
     1381 caaagccgtc tacgagaaga tgttcctgtg gatggtcacc cgcatcaacc agcagctgga
     1441 caccaagcag cccaggcagt acttcatcgg ggtcttggac attgctggct ttgagatctt
     1501 tgatttcaac agcctggagc agctgtgcat caacttcacc aatgagaaac tgcaacagtt
     1561 tttcaaccac cacatgttcg tgctggagca ggaagagtac aagaaggaag gcatcgagtg
     1621 ggagttcatt gacttcggaa tggacctggc tgcctgcatc gagctcatcg agaagcctat
     1681 gggcatcttc tccatcctgg aagaggagtg catgttcccc aaggcaacag acacctcctt
     1741 caagaacaag ctgtatgacc agcatcttgg aaaatccaac aacttccaga agcccaagcc
     1801 tgccaaaggc aaggctgagg ctcacttctc gctggtgcac tatgccggca ccgtggacta
     1861 caacatcgcc ggctggctgg acaaaaacaa ggaccccctg aacgagactg tggtggggct
     1921 gtaccagaag tcttcgctga agcttctctc cttccttttt tccaactatg ctggtgcaga
     1981 gacaggcgac tccggaggaa gcaagaaggg cgggaagaag aagggctcct ctttccagac
     2041 cgtgtcggcc gtgttcaggg aaaatttaaa caaattgatg actaacttaa ggagcaccca
     2101 ccctcacttt gtacgatgtc tgattcccaa tgagaccaag actcctggtg tgatggacca
     2161 ctacttggtc atgcaccagc tgcgctgtaa cggggtcctc gagggcatcc ggatttgcag
     2221 gaagggattc cccagccgga tcctctatgc tgacttcaag cagcggtacc ggatcctcaa
     2281 tgccagtgct atccctgaag ggcagttcat tgacagcaaa aatgcctcag agaagctcct
     2341 caactccatc gatgtggacc gggagcagtt caggttcggc aacaccaagg tgtttttcaa
     2401 agctgggctc ctgggacttt tggaggagat gagagatgag aagctggtga cgctgatgac
     2461 aagcacgcag gcggtgtgca gggggtacct gatgcgggtg gagttcaaga agatgatgga
     2521 gaggagggac tccatcttct gcatccagta caacatccgc tcttttatga acgtcaagca
     2581 ctggccctgg atgaacctgt tcttcaaaat caagcccctg ctgaagagtg cagaggccga
     2641 gaaggagatg gccaccatga aggaagactt tgagaggacc aaggaagaac tggcccgatc
     2701 tgaggctcgc cggaaggagc tggaggagaa aatggtctcc ctcctgcagg agaagaatga
     2761 cctccaattg caggtccagt ctgaaacaga aaatctgatg gacgctgagg aacggtgtga
     2821 aggactcatc aaaagcaaga tcctactgga agcaaaagtc aaggagctga cggagagatt
     2881 ggaagaggaa gaggagatga attctgaatt ggttgccaag aagaggaatc tggaagataa
     2941 atgctcctct ctcaagagag acattgatga cctggagctg accttgacga aagttgaaaa
     3001 ggagaagcat gccacagaga acaaggtaaa gaatctttcc gaagaaatga cagcacttga
     3061 agaaaacatt tccaaattga ccaaagaaaa gaaatctcta caggaggccc atcagcaaac
     3121 actggatgat cttcaggtgg aagaagataa agtcaatggt ctaatcaaaa taaatgccaa
     3181 gcttgaacag caaacagatg atcttgaggg ttccttagag caggagaaga aactgcgggc
     3241 ggacttggaa agggcgaaga ggaagctgga aggagatctg aaaatgtccc aggaatccat
     3301 tatggatcta gaaaatgaca agcagcaaat agaagagaaa ttgaaaaaga aggagtttga
     3361 actcagtcag ttacaagcca aaatagatga cgaacaagtc cacagtttgc agtttcaaaa
     3421 gaagattaaa gaactgcaag cccgcataga agagctggag gaggaaattg aagcggaaca
     3481 cacgctcaga gccaagattg agaagcagcg ctcagatctg gccagggaac tggaggagat
     3541 cagcgagagg ctggaagaag ccagtggggc cacttcagcc cagattgaga tgaacaagaa
     3601 gagggaggct gagttccaga aaatgcgcag ggacctggag gaggccaccc tgcagcacga
     3661 agccacagca gccaccctga ggaagaagca agcagatagt gtggccgagc ttggggagca
     3721 gattgacaac ctgcagcggg tgaagcagaa gctggagaag gagaagagcg agctgaagat
     3781 ggagattgac gacatggcca gcaacatcga ggctctctcc aagtcaaaga gtaacataga
     3841 aagaacgtgc cggacggtag aagatcaatt tagtgaaatc aaagccaagg acgagcaaca
     3901 gacacagttg atccatgatc tgaacatgca gaaagcaaga ctgcagaccc aaaatgggga
     3961 gctgagccac cgagtggaag agaaggagtc tctgatttca cagctgacca aaagcaagca
     4021 ggccctcacc cagcagctgg aggagcttaa gaggcaaatg gaagaagaaa ccaaggccaa
     4081 gaacgccatg gcgcacgccc tgcagtcctc ccgccacgac tgtgacctgc tgcgggaaca
     4141 gtatgaggag gagcaggaag ccaaggccga gctgcagagg gcgctgtcca aggccaacag
     4201 tgaggttgcc cagtggagga ccaaatacga gacggacgcc attcagcgca cagaggagct
     4261 ggaggaggcc aagaaaaaac tggcccagag gctccaggaa gcagaggaga acacggagac
     4321 ggcgaactcc aagtgcgcat cgttggagaa aaccaagcag aggctgcagg gagaggtgga
     4381 ggatctgatg cgggatctgg agcgctccca caccgcctgt gccacactgg acaagaagca
     4441 gaggaacttc gacaaggtcc ttgcagagtg gaagcaaaag ctggacgaaa gccaggctga
     4501 gttggaagct gctcagaagg agtccaggtc actcagcact gaactcttca agatgaggaa
     4561 tgcctatgag gaggtggtgg accagttaga gacactgagg cgagagaaca aaaatctgca
     4621 agaagagatt tccgacttaa ctgagcagat tgcagaaact ggcaagaatc ttcaggaagc
     4681 ggaaaagacc aagaagctag tggagcagga aaagtcagat ctgcaggtcg ccttagaaga
     4741 agtggagggt tccttggaac acgaggagag caagatcttg cgcgtgcagc tagagctgag
     4801 ccaggtgaaa tccgagctag accgcaaggt cattgagaag gatgaagaaa tcgagcagct
     4861 aaaaagaaac agccagcggg cagcagaggc cctgcagagc gtgctggatg ctgaaatccg
     4921 cagccggaac gacgccctga ggctaaagaa gaagatggag ggagacctta atgagatgga
     4981 gattcagctg ggccactcca accgccagat ggcagagacc cagaagcatc tgcgcacggt
     5041 ccagggccag ctcaaggact cccagctgca tctcgatgac gccctgagga gcaatgagga
     5101 cctcaaggag cagctggcca tcgtggagcg caggaatggc ctcctgctgg aggagctgga
     5161 ggaaatgaag gtggccctgg aacagacgga gcggacccgc aggctgtcag agcaggagct
     5221 gctggacgcc agcgaccgcg tgcagctcct gcactcccag aacacaagcc tgataaatac
     5281 caagaaaaaa ctggaggctg acatagctca gtgccaggca gaggtggaga actcgatcca
     5341 ggagtccagg aacgcagagg agaaggccaa gaaggccatc acggatgctg ccatgatggc
     5401 tgaggagcta aagaaggaac aggacaccag cgcccacctg gagcggatga agaagaacct
     5461 ggagcagacg gtgaaggacc tgcagcaccg tctagatgag gctgaacaac tggcgctgaa
     5521 gggcgggaag aagcagatcc agaaactgga gaaccgggtg cgggagctgg aaaatgagct
     5581 tgatgtggaa cagaagaggg gagctgaagc cctgaaggga gcccacaagt acgaacgcaa
     5641 agtcaaggag atgacttacc aggctgagga ggaccacaag aatatcctta ggctccagga
     5701 cctggtggac aagctgcagg ccaaagtgaa gtcttacaag aggcaggctg aggaggcgga
     5761 ggagcaggcc aacacgcagc tgtccagatg ccggagagtc cagcatgagc tagaggaggc
     5821 cgcggagagg gcggacatcg ctgagtccca ggtcaacaag ctgagggcca agagccgaga
     5881 cgtgggcagc cagaagatgg aagaatgagg ctcacctgat gctcgttgcc atgggacacc
     5941 tccgagagag tggagggaaa atgtgtgaga aataaattct cctaaatact cgga
//
