LOCUS       NM_002474               6880 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens myosin heavy chain 11 (MYH11), transcript variant
            SM1A, mRNA.
ACCESSION   NM_002474 NM_022870
VERSION     NM_002474.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6880)
  AUTHORS   Wei,X., Ma,Y., Xie,B., Gui,C., Shi,M., Wei,X., Huang,Y., Fan,X.,
            Wei,Q., Huang,Q., Deng,L., Zhang,C., Deng,X., Gui,B. and Chen,Y.
  TITLE     Complex genotype-phenotype correlation of MYH11: new insights from
            monozygotic twins with highly variable expressivity and outcomes
  JOURNAL   BMC Med Genomics 17 (1), 135 (2024)
   PUBMED   38773466
  REMARK    GeneRIF: Complex genotype-phenotype correlation of MYH11: new
            insights from monozygotic twins with highly variable expressivity
            and outcomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6880)
  AUTHORS   Billon,C., Piccoli,G.B., de Sainte Agathe,J.M., Stoeva,R.,
            Derive,N., Heidet,L., Berrebi,D., Bruneval,P., Jeunemaitre,X. and
            Hureaux,M.
  TITLE     Genome-wide analysis identifies MYH11 compound heterozygous
            variants leading to visceral myopathy corresponding to late-onset
            form of megacystis-microcolon-intestinal hypoperistalsis syndrome
  JOURNAL   Mol Genet Genomics 299 (1), 44 (2024)
   PUBMED   38625590
  REMARK    GeneRIF: Genome-wide analysis identifies MYH11 compound
            heterozygous variants leading to visceral myopathy corresponding to
            late-onset form of megacystis-microcolon-intestinal hypoperistalsis
            syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6880)
  AUTHORS   Pan,M., Tan,X., Sun,T., Zhu,W., Liu,H., Liu,Q. and Dong,H.
  TITLE     A harmful MYH11 variant detected in a family with thoracic aortic
            dissection and patent ductus arteriosus
  JOURNAL   Forensic Sci Med Pathol 20 (1), 212-218 (2024)
   PUBMED   37306888
  REMARK    GeneRIF: A harmful MYH11 variant detected in a family with thoracic
            aortic dissection and patent ductus arteriosus.
REFERENCE   4  (bases 1 to 6880)
  AUTHORS   Jiang,Y., Chao,H.Y., Lu,X.Z., Wu,P. and Sun,X.C.
  TITLE     [Molecular Genetic Characteristics of Acute Myeloid Leukemia
            Patients with CBFbeta-MYH11 Positive]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (6), 1661-1667 (2022)
   PUBMED   36476886
  REMARK    GeneRIF: [Molecular Genetic Characteristics of Acute Myeloid
            Leukemia Patients with CBFbeta-MYH11 Positive].
REFERENCE   5  (bases 1 to 6880)
  AUTHORS   Aikawa,M., Sivam,P.N., Kuro-o,M., Kimura,K., Nakahara,K.,
            Takewaki,S., Ueda,M., Yamaguchi,H., Yazaki,Y., Periasamy,M. et al.
  TITLE     Human smooth muscle myosin heavy chain isoforms as molecular
            markers for vascular development and atherosclerosis
  JOURNAL   Circ Res 73 (6), 1000-1012 (1993)
   PUBMED   7916668
REFERENCE   6  (bases 1 to 6880)
  AUTHORS   van der Reijden,B.A., Dauwerse,J.G., Wessels,J.W., Beverstock,G.C.,
            Hagemeijer,A., van Ommen,G.J. and Breuning,M.H.
  TITLE     A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in
            acute nonlymphocytic leukemia M4Eo
  JOURNAL   Blood 82 (10), 2948-2952 (1993)
   PUBMED   8219185
REFERENCE   7  (bases 1 to 6880)
  AUTHORS   Deng,Z., Liu,P., Marlton,P., Claxton,D.F., Lane,S., Callen,D.F.,
            Collins,F.S. and Siciliano,M.J.
  TITLE     Smooth muscle myosin heavy chain locus (MYH11) maps to
            16p13.13-p13.12 and establishes a new region of conserved synteny
            between human 16p and mouse 16
  JOURNAL   Genomics 18 (1), 156-159 (1993)
   PUBMED   8276405
REFERENCE   8  (bases 1 to 6880)
  AUTHORS   Matsuoka,R., Yoshida,M.C., Furutani,Y., Imamura,S., Kanda,N.,
            Yanagisawa,M., Masaki,T. and Takao,A.
  TITLE     Human smooth muscle myosin heavy chain gene mapped to chromosomal
            region 16q12
  JOURNAL   Am J Med Genet 46 (1), 61-67 (1993)
   PUBMED   7684189
REFERENCE   9  (bases 1 to 6880)
  AUTHORS   Ambartsumyan,L.
  TITLE     Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31070878
REFERENCE   10 (bases 1 to 6880)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX489788.1, AY520817.1,
            BC104906.1 and AA552189.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002474.2.
            
            Summary: The protein encoded by this gene is a smooth muscle myosin
            belonging to the myosin heavy chain family. The gene product is a
            subunit of a hexameric protein that consists of two heavy chain
            subunits and two pairs of non-identical light chain subunits. It
            functions as a major contractile protein, converting chemical
            energy into mechanical energy through the hydrolysis of ATP. A
            chromosomal rearrangement involving this gene is associated with
            acute myeloid leukemia of the M4Eo subtype. Mutations in this gene
            are associated with visceral myopathy,
            megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and
            familial thoracic aortic aneurysm 4. [provided by RefSeq, May
            2022].
            
            Transcript Variant: This variant (SM1A) lacks two segments in the
            coding region, compared to variant SM2B. The encoded isoform (SM1A)
            is shorter and varies in the carboxyl terminus, compared to isoform
            SM2B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ900967.1, AB020673.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300036.6/ ENSP00000300036.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BX489788.1         3-19
            18-738              AY520817.1         1-721
            739-2576            AY520817.1         743-2580
            2577-5891           BC104906.1         2543-5857
            5892-6843           AY520817.1         5935-6886
            6844-6880           AA552189.1         137-173
FEATURES             Location/Qualifiers
     source          1..6880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..6880
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="myosin heavy chain 11"
                     /db_xref="GeneID:4629"
                     /db_xref="HGNC:HGNC:7569"
                     /db_xref="MIM:160745"
     exon            1..88
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            89..450
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..607
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..635
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..738
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..831
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..895
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..994
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1138
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1234
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1353
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1506
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1680
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1854
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1969
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2163
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2285
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2355
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2516
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2625
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2757
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2964
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3102
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3226
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3398
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3611
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3756
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3963
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4068
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4221
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4470
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4683
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4896
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..5058
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5187
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5276
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5400
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5609
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5610..5718
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5891
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5892..6880
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6066
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
     regulatory      6859..6864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="hexamer: AATAAA"
     polyA_site      6880
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="major polyA site"
ORIGIN      
        1 gagatttgga cgctccggcc tgggaggtgc gtcagatccg agctcgccat ccagtttcct
       61 ctccactagt ccccccagtt ggagatctgg gaccaacaag gcaccatggc gcagaagggc
      121 caactcagtg acgatgagaa gttcctcttt gtggacaaaa acttcatcaa cagcccagtg
      181 gcccaggctg actgggccgc caagagactc gtctgggtcc cctcggagaa gcagggcttc
      241 gaggcagcca gcattaagga ggagaagggg gatgaggtgg ttgtggagct ggtggagaat
      301 ggcaagaagg tcacggttgg gaaagatgac atccagaaga tgaacccacc caagttctcc
      361 aaggtggagg acatggcgga gctgacgtgc ctcaacgaag cctccgtgct acacaacctg
      421 agggagcggt acttctcagg gctaatatat acgtactctg gcctcttctg cgtggtggtc
      481 aacccctata aacacctgcc catctactcg gagaagatcg tcgacatgta caagggcaag
      541 aagaggcacg agatgccgcc tcacatctac gccatcgcag acacggccta ccggagcatg
      601 cttcaagatc gggaggacca gtccattcta tgcacaggcg agtctggagc cgggaaaacc
      661 gaaaacacca agaaggtcat tcagtacctg gccgtggtgg cctcctccca caagggcaag
      721 aaagacacaa gtatcacggg agagctggaa aagcagcttc tacaagcaaa cccgattctg
      781 gaggctttcg gcaacgccaa aacagtgaag aacgacaact cctcacgatt cggcaaattc
      841 atccgcatca acttcgacgt cacgggttac atcgtgggag ccaacattga gacctatctg
      901 ctagaaaaat cacgggcaat tcgccaagcc agagacgaga ggacattcca catcttttac
      961 tacatgattg ctggagccaa ggagaagatg agaagtgact tgcttttgga gggcttcaac
     1021 aactacacct tcctctccaa tggctttgtg cccatcccag cagcccagga tgatgagatg
     1081 ttccaggaaa ccgtggaggc catggcaatc atgggtttca gcgaggagga gcagctatcc
     1141 atattgaagg tggtatcatc ggtcctgcag cttggaaata tcgtcttcaa gaaggaaaga
     1201 aacacagacc aggcgtccat gccagataac acagctgctc agaaagtttg ccacctcatg
     1261 ggaattaatg tgacagattt caccagatcc atcctcactc ctcgtatcaa ggttgggcga
     1321 gatgtggtac agaaagctca gacaaaagaa caggctgact ttgctgtaga ggctttggcc
     1381 aaggcaacat atgagcgcct tttccgctgg atactcaccc gcgtgaacaa agccctggac
     1441 aagacccatc ggcaaggggc ttccttcctg gggatcctgg atatagctgg atttgagatc
     1501 tttgaggtga actccttcga gcagctgtgc atcaactaca ccaacgagaa gctgcagcag
     1561 ctcttcaacc acaccatgtt catcctggag caggaggagt accagcgcga gggcatcgag
     1621 tggaacttca tcgactttgg gctggaccta cagccctgca tcgagctcat cgagcgaccg
     1681 aacaaccctc caggtgtgct ggccctgctg gacgaggaat gctggttccc caaagccacg
     1741 gacaagtctt tcgtggagaa gctgtgcacg gagcagggca gccaccccaa gttccagaag
     1801 cccaagcagc tcaaggacaa gactgagttc tccatcatcc attatgctgg gaaggtggac
     1861 tataatgcga gtgcctggct gaccaagaat atggacccgc tgaatgacaa cgtgacttcc
     1921 ctgctcaatg cctcctccga caagtttgtg gccgacctgt ggaaggacgt ggaccgcatc
     1981 gtgggcctgg accagatggc caagatgacg gagagctcgc tgcccagcgc ctccaagacc
     2041 aagaagggca tgttccgcac agtggggcag ctgtacaagg agcagctggg caagctgatg
     2101 accacgctac gcaacaccac gcccaacttc gtgcgctgca tcatccccaa ccacgagaag
     2161 aggtccggca agctggatgc gttcctggtg ctggagcagc tgcggtgcaa tggggtgctg
     2221 gaaggcattc gcatctgccg gcagggcttc cccaaccgga tcgtcttcca ggagttccgc
     2281 caacgctacg agatcctggc ggcgaatgcc atccccaaag gcttcatgga cgggaagcag
     2341 gcctgcattc tcatgatcaa agccctggaa cttgacccca acttatacag gatagggcag
     2401 agcaaaatct tcttccgaac tggcgtcctg gcccacctag aggaggagcg agatttgaag
     2461 atcaccgatg tcatcatggc cttccaggcg atgtgtcgtg gctacttggc cagaaaggct
     2521 tttgccaaga ggcagcagca gctgaccgcc atgaaggtga ttcagaggaa ctgcgccgcc
     2581 tacctcaagc tgcggaactg gcagtggtgg aggcttttca ccaaagtgaa gccactgctg
     2641 caggtgacac ggcaggagga ggagatgcag gccaaggagg atgaactgca gaagaccaag
     2701 gagcggcagc agaaggcaga gaatgagctt aaggagctgg aacagaagca ctcgcagctg
     2761 accgaggaga agaacctgct acaggaacag ctgcaggcag agacagagct gtatgcagag
     2821 gctgaggaga tgcgggtgcg gctggcggcc aagaagcagg agctggagga gatactgcat
     2881 gagatggagg cccgcctgga ggaggaggaa gacaggggcc agcagctaca ggctgaaagg
     2941 aagaagatgg cccagcagat gctggacctt gaagaacagc tggaggagga ggaagctgcc
     3001 aggcagaagc tgcaacttga gaaggtcacg gctgaggcca agatcaagaa actggaggat
     3061 gagatcctgg tcatggatga tcagaacaat aaactatcaa aagaacgaaa actccttgag
     3121 gagaggatta gtgacttaac gacaaatctt gcagaagagg aagaaaaggc caagaatctt
     3181 accaagctga aaaacaagca tgaatctatg atttcagaac tggaagtgcg gctaaagaag
     3241 gaagagaaga gccgacagga gctggagaag ctgaaacgga agctggaggg tgatgccagc
     3301 gacttccacg agcagatcgc tgacctccag gcgcagatcg cagagctcaa gatgcagctg
     3361 gccaagaagg aggaggagct gcaggcggcc ctggccaggc ttgacgatga aatcgctcag
     3421 aagaacaatg ccctgaagaa gatccgggag ctggagggcc acatctcaga cctccaggag
     3481 gacctggact cagagcgggc cgccaggaac aaggctgaaa agcagaagcg agacctcggc
     3541 gaggagctgg aggccctaaa gacagagctg gaagacacac tggacagcac agccactcag
     3601 caggagctca gggccaagag ggagcaggag gtgacggtgc tgaagaaggc cctggatgaa
     3661 gagacgcggt cccatgaggc tcaggtccag gagatgaggc agaaacacgc acaggcggtg
     3721 gaggagctca cagagcagct tgagcagttc aagagggcca aggcgaacct agacaagaat
     3781 aagcagacgc tggagaaaga gaacgcagac ctggccgggg agctgcgggt cctgggccag
     3841 gccaagcagg aggtggaaca taagaagaag aagctggagg cgcaggtgca ggagctgcag
     3901 tccaagtgca gcgatgggga gcgggcccgg gcggagctca atgacaaagt ccacaagctg
     3961 cagaatgaag ttgagagcgt cacagggatg cttaacgagg ccgaggggaa ggccattaag
     4021 ctggccaagg acgtggcgtc cctcagttcc cagctccagg acacccagga gctgcttcaa
     4081 gaagaaaccc ggcagaagct caacgtgtct acgaagctgc gccagctgga ggaggagcgg
     4141 aacagcctgc aagaccagct ggacgaggag atggaggcca agcagaacct ggagcgccac
     4201 atctccactc tcaacatcca gctctccgac tcgaagaaga agctgcagga ctttgccagc
     4261 accgtggaag ctctggaaga ggggaagaag aggttccaga aggagatcga gaacctcacc
     4321 cagcagtacg aggagaaggc ggccgcttat gataaactgg aaaagaccaa gaacaggctt
     4381 cagcaggagc tggacgacct ggttgttgat ttggacaacc agcggcaact cgtgtccaac
     4441 ctggaaaaga agcagaggaa atttgatcag ttgttagccg aggagaaaaa catctcttcc
     4501 aaatacgcgg atgagaggga cagagctgag gcagaagcca gggagaagga aaccaaggcc
     4561 ctgtccctgg ctcgggccct tgaagaggcc ttggaagcca aagaggaact cgagcggacc
     4621 aacaaaatgc tcaaagccga aatggaagac ctggtcagct ccaaggatga cgtgggcaag
     4681 aacgtccatg agctggagaa gtccaagcgg gccctggaga cccagatgga ggagatgaag
     4741 acgcagctgg aagagctgga ggacgagctg caagccacgg aggacgccaa actgcggctg
     4801 gaagtcaaca tgcaggcgct caagggccag ttcgaaaggg atctccaagc ccgggacgag
     4861 cagaatgagg agaagaggag gcaactgcag agacagcttc acgagtatga gacggaactg
     4921 gaagacgagc gaaagcaacg tgccctggca gctgcagcaa agaagaagct ggaaggggac
     4981 ctgaaagacc tggagcttca ggccgactct gccatcaagg ggagggagga agccatcaag
     5041 cagctacgca aactgcaggc tcagatgaag gactttcaaa gagagctgga agatgcccgt
     5101 gcctccagag atgagatctt tgccacagcc aaagagaatg agaagaaagc caagagcttg
     5161 gaagcagacc tcatgcagct acaagaggac ctcgccgccg ctgagagggc tcgcaaacaa
     5221 gcggacctcg agaaggagga actggcagag gagctggcca gtagcctgtc gggaaggaac
     5281 gcactccagg acgagaagcg ccgcctggag gcccggatcg cccagctgga ggaggagctg
     5341 gaggaggagc agggcaacat ggaggccatg agcgaccggg tccgcaaagc cacacagcag
     5401 gccgagcagc tcagcaacga gctggccaca gagcgcagca cggcccagaa gaatgagagt
     5461 gcccggcagc agctcgagcg gcagaacaag gagctccgga gcaagctcca cgagatggag
     5521 ggggccgtca agtccaagtt caagtccacc atcgcggcgc tggaggccaa gattgcacag
     5581 ctggaggagc aggtcgagca ggaggccaga gagaaacagg cggccaccaa gtcgctgaag
     5641 cagaaagaca agaagctgaa ggaaatcttg ctgcaggtgg aggacgagcg caagatggcc
     5701 gagcagtaca aggagcaggc agagaaaggc aatgccaggg tcaagcagct caagaggcag
     5761 ctggaggagg cagaggagga gtcccagcgc atcaacgcca accgcaggaa gctgcagcgg
     5821 gagctggatg aggccacgga gagcaacgag gccatgggcc gcgaggtgaa cgcactcaag
     5881 agcaagctca ggcgaggaaa cgagacctct ttcgttcctt ctagaaggtc tggaggacgt
     5941 agagttattg aaaatgcaga tggttctgag gaggaaacgg acactcgaga cgcagacttc
     6001 aatggaacca aggccagtga ataagcaact ttctacagtt ttgcaccacg gcaagaaaac
     6061 caaaaaccaa aacaaacaaa caaaaaaaac ccaacaacaa cccagaacaa agcaaaaccc
     6121 agcagactgt acttagcatt gtctaaatcc attctcaaat tccaaatatc acagacaccc
     6181 ctcacacaag gaatataaaa accaccaccc tccagcctgg gcaacgtagt aaaacctcat
     6241 ctatacaaga atttaaaaat aagctgggcg tggtggtaca cacctgtggt cccagctact
     6301 agggaggctg agccaggaag aacgctccag cccaggactt cgaggctgca atgagctata
     6361 attgcatcat tgcactccag cctgggcaac agagaccctg tctcaaccac caccaccacc
     6421 accaccccta ctacccctgt attcaaggta aaaattgaag tttgtatgat gtaagagatg
     6481 agaaaaaccc aacaggaaac acagacacat cctccagttc tatcaatgga ttgtgcagac
     6541 actgagtttt tagaaaaaca tatccacggt aaccggtccc tggcaattct gtttacatga
     6601 aatggggaga aagtcaccga aatgggtgcc gccggccccc actcccaatt cattccctaa
     6661 cctgcaaacc tttccaactt ctcacgtcag gcctttgaga attctttccc cctctcctgg
     6721 tttccacacc tcagacacgc acagttcacc aagtgccttc tgtagtcaca tgaattgaaa
     6781 aggagacgct gctcccacgg aggggagcag gaatgctgca ctgtttacac cctgactgtg
     6841 cttaaaaaca ctttcactaa taaatggtta taaatcacaa
//
