LOCUS       NM_001040114            6901 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens myosin heavy chain 11 (MYH11), transcript variant
            SM1B, mRNA.
ACCESSION   NM_001040114
VERSION     NM_001040114.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6901)
  AUTHORS   Wei,X., Ma,Y., Xie,B., Gui,C., Shi,M., Wei,X., Huang,Y., Fan,X.,
            Wei,Q., Huang,Q., Deng,L., Zhang,C., Deng,X., Gui,B. and Chen,Y.
  TITLE     Complex genotype-phenotype correlation of MYH11: new insights from
            monozygotic twins with highly variable expressivity and outcomes
  JOURNAL   BMC Med Genomics 17 (1), 135 (2024)
   PUBMED   38773466
  REMARK    GeneRIF: Complex genotype-phenotype correlation of MYH11: new
            insights from monozygotic twins with highly variable expressivity
            and outcomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6901)
  AUTHORS   Billon,C., Piccoli,G.B., de Sainte Agathe,J.M., Stoeva,R.,
            Derive,N., Heidet,L., Berrebi,D., Bruneval,P., Jeunemaitre,X. and
            Hureaux,M.
  TITLE     Genome-wide analysis identifies MYH11 compound heterozygous
            variants leading to visceral myopathy corresponding to late-onset
            form of megacystis-microcolon-intestinal hypoperistalsis syndrome
  JOURNAL   Mol Genet Genomics 299 (1), 44 (2024)
   PUBMED   38625590
  REMARK    GeneRIF: Genome-wide analysis identifies MYH11 compound
            heterozygous variants leading to visceral myopathy corresponding to
            late-onset form of megacystis-microcolon-intestinal hypoperistalsis
            syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6901)
  AUTHORS   Pan,M., Tan,X., Sun,T., Zhu,W., Liu,H., Liu,Q. and Dong,H.
  TITLE     A harmful MYH11 variant detected in a family with thoracic aortic
            dissection and patent ductus arteriosus
  JOURNAL   Forensic Sci Med Pathol 20 (1), 212-218 (2024)
   PUBMED   37306888
  REMARK    GeneRIF: A harmful MYH11 variant detected in a family with thoracic
            aortic dissection and patent ductus arteriosus.
REFERENCE   4  (bases 1 to 6901)
  AUTHORS   Jiang,Y., Chao,H.Y., Lu,X.Z., Wu,P. and Sun,X.C.
  TITLE     [Molecular Genetic Characteristics of Acute Myeloid Leukemia
            Patients with CBFbeta-MYH11 Positive]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (6), 1661-1667 (2022)
   PUBMED   36476886
  REMARK    GeneRIF: [Molecular Genetic Characteristics of Acute Myeloid
            Leukemia Patients with CBFbeta-MYH11 Positive].
REFERENCE   5  (bases 1 to 6901)
  AUTHORS   Aikawa,M., Sivam,P.N., Kuro-o,M., Kimura,K., Nakahara,K.,
            Takewaki,S., Ueda,M., Yamaguchi,H., Yazaki,Y., Periasamy,M. et al.
  TITLE     Human smooth muscle myosin heavy chain isoforms as molecular
            markers for vascular development and atherosclerosis
  JOURNAL   Circ Res 73 (6), 1000-1012 (1993)
   PUBMED   7916668
REFERENCE   6  (bases 1 to 6901)
  AUTHORS   van der Reijden,B.A., Dauwerse,J.G., Wessels,J.W., Beverstock,G.C.,
            Hagemeijer,A., van Ommen,G.J. and Breuning,M.H.
  TITLE     A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in
            acute nonlymphocytic leukemia M4Eo
  JOURNAL   Blood 82 (10), 2948-2952 (1993)
   PUBMED   8219185
REFERENCE   7  (bases 1 to 6901)
  AUTHORS   Deng,Z., Liu,P., Marlton,P., Claxton,D.F., Lane,S., Callen,D.F.,
            Collins,F.S. and Siciliano,M.J.
  TITLE     Smooth muscle myosin heavy chain locus (MYH11) maps to
            16p13.13-p13.12 and establishes a new region of conserved synteny
            between human 16p and mouse 16
  JOURNAL   Genomics 18 (1), 156-159 (1993)
   PUBMED   8276405
REFERENCE   8  (bases 1 to 6901)
  AUTHORS   Matsuoka,R., Yoshida,M.C., Furutani,Y., Imamura,S., Kanda,N.,
            Yanagisawa,M., Masaki,T. and Takao,A.
  TITLE     Human smooth muscle myosin heavy chain gene mapped to chromosomal
            region 16q12
  JOURNAL   Am J Med Genet 46 (1), 61-67 (1993)
   PUBMED   7684189
REFERENCE   9  (bases 1 to 6901)
  AUTHORS   Ambartsumyan,L.
  TITLE     Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31070878
REFERENCE   10 (bases 1 to 6901)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX489788.1, AY520817.1,
            BC104906.1 and AA552189.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001040114.1.
            
            Summary: The protein encoded by this gene is a smooth muscle myosin
            belonging to the myosin heavy chain family. The gene product is a
            subunit of a hexameric protein that consists of two heavy chain
            subunits and two pairs of non-identical light chain subunits. It
            functions as a major contractile protein, converting chemical
            energy into mechanical energy through the hydrolysis of ATP. A
            chromosomal rearrangement involving this gene is associated with
            acute myeloid leukemia of the M4Eo subtype. Mutations in this gene
            are associated with visceral myopathy,
            megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and
            familial thoracic aortic aneurysm 4. [provided by RefSeq, May
            2022].
            
            Transcript Variant: This variant (SM1B) lacks a segment in the
            coding region, which leads to a frameshift, compared to variant
            SM2B. The encoded isoform (SM1B) is longer and varies in the
            carboxyl terminus, compared to isoform SM2B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY520816.1, SRR18074969.1775654.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BX489788.1         3-19
            18-2597             AY520817.1         1-2580
            2598-5912           BC104906.1         2543-5857
            5913-6864           AY520817.1         5935-6886
            6865-6901           AA552189.1         137-173
FEATURES             Location/Qualifiers
     source          1..6901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..6901
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="myosin heavy chain 11"
                     /db_xref="GeneID:4629"
                     /db_xref="HGNC:HGNC:7569"
                     /db_xref="MIM:160745"
     exon            1..88
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            89..450
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..6045
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="isoform SM1B is encoded by transcript variant SM1B;
                     myosin, heavy polypeptide 11, smooth muscle; myosin, heavy
                     chain 11, smooth muscle; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="myosin-11 isoform SM1B"
                     /protein_id="NP_001035203.1"
                     /db_xref="CCDS:CCDS45423.1"
                     /db_xref="GeneID:4629"
                     /db_xref="HGNC:HGNC:7569"
                     /db_xref="MIM:160745"
                     /translation="MAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQG
                     FEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVL
                     HNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADT
                     AYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAY
                     GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKS
                     RAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQ
                     ETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLM
                     GINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKA
                     LDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQR
                     EGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGS
                     HPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVAD
                     LWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNF
                     VRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAA
                     NAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIM
                     AFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR
                     QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE
                     EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA
                     RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK
                     NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL
                     KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK
                     QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM
                     RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK
                     KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL
                     SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI
                     QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL
                     DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS
                     LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK
                     TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET
                     ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL
                     EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS
                     SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER
                     STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR
                     EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES
                     QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENA
                     DGSEEETDTRDADFNGTKASE"
     exon            451..607
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..635
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..738
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..759
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..852
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..916
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1015
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1159
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1255
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1374
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1527
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1701
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1875
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1990
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2184
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2306
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2376
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2537
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2646
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2778
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2985
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3123
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3247
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3419
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3632
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3777
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3984
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4089
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4242
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4491
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4704
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4917
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5079
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5080..5208
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5209..5297
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5298..5421
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5630
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5739
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5740..5912
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5913..6901
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6087
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
     regulatory      6880..6885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="hexamer: AATAAA"
     polyA_site      6901
                     /gene="MYH11"
                     /gene_synonym="AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2"
                     /note="major polyA site"
ORIGIN      
        1 gagatttgga cgctccggcc tgggaggtgc gtcagatccg agctcgccat ccagtttcct
       61 ctccactagt ccccccagtt ggagatctgg gaccaacaag gcaccatggc gcagaagggc
      121 caactcagtg acgatgagaa gttcctcttt gtggacaaaa acttcatcaa cagcccagtg
      181 gcccaggctg actgggccgc caagagactc gtctgggtcc cctcggagaa gcagggcttc
      241 gaggcagcca gcattaagga ggagaagggg gatgaggtgg ttgtggagct ggtggagaat
      301 ggcaagaagg tcacggttgg gaaagatgac atccagaaga tgaacccacc caagttctcc
      361 aaggtggagg acatggcgga gctgacgtgc ctcaacgaag cctccgtgct acacaacctg
      421 agggagcggt acttctcagg gctaatatat acgtactctg gcctcttctg cgtggtggtc
      481 aacccctata aacacctgcc catctactcg gagaagatcg tcgacatgta caagggcaag
      541 aagaggcacg agatgccgcc tcacatctac gccatcgcag acacggccta ccggagcatg
      601 cttcaagatc gggaggacca gtccattcta tgcacaggcg agtctggagc cgggaaaacc
      661 gaaaacacca agaaggtcat tcagtacctg gccgtggtgg cctcctccca caagggcaag
      721 aaagacacaa gtatcacgca aggcccatct tttgcctacg gagagctgga aaagcagctt
      781 ctacaagcaa acccgattct ggaggctttc ggcaacgcca aaacagtgaa gaacgacaac
      841 tcctcacgat tcggcaaatt catccgcatc aacttcgacg tcacgggtta catcgtggga
      901 gccaacattg agacctatct gctagaaaaa tcacgggcaa ttcgccaagc cagagacgag
      961 aggacattcc acatctttta ctacatgatt gctggagcca aggagaagat gagaagtgac
     1021 ttgcttttgg agggcttcaa caactacacc ttcctctcca atggctttgt gcccatccca
     1081 gcagcccagg atgatgagat gttccaggaa accgtggagg ccatggcaat catgggtttc
     1141 agcgaggagg agcagctatc catattgaag gtggtatcat cggtcctgca gcttggaaat
     1201 atcgtcttca agaaggaaag aaacacagac caggcgtcca tgccagataa cacagctgct
     1261 cagaaagttt gccacctcat gggaattaat gtgacagatt tcaccagatc catcctcact
     1321 cctcgtatca aggttgggcg agatgtggta cagaaagctc agacaaaaga acaggctgac
     1381 tttgctgtag aggctttggc caaggcaaca tatgagcgcc ttttccgctg gatactcacc
     1441 cgcgtgaaca aagccctgga caagacccat cggcaagggg cttccttcct ggggatcctg
     1501 gatatagctg gatttgagat ctttgaggtg aactccttcg agcagctgtg catcaactac
     1561 accaacgaga agctgcagca gctcttcaac cacaccatgt tcatcctgga gcaggaggag
     1621 taccagcgcg agggcatcga gtggaacttc atcgactttg ggctggacct acagccctgc
     1681 atcgagctca tcgagcgacc gaacaaccct ccaggtgtgc tggccctgct ggacgaggaa
     1741 tgctggttcc ccaaagccac ggacaagtct ttcgtggaga agctgtgcac ggagcagggc
     1801 agccacccca agttccagaa gcccaagcag ctcaaggaca agactgagtt ctccatcatc
     1861 cattatgctg ggaaggtgga ctataatgcg agtgcctggc tgaccaagaa tatggacccg
     1921 ctgaatgaca acgtgacttc cctgctcaat gcctcctccg acaagtttgt ggccgacctg
     1981 tggaaggacg tggaccgcat cgtgggcctg gaccagatgg ccaagatgac ggagagctcg
     2041 ctgcccagcg cctccaagac caagaagggc atgttccgca cagtggggca gctgtacaag
     2101 gagcagctgg gcaagctgat gaccacgcta cgcaacacca cgcccaactt cgtgcgctgc
     2161 atcatcccca accacgagaa gaggtccggc aagctggatg cgttcctggt gctggagcag
     2221 ctgcggtgca atggggtgct ggaaggcatt cgcatctgcc ggcagggctt ccccaaccgg
     2281 atcgtcttcc aggagttccg ccaacgctac gagatcctgg cggcgaatgc catccccaaa
     2341 ggcttcatgg acgggaagca ggcctgcatt ctcatgatca aagccctgga acttgacccc
     2401 aacttataca ggatagggca gagcaaaatc ttcttccgaa ctggcgtcct ggcccaccta
     2461 gaggaggagc gagatttgaa gatcaccgat gtcatcatgg ccttccaggc gatgtgtcgt
     2521 ggctacttgg ccagaaaggc ttttgccaag aggcagcagc agctgaccgc catgaaggtg
     2581 attcagagga actgcgccgc ctacctcaag ctgcggaact ggcagtggtg gaggcttttc
     2641 accaaagtga agccactgct gcaggtgaca cggcaggagg aggagatgca ggccaaggag
     2701 gatgaactgc agaagaccaa ggagcggcag cagaaggcag agaatgagct taaggagctg
     2761 gaacagaagc actcgcagct gaccgaggag aagaacctgc tacaggaaca gctgcaggca
     2821 gagacagagc tgtatgcaga ggctgaggag atgcgggtgc ggctggcggc caagaagcag
     2881 gagctggagg agatactgca tgagatggag gcccgcctgg aggaggagga agacaggggc
     2941 cagcagctac aggctgaaag gaagaagatg gcccagcaga tgctggacct tgaagaacag
     3001 ctggaggagg aggaagctgc caggcagaag ctgcaacttg agaaggtcac ggctgaggcc
     3061 aagatcaaga aactggagga tgagatcctg gtcatggatg atcagaacaa taaactatca
     3121 aaagaacgaa aactccttga ggagaggatt agtgacttaa cgacaaatct tgcagaagag
     3181 gaagaaaagg ccaagaatct taccaagctg aaaaacaagc atgaatctat gatttcagaa
     3241 ctggaagtgc ggctaaagaa ggaagagaag agccgacagg agctggagaa gctgaaacgg
     3301 aagctggagg gtgatgccag cgacttccac gagcagatcg ctgacctcca ggcgcagatc
     3361 gcagagctca agatgcagct ggccaagaag gaggaggagc tgcaggcggc cctggccagg
     3421 cttgacgatg aaatcgctca gaagaacaat gccctgaaga agatccggga gctggagggc
     3481 cacatctcag acctccagga ggacctggac tcagagcggg ccgccaggaa caaggctgaa
     3541 aagcagaagc gagacctcgg cgaggagctg gaggccctaa agacagagct ggaagacaca
     3601 ctggacagca cagccactca gcaggagctc agggccaaga gggagcagga ggtgacggtg
     3661 ctgaagaagg ccctggatga agagacgcgg tcccatgagg ctcaggtcca ggagatgagg
     3721 cagaaacacg cacaggcggt ggaggagctc acagagcagc ttgagcagtt caagagggcc
     3781 aaggcgaacc tagacaagaa taagcagacg ctggagaaag agaacgcaga cctggccggg
     3841 gagctgcggg tcctgggcca ggccaagcag gaggtggaac ataagaagaa gaagctggag
     3901 gcgcaggtgc aggagctgca gtccaagtgc agcgatgggg agcgggcccg ggcggagctc
     3961 aatgacaaag tccacaagct gcagaatgaa gttgagagcg tcacagggat gcttaacgag
     4021 gccgagggga aggccattaa gctggccaag gacgtggcgt ccctcagttc ccagctccag
     4081 gacacccagg agctgcttca agaagaaacc cggcagaagc tcaacgtgtc tacgaagctg
     4141 cgccagctgg aggaggagcg gaacagcctg caagaccagc tggacgagga gatggaggcc
     4201 aagcagaacc tggagcgcca catctccact ctcaacatcc agctctccga ctcgaagaag
     4261 aagctgcagg actttgccag caccgtggaa gctctggaag aggggaagaa gaggttccag
     4321 aaggagatcg agaacctcac ccagcagtac gaggagaagg cggccgctta tgataaactg
     4381 gaaaagacca agaacaggct tcagcaggag ctggacgacc tggttgttga tttggacaac
     4441 cagcggcaac tcgtgtccaa cctggaaaag aagcagagga aatttgatca gttgttagcc
     4501 gaggagaaaa acatctcttc caaatacgcg gatgagaggg acagagctga ggcagaagcc
     4561 agggagaagg aaaccaaggc cctgtccctg gctcgggccc ttgaagaggc cttggaagcc
     4621 aaagaggaac tcgagcggac caacaaaatg ctcaaagccg aaatggaaga cctggtcagc
     4681 tccaaggatg acgtgggcaa gaacgtccat gagctggaga agtccaagcg ggccctggag
     4741 acccagatgg aggagatgaa gacgcagctg gaagagctgg aggacgagct gcaagccacg
     4801 gaggacgcca aactgcggct ggaagtcaac atgcaggcgc tcaagggcca gttcgaaagg
     4861 gatctccaag cccgggacga gcagaatgag gagaagagga ggcaactgca gagacagctt
     4921 cacgagtatg agacggaact ggaagacgag cgaaagcaac gtgccctggc agctgcagca
     4981 aagaagaagc tggaagggga cctgaaagac ctggagcttc aggccgactc tgccatcaag
     5041 gggagggagg aagccatcaa gcagctacgc aaactgcagg ctcagatgaa ggactttcaa
     5101 agagagctgg aagatgcccg tgcctccaga gatgagatct ttgccacagc caaagagaat
     5161 gagaagaaag ccaagagctt ggaagcagac ctcatgcagc tacaagagga cctcgccgcc
     5221 gctgagaggg ctcgcaaaca agcggacctc gagaaggagg aactggcaga ggagctggcc
     5281 agtagcctgt cgggaaggaa cgcactccag gacgagaagc gccgcctgga ggcccggatc
     5341 gcccagctgg aggaggagct ggaggaggag cagggcaaca tggaggccat gagcgaccgg
     5401 gtccgcaaag ccacacagca ggccgagcag ctcagcaacg agctggccac agagcgcagc
     5461 acggcccaga agaatgagag tgcccggcag cagctcgagc ggcagaacaa ggagctccgg
     5521 agcaagctcc acgagatgga gggggccgtc aagtccaagt tcaagtccac catcgcggcg
     5581 ctggaggcca agattgcaca gctggaggag caggtcgagc aggaggccag agagaaacag
     5641 gcggccacca agtcgctgaa gcagaaagac aagaagctga aggaaatctt gctgcaggtg
     5701 gaggacgagc gcaagatggc cgagcagtac aaggagcagg cagagaaagg caatgccagg
     5761 gtcaagcagc tcaagaggca gctggaggag gcagaggagg agtcccagcg catcaacgcc
     5821 aaccgcagga agctgcagcg ggagctggat gaggccacgg agagcaacga ggccatgggc
     5881 cgcgaggtga acgcactcaa gagcaagctc aggcgaggaa acgagacctc tttcgttcct
     5941 tctagaaggt ctggaggacg tagagttatt gaaaatgcag atggttctga ggaggaaacg
     6001 gacactcgag acgcagactt caatggaacc aaggccagtg aataagcaac tttctacagt
     6061 tttgcaccac ggcaagaaaa ccaaaaacca aaacaaacaa acaaaaaaaa cccaacaaca
     6121 acccagaaca aagcaaaacc cagcagactg tacttagcat tgtctaaatc cattctcaaa
     6181 ttccaaatat cacagacacc cctcacacaa ggaatataaa aaccaccacc ctccagcctg
     6241 ggcaacgtag taaaacctca tctatacaag aatttaaaaa taagctgggc gtggtggtac
     6301 acacctgtgg tcccagctac tagggaggct gagccaggaa gaacgctcca gcccaggact
     6361 tcgaggctgc aatgagctat aattgcatca ttgcactcca gcctgggcaa cagagaccct
     6421 gtctcaacca ccaccaccac caccacccct actacccctg tattcaaggt aaaaattgaa
     6481 gtttgtatga tgtaagagat gagaaaaacc caacaggaaa cacagacaca tcctccagtt
     6541 ctatcaatgg attgtgcaga cactgagttt ttagaaaaac atatccacgg taaccggtcc
     6601 ctggcaattc tgtttacatg aaatggggag aaagtcaccg aaatgggtgc cgccggcccc
     6661 cactcccaat tcattcccta acctgcaaac ctttccaact tctcacgtca ggcctttgag
     6721 aattctttcc ccctctcctg gtttccacac ctcagacacg cacagttcac caagtgcctt
     6781 ctgtagtcac atgaattgaa aaggagacgc tgctcccacg gaggggagca ggaatgctgc
     6841 actgtttaca ccctgactgt gcttaaaaac actttcacta ataaatggtt ataaatcaca
     6901 a
//
