LOCUS       NM_021640               1202 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MYG1 exonuclease (MYG1), mRNA.
ACCESSION   NM_021640
VERSION     NM_021640.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   Chen,J., Duan,S., Wang,Y., Ling,Y., Hou,X., Zhang,S., Liu,X.,
            Long,X., Lan,J., Zhou,M., Xu,H., Zheng,H. and Zhou,J.
  TITLE     MYG1 drives glycolysis and colorectal cancer development through
            nuclear-mitochondrial collaboration
  JOURNAL   Nat Commun 15 (1), 4969 (2024)
   PUBMED   38862489
  REMARK    GeneRIF: MYG1 drives glycolysis and colorectal cancer development
            through nuclear-mitochondrial collaboration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1202)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1202)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1202)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1202)
  AUTHORS   Grover,R., Burse,S.A., Shankrit,S., Aggarwal,A., Kirty,K.,
            Narta,K., Srivastav,R., Ray,A.K., Malik,G., Vats,A., Motiani,R.K.,
            Thukral,L., Roy,S.S., Bhattacharya,S., Sharma,R., Natarajan,K.,
            Mukerji,M., Pandey,R., Gokhale,R.S. and Natarajan,V.T.
  TITLE     Myg1 exonuclease couples the nuclear and mitochondrial
            translational programs through RNA processing
  JOURNAL   Nucleic Acids Res 47 (11), 5852-5866 (2019)
   PUBMED   31081026
  REMARK    GeneRIF: analysis of the widely conserved dually localized protein
            Myg1 shows that it has a role as a 3'-5' RNA exonuclease
REFERENCE   7  (bases 1 to 1202)
  AUTHORS   Dwivedi,M., Laddha,N.C. and Begum,R.
  TITLE     Correlation of increased MYG1 expression and its promoter
            polymorphism with disease progression and higher susceptibility in
            vitiligo patients
  JOURNAL   J Dermatol Sci 71 (3), 195-202 (2013)
   PUBMED   23706493
  REMARK    GeneRIF: Significant increase in MYG1 mRNA expression was observed
            in vitiligo patients compared to controls. The MYG1 mRNA expression
            was increased in patients with active and generalized vitiligo as
            compared to stable and localized vitiligo.
REFERENCE   8  (bases 1 to 1202)
  AUTHORS   Philips,M.A., Kingo,K., Karelson,M., Ratsep,R., Aunin,E.,
            Reimann,E., Reemann,P., Porosaar,O., Vikesa,J., Nielsen,F.C.,
            Vasar,E., Silm,H. and Koks,S.
  TITLE     Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to
            vitiligo susceptibility and Arg4Gln affects mitochondrial entrance
            of Myg1
  JOURNAL   BMC Med Genet 11, 56 (2010)
   PUBMED   20377893
  REMARK    GeneRIF: Both MYG1 promoter polymorphism and Arg4Gln polymorphism
            in the mitochondrial signal of Myg1 have an impact on the
            regulation of the MYG1 gene and promoter polymorphism is related
            with suspectibility for actively progressing vitiligo.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1202)
  AUTHORS   Philips,M.A., Vikesa,J., Luuk,H., Jonson,L., Lillevali,K.,
            Rehfeld,J.F., Vasar,E., Koks,S. and Nielsen,F.C.
  TITLE     Characterization of MYG1 gene and protein: subcellular distribution
            and function
  JOURNAL   Biol Cell 101 (6), 361-373 (2009)
   PUBMED   19014353
  REMARK    GeneRIF: Human and mouse MYG1 is ubiquitously expressed, with the
            highest level in the testis.
REFERENCE   10 (bases 1 to 1202)
  AUTHORS   Kingo,K., Philips,M.A., Aunin,E., Luuk,H., Karelson,M., Ratsep,R.,
            Silm,H., Vasar,E. and Koks,S.
  TITLE     MYG1, novel melanocyte related gene, has elevated expression in
            vitiligo
  JOURNAL   J Dermatol Sci 44 (2), 119-122 (2006)
   PUBMED   16996721
  REMARK    GeneRIF: demonstrates possible role of MYG1 in vitiligo
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073611.29.
            
            On Nov 23, 2018 this sequence version replaced NM_021640.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.78169.1,
                                           SRR5189667.119582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267103.10/ ENSP00000267103.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC073611.29        25459-25717
            260-372             AC073611.29        25914-26026
            373-532             AC073611.29        28798-28957
            533-685             AC073611.29        31672-31824
            686-808             AC073611.29        31962-32084
            809-990             AC073611.29        32444-32625
            991-1202            AC073611.29        32730-32941
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1202
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /note="MYG1 exonuclease"
                     /db_xref="GeneID:60314"
                     /db_xref="HGNC:HGNC:17590"
                     /db_xref="MIM:611366"
     exon            1..259
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1174
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /note="melanocyte related; UPF0160 protein MYG1,
                     mitochondrial; melanocyte proliferating gene 1"
                     /codon_start=1
                     /product="MYG1 exonuclease precursor"
                     /protein_id="NP_067653.4"
                     /db_xref="CCDS:CCDS31810.1"
                     /db_xref="GeneID:60314"
                     /db_xref="HGNC:HGNC:17590"
                     /db_xref="MIM:611366"
                     /translation="MGHQFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAP
                     PRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRR
                     HRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTL
                     YDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFK
                     RAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQVDPSGEIVELAKGACPWKEHL
                     YHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQV
                     SGIPGCIFVHASGFTGGHHTREGALSMARATLAQRSYLPQIS"
     exon            260..372
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     exon            373..532
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     exon            533..685
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     exon            686..808
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     exon            809..990
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1202
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /note="hexamer: AATAAA"
     polyA_site      1202
                     /gene="MYG1"
                     /gene_synonym="C12orf10; Gamm1; MST024; MSTP024; MYG"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggg tcggcgctcc tgcctccctg cagggagctg cttatgggac accaattcct
       61 gcgcggcctc ttaacgctgc tgctgccgcc gccacccctg tatacccggc accgcatgct
      121 cggtccagag tccgtcccgc ccccaaaacg atcccgcagc aaactcatgg caccgccccg
      181 aatcgggacg cacaatggca ccttccactg cgacgaggca ctggcatgcg cactgcttcg
      241 cctcctgccg gagtaccggg atgcagagat tgtgcggacc cgggatcccg aaaaactcgc
      301 ttcctgtgac atcgtggtgg acgtgggggg cgagtacgac cctcggagac accgatatga
      361 ccatcaccag aggtctttca cagagaccat gagctccctg tcccctggga agccgtggca
      421 gaccaagctg agcagtgcgg gactcatcta tctgcacttc gggcacaagc tgctggccca
      481 gttgctgggc actagtgaag aggacagcat ggtgggcacc ctctatgaca agatgtatga
      541 gaactttgtg gaggaggtgg atgctgtgga caatgggatc tcccagtggg cagaggggga
      601 gcctcgatat gcactgacca ctaccctgag tgcacgagtt gctcgactta atcctacctg
      661 gaaccacccc gaccaagaca ctgaggcagg gttcaagcgt gcaatggatc tggttcaaga
      721 ggagtttctg cagagattag atttctacca acacagctgg ctgccagccc gggccttggt
      781 ggaagaggcc cttgcccagc gattccaggt ggacccaagt ggagagattg tggaactggc
      841 gaaaggtgca tgtccctgga aggagcatct ctaccacctg gaatctgggc tgtcccctcc
      901 agtggccatc ttctttgtta tctacactga ccaggctgga cagtggcgaa tacagtgtgt
      961 gcccaaggag ccccactcat tccaaagccg gctgcccctg ccagagccat ggcggggtct
     1021 tcgggacgag gccctggacc aggtcagtgg gatccctggc tgcatcttcg tccatgcaag
     1081 cggcttcact ggcggtcacc acacccgaga gggtgccttg agcatggccc gtgccacctt
     1141 ggcccagcgc tcatacctcc cacaaatctc ctagtctaat aaaaccttcc atctcatact
     1201 ga
//
