LOCUS       NM_002469               1329 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myogenic factor 6 (MYF6), mRNA.
ACCESSION   NM_002469
VERSION     NM_002469.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Arons,E., Zhou,H., Sokolsky,M., Gorelik,D., Potocka,K., Davies,S.,
            Fykes,E., Still,K., Edelman,D.C., Wang,Y., Meltzer,P.S.,
            Raffeld,M., Wiestner,A., Xi,L., Wang,H.W., Stetler-Stevenson,M.,
            Yuan,C. and Kreitman,R.J.
  TITLE     Expression of the muscle-associated gene MYF6 in hairy cell
            leukemia
  JOURNAL   PLoS One 15 (2), e0227586 (2020)
   PUBMED   32040482
  REMARK    GeneRIF: Hypomethylation status of MYF6 supported expression in
            Hairy cell leukemia more than Hairy cell leukemia variant.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M.,
            Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M.,
            Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E.,
            Orwoll,E.S. and Zmuda,J.M.
  CONSRTM   MrOS Research Group
  TITLE     High-density association study of 383 candidate genes for
            volumetric BMD at the femoral neck and lumbar spine among older men
  JOURNAL   J Bone Miner Res 24 (12), 2039-2049 (2009)
   PUBMED   19453261
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Kwon,H.S., Lee,D.K., Lee,J.J., Edenberg,H.J., Ahn,Y.H. and Hur,M.W.
  TITLE     Posttranscriptional regulation of human ADH5/FDH and Myf6 gene
            expression by upstream AUG codons
  JOURNAL   Arch Biochem Biophys 386 (2), 163-171 (2001)
   PUBMED   11368338
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Kong,Y., Flick,M.J., Kudla,A.J. and Konieczny,S.F.
  TITLE     Muscle LIM protein promotes myogenesis by enhancing the activity of
            MyoD
  JOURNAL   Mol Cell Biol 17 (8), 4750-4760 (1997)
   PUBMED   9234731
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Cupelli,L., Renault,B., Leblanc-Straceski,J., Banks,A., Ward,D.,
            Kucherlapati,R.S. and Krauter,K.
  TITLE     Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene
            cluster to 12q21 by in situ hybridization and physical mapping of
            the locus between D12S350 and D12S106
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 250-251 (1996)
   PUBMED   8978788
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Braun,T. and Arnold,H.H.
  TITLE     The four human muscle regulatory helix-loop-helix proteins
            Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding
            properties
  JOURNAL   Nucleic Acids Res 19 (20), 5645-5651 (1991)
   PUBMED   1945842
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Braun,T., Bober,E., Winter,B., Rosenthal,N. and Arnold,H.H.
  TITLE     Myf-6, a new member of the human gene family of myogenic
            determination factors: evidence for a gene cluster on chromosome 12
  JOURNAL   EMBO J 9 (3), 821-831 (1990)
   PUBMED   2311584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA899591.1, BC017834.1 and
            AA176491.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002469.2.
            
            Summary: The protein encoded by this gene is a probable basic
            helix-loop-helix (bHLH) DNA binding protein involved in muscle
            differentiation. The encoded protein likely acts as a heterodimer
            with another bHLH protein. Defects in this gene are a cause of
            autosomal dominant centronuclear myopathy (ADCNM). [provided by
            RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313287.1, BC017834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228641.4/ ENSP00000228641.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                DA899591.1         6-72
            68-1325             BC017834.1         1-1258
            1326-1329           AA176491.1         9-12                c
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..1329
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /note="myogenic factor 6"
                     /db_xref="GeneID:4618"
                     /db_xref="HGNC:HGNC:7566"
                     /db_xref="MIM:159991"
     exon            1..605
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /inference="alignment:Splign:2.1.0"
     exon            606..696
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1329
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /note="hexamer: ATTAAA"
     polyA_site      1329
                     /gene="MYF6"
                     /gene_synonym="bHLHc4; CNM3; MRF4; myf-6"
                     /note="major polyA site"
ORIGIN      
        1 actaattaaa tgccatctgg gtggttcctc tgggtttttg agtccatcac ccagttcaga
       61 tcgagtcaga ggccaaggag gagaacatga tgatggacct ttttgaaact ggctcctatt
      121 tcttctactt ggatggggaa aatgttactc tgcagccatt agaagtggca gaaggctctc
      181 ctttgtatcc agggagtgat ggtaccttgt ccccctgcca ggaccaaatg cccccggaag
      241 cggggagcga cagcagcgga gaggaacatg tcctggcgcc cccgggcctg cagcctccac
      301 actgccccgg ccagtgtctg atctgggctt gcaagacctg caagagaaaa tctgccccca
      361 ctgaccggcg aaaagccgcc accctgcgcg aaaggaggag gctaaagaaa atcaacgagg
      421 ccttcgaggc actgaagcgg cgaactgtgg ccaaccccaa ccagaggctg cccaaggtgg
      481 agattctgcg gagcgccatc agctatattg agcggctgca ggacctgctg caccggctgg
      541 atcagcagga gaagatgcag gagctggggg tggacccctt cagctacaga cccaaacaag
      601 aaaatcttga gggtgcggat ttcctgcgca cctgcagctc ccagtggcca agtgtttccg
      661 atcattccag ggggctcgtg ataacggcta aggaaggagg agcaagtatt gattcgtcag
      721 cctcgagtag ccttcgatgc ctttcttcca tcgtggacag tatttcctcg gaggaacgca
      781 aactcccctg cgtggaggaa gtggtggaga agtaactgag cctgcgcttg agaccttctc
      841 cacgcagcag gaagatccca ccgacccttc ctggcctaat cctttagatt aggtcacatt
      901 acattaacat ttaggaaccc agaccgaaaa gttgctgaaa gggaaggaga cacattcaca
      961 aagaaacgtt gcgaaaattg cgaaatctgt tgtgcatgct caaatgaaaa cgcctttcgg
     1021 ctttgggctt ttattttttt ggaactgcga gtggcttagg tctagcctca ttttgttttt
     1081 gtttggttgg ttttatacta tattaacttt tattacggtg atccttttgt gccatgttca
     1141 aaagaagttc attcctgtct aaagtgggaa agttgcattt aatgttaggg gtatttaatg
     1201 tatttttgta aatagtttaa cactttcttt ttttacgtaa acctgaaata tattttaaat
     1261 gtggaatgat gtatataaaa tgtgcgagga tcctggtatt gtaatattaa aaagaagttt
     1321 ctatatgaa
//
