LOCUS       NM_001293291            2381 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens myeloma overexpressed (MYEOV), transcript variant 1,
            mRNA.
ACCESSION   NM_001293291
VERSION     NM_001293291.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Ou,D., Wu,Y., Zhang,J., Liu,J., Liu,Z., Shao,M., Guo,X. and Cui,S.
  TITLE     MYEOV with High Frequencies of Mutations in Head and Neck Cancers
            Facilitates Cancer Cell Malignant Behaviors
  JOURNAL   Biochem Genet 62 (3), 1657-1674 (2024)
   PUBMED   37667096
  REMARK    GeneRIF: MYEOV with High Frequencies of Mutations in Head and Neck
            Cancers Facilitates Cancer Cell Malignant Behaviors.
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Luo,S., Luo,Y., Wang,Z., Yin,H., Wu,Q., Du,X. and Xie,X.
  TITLE     Super-enhancer mediated upregulation of MYEOV suppresses
            ferroptosis in lung adenocarcinoma
  JOURNAL   Cancer Lett 589, 216811 (2024)
   PUBMED   38490328
  REMARK    GeneRIF: Super-enhancer mediated upregulation of MYEOV suppresses
            ferroptosis in lung adenocarcinoma.
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Tange,S., Hirano,T., Idogawa,M., Hirata,E., Imoto,I. and Tokino,T.
  TITLE     MYEOV overexpression induced by demethylation of its promoter
            contributes to pancreatic cancer progression via activation of the
            folate cycle/c-Myc/mTORC1 pathway
  JOURNAL   BMC Cancer 23 (1), 85 (2023)
   PUBMED   36698109
  REMARK    GeneRIF: MYEOV overexpression induced by demethylation of its
            promoter contributes to pancreatic cancer progression via
            activation of the folate cycle/c-Myc/mTORC1 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   Shen,H., Ye,F., Xu,D., Fang,L., Zhang,X. and Zhu,J.
  TITLE     The MYEOV-MYC association promotes oncogenic miR-17/93-5p
            expression in pancreatic ductal adenocarcinoma
  JOURNAL   Cell Death Dis 13 (1), 15 (2021)
   PUBMED   34930894
  REMARK    GeneRIF: The MYEOV-MYC association promotes oncogenic miR-17/93-5p
            expression in pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2381)
  AUTHORS   Fang,L., Wu,S., Zhu,X., Cai,J., Wu,J., He,Z., Liu,L., Zeng,M.,
            Song,E., Li,J., Li,M. and Guan,H.
  TITLE     MYEOV functions as an amplified competing endogenous RNA in
            promoting metastasis by activating TGF-beta pathway in NSCLC
  JOURNAL   Oncogene 38 (6), 896-912 (2019)
   PUBMED   30181549
  REMARK    GeneRIF: experiments demonstrated that the MYEOV ceRNA sequestered
            miR-30c-2-3p from binding its targets TGFBR2 and USP15 mRNAs, which
            in turn leading to constitutive activation of TGF-beta signaling
            and tumor progression in Non-small cell lung cancer.
REFERENCE   6  (bases 1 to 2381)
  AUTHORS   Leyden,J., Murray,D., Moss,A., Arumuguma,M., Doyle,E., McEntee,G.,
            O'Keane,C., Doran,P. and MacMathuna,P.
  TITLE     Net1 and Myeov: computationally identified mediators of gastric
            cancer
  JOURNAL   Br J Cancer 94 (8), 1204-1212 (2006)
   PUBMED   16552434
  REMARK    GeneRIF: The putative role for MYEOV genes may provide important
            targets for intervention in Gastric adenocarcinoma, evidenced by
            their role in promoting invasion and proliferation, key phenotypic
            hallmarks of cancer cells.
REFERENCE   7  (bases 1 to 2381)
  AUTHORS   de Almeida,R.A., Heuser,T., Blaschke,R., Bartram,C.R. and
            Janssen,J.W.
  TITLE     Control of MYEOV protein synthesis by upstream open reading frames
  JOURNAL   J Biol Chem 281 (2), 695-704 (2006)
   PUBMED   16275643
  REMARK    GeneRIF: MYEOV protein synthesis is regulated by upstream open
            reading frames
REFERENCE   8  (bases 1 to 2381)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2381)
  AUTHORS   Janssen,J.W., Imoto,I., Inoue,J., Shimada,Y., Ueda,M., Imamura,M.,
            Bartram,C.R. and Inazawa,J.
  TITLE     MYEOV, a gene at 11q13, is coamplified with CCND1, but
            epigenetically inactivated in a subset of esophageal squamous cell
            carcinomas
  JOURNAL   J Hum Genet 47 (9), 460-464 (2002)
   PUBMED   12202983
  REMARK    GeneRIF: Epigenetic inactivation of myeov is associated with
            esophageal squamous cell carcinomas
REFERENCE   10 (bases 1 to 2381)
  AUTHORS   Janssen,J.W., Vaandrager,J.W., Heuser,T., Jauch,A., Kluin,P.M.,
            Geelen,E., Bergsagel,P.L., Kuehl,W.M., Drexler,H.G., Otsuki,T.,
            Bartram,C.R. and Schuuring,E.
  TITLE     Concurrent activation of a novel putative transforming gene, myeov,
            and cyclin D1 in a subset of multiple myeloma cell lines with
            t(11;14)(q13;q32)
  JOURNAL   Blood 95 (8), 2691-2698 (2000)
   PUBMED   10753852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB147813.1, AK290121.1, BC011815.2 and AK026148.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001293291.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290121.1, BM809741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441339.3/ ENSP00000412482.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               CB147813.1         18-425
            409-1334            AK290121.1         408-1333
            1335-1610           BC011815.2         1216-1491
            1611-2381           AK026148.1         1536-2306
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..2381
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /note="myeloma overexpressed"
                     /db_xref="GeneID:26579"
                     /db_xref="HGNC:HGNC:7563"
                     /db_xref="MIM:605625"
     exon            1..422
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /inference="alignment:Splign:2.1.0"
     exon            423..685
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..1486
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myeloma overexpressed gene (in a subset of t(11;14)
                     positive multiple myelomas); oncogene in multiple myeloma;
                     myeloma-overexpressed gene protein; myeloma overexpressed
                     (in a subset of t(11;14) positive multiple myelomas)"
                     /codon_start=1
                     /product="myeloma-overexpressed gene protein isoform 1"
                     /protein_id="NP_001280220.1"
                     /db_xref="CCDS:CCDS8190.1"
                     /db_xref="GeneID:26579"
                     /db_xref="HGNC:HGNC:7563"
                     /db_xref="MIM:605625"
                     /translation="MALRICVTYTPALPIGLCTRCCLCLEQSPSWCHCLRGVSFLTFH
                     LHQSVPLGDRDSLLMFTRQAGHFVEGSKAGRSRGRLCLSQALRVAVRGAFVSLWFAAG
                     AGDRERNKGDKGAQTGAGLSQEAEDVDVSRARRVTDAPQGTLCGTGNRNSGSQSARVV
                     GVAHLGEAFRVGVEQAISSCPEEVHGRHGLSMEIMWARMDVALRSPGRGLLAGAGALC
                     MTLAESSCPDYERGRRACLTLHRHPTPHCSTWGLPLRVAGSWLTVVTVEALGGWRMGV
                     RRTGQVGPTMHPPPVSGASPLLLHHLLLLLLIIILTC"
     exon            686..2381
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /note="hexamer: AATAAA"
     polyA_site      2381
                     /gene="MYEOV"
                     /gene_synonym="OCIM"
                     /note="major polyA site"
ORIGIN      
        1 gttactgtcc cgcgaaccca catccctaca aagcaggaaa gtatgcttgg gagaggccaa
       61 gtgagtgggg aatcagccca aagccaggcg tccagggtct ccctcacctg aagctgactt
      121 tttccccacc ttggacagag ggcgggagat gccatcccca ctgaacccag tgctttcacc
      181 agccatatta gctcccactc accccccgtc gtggaagcct cggccgtcac acctgcaggg
      241 ccggggcgtg catggcctca gggatggcct gttcagctgc tgggtgactc gggtccaggt
      301 gcctcaccac ctgctgagct ctgtgtgatt tctggacact tctgctcgtt gcctttgggc
      361 tcagtgaaga gtctggagtt tatctggagt gaggtggccg gttcttggtg ggatctgagc
      421 agagtccatt caggagcagg aaagttcatc tcagacccta aatccagcca cgtcatgcca
      481 cgcttaacac ctctaacaac ttcccctggc acttaggaca gcgtctggct ccttccctcg
      541 gctcatggcc ctcagaatct gcgtcacata caccccagct ctcccgatag gtctctgcac
      601 tcgctgttgc ctctgcctgg aacagtctcc ctcctggtgt cattgtctcc gtggtgtgtc
      661 cttcctgacc ttccacctcc accagtctgt cccccttggg gacagggact cgttgctcat
      721 gttcacccgg caggctggac acttcgtgga gggctccaaa gccggcagat cccggggccg
      781 cctctgtctc tcccaggccc tgcgtgttgc ggtgagagga gcatttgtgt ctctgtggtt
      841 tgctgctgga gctggtgacc gggagagaaa caagggagac aagggtgccc agacaggtgc
      901 ggggctcagc caggaggcag aagacgtgga cgtgtcccgg gccaggaggg tcacagatgc
      961 accacaaggc actctgtgtg gcactgggaa caggaattct gggagtcagt ctgcaagggt
     1021 ggtgggcgtt gctcacctgg gagaagcctt tagagtgggc gttgagcagg ccattagctc
     1081 gtgccctgag gaggtgcatg ggcggcatgg gctctccatg gaaattatgt gggcgcgaat
     1141 ggatgtggct ctgcgctcac ctgggcgagg acttctggcc ggtgccgggg cactctgcat
     1201 gaccctggca gaatcgagct gccctgacta tgaaagggga agaagagcat gcctgaccct
     1261 ccaccggcac cccacccctc actgctccac ctggggcctg cctctgcggg tggctgggtc
     1321 ctggctgact gttgtgactg ttgaggccct gggggggtgg cgcatgggag ttaggaggac
     1381 tggccaggtg gggcccacta tgcacccacc cccagtgtca ggtgcttctc ctctcctcct
     1441 ccaccacctc ctcctcctcc tcctcatcat catcctcact tgttgaggac gtcctgtgtg
     1501 ccaagtggtt tatatgccca gcctcattta atcctcagaa tgactccatg aggtagctac
     1561 taaaaccccc cacttaacag atgaggaaac tgaggcctag agaagctcaa caagttgcct
     1621 aagttccaag tttcctctcc caactctcct accctctcct cttccttctc ctttctccca
     1681 ttcttccctg cctcttccct aactagacaa ttttttattg agtgtctccc aggtgcaggc
     1741 atgagccagg tgctgggaaa atcatgataa cccagctcct tctggtcatt ttctcagctg
     1801 gttagaggct gggaggacac gcaagttcag ctccagccga ctggggcatt ggtggtagcc
     1861 cctggagaca ttgtgcaatg gggctacgag gctgcatctg gctccaggga agcgtgttgc
     1921 aatccatgag tgatgtctgc catgcgtaca ggcatggaga gtgaggcgcc tgtactgtct
     1981 ttctgtagac cctagactgg tggggcctct gaaatgcatc cagacactgt gctgggtgtg
     2041 ttgcatggcc ctcccaacca attcagtatt tttctcccca ttttccaggg agaaatctaa
     2101 ggcgtcagaa tgtaaggttc ttattggaac ccaggctcca gggtccctgg ttttctgtga
     2161 catcatgctg caggaccctg tttctctctt tgctttggct gctggggagc tcagaaggga
     2221 gctttaggct tgctctcagt caccacatta gctcaggggt ttgggcattt ttgtcgccgt
     2281 ctcctttggg ctctgtctcc tccctgctgt gcttcctgag gagcaggccg gatgtaagtt
     2341 atcaactata aataaaacca agacttccgt tctggctctc a
//
