LOCUS       NM_001301210           10065 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myelin expression factor 2 (MYEF2), transcript variant
            2, mRNA.
ACCESSION   NM_001301210 XM_005254423
VERSION     NM_001301210.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10065)
  AUTHORS   Zhang,P., Zhao,J.H., Chen,L., Bian,Z.L., Ju,L.L., Wang,H.X. and
            Cai,W.H.
  TITLE     Expression and function of myelin expression factor 2 in
            hepatocellular carcinoma
  JOURNAL   BMC Gastroenterol 23 (1), 20 (2023)
   PUBMED   36658471
  REMARK    GeneRIF: Expression and function of myelin expression factor 2 in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10065)
  AUTHORS   Malone,S.M., McGue,M. and Iacono,W.G.
  TITLE     What can time-frequency and phase coherence measures tell us about
            the genetic basis of P3 amplitude?
  JOURNAL   Int J Psychophysiol 115, 40-56 (2017)
   PUBMED   27871913
  REMARK    GeneRIF: This study demonstrated that none of the associations
            between time-frequency phenotypes and MYEF2 were significant.
REFERENCE   4  (bases 1 to 10065)
  AUTHORS   Mishra,A., Nizammuddin,S., Mallick,C.B., Singh,S., Prakash,S.,
            Siddiqui,N.A., Rai,N., Carlus,S.J., Sudhakar,D.V.S., Tripathi,V.P.,
            Mols,M., Kim-Howard,X., Dewangan,H., Mishra,A., Reddy,A.G., Roy,B.,
            Pandey,K., Chaubey,G., Das,P., Nath,S.K., Singh,L. and Thangaraj,K.
  TITLE     Genotype-Phenotype Study of the Middle Gangetic Plain in India
            Shows Association of rs2470102 with Skin Pigmentation
  JOURNAL   J Invest Dermatol 137 (3), 670-677 (2017)
   PUBMED   27866970
  REMARK    GeneRIF: both polymorphisms (rs1426654 and rs2470102) play an
            important role in the skin pigmentation diversity of South Asians
REFERENCE   5  (bases 1 to 10065)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 10065)
  AUTHORS   Lee,K.S., Cao,Y., Witwicka,H.E., Tom,S., Tapscott,S.J. and
            Wang,E.H.
  TITLE     RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte
            enhancer factor 2 (Mef2) {beta}-exon splicing
  JOURNAL   J Biol Chem 285 (44), 33779-33787 (2010)
   PUBMED   20709755
  REMARK    GeneRIF: RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts
            myocyte enhancer factor 2 (Mef2) {beta}-exon splicing
REFERENCE   7  (bases 1 to 10065)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   8  (bases 1 to 10065)
  AUTHORS   McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
            Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
  TITLE     hMEF2C gene encodes skeletal muscle- and brain-specific
            transcription factors
  JOURNAL   Mol Cell Biol 13 (4), 2564-2577 (1993)
   PUBMED   8455629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066612.7, AC090526.3 and KF456039.1.
            
            On May 31, 2019 this sequence version replaced NM_001301210.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.137239.1,
                                           SRR1803615.221699.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC066612.7         97982-98200         c
            220-428             AC066612.7         88536-88744         c
            429-481             AC066612.7         87254-87306         c
            482-489             AC066612.7         86026-86033         c
            490-583             AC066612.7         85838-85931         c
            584-775             AC066612.7         79518-79709         c
            776-929             AC066612.7         78674-78827         c
            930-979             AC066612.7         78080-78129         c
            980-1043            AC066612.7         77898-77961         c
            1044-1145           AC090526.3         166216-166317       c
            1146-1196           AC090526.3         164658-164708       c
            1197-1265           AC090526.3         164298-164366       c
            1266-1364           KF456039.1         166-264             c
            1365-1573           AC090526.3         161587-161795       c
            1574-1625           AC090526.3         161456-161507       c
            1626-10065          AC090526.3         147056-155495       c
FEATURES             Location/Qualifiers
     source          1..10065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..10065
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="myelin expression factor 2"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
     exon            1..219
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1789
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="isoform b is encoded by transcript variant 2;
                     myelin gene expression factor 2"
                     /codon_start=1
                     /product="myelin expression factor 2 isoform b"
                     /protein_id="NP_001288139.2"
                     /db_xref="CCDS:CCDS73722.1"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
                     /translation="MADANKAEVPGATGGDSPHLQPAEPPGEPRREPHPAEAEKQQPQ
                     HSSSSNGVKMENDESAKEEKSDLKEKSTGSKKANRFHPYSKDKNSGAGEKKGPNRNRV
                     FISNIPYDMKWQAIKDLMREKVGEVTYVELFKDAEGKSRGCGVVEFKDEEFVKKALET
                     MNKYDLSGRPLNIKEDPDGENARRALQRTGGSFPGGHVPDMGSGLMNLPPSILNNPNI
                     PPEVISNLQAGRLGSTIFVANLDFKVGWKKLKEVFSIAGTVKRADIKEDKDGKSRGMG
                     TVTFEQAIEAVQAISMFNGQFLFDRPMHVKMDDKSVPHEEYRSHDGKTPQLPRGLGGI
                     GMGLGPGGQPISASQLNIGGVMGNLGPGGMGMDGPGFGGMNRIGGGIGFGGLEAMNSM
                     GGFGGVGRMGELYRGAMTSSMERDFGRGDIGINRGFGDSFGRLGGGMGSMNSVTGGMG
                     MGLDRMSSSFDRMGPGIGAILERSIDMDRGFLSGPMGSGMRERIGSKGNQIFVRNLPF
                     DLTWQKLKEKFSQCGHVMFAEIKMENGKSKGCGTVRFDSPESAEKACRIMNGIKISGR
                     EIDVRLDRNA"
     exon            220..428
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..481
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..489
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..583
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..775
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..929
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..979
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1043
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1145
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1196
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1265
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1364
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1573
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1625
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..10065
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2900
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="major polyA site"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="hexamer: AATAAA"
     polyA_site      5270
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
     regulatory      10046..10051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /note="hexamer: AATAAA"
     polyA_site      10065
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
ORIGIN      
        1 attgtcgcgc tcggagcccc tcagctcagg cggccgaggc ggaggcagcg gcggcgggat
       61 ggcggacgcc aacaaggccg aggtgcccgg ggccactggt ggcgacagcc cgcacctgca
      121 gcccgcagag ccgccgggcg agccgcggcg agagccgcac cccgcggagg cggagaagca
      181 gcagccgcag cacagcagca gctccaatgg cgttaaaatg gagaatgatg aatcagcaaa
      241 agaagagaaa tctgacttaa aggaaaaatc tacaggaagt aagaaggcca atagatttca
      301 tccttattca aaagacaaga attcgggcgc tggagaaaag aagggtccaa atcgtaacag
      361 agttttcatt agcaacatcc catatgacat gaaatggcaa gctattaaag atctaatgag
      421 agagaaagtt ggtgaggtta catacgtgga gctctttaag gatgcggaag gaaaatcaag
      481 gggttgtggt gtggttgaat tcaaagatga agaatttgta aagaaagccc tagaaactat
      541 gaacaaatat gatcttagtg gaagacccct taatattaaa gaggatcctg atggagaaaa
      601 tgctcgtagg gcattgcagc gaacaggagg atcatttcca ggaggacacg tccctgatat
      661 gggatcaggg ttgatgaatt taccaccttc catactcaat aatccaaaca ttcctcctga
      721 agtcatcagt aatttgcagg ccggtagact tggttccaca atttttgttg ccaatcttga
      781 cttcaaagtt ggttggaaga agctaaagga agtgttcagc atagctggaa ctgtgaagcg
      841 ggcagatatt aaagaagaca aagatggcaa gagcagagga atgggcactg tcacttttga
      901 gcaagcaatt gaagcagttc aagcaatttc tatgttcaat gggcagtttt tatttgatag
      961 acctatgcat gtgaaaatgg atgacaagtc tgttcctcat gaagagtacc gttcacatga
     1021 tggtaaaaca ccacaattac cacgtggtct tggaggcatt gggatgggac ttggtccggg
     1081 tggacagcct attagtgcca gccagttgaa cataggtgga gtaatgggaa atttaggtcc
     1141 aggtggtatg ggaatggatg gtccaggttt tggaggaatg aatagaattg gaggaggaat
     1201 agggtttggt ggtctggaag caatgaatag catgggagga tttggaggag ttggccgaat
     1261 gggagagctg taccgtggtg cgatgactag tagcatggag cgagattttg gacgtggtga
     1321 tattggaata aatcgaggct ttggagattc ctttggtaga cttggtggtg gaatgggtag
     1381 catgaacagt gtgactggag gaatggggat gggactggac cggatgagtt ccagctttga
     1441 tagaatggga ccaggtatag gagctatact ggaaaggagc atcgatatgg atcgaggatt
     1501 tttatcgggt ccaatgggaa gcggaatgag agagagaata ggctccaaag gcaaccagat
     1561 atttgtcaga aatctacctt ttgacttgac ttggcagaaa ctaaaagaga aattcagtca
     1621 gtgtggtcat gtaatgtttg cagaaataaa aatggagaat ggaaagtcaa aaggctgtgg
     1681 aacagtcaga tttgactccc cagaatcagc tgaaaaagcc tgcagaataa tgaatggcat
     1741 aaaaatcagt ggcagagaaa ttgatgttcg cttggatcgt aatgcataat ttcaagccat
     1801 ggttggaaca ttcctacatc tgttttgctg aatctcctag taaaagtcat ttttttaaag
     1861 taatattgta tgcttacaaa agctgtaaaa atgaactttt aaaactccca ccagctttta
     1921 acagtataat gttaaaaata tactgtaatt tttgttaatc tcaagtttgg gtttttaaag
     1981 acagcaagtc tggtcattca gtttaaatga atggttatac tgtttttaat gaaataagcc
     2041 attttcttgt tgttttcagt actacatagt tggatttgtt tgttctagtt tctccagttt
     2101 ttgtcaactt attgtatggt aaaacataga ttttttcccc ccaaacttct gttttataat
     2161 atgtaatttt tcatgaaaag aaagggctca gaaaaattag gatgtgattt tggttggttt
     2221 taaattactg taagttttag attctaaggt tcaagatttt taaaatttga tttaaatgaa
     2281 gaaatggatt tttctctctg cccctccctg ccattcatat tttctgcata acactattaa
     2341 taatatcaac ctccacagcc ccttatttta ttatttccaa taattccaag ttcatataga
     2401 actgataatg tagcaagccc caagtatgat aataggcaga ctattcccaa ctttctgtct
     2461 agtttccagc cattgaagtg aactgctaaa aaaagaaaaa taattgaaat gttgagagag
     2521 atggttatgt aagttagtcc tctgctgttt acttctgcag gagctgatcc atttataaat
     2581 gcagttttaa taaaccatgg aataccaagg cacaacatat caaacacatt ggatcccacg
     2641 atgttagaca tagccatatc tcctttccct acaaaagaaa agcatactgt taaaatgtgc
     2701 ttaccaatac tgtgttttat taataatctt cataagaaaa gaaacactgg atactttttt
     2761 gttgttgatt cgttttgaaa aattgttgtt agagcaaaag tcttactgaa tttgtatttt
     2821 taaatttttc ttgggttagt atttaaagtc ttaacattta tttaataatt atatttatta
     2881 aaccattttt caataaggta tatagcttat ttgttgcttt tcattgtaat ttaacatggt
     2941 taatggttaa ttactattta acacacattt caaatgaata ttatttgggg gattagattg
     3001 agtgaaatta acctgctatt aaatagtaaa cttttcctct ggagtcactt ttttccccct
     3061 tcaaagtatg ttactgagga agtaaacttt tttttttttt tttggttttt gttttttgag
     3121 acacagtctc gctctgttgc ccaggctgct ggagtgccgt ggcgcaatct cggctcactg
     3181 caacctccgc ctcctggatt caaacaattc tcctgcctca gcctcctgag tagctgggat
     3241 tacaggcaca tgccaccacg cccggctaat ttttgtattt ttagtagaga ctgggtttca
     3301 ccatgttggt caggctggtc tcaaactcct gacctcgtga tccacccgcc tcggcctccc
     3361 aaaatcctgg gattacaggc gcgagccacc acacccggct ggaagtaaac atttttaaag
     3421 ctacttttac tcattctagc cttgtagaat gaccattgca gcttgaggga cctagttctt
     3481 accttttctt gcaaccaaca cacttgcaat tgtgtctggt atgcttgttc ctgctgctaa
     3541 taaagtaagg cccattactg tatcgggaat ttctagtgtt tcccctgtaa taaacagata
     3601 tttcaagtta caaatcttaa agattcacta accatccttt gcagttattt tggatatttc
     3661 cttcgtgaac aaaaataaaa taggcacatt tagaattcag agccaatatg tgcttgctta
     3721 ttagtttttt agctagcaac atatttgaat caggctggta attcgggtaa cccaggtagc
     3781 acagattttt aatgacatat ctaaagatac gtaacagcta aaattctgcc agtgagaaat
     3841 tttcctgttt gatattctta caaaagatgt ttatgtccac cattatctca tcagggctgt
     3901 gctgaatatt tgataatgag actgatcatt ccgctttttc tttcttaaaa atattagtca
     3961 gagttaagca aattaattat agctatcttt aagctataaa tgtgttaaca tgtatatata
     4021 ccatttatta tgttctactt tagtgatata ccttaattta gtgggctttg gcagggcggg
     4081 ggagggggaa cgttcattaa tctctgagga aaacaaaacc tgttttctac ttgagtctaa
     4141 catatggtcc caatttatta atacttctgt taaatttgat gtcaggtcaa catttttcag
     4201 aaatgtattt attctcagaa acagaaccag agagaagtta aacaaaaggt tatgtaactg
     4261 ttcctttaat gttgtaattg aaaacttggt ttagcgtctt ttttttcttt ctcttttttt
     4321 ttcttaaaat gccaactaaa ataattagaa agtagcttat ttattgcatg cttatacatt
     4381 gatattggaa ttggaattgg ttgttaattt ctgttactgg ctttgctaga attcatatgt
     4441 gcataaataa cactaatatt tatcatcttg ggggctgttc tgtgatctat tacatgattt
     4501 ttgctctctt tttatttttc tagtatcaaa tgtgttctgg ctgagtgaat ttggatagat
     4561 ataatatgca agctaattgg actttttcat ttttctcatt aaaaaaagga agaagtagtc
     4621 cactttttgc tagcatacta ttctgagact tacattaatt tgggaaaagt caagggtcaa
     4681 caaatttttg tgtctgtgag gggccagata gtaattattt aggctttgca ggctgtgtga
     4741 tttctgttgc agttattcag ctttgccaat gtagtgtgaa aacaatcata gataatatgt
     4801 aaaaccttac taataaaaac aagctgggtt atgttggcac acaggcagta gtttgttcac
     4861 ctctgctgta agttaatttg ggttaacctt tgtaggagaa attacagatt atttttgtct
     4921 ttgttcatag tttttttgtt tagggactgt agtggattat ggccaagcag cagtagctag
     4981 ttaagtctta atcatgaagg tagtagaaac ctagaataaa attattatgc ccttttcact
     5041 catttcataa tatgtttgta ttgccgtgtt gaaaagccaa ataaaataca atccagttaa
     5101 gcagtgagca cccattgttt tcccaaaaat agagctcctt gctttgtttt tgtttttttg
     5161 ttcttttttt tttttattat ggaatggaat tcaatataaa gagtttattg tggaccccat
     5221 ggaatgtgat taaattatta gcataataaa aagacatcct atgaatttga tttcatttat
     5281 aagatctctt gaattgtacc ccaggctaaa taacagtgga aaatacagtt tatatataat
     5341 atgcaactca caaactccag tgatcttgtt atagtaatac ttaatcattt tgtaaatggt
     5401 actaatcttc aatcttgctg aaaagaaatt tgctgtgtag ctagactact ttgagtgaac
     5461 atatgcaatt tgttcttata tgaatatttt caagttgtgc tattgtactt aaaatacata
     5521 ccagttattg tgaccatcca aaccaggata tatgtaaatg cggatatcca tattgcagac
     5581 atgaaaaagg ttatcacaaa gtagtttttc caaaactttt ttctacaatc tggtgtggtt
     5641 agaaaaagta atgtaataat aggaagggat aatacccaaa aaattctttt taagtctgct
     5701 tcaggcatgt tgaaaacact tggtggatct gttgtggaaa aagtaaacac ttttgagttt
     5761 tctcaaatgg ctaattaagt tagaaatgcc tatttagaaa gttatattga aataaattag
     5821 ctgtatcagt ttttaaaagg ctgtttaaaa catttgagta cctcattact gatattgctg
     5881 gtgaaaagaa actaattgaa actttagggc agacaatgta agatgtgata ctccgcattt
     5941 ctttatttgg ggccttaaat ctataaaaat gtcttgggcc attcgttaaa tatattgtag
     6001 atagtgttta tgaagtgtca attggacatc tcctgtggat tgtcttcagt aactttttgc
     6061 ttaagggatt aacctggttt ctaacctagc tactccagtt gtctccactt cataatattg
     6121 atgatgcctc tgcctgccct atgtaccaga taatgtatac ttaaagaata taaaataatc
     6181 atagcataat ttttttatta agtcgcatat cctaattctt agtggaagtg gtttttttgt
     6241 cctatttcat tactatttta tttattaaat tcagacttta ccacagttca tagaaataac
     6301 cttaaagtag gaggtagtat atcatctaaa gtacaattta tgaaaattga gtatatttct
     6361 ttattcaatt taatttagta gaaggataat gataatatat tggataaaaa ttcgaattca
     6421 aaaatgttca aaatttgtat ggcatttaca aaataatgta acaattggat gaaatcatgt
     6481 taaaactaat gttagtacaa caactcataa aaagtttgcc aagcttcaac caatgtgcca
     6541 ttaagtaata ttagatataa ttttaacata atcaaagaat ttggattggt tcttttgcgt
     6601 ttcttattat aaacttaatt tggagaggca tacctcttat acctgaaaga gtagaagcta
     6661 aaatttttgt aaaaaggggg aaaagtcatg ttttaaaatt ttaagtagta gattagaata
     6721 aaaccctcct aaaggcttaa ttaaatttag aatctgtttt ggacaaccac tttataaaaa
     6781 ggtaacccat gaacttataa ttttgaccat agctgaattt tctgacttcc tactgaacct
     6841 atttacctaa aagttttgct attgctttaa acaatggtaa acctcagctg tttttcttct
     6901 ttcttccaaa ccagcccctt tttctgagtt cccagtttta ataagtgctg ttcccatttt
     6961 ctcagtcaag attaaaacat aggaggtgtc tttgttcctt tttctggccc catatagtct
     7021 tggtgatgct tccttcatat agtctcacat ctgttctcat ttattcccac cactttcact
     7081 tggtctaggc acctagtaaa cacatcagct gttgtaatag cctctcttac agacctcttt
     7141 gtctcttcat attttagttc ggtgaacatc attttgggta acattactaa gataacagtt
     7201 ctaataattt ctctcctcag aaaccttcca agattcttaa aatagcattt aagattcttc
     7261 ttatcctatt cctttctacc tttcctctcc ttccttccta tgcacatact gtgctctatg
     7321 tgttttatct ctgcatcatt tatggaatga agacctcagt agctgctact tattggtcat
     7381 aacatatgtc attagttaaa gtctttcctg tccagcaagg cccaatttaa atgctccctt
     7441 ctctgtgaaa atctcctatc tgtcctcacc acattttggc aatctgtccc atttgtgaac
     7501 cacagtcaca ctttattttt ctctttttat ggtacttaac gttcatactt tagctatttt
     7561 gtatttcctg tgatattgga agttccttaa aggtagggac ttggtcttta tcatttctga
     7621 gtcttcacag tcttttttac ataaaaagca cacaatactt gctgaattga aatgaaattt
     7681 taaagttttt cctttgcgaa tagacttaat aatgggcaag atttagtgat taccttcaga
     7741 aacctgacta aggccatgta aacttataga gagctgagag tagccagaat cttcataaaa
     7801 tattccacta tcagttcttg attgccgacg aatgaatggt tgaccttcat cttcccagcc
     7861 catcagtggc tgttgttcac ttctctccat agctttggca agacaggcgc agcaaggact
     7921 gcatttcttt ataatatatt ggttaatttt aatgtcaaaa cacagcacca aaacatacaa
     7981 tccatatatc aaaagcagta aagccccttc atacctacaa aagagaaatt tgtgttttta
     8041 aattaaaagt gaaagtcatt ttagagttga tagcttttgg gcagtatcta ttgaatgatt
     8101 ttctaacaaa agtagccata gaacaatcaa acatttctag atattttttg ttttgtagat
     8161 ttgtccagac ttgattacag cattattatg tttattgata aaagctggac acttctgtgt
     8221 tgtttttttt tttttaaaaa caagatcaac aaactcgttt ttacttgtag attccttcca
     8281 aatgataggt ataaaaatgc aaggaaaatg ataattggag attttcaaaa taaatgtaaa
     8341 attaataaat agtggtgaac attttctgcc tcagctcatt ggcataatac attccccaac
     8401 atacataata attataaaat aatatagtaa ctgttaagtt atttcaactg tccaagtttt
     8461 ctggtatagg aactttgtgt aaaatattac tcagatatgg gaggcttagg ctgggatttt
     8521 tcagtttgtc atacagagca tttttaatga tttgaatgta gctgaatttg gcttacagtc
     8581 acaagaaaac aagatgttct aaaatataaa attataccct tggaaccaag aactgtttcc
     8641 ctgtactctg gcagttagct aatgccatca catttgaacc ttgcatttac cttttatagc
     8701 cagtgaatct ctgtctgctg tatcttaaag aacagttctg atttccctaa tggaggaaga
     8761 attagcttgg atactctcac agtcactatc ccttacagac aactgctgag ttctagaagg
     8821 atttctattc taccaacaca gtgtcttagg gagacggact agaggacagg atgattagtt
     8881 tagaaattat gcttctggct aggttttaag tttcttgata gcaggtatta cgccgtgctg
     8941 caaggttatg gttctccaga tggacaccat tacatttttt ttttttcata tttttctggt
     9001 gtcctctgga gttatgcaat gtatataacc tgtgtagctg tgttttacat ttcattatcc
     9061 cttatgatat ctagcatagt gagaaggacc tagtaggtgc ctgctgctta ctagttgaaa
     9121 aagttagtat ctgtccactc agtcaccacc tttttcattt tcttggacca gctaggcaca
     9181 gagagattgt aaggaaagca aacaattttt aatatgaaaa gctaagcatt gttatttctt
     9241 agaggaaggc tatagtttct cctgaatgag catcagaagt ttggaggaat ttaaaaagac
     9301 ttcttttact tcctctacca tccttctcca gtcttttgtg gccatgaaca cttctaacca
     9361 aggcaaggtg agcagtaacc cagcagaaga aaaagtcaac tgttgtggct ttaatggaca
     9421 acaggagttg ggaaactttc tgaataggca gccagtgggg agaaggaaaa gtggtggtct
     9481 ccagtgacta gtgagagaaa aaaggagact gtgaagtgat taagaagaaa ttgcaaacta
     9541 gtgagaagaa ctcaatcagc aattgtgatg aggttaactc acagacctgt tggaatatgg
     9601 tatagaagtg gcagattaag tgactgaaat aacatttctg aaaaaaaatt actgaaccat
     9661 cagaaattca taaaatctct aatttttaca taagaattat tttcaagctt accagtaaac
     9721 ttggttgtca tatattatac caagaactgc tgctgcacta attgtgtacg ctgcacagtc
     9781 tctgaatagg ggccaacatg atagtgttga gacctgtaat atggtaagtt attatttcca
     9841 ttacattgta acttcttcaa gtacaatcct tagtataata ctaaaattgt ttatatattt
     9901 gtagttaaat attgttatct tttgcatatt gcttagagaa aaaaatgtaa aattgtgttc
     9961 taacttacac agactttcat aaatctgacc aagagctatt tgtggattaa cattaaattg
    10021 aatacatgtt gtttttctac tgattaataa atttgattgc acata
//
