LOCUS       NM_019107                990 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens myeloid derived growth factor (MYDGF), mRNA.
ACCESSION   NM_019107 XM_035638
VERSION     NM_019107.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Xu,J., Song,Y., Ding,S., Duan,W., Xiang,G. and Wang,Z.
  TITLE     Myeloid-derived growth factor and its effects on cardiovascular and
            metabolic diseases
  JOURNAL   Cytokine Growth Factor Rev 76, 77-85 (2024)
   PUBMED   38185568
  REMARK    GeneRIF: Myeloid-derived growth factor and its effects on
            cardiovascular and metabolic diseases.
            Review article
REFERENCE   2  (bases 1 to 990)
  AUTHORS   Grosse-Segerath,L., Follert,P., Behnke,K., Ettich,J., Buschmann,T.,
            Kirschner,P., Hartwig,S., Lehr,S., Korf-Klingebiel,M., Eberhard,D.,
            Lehwald-Tywuschik,N., Al-Hasani,H., Knoefel,W.T., Heinrich,S.,
            Levkau,B., Wollert,K.C., Scheller,J. and Lammert,E.
  TITLE     Identification of myeloid-derived growth factor as a
            mechanically-induced, growth-promoting angiocrine signal for human
            hepatocytes
  JOURNAL   Nat Commun 15 (1), 1076 (2024)
   PUBMED   38316785
  REMARK    GeneRIF: Identification of myeloid-derived growth factor as a
            mechanically-induced, growth-promoting angiocrine signal for human
            hepatocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 990)
  AUTHORS   Wang,J., Ma,R., Wang,Y., Zhang,S., Wang,J., Zheng,J., Xue,W. and
            Ding,X.
  TITLE     rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting
            Inflammation and Apoptosis via the Akt Pathway
  JOURNAL   Transplantation 107 (8), 1729-1739 (2023)
   PUBMED   36698245
  REMARK    GeneRIF: rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting
            Inflammation and Apoptosis via the Akt Pathway.
REFERENCE   4  (bases 1 to 990)
  AUTHORS   Tang,Y., Bai,Z., Qi,J., Lu,Z., Ahmad, Wang,G., Jin,M., Wang,B.,
            Chen,H. and Li,X.
  TITLE     Altered peripheral B lymphocyte homeostasis and functions mediated
            by IL-27 via activating the mammalian target of rapamycin signaling
            pathway in patients with rheumatoid arthritis
  JOURNAL   Clin Exp Immunol 206 (3), 354-365 (2021)
   PUBMED   34558072
  REMARK    GeneRIF: Altered peripheral B lymphocyte homeostasis and functions
            mediated by IL-27 via activating the mammalian target of rapamycin
            signaling pathway in patients with rheumatoid arthritis.
REFERENCE   5  (bases 1 to 990)
  AUTHORS   Ran,Y., Huang,D., Mei,Y., Liu,Z., Zhou,Y., He,J., Zhang,H., Yin,N.
            and Qi,H.
  TITLE     Identification of the correlations between interleukin-27 (IL-27)
            and immune-inflammatory imbalance in preterm birth
  JOURNAL   Bioengineered 12 (1), 3201-3218 (2021)
   PUBMED   34224308
  REMARK    GeneRIF: Identification of the correlations between interleukin-27
            (IL-27) and immune-inflammatory imbalance in preterm birth.
REFERENCE   6  (bases 1 to 990)
  AUTHORS   Sunagozaka,H., Honda,M., Yamashita,T., Nishino,R., Takatori,H.,
            Arai,K., Yamashita,T., Sakai,Y. and Kaneko,S.
  TITLE     Identification of a secretory protein c19orf10 activated in
            hepatocellular carcinoma
  JOURNAL   Int J Cancer 129 (7), 1576-1585 (2011)
   PUBMED   21128247
  REMARK    GeneRIF: Taken together, these data suggest that c19orf10 might be
            one of the growth factors and potential molecular targets activated
            in HCC.
REFERENCE   7  (bases 1 to 990)
  AUTHORS   Weiler,T., Du,Q., Krokhin,O., Ens,W., Standing,K., El-Gabalawy,H.
            and Wilkins,J.A.
  TITLE     The identification and characterization of a novel protein,
            c19orf10, in the synovium
  JOURNAL   Arthritis Res Ther 9 (2), R30 (2007)
   PUBMED   17362502
  REMARK    GeneRIF: we identified a novel protein, c19orf10 (chromosome 19
            open reading frame 10), produced by fibroblast-like synoviocytes
REFERENCE   8  (bases 1 to 990)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 990)
  AUTHORS   Buning,C., Genschel,J., Weltrich,R., Lochs,H. and Schmidt,H.
  TITLE     The interleukin-25 gene located in the inflammatory bowel disease
            (IBD) 4 region: no association with inflammatory bowel disease
  JOURNAL   Eur J Immunogenet 30 (5), 329-333 (2003)
   PUBMED   14641539
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 990)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098829.1 and BC014655.1.
            
            On Jul 18, 2019 this sequence version replaced NM_019107.3.
            
            Summary: The protein encoded by this gene was previously thought to
            support proliferation of lymphoid cells and was considered an
            interleukin. However, this activity has not been reproducible and
            the function of this protein is currently unknown. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010129.2, AK098829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262947.8/ ENSP00000262947.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-987               AK098829.1         1-987
            988-990             BC014655.1         987-989
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..990
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /note="myeloid derived growth factor"
                     /db_xref="GeneID:56005"
                     /db_xref="HGNC:HGNC:16948"
                     /db_xref="MIM:606746"
     exon            1..182
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..530
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /note="interleukin 27 working designation; interleukin-25;
                     stromal cell-derived growth factor SF20; UPF0556 protein
                     C19orf10"
                     /codon_start=1
                     /product="myeloid-derived growth factor precursor"
                     /protein_id="NP_061980.1"
                     /db_xref="CCDS:CCDS12133.1"
                     /db_xref="GeneID:56005"
                     /db_xref="HGNC:HGNC:16948"
                     /db_xref="MIM:606746"
                     /translation="MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRP
                     GGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSY
                     LYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELS
                     KLVIVAKASRTEL"
     exon            183..233
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     exon            234..295
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     exon            296..377
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     exon            378..450
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     exon            451..990
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /note="hexamer: ATTAAA"
     polyA_site      990
                     /gene="MYDGF"
                     /gene_synonym="C19orf10; EUROIMAGE1875335; IL25; IL27;
                     IL27w; R33729_1; SF20"
                     /note="major polyA site"
ORIGIN      
        1 agtccaacat ggcggcgccc agcggagggt ggaacggcgt cggcgcgagc ttgtgggccg
       61 cgctgctcct aggggccgtg gcgctgaggc cggcggaggc ggtgtccgag cccacgacgg
      121 tggcgtttga cgtgcggccc ggcggcgtcg tgcattcctt ctcccataac gtgggcccgg
      181 gggacaaata tacgtgtatg ttcacttacg cctctcaagg agggaccaat gagcaatggc
      241 agatgagtct ggggaccagc gaagaccacc agcacttcac ctgcaccatc tggaggcccc
      301 aggggaagtc ctatctgtac ttcacacagt tcaaggcaga ggtgcggggc gctgagattg
      361 agtacgccat ggcctactct aaagccgcat ttgaaaggga aagtgatgtc cctctgaaaa
      421 ctgaggaatt tgaagtgacc aaaacagcag tggctcacag gcccggggca ttcaaagctg
      481 agctgtccaa gctggtgatt gtggccaagg catcgcgcac tgagctgtga ccagcagccc
      541 tgttgcgggt ggcaccttct catctccggt gaagctgaag gggcctgtgt ccctgaaagg
      601 gccagcacat cactggtttt ctaggaggga ctcttaagtt ttctacctgg gctgacgttg
      661 ccttgtccgg aggggcttgc agggtggctg aagccctggg gcagagaaca gagggtccag
      721 ggccctcctg gctcccaaca gcttctcagt tcccacttcc tgctgagctc ttctggactc
      781 aggatcgcag atccggggca caaagagggt ggggaacatg ggggctatgc tggggaaagc
      841 agccatgctc cccccgacct ccagccgagc atccttcatg agcctgcaga actgctttcc
      901 tatgtttacc caggggacct cctttcagat gaactgggaa gagatgaaat gttttttcat
      961 atttaaataa ataagaacat taaaaagcaa
//
