LOCUS       NM_002468               2667 bp    mRNA    linear   PRI 02-MAR-2025
DEFINITION  Homo sapiens MYD88 innate immune signal transduction adaptor
            (MYD88), transcript variant 2, mRNA.
ACCESSION   NM_002468
VERSION     NM_002468.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Scuruchi,M., Avenoso,A., Aliquo,F., Pantano,A., Campo,G.M.,
            Campo,S. and D'Ascola,A.
  TITLE     miR-21 attenuated inflammation targeting MyD88 in human
            chondrocytes stimulated with Hyaluronan oligosaccharides
  JOURNAL   Arch Biochem Biophys 759, 110112 (2024)
   PUBMED   39111613
  REMARK    GeneRIF: miR-21 attenuated inflammation targeting MyD88 in human
            chondrocytes stimulated with Hyaluronan oligosaccharides.
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Ning,F., Wang,H., Liang,Z. and Lan,J.
  TITLE     TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma
            Progression by Promoting Autophagy through TLR4/MyD88/NF-kappaB
            Signaling Pathway
  JOURNAL   Discov Med 36 (187), 1627-1640 (2024)
   PUBMED   39190378
  REMARK    GeneRIF: TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell
            Lymphoma Progression by Promoting Autophagy through
            TLR4/MyD88/NF-kappaB Signaling Pathway.
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Lee,F.F.Y., Harris,C. and Alper,S.
  TITLE     RNA Binding Proteins that Mediate LPS-induced Alternative Splicing
            of the MyD88 Innate Immune Regulator
  JOURNAL   J Mol Biol 436 (8), 168497 (2024)
   PUBMED   38369277
  REMARK    GeneRIF: RNA Binding Proteins that Mediate LPS-induced Alternative
            Splicing of the MyD88 Innate Immune Regulator.
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Jaunin,F., Burns,K., Tschopp,J., Martin,T.E. and Fakan,S.
  TITLE     Ultrastructural distribution of the death-domain-containing MyD88
            protein in HeLa cells
  JOURNAL   Exp Cell Res 243 (1), 67-75 (1998)
   PUBMED   9716450
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Burns,K., Martinon,F., Esslinger,C., Pahl,H., Schneider,P.,
            Bodmer,J.L., Di Marco,F., French,L. and Tschopp,J.
  TITLE     MyD88, an adapter protein involved in interleukin-1 signaling
  JOURNAL   J Biol Chem 273 (20), 12203-12209 (1998)
   PUBMED   9575168
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Wesche,H., Henzel,W.J., Shillinglaw,W., Li,S. and Cao,Z.
  TITLE     MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
  JOURNAL   Immunity 7 (6), 837-847 (1997)
   PUBMED   9430229
REFERENCE   7  (bases 1 to 2667)
  AUTHORS   Muzio,M., Ni,J., Feng,P. and Dixit,V.M.
  TITLE     IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators
            of IL-1 signaling
  JOURNAL   Science 278 (5343), 1612-1615 (1997)
   PUBMED   9374458
REFERENCE   8  (bases 1 to 2667)
  AUTHORS   Hardiman,G., Jenkins,N.A., Copeland,N.G., Gilbert,D.J.,
            Garcia,D.K., Naylor,S.L., Kastelein,R.A. and Bazan,J.F.
  TITLE     Genetic structure and chromosomal mapping of MyD88
  JOURNAL   Genomics 45 (2), 332-339 (1997)
   PUBMED   9344657
REFERENCE   9  (bases 1 to 2667)
  AUTHORS   Bonnert,T.P., Garka,K.E., Parnet,P., Sonoda,G., Testa,J.R. and
            Sims,J.E.
  TITLE     The cloning and characterization of human MyD88: a member of an
            IL-1 receptor related family
  JOURNAL   FEBS Lett 402 (1), 81-84 (1997)
   PUBMED   9013863
REFERENCE   10 (bases 1 to 2667)
  AUTHORS   Hardiman,G., Rock,F.L., Balasubramanian,S., Kastelein,R.A. and
            Bazan,J.F.
  TITLE     Molecular characterization and modular analysis of human MyD88
  JOURNAL   Oncogene 13 (11), 2467-2475 (1996)
   PUBMED   8957090
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP242808.1, BC013589.1 and
            BP339466.1.
            
            On Sep 20, 2018 this sequence version replaced NM_002468.4.
            
            Summary: This gene encodes a cytosolic adapter protein that plays a
            central role in the innate and adaptive immune response. This
            protein functions as an essential signal transducer in the
            interleukin-1 and Toll-like receptor signaling pathways. These
            pathways regulate that activation of numerous proinflammatory
            genes. The encoded protein consists of an N-terminal death domain
            and a C-terminal Toll-interleukin1 receptor domain. Patients with
            defects in this gene have an increased susceptibility to pyogenic
            bacterial infections. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1104522.1, BC013589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000650905.2/
                                                ENSP00000498360.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP242808.1         184-184
            2-1537              BC013589.1         1-1536
            1538-1538           BP339466.1         357-357
            1539-2667           BC013589.1         1538-2666
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..2667
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /note="MYD88 innate immune signal transduction adaptor"
                     /db_xref="GeneID:4615"
                     /db_xref="HGNC:HGNC:7562"
                     /db_xref="MIM:602170"
     exon            1..368
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..931
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myeloid differentiation primary response protein MyD88;
                     myeloid differentiation primary response 88; myeloid
                     differentiation primary response gene (88); mutant myeloid
                     differentiation primary response 88; TLR adaptor MYD88"
                     /codon_start=1
                     /product="myeloid differentiation primary response protein
                     MyD88 isoform 2"
                     /protein_id="NP_002459.3"
                     /db_xref="CCDS:CCDS2674.3"
                     /db_xref="GeneID:4615"
                     /db_xref="HGNC:HGNC:7562"
                     /db_xref="MIM:602170"
                     /translation="MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVA
                     ADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVL
                     LELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPER
                     FDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRR
                     MVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDY
                     TNPCTKSWFWTRLAKALSLP"
     exon            369..503
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..684
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..776
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2667
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2647..2652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /note="hexamer: AATAAT"
     polyA_site      2667
                     /gene="MYD88"
                     /gene_synonym="IMD68; MYD88D; WM1"
                     /note="major polyA site"
ORIGIN      
        1 aatgcgaccc gaccgcgctg aggctccagg accgcccgcc atggctgcag gaggtcccgg
       61 cgcggggtct gcggccccgg tctcctccac atcctccctt cccctggctg ctctcaacat
      121 gcgagtgcgg cgccgcctgt ctctgttctt gaacgtgcgg acacaggtgg cggccgactg
      181 gaccgcgctg gcggaggaga tggactttga gtacttggag atccggcaac tggagacaca
      241 agcggacccc actggcaggc tgctggacgc ctggcaggga cgccctggcg cctctgtagg
      301 ccgactgctc gagctgctta ccaagctggg ccgcgacgac gtgctgctgg agctgggacc
      361 cagcattgag gaggattgcc aaaagtatat cttgaagcag cagcaggagg aggctgagaa
      421 gcctttacag gtggccgctg tagacagcag tgtcccacgg acagcagagc tggcgggcat
      481 caccacactt gatgaccccc tggggcatat gcctgagcgt ttcgatgcct tcatctgcta
      541 ttgccccagc gacatccagt ttgtgcagga gatgatccgg caactggaac agacaaacta
      601 tcgactgaag ttgtgtgtgt ctgaccgcga tgtcctgcct ggcacctgtg tctggtctat
      661 tgctagtgag ctcatcgaaa agaggtgccg ccggatggtg gtggttgtct ctgatgatta
      721 cctgcagagc aaggaatgtg acttccagac caaatttgca ctcagcctct ctccaggtgc
      781 ccatcagaag cgactgatcc ccatcaagta caaggcaatg aagaaagagt tccccagcat
      841 cctgaggttc atcactgtct gcgactacac caacccctgc accaaatctt ggttctggac
      901 tcgccttgcc aaggccttgt ccctgccctg aagactgttc tgaggccctg ggtgtgtgtg
      961 tatctgtctg cctgtccatg tacttctgcc ctgcctcctc ctttcgttgt aggaggaatc
     1021 tgtgctctac ttacctctca attcctggag atgccaactt cacagacacg tctgcagcag
     1081 ctggacatca catttcatgt cctgcatgga accagtggct gtgagtggca tgtccacttg
     1141 ctggattatc agccaggaca ctatagaaca ggaccagctg agactaagaa ggaccagcag
     1201 agccagctca gctctgagcc attcacacat cttcaccctc agtttcctca cttgaggagt
     1261 gggatgggga gaacagagag tagctgtgtt tgaatccctg taggaaatgg tgaagcatag
     1321 ctctgggtct cctgggggag accaggcttg gctgcgggag agctggctgt tgctggacta
     1381 catgctggcc actgctgtga ccacgacact gctggggcag cttcttccac agtgatgcct
     1441 actgatgctt cagtgcctct gcacaccgcc cattccactt cctccttccc cacagggcag
     1501 gtggggaagc agtttggccc agcccaagga gaccccacct tgagccttat ttcctaatgg
     1561 gtccacctct catctgcatc tttcacacct cccagcttct gcccaacctt cagcagtgac
     1621 aagtccccaa gagactcgcc tgagcagctt gggctgcttt tcatttccac ctgtcaggat
     1681 gcctgtggtc atgctctcag ctccacctgg catgagaagg gatcctggcc tctggcatat
     1741 tcatcaagta tgagttctgg ggatgagtca ctgtaatgat gtgagcaggg agccttcctc
     1801 cctgggccac ctgcagagag ctttcccacc aactttgtac cttgattgcc ttacaaagtt
     1861 atttgtttac aaacagcgac catataaaag cctcctgccc caaagcttgt gggcacatgg
     1921 gcacatacag actcacatac agacacacac atatatgtac agacatgtac tctcacacac
     1981 acaggcacca gcatacacac gtttttctag gtacagctcc caggaacagc taggtgggaa
     2041 agtcccatca ctgagggagc ctaaccatgt ccctgaacaa aaattgggca ctcatctatt
     2101 ccttttctct tgtgtcccta ctcattgaaa ccaaactctg gaaaggaccc aatgtaccag
     2161 tatttatacc tctaatgaag cacagagaga ggaagagagc tgcttaaact cacacaacaa
     2221 tgaactgcag acacagctgt tctctccctc tctccttccc agagcaattt atactttacc
     2281 ctcaggctgt cctctgggga gaaggtgcca tggtcttagg tgtctgtgcc ccaggacaga
     2341 ccctaggacc ctaaatccaa tagaaaatgc atatctttgc tccactttca gccaggctgg
     2401 agcaaggtac cttttcttag gatcttggga gggaatggat gcccctctct gcatgatctt
     2461 gttgaggcat ttagctgcca tgcacctgtc cccctttaat actgggcatt ttaaagccat
     2521 ctcaagaggc atcttctaca tgttttgtac gcattaaaat aatttcaaag atatctgaga
     2581 aaagccgata tttgccattc ttcctatatc ctggaatata tcttgcatcc tgagtttata
     2641 ataataaata atattctacc ttggaaa
//
