LOCUS       NM_025107               3030 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens MYC target 1 (MYCT1), transcript variant 1, mRNA.
ACCESSION   NM_025107
VERSION     NM_025107.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3030)
  AUTHORS   Dong,X., Xue,S., Chen,C., Jiang,Z., Wu,X. and Wang,W.
  TITLE     MYCT-1 Gene Expression in Patients with Gastric Cancer: an Ex Vivo
            Study
  JOURNAL   Appl Biochem Biotechnol 196 (8), 5114-5126 (2024)
   PUBMED   38112991
  REMARK    GeneRIF: MYCT-1 Gene Expression in Patients with Gastric Cancer: an
            Ex Vivo Study.
REFERENCE   2  (bases 1 to 3030)
  AUTHORS   Liang,Y., Wei,X., Yue,P.J., Zhang,H.C., Li,Z.N., Wang,X.X.,
            Sun,Y.Y. and Fu,W.N.
  TITLE     MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by
            suppressing RUNX1 transcription
  JOURNAL   Cell Mol Biol Lett 29 (1), 5 (2024)
   PUBMED   38172714
  REMARK    GeneRIF: MYCT1 inhibits hematopoiesis in diffuse large B-cell
            lymphoma by suppressing RUNX1 transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3030)
  AUTHORS   Xu,J., Sun,Y., Fu,W. and Fu,S.
  TITLE     MYCT1 in cancer development: Gene structure, regulation, and
            biological implications for diagnosis and treatment
  JOURNAL   Biomed Pharmacother 165, 115208 (2023)
   PUBMED   37499454
  REMARK    GeneRIF: MYCT1 in cancer development: Gene structure, regulation,
            and biological implications for diagnosis and treatment.
            Review article
REFERENCE   4  (bases 1 to 3030)
  AUTHORS   Yan,F., Wang,J., Wu,X., Lu,X.T., Wang,Y., Cheng,W., Cui,X.P.,
            Jiang,F. and Guo,X.S.
  TITLE     Nitrosative stress induces downregulation of ribosomal protein
            genes via MYCT1 in vascular smooth muscle cells
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (18), 5653-5663 (2021)
   PUBMED   34604957
  REMARK    GeneRIF: Nitrosative stress induces downregulation of ribosomal
            protein genes via MYCT1 in vascular smooth muscle cells.
            Erratum:[Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):6893. doi:
            10.26355/eurrev_202210_29866.. PMID: 36263566]
REFERENCE   5  (bases 1 to 3030)
  AUTHORS   Kabir,A.U., Subramanian,M., Lee,D.H., Wang,X., Krchma,K., Wu,J.,
            Naismith,T., Halabi,C.M., Kim,J.Y., Pulous,F.E., Petrich,B.G.,
            Kim,S., Park,H.C., Hanson,P.I., Pan,H., Wickline,S.A.,
            Fremont,D.H., Park,C. and Choi,K.
  TITLE     Dual role of endothelial Myct1 in tumor angiogenesis and tumor
            immunity
  JOURNAL   Sci Transl Med 13 (583) (2021)
   PUBMED   33658356
  REMARK    GeneRIF: Dual role of endothelial Myct1 in tumor angiogenesis and
            tumor immunity.
REFERENCE   6  (bases 1 to 3030)
  AUTHORS   Yang,M., Li,W., Liu,Y.Y., Fu,S., Qiu,G.B., Sun,K.L. and Fu,W.N.
  TITLE     Promoter hypermethylation-induced transcriptional down-regulation
            of the gene MYCT1 in laryngeal squamous cell carcinoma
  JOURNAL   BMC Cancer 12, 219 (2012)
   PUBMED   22672838
  REMARK    GeneRIF: hypermethylation contributed to the transcriptional
            down-regulation of MYCT1 and could inhibit cancer cell
            differentiation in laryngeal squamous cell cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3030)
  AUTHORS   Liddiard,K., Burnett,A.K., Darley,R.L. and Tonks,A.
  TITLE     RUNX1-ETO deregulates the proliferation and growth factor
            responsiveness of human hematopoietic progenitor cells downstream
            of the myeloid transcription factor, MYCT1
  JOURNAL   Leukemia 26 (1), 177-179 (2012)
   PUBMED   21799513
  REMARK    GeneRIF: results suggest MYCT1 transcription can be activated
            downstream of RUNX1-ETO as well as MYC, contributing to key aspects
            of the leukaemic phenotypes these oncoproteins promote
REFERENCE   8  (bases 1 to 3030)
  AUTHORS   Fu,S., Guo,Y., Chen,H., Xu,Z.M., Qiu,G.B., Zhong,M., Sun,K.L. and
            Fu,W.N.
  TITLE     MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc and may
            participate in laryngeal carcinogenesis
  JOURNAL   PLoS One 6 (10), e25648 (2011)
   PUBMED   21998677
  REMARK    GeneRIF: MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc
            and down-regulation of MYCT1-TV/MYCT1 could contribute to LSCC
            development and function
REFERENCE   9  (bases 1 to 3030)
  AUTHORS   Qiu,G.B., Gong,L.G., Hao,D.M., Zhen,Z.H. and Sun,K.L.
  TITLE     Expression of MTLC gene in gastric carcinoma
  JOURNAL   World J Gastroenterol 9 (10), 2160-2163 (2003)
   PUBMED   14562369
  REMARK    GeneRIF: MTLC was down-regulated in the majority of gastric cancer
            tissues and could promote apoptosis of GC cell lines, which
            suggests that MTLC may play an important role in the carcinogenesis
            of gastric carcinoma.
REFERENCE   10 (bases 1 to 3030)
  AUTHORS   Qiu,G., Qiu,G., Xu,Z., Huang,D., Gong,L., Li,C., Sun,X. and Sun,K.
  TITLE     [Cloning and characterization of MTLC, a novel gene in 6q25]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20 (2), 94-97 (2003)
   PUBMED   12673574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390960.20.
            
            On Feb 22, 2021 this sequence version replaced NM_025107.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022556.1, AL834500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367245.6/ ENSP00000356214.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AL390960.20        41378-41579
            203-3030            AL390960.20        65223-68050
FEATURES             Location/Qualifiers
     source          1..3030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..3030
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /note="MYC target 1"
                     /db_xref="GeneID:80177"
                     /db_xref="HGNC:HGNC:23172"
                     /db_xref="MIM:616805"
     exon            1..202
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..714
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /note="isoform 1 is encoded by transcript variant 1; myc
                     target protein 1; myc target in myeloid cells 1; myc
                     target in myeloid cells protein 1"
                     /codon_start=1
                     /product="myc target protein 1 isoform 1"
                     /protein_id="NP_079383.2"
                     /db_xref="CCDS:CCDS5239.1"
                     /db_xref="GeneID:80177"
                     /db_xref="HGNC:HGNC:23172"
                     /db_xref="MIM:616805"
                     /translation="MRTQVYEGLCKNYFSLAVLQRDRIKLLFFDILVFLSVFLLFLLF
                     LVDIMANNTTSLGSPWPENFWEDLIMSFTVSMAIGLVLGGFIWAVFICLSRRRRASAP
                     ISQWSSSRRSRSSYTHGLNRTGFYRHSGCERRSNLSLASLTFQRQASLEQANSFPRKS
                     SFRASTFHPFLQCPPLPVETESQLVTLPSSNISPTISTSHSLSRPDYWSSNSLRVGLS
                     TPPPPAYESIIKAFPDS"
     exon            203..3030
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /note="hexamer: AATAAA"
     polyA_site      3030
                     /gene="MYCT1"
                     /gene_synonym="MTLC"
                     /note="major polyA site"
ORIGIN      
        1 ccttttatgc gaacacaagt atatgagggg ttgtgtaaaa attatttttc tcttgctgta
       61 ctacaaagag atagaatcaa actgcttttt ttcgacatac tggtttttct ttctgttttt
      121 cttctctttc ttctatttct tgtggatatt atggctaata acacaacaag tttagggagt
      181 ccatggccag aaaacttttg ggaggacctt atcatgtcct tcactgtatc catggcaatc
      241 gggctggtac ttggaggatt tatttgggct gtgttcattt gtctgtctcg aagaagaaga
      301 gccagtgctc ccatctcaca gtggagttca agcaggagat ctaggtcttc ttacacccac
      361 ggcctcaaca gaactggatt ttaccgccac agtggctgtg aacgtcgaag caacctcagc
      421 ctggccagtc tcaccttcca gcgacaagct tccctggaac aagcaaattc ctttccaaga
      481 aaatcaagtt tcagagcttc tactttccat ccctttctgc aatgtccacc acttcctgtg
      541 gaaactgaga gtcagctggt gactctccct tcttccaata tctctcccac catcagcact
      601 tcccacagtc tgagccgtcc tgactactgg tccagtaaca gtcttcgagt gggcctttca
      661 acaccgcccc cacctgccta tgagtccatc atcaaggcat tcccagattc ctgagtaggg
      721 tggcttttgg tttttgtttc tttcttgtct tgtcttttat tgaaaggaaa tcaaaaatag
      781 gctaaacaga attttgaggg catggcccaa ataactcatg agttccaagt tgaaacatgg
      841 ttgtgcaagt tggacattac aatgtaaaac acattttctt caaacacgtt ttcccttttg
      901 tttcaaaaaa tgtaatattt tcccccaagc gttttatatt tatgtatttt gtattcaatg
      961 tgaggcttat taaaaatagt gattctaatg taagaatcag ctaagatgca ttatatatat
     1021 tttaattaaa attaaaactt cagatatttg tggattacaa tcctcattta cttccaatgt
     1081 gactaaaaag agaaaaaaaa tcactgtgtc actttaaaga aaaatcttct aagggatttg
     1141 gattttactt tctttagaat gacaagtgaa tcatattgac attttacaat cttagatttt
     1201 tctttttttt tcttttgaga cagggtcttg atccgtcgcc caggcgggag ttgcagtagc
     1261 atgatcagga ctcactgcag cctctatctc ccaggctcaa gtaatcctcc catcttagtg
     1321 ccccaagtag ctgggactac aggggtgcac taccacaccg ggttgaattt ttttttaatt
     1381 ttagtagaga tgaagtgtca ctatgttacc aaggctggtc tcaaactcct aaactcagat
     1441 gatcctcctg cctcggcctc ccaaagtgct ggaattagcc tggccaatct tggattttta
     1501 atggaatatg tgggcacaaa atgacagaac ataggacatt ctaaagttcc ttgatttgat
     1561 cattataaga agtgtgggac tcaagcacag gaaactgaac tcttttggtg tcattggatg
     1621 tttcattttt gacactaatt ttttctggac aaactcttta tgtgtttttc ccaagaatag
     1681 ttatctactt cctggaggca aaatccttgg atttactaac atgatgattt accttttctt
     1741 caccgttgtc gttacattgt tagaaaagca acaggaaaaa atccaattca tttgacctaa
     1801 aaacaagcct caagtttaaa accaagctca cgtttttctt aagggaaaaa ttttctttct
     1861 taaacttaca tctagcaact tggaaagcac tttctctggg gatcttcttt tgtaactttg
     1921 cagacaaata agtatgagtc actggggaga gagtttgtta ttgaaataga tgttgcccat
     1981 gaagaattct ccttcctgga ttgactctta atcatcaggc atcattcctg gtttgcttct
     2041 ctacgaatct caattccaac ttctctgcag agtctgtaca gtgattaagc catgccagat
     2101 ggtctttggt gcacacagtt atttaagaat ccacttccac aggtggctgc ccttgtaagg
     2161 aagaatgcat ccctaaatgt ggccaccaga gagttccagt gggcagatgt ctgtggctgc
     2221 ccttctcatt taaggacatg agttcactgg agtattactc aaaaagtctg tggttcattt
     2281 ccagtattgt gaatatttag tttatgtggc cgtttctttg tttctttgaa cagtgggatt
     2341 ttcagtgaaa aagtaccctc tttttcattt cctattgcag tggtcacagc taatagtgtc
     2401 tgaacatggt tcaagaataa gagattccat gtagcatttt ctttattatt ttcatttccc
     2461 ttatattatc catcattcct taaggacaat tattcttaat aatgcttata gaaaatgttc
     2521 tctaattaaa catgccaaaa ggaaaaagta agagaaagag ggagcaagaa gaaaatggaa
     2581 gaaaaaggga aaaaagctaa ccggataacc aatttgttat aagttggttt tcaacaaaga
     2641 aatttagcag ccaagtaagg tttcaaggga atattaactt ggtatcaggg ctactttttt
     2701 tttttttttt ttacttgcat gtcatcctta atgtctaaca tgaaaaatca gcaaagagta
     2761 tggtttttat caagaatttg tgttgggagt aaaaactgct ttatagctcc caaattagga
     2821 agagaagagc agaaatcctc tggggcattt aaccatctgg cagaattgtt gctgcaccct
     2881 tatcccagtt ataagacagt caaaatgact atttcctaaa tattgtgagt gtatgaaatg
     2941 tgaaattaaa gcaaaaactg gagactttta atgtatttct ttaatttgaa atgttttgtg
     3001 gattgtgaaa taaaaataaa tttatgtcaa
//
