LOCUS       NM_001033081            3522 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens MYCL proto-oncogene, bHLH transcription factor (MYCL),
            transcript variant 1, mRNA.
ACCESSION   NM_001033081
VERSION     NM_001033081.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3522)
  AUTHORS   Shabir,S. and Asiaf,A.
  TITLE     Comparative study on the mutation spectrum of L-MYC and C-MYC genes
            of blood cfDNA in patients with ovarian cancer and healthy females
  JOURNAL   J Obstet Gynaecol Res 49 (12), 2894-2904 (2023)
   PUBMED   37827180
  REMARK    GeneRIF: Comparative study on the mutation spectrum of L-MYC and
            C-MYC genes of blood cfDNA in patients with ovarian cancer and
            healthy females.
REFERENCE   2  (bases 1 to 3522)
  AUTHORS   Jiang,H., Li,X., Wang,W., Hu,Y. and Ren,D.
  TITLE     MYCL promotes the progression of triple-negative breast cancer by
            activating the JAK/STAT3 pathway
  JOURNAL   Oncol Rep 48 (5) (2022)
   PUBMED   36177900
  REMARK    GeneRIF: MYCL promotes the progression of triplenegative breast
            cancer by activating the JAK/STAT3 pathway.
REFERENCE   3  (bases 1 to 3522)
  AUTHORS   Akifuji,C., Iwasaki,M., Kawahara,Y., Sakurai,C., Cheng,Y.S.,
            Imai,T. and Nakagawa,M.
  TITLE     MYCL promotes iPSC-like colony formation via MYC Box 0 and 2
            domains
  JOURNAL   Sci Rep 11 (1), 24254 (2021)
   PUBMED   34930932
  REMARK    GeneRIF: MYCL promotes iPSC-like colony formation via MYC Box 0 and
            2 domains.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3522)
  AUTHORS   FitzGerald,M.J., Arsura,M., Bellas,R.E., Yang,W., Wu,M., Chin,L.,
            Mann,K.K., DePinho,R.A. and Sonenshein,G.E.
  TITLE     Differential effects of the widely expressed dMax splice variant of
            Max on E-box vs initiator element-mediated regulation by c-Myc
  JOURNAL   Oncogene 18 (15), 2489-2498 (1999)
   PUBMED   10229200
REFERENCE   5  (bases 1 to 3522)
  AUTHORS   Speleman,F., Van Camp,G. and Van Roy,N.
  TITLE     Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 189-190 (1996)
   PUBMED   8978772
REFERENCE   6  (bases 1 to 3522)
  AUTHORS   Atchley,W.R. and Fitch,W.M.
  TITLE     Myc and Max: molecular evolution of a family of proto-oncogene
            products and their dimerization partner
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10217-10221 (1995)
   PUBMED   7479755
REFERENCE   7  (bases 1 to 3522)
  AUTHORS   Ikegaki,N., Minna,J. and Kennett,R.H.
  TITLE     The human L-myc gene is expressed as two forms of protein in small
            cell lung carcinoma cell lines: detection by monoclonal antibodies
            specific to two myc homology box sequences
  JOURNAL   EMBO J 8 (6), 1793-1799 (1989)
   PUBMED   2548855
REFERENCE   8  (bases 1 to 3522)
  AUTHORS   De Greve,J., Battey,J., Fedorko,J., Birrer,M., Evan,G., Kaye,F.,
            Sausville,E. and Minna,J.
  TITLE     The human L-myc gene encodes multiple nuclear phosphoproteins from
            alternatively processed mRNAs
  JOURNAL   Mol Cell Biol 8 (10), 4381-4388 (1988)
   PUBMED   3054516
REFERENCE   9  (bases 1 to 3522)
  AUTHORS   Kaye,F., Battey,J., Nau,M., Brooks,B., Seifter,E., De Greve,J.,
            Birrer,M., Sausville,E. and Minna,J.
  TITLE     Structure and expression of the human L-myc gene reveal a complex
            pattern of alternative mRNA processing
  JOURNAL   Mol Cell Biol 8 (1), 186-195 (1988)
   PUBMED   2827002
REFERENCE   10 (bases 1 to 3522)
  AUTHORS   DePinho,R.A., Hatton,K.S., Tesfaye,A., Yancopoulos,G.D. and
            Alt,F.W.
  TITLE     The human myc gene family: structure and activity of L-myc and an
            L-myc pseudogene
  JOURNAL   Genes Dev 1 (10), 1311-1326 (1987)
   PUBMED   3322939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033527.26 and AI144219.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001033081.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.188700.1,
                                           SRR1660807.29451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372816.3/ ENSP00000361903.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-979               AL033527.26        141469-142447       c
            980-3494            AL033527.26        135986-138500       c
            3495-3522           AI144219.1         5-32                c
FEATURES             Location/Qualifiers
     source          1..3522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..3522
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /note="MYCL proto-oncogene, bHLH transcription factor"
                     /db_xref="GeneID:4610"
                     /db_xref="HGNC:HGNC:7555"
                     /db_xref="MIM:164850"
     exon            1..979
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..1578
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myc-related gene from lung cancer; l-myc-1 proto-oncogene;
                     protein L-Myc-1; class E basic helix-loop-helix protein
                     38; v-myc myelocytomatosis viral oncogene homolog 1, lung
                     carcinoma derived; v-myc avian myelocytomatosis viral
                     oncogene lung carcinoma derived homolog"
                     /codon_start=1
                     /product="protein L-Myc isoform 1"
                     /protein_id="NP_001028253.1"
                     /db_xref="CCDS:CCDS30682.1"
                     /db_xref="GeneID:4610"
                     /db_xref="HGNC:HGNC:7555"
                     /db_xref="MIM:164850"
                     /translation="MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPP
                     WGLGPGAGDPAPGIGPPEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFSAR
                     ERLERAVSDRLAPGAPRGNPPKASAAPDCTPSLEAGNPAPAAPCPLGEPKTQACSGSE
                     SPSDSENEEIDVVTVEKRQSLGIRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARF
                     PPESCSQEEASERGPQEEVLERDAAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSD
                     TEDVTKRKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALV
                     GAEKRMATEKRQLRCRQQQLQKRIAYLTGY"
     exon            980..3522
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /note="hexamer: AATAAA"
     polyA_site      3522
                     /gene="MYCL"
                     /gene_synonym="bHLHe38; L-Myc; LMYC; MYCL1"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgggc cgcgctctcg gcggcgcgca tgtgcgtgtg tgctggctgc cgggctgccc
       61 cgagccggcg gggagccggt ccgctccagg tggcgggcgg ctggagcgag gtgaggctgc
      121 gggtggccag ggcacgggcg cgggtcccgc ggtgcgggct ggctgcaggc tgccttctgg
      181 gcacggcgcg cccccgcccg gccccgccgg gccctgggag ctgcgctccg ggcggcgctg
      241 gcaaagtttg ctttgaactc gctgcccaca gtcgggtccg cgcgctgcga ttggcttccc
      301 ctaccactct gacccggggc ccggcttccc gggacgcgag gactgggcgc aggctgcaag
      361 ctggtggggt tggggaggaa cgagagcccg gcagccgact gtgccgaggg acccggggac
      421 acctccttcg cccggccggc acccggtcag cacgtccccc cttccctccc gcagggagcg
      481 gacatggact acgactcgta ccagcactat ttctacgact atgactgcgg ggaggatttc
      541 taccgctcca cggcgcccag cgaggacatc tggaagaaat tcgagctggt gccatcgccc
      601 cccacgtcgc cgccctgggg cttgggtccc ggcgcagggg acccggcccc cgggattggt
      661 cccccggagc cgtggcccgg agggtgcacc ggagacgaag cggaatcccg gggccactcg
      721 aaaggctggg gcaggaacta cgcctccatc atacgccgtg actgcatgtg gagcggcttc
      781 tcggcccggg aacggctgga gagagctgtg agcgaccggc tcgctcctgg cgcgccccgg
      841 gggaacccgc ccaaggcgtc cgccgccccg gactgcactc ccagcctcga agccggcaac
      901 ccggcgcccg ccgccccctg tccgctgggc gaacccaaga cccaggcctg ctccgggtcc
      961 gagagcccaa gcgactcgga gaatgaagaa attgatgttg tgacagtaga gaagaggcag
     1021 tctctgggta ttcggaagcc ggtcaccatc acggtgcgag cagaccccct ggatccctgc
     1081 atgaagcatt tccacatctc catccatcag caacagcaca actatgctgc ccgttttcct
     1141 ccagaaagct gctcccaaga agaggcttca gagaggggtc cccaagaaga ggttctggag
     1201 agagatgctg caggggaaaa ggaagatgag gaggatgaag agattgtgag tcccccacct
     1261 gtagaaagtg aggctgccca gtcctgccac cccaaacctg tcagttctga tactgaggat
     1321 gtgaccaaga ggaagaatca caacttcctg gagcgcaaga ggcggaatga cctgcgttcg
     1381 cgattcttgg cgctgaggga ccaggtgccc accctggcca gctgctccaa ggcccccaaa
     1441 gtagtgatcc taagcaaggc cttggaatac ttgcaagccc tggtgggggc tgagaagagg
     1501 atggctacag agaaaagaca gctccgatgc cggcagcagc agttgcagaa aagaattgca
     1561 tacctcactg gctactaact gaccaaaaag cctgacagtt ctgtcttacg aagacacaag
     1621 tttatttttt aacctccctc tcccctttag taatttgcac attttggtta tggtgggaca
     1681 gtctggacag tagatcccag aatgcattgc agccggtgca cacacaataa aggcttgcat
     1741 tcttggaaac cttgaaaccc agctctccct cttccctgac tcatgggagt gctgtatgtt
     1801 ctctggcgcc tttggcttcc cagcaggcag ctgactgagg agccttgggg tctgcctagc
     1861 tcactagctc tgaagaaaag gctgacagat gctatgcaac aggtggtgga tgttgtcagg
     1921 ggctccagcc tgcatgaaat ctcacactct gcatgagctt taggctagga aaggatgctc
     1981 ccaactggtg tctctggggt gatgcaagga cagctgggcc tggatgctct ccctgaggct
     2041 cctttttcca gaagacacac gagctgtctt gggtgaagac aagcttgcag acttgatcaa
     2101 cattgaccat tacctcactg tcagacactt tacagtagcc aaggagttgg aaacctttat
     2161 atattatgat gttagctgac ccccttcctc ccactcccaa tgctgcgacc ctgggaacac
     2221 ttaaaaagct tggcctctag attctttgtc tcagagccct ctgggctctc tcctctgagg
     2281 gagggacctt tctttcctca caagggactt ttttgttcca ttatgccttg ttatgcaatg
     2341 ggctctacag caccctttcc cacaggtcag aaatatttcc ccaagacaca gggaaatcgg
     2401 tcctagcctg gggcctgggg atagcttgga gtcctggccc atgaacttga tccctgccca
     2461 ggtgttttcc gaggggcact tgaggcccag tcttttctca aggcaggtgt aagacacctc
     2521 agagggagaa ctgtactgct gcctctttcc cacctgcctc atctcaatcc ttgagcggca
     2581 agtttgaagt tcttctggaa ccatgcaaat ctgtcctcct catgcaattc caaggagctt
     2641 gctggctctg cagccaccct tgggcccctt ccagcctgcc atgaatcaga tatctttccc
     2701 agaatctggg cgtttctgaa gttttgggga gagctgttgg gactcatcca gtgctccaga
     2761 aggtggactt gcttctggtg ggttttaaag gagcctccag gagatatgct tagccaacca
     2821 tgatggattt taccccagct ggactcggca gctccaagtg gaatccacgt gcagcttcta
     2881 gtctgggaaa gtcacccaac ctagcagttg tcatgtgggt aacctcaggc acctctaagc
     2941 ctgtcctgga agaaggacca gcagcccctc cagaactctg cccaggacag caggtgcctg
     3001 ctggctctgg gtttggaagt tggggtgggt agggggtggt aagtactata tatggctctg
     3061 gaaaaccagc tgctacttcc aaatctattg tccataatgg tttctttctg aggttgcttc
     3121 ttggcctcag aggaccccag gggatgtttg gaaatagcct ctctaccctt ctggagcatg
     3181 gtttacaaaa gccagctgac ttctggaatt gtctatggag gacagtttgg gtgtaggtta
     3241 ctgatgtctc aactgaatag cttgtgtttt ataagctgct gttggctatt atgctggggg
     3301 agtctttttt ttttatattg tatttttgta tgccttttgc aaagtggtgt taactgtttt
     3361 tgtacaagga aaaaaactct tggggcaatt tcctgttgca agggtctgat ttattttgaa
     3421 aggcaagttc acctgaaatt ttgtatttag ttgtgattac tgattgcctg attttaaaat
     3481 gttgccttct gggacatctt ctaataaaag atttctcaaa ca
//
