LOCUS       NM_032133               3135 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens MYCBP associated protein (MYCBPAP), transcript variant
            1, mRNA.
ACCESSION   NM_032133
VERSION     NM_032133.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AAT-1, a novel testis-specific AMY-1-binding protein, forms a
            quaternary complex with AMY-1, A-kinase anchor protein 84, and a
            regulatory subunit of cAMP-dependent protein kinase and is
            phosphorylated by its kinase
  JOURNAL   J Biol Chem 277 (47), 45480-45492 (2002)
   PUBMED   12223483
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AMAP-1, a novel testis-specific AMY-1-binding protein, is
            differentially expressed during the course of spermatogenesis
  JOURNAL   Biochim Biophys Acta 1577 (1), 126-132 (2002)
   PUBMED   12151104
  REMARK    GeneRIF: sequence analysis of AMAP-1 and identification of AMY-1 as
            binding protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK303041.1 and AB083068.1.
            
            On May 17, 2019 this sequence version replaced NM_032133.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005627.1, AB083068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000323776.11/
                                                ENSP00000323184.6
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               AK303041.1         56-716
            662-1845            AB083068.1         510-1693
            1846-2761           AK303041.1         1901-2816
            2762-3135           AB083068.1         2610-2983
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3135
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /note="MYCBP associated protein"
                     /db_xref="GeneID:84073"
                     /db_xref="HGNC:HGNC:19677"
                     /db_xref="MIM:609835"
     exon            1..312
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..3062
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Mycbp-associated protein; AMY1-associating protein 1;
                     AMAM-1; AMY-1-binding protein 1; testis secretory
                     sperm-binding protein Li 214e"
                     /codon_start=1
                     /product="MYCBP-associated protein isoform 1"
                     /protein_id="NP_115509.5"
                     /db_xref="CCDS:CCDS32680.3"
                     /db_xref="GeneID:84073"
                     /db_xref="HGNC:HGNC:19677"
                     /db_xref="MIM:609835"
                     /translation="MKSLKKDSRLRITPTRLLEASENVKEKKRAKGPEQPTPTIQEEP
                     EPVSNVLQGDDILALAIKKEDLKEQHIPRLTEKEDKRVITQKFIIRKLKPMDPRRKVC
                     HLVARPANPDEATKPLDYSGPGDSFDGSDQILPHHILGSLQDFKRIALARGNTQLAER
                     IPTSPCLMTLISAEGESKQKAPKEEKRPPWAPPPQHNFLKNWQRNTALRKKQQEALSE
                     HLKKPVSELLMHTGETYRRIQEERELIDCTLPTRRDRKSWENSGFWSRLEYLGDEMTG
                     LVMTKTKTQRGLMEPITHIRKPHSIRVETGLPAQRDASYRYTWDRSLFLIYRRKELQR
                     IMEELDFSQQDIDGLEVVGKGWPFSAVTVEDYTVFERSQGSSSEDTAYLGTLASSSDV
                     SMPILGPSLLFCGKPACWIRGSNPQDKRQVGIAAHLTFETLEGEKTSSELTVVNNGTV
                     AIWYDWRRQHQPDTFQDLKKNRMQRFYFDNREGVILPGEIKTFTFFFKSLTAGVFREF
                     WEFRTHPTLLGGAILQVNLHAVSLTQDVFEDERKVLESKLTAHEAVTVVREVLQELLM
                     GVLTPERTPSPVDAYLTEEDLFRHRNPPLHYEHQVVQSLHQLWRQYMTLPAKAEEARP
                     GDKEHVSPIATEKASVNAELLPRFRSPISETQVPRPENEALRESGSQKARVGTKSPQR
                     KSIMEEILVEESPDVDSTKSPWEPDGLPLLEWNLCLEDFRKAVMVLPDENHREDALMR
                     LNKAALELCQKPRPLQSNLLHQMCLQLWRDVIDSLVGHSMWLRSVLGLPEKETIYLNV
                     PEEQDQKSPPIMEVKVPVGKAGKEERKGAAQEKKQLGIKDKEDKKGAKLLGKEDRPNS
                     KKHKAKDDKKVIKSASQDRFSLEDPTPDIILSSQEPIDPLVMGKYTQSLHSEVRGLLD
                     TLVTDLMVLADELSPIKNVEEALRLCR"
     exon            313..440
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..600
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..704
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..888
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1004
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1152
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1268
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1384
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1493
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1683
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1871
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2018
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2405
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2527
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2643
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2789
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2960
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3135
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /note="hexamer: AATAAA"
     polyA_site      3135
                     /gene="MYCBPAP"
                     /gene_synonym="AMAP-1; AMAP1"
                     /note="major polyA site"
ORIGIN      
        1 agggctttct aggggtccgt cgctcttgaa gccgccggcg gcgggcgcgt gcgcggcccg
       61 atgaagaagg aggtttccaa gccgtctccg cccaagttga tcggtggatg cgcgcccccg
      121 cgcggggcac cggttgctgt ggacgcagtg gcggccgttg gctggcgggt gcggcgcagc
      181 ctcggtgtct ctgggccggc ggtgcagggc aacgtttcat ggtgccgggc ggcaccatga
      241 agtctctaaa gaaggattcc cgcctcagaa taactccgac cagattatta gaggcctcag
      301 agaatgtcaa agaaaagaag cgggcaaagg gacctgaaca acccacaccc acaattcagg
      361 aagagcctga acctgttagc aatgtcctac aaggagatga cattcttgcc ttggccatta
      421 agaaggaaga cttgaaggag caacacattc ctcgccttac tgaaaaggaa gataaacgtg
      481 tcatcaccca gaaatttatc atccgtaaac tcaaacccat ggatcctagg aggaaggtct
      541 gccaccttgt agcacgtcct gcgaatcctg atgaagccac aaagcctctg gactactccg
      601 gtcccggtga cagcttcgat ggcagtgacc agatcctgcc ccaccacatc ttggggagtc
      661 tccaggattt taagagaatt gcacttgctc gagggaacac ccagctggct gagcggatac
      721 ctacctcacc ctgtctgatg accctcatct ctgctgaagg agagtcaaag caaaaagccc
      781 caaaagaaga gaagagacct ccctgggccc cacctcctca gcacaacttt ctgaaaaact
      841 ggcagcgtaa cacagccctg cggaagaagc agcaggaagc cctcagcgaa cacctaaaga
      901 agccagtgag tgagctgctc atgcacaccg gggagaccta cagacggatc caggaggagc
      961 gggagctcat tgactgcaca cttccaaccc ggcgtgatag gaaaagctgg gagaacagtg
     1021 ggttctggag tcgactggaa tacttgggag atgagatgac aggtctggtc atgaccaaga
     1081 caaaaactca gcgtggcctc atggagccca tcactcacat caggaagccc cactccatcc
     1141 gggtggagac aggattacca gcccagaggg acgcttcata ccgctacacc tgggatcgga
     1201 gtctgtttct gatctaccga cgcaaggagc tgcagagaat catggaagag ctggatttca
     1261 gccagcagga tattgatggc ctggaggtgg tgggcaaagg gtggcccttc tcggctgtta
     1321 ctgtggaaga ctacacagtg tttgaaagaa gtcagggaag ctcctctgaa gacacagcat
     1381 acttaggcac attggccagt tcctctgatg tctccatgcc tattctcggc ccttctctgc
     1441 tgttctgtgg gaagccagct tgctggatca gaggcagtaa tccacaggac aagaggcagg
     1501 ttgggattgc tgctcacttg acctttgaaa ccctagaagg cgagaaaacc tcctcagaac
     1561 tgactgtggt caataatggc accgtggcca tttggtatga ctggcgacgg cagcaccagc
     1621 cggacacttt ccaagacctt aagaaaaaca ggatgcagcg attttacttt gacaaccggg
     1681 aaggtgtgat tctgcctgga gaaattaaaa catttacctt cttcttcaag tctttgactg
     1741 ctggggtctt cagggaattt tgggagtttc gaacccatcc tactctatta ggaggtgcta
     1801 tactgcaggt caatctccac gcggtctccc tgacccagga cgtttttgag gatgagagga
     1861 aagtactgga gagcaagctg actgcccatg aggcagtcac cgtcgttcgc gaagtgctgc
     1921 aggagctgct gatgggggtc ttgaccccgg agcgcacacc atcacctgtg gatgcctatc
     1981 tcaccgagga agacttgttc cggcacagaa atcctccgct gcattatgag caccaagtgg
     2041 tgcaaagcct gcaccaactg tggcgccagt acatgaccct gcccgccaag gctgaggagg
     2101 ccaggccagg ggacaaggag cacgtcagcc ccatagccac agagaaggcc tctgtgaatg
     2161 ctgagctgtt accacgcttt aggagcccca tctccgaaac tcaagtgccc cggcctgaga
     2221 acgaggccct cagggaatcc gggtcccaga aggccagagt ggggaccaag agtcctcagc
     2281 ggaagagcat catggaggag atcctggtgg aggaaagccc agatgtggac agcaccaaga
     2341 gcccctggga gccggatggc cttcccctgc tggagtggaa cctctgcttg gaggacttca
     2401 gaaaggcagt gatggtgctc cctgatgaga accacagaga ggatgcgttg atgaggctca
     2461 acaaagcagc cctggagctg tgccagaagc caaggccatt gcagtccaac ctcctgcacc
     2521 agatgtgttt gcagctgtgg cgagatgtga ttgacagcct ggtgggccat tccatgtggc
     2581 tgaggtctgt gctgggcctg cctgagaagg agaccatcta tttgaatgtg cctgaagagc
     2641 aagatcaaaa atcacctcct atcatggaag tgaaggtacc tgtggggaaa gctgggaagg
     2701 aggagcggaa aggagcagcc caggaaaaga agcaactggg gatcaaagac aaagaagaca
     2761 agaaaggagc caagctgctc gggaaagagg accgtcccaa cagcaagaag cacaaggcaa
     2821 aggatgacaa gaaagtcata aaatctgcaa gtcaggacag gttttctttg gaagacccta
     2881 cccctgacat catcctctct tctcaagaac ccatagaccc cctggtcatg gggaaataca
     2941 cccagagcct gcacagtgag gtccgtgggc tgctggacac cctggtgact gacctgatgg
     3001 tcctggctga tgagctcagc cccataaaga atgtcgagga ggctttgcgc ctctgcaggt
     3061 gactctcggg cccaagcaac cttctggaaa acgggttaat aaataaatca ataaagaacc
     3121 ttcaagtttc tacta
//
