LOCUS       NM_015057              15077 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MYC binding protein 2 (MYCBP2), mRNA.
ACCESSION   NM_015057
VERSION     NM_015057.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15077)
  AUTHORS   Chang,C., Banerjee,S.L., Park,S.S., Zhang,X.L., Cotnoir-White,D.,
            Opperman,K.J., Desbois,M., Grill,B. and Kania,A.
  TITLE     Ubiquitin ligase and signalling hub MYCBP2 is required for
            efficient EPHB2 tyrosine kinase receptor function
  JOURNAL   Elife 12, 89176 (2024)
   PUBMED   38289221
  REMARK    GeneRIF: Ubiquitin ligase and signalling hub MYCBP2 is required for
            efficient EPHB2 tyrosine kinase receptor function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15077)
  AUTHORS   AlAbdi,L., Desbois,M., Rusnac,D.V., Sulaiman,R.A., Rosenfeld,J.A.,
            Lalani,S., Murdock,D.R., Burrage,L.C., Billie Au,P.Y., Towner,S.,
            Wilson,W.G., Wong,L., Brunet,T., Strobl-Wildemann,G., Burton,J.E.,
            Hoganson,G., McWalter,K., Begtrup,A., Zarate,Y.A.,
            Christensen,E.L., Opperman,K.J., Giles,A.C., Helaby,R., Kania,A.,
            Zheng,N., Grill,B. and Alkuraya,F.S.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Loss-of-function variants in MYCBP2 cause neurobehavioural
            phenotypes and corpus callosum defects
  JOURNAL   Brain 146 (4), 1373-1387 (2023)
   PUBMED   36200388
  REMARK    GeneRIF: Loss-of-function variants in MYCBP2 cause neurobehavioural
            phenotypes and corpus callosum defects.
REFERENCE   3  (bases 1 to 15077)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 15077)
  AUTHORS   Wang,G., Miao,C., Mo,L., Kahlert,U.D., Wu,J., Ou,M., Huang,R.,
            Feng,R., Pang,W. and Shi,W.
  TITLE     MYCBP2 expression correlated with inflammatory cell infiltration
            and prognosis immunotherapy in thyroid cancer patients
  JOURNAL   Front Immunol 13, 1048503 (2022)
   PUBMED   36582246
  REMARK    GeneRIF: MYCBP2 expression correlated with inflammatory cell
            infiltration and prognosis immunotherapy in thyroid cancer
            patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15077)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 15077)
  AUTHORS   Grill,B., Murphey,R.K. and Borgen,M.A.
  TITLE     The PHR proteins: intracellular signaling hubs in neuronal
            development and axon degeneration
  JOURNAL   Neural Dev 11, 8 (2016)
   PUBMED   27008623
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 15077)
  AUTHORS   Pierre,S.C., Hausler,J., Birod,K., Geisslinger,G. and Scholich,K.
  TITLE     PAM mediates sustained inhibition of cAMP signaling by
            sphingosine-1-phosphate
  JOURNAL   EMBO J 23 (15), 3031-3040 (2004)
   PUBMED   15257286
  REMARK    GeneRIF: PAM the longest lasting nontranscriptional regulator of
            adenylyl cyclase activity known to date and presents a novel
            mechanism for the temporal regulation of cAMP signaling
REFERENCE   8  (bases 1 to 15077)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 15077)
  AUTHORS   Murthy,V., Han,S., Beauchamp,R.L., Smith,N., Haddad,L.A., Ito,N.
            and Ramesh,V.
  TITLE     Pam and its ortholog highwire interact with and may negatively
            regulate the TSC1.TSC2 complex
  JOURNAL   J Biol Chem 279 (2), 1351-1358 (2004)
   PUBMED   14559897
  REMARK    GeneRIF: Pam, through its interaction with tuberin, could regulate
            the ubiquitination and proteasomal degradation of the
            tuberin-hamartin complex particularly in the CNS
REFERENCE   10 (bases 1 to 15077)
  AUTHORS   Guo,Q., Xie,J., Dang,C.V., Liu,E.T. and Bishop,J.M.
  TITLE     Identification of a large Myc-binding protein that contains
            RCC1-like repeats
  JOURNAL   Proc Natl Acad Sci U S A 95 (16), 9172-9177 (1998)
   PUBMED   9689053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL159158.12, AF075587.1,
            AL159154.16, AL359257.9 and AC001226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015057.4.
            
            Summary: This gene encodes an E3 ubiquitin-protein ligase and
            member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of
            proteins. The encoded protein plays a role in axon guidance and
            synapse formation in the developing nervous system. In mammalian
            cells, this protein regulates the cAMP and mTOR signaling pathways,
            and may additionally regulate autophagy. Reduced expression of this
            gene has been observed in acute lymphoblastic leukemia patients and
            a mutation in this gene has been identified in patients with a rare
            inherited vision defect. [provided by RefSeq, Mar 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544440.7/ ENSP00000444596.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-621               AL159158.12        53337-53957         c
            622-913             AF075587.1         335-626
            914-1067            AL159158.12        5621-5774           c
            1068-1750           AF075587.1         781-1463
            1751-1889           AL159154.16        115378-115516       c
            1890-2171           AF075587.1         1603-1884
            2172-2336           AL159154.16        112155-112319       c
            2337-2948           AF075587.1         2050-2661
            2949-3056           AL159154.16        84883-84990         c
            3057-4763           AF075587.1         2770-4476
            4764-5038           AL159154.16        36830-37104         c
            5039-6659           AF075587.1         4752-6372
            6660-6778           AL159154.16        17000-17118         c
            6779-8459           AF075587.1         6492-8172
            8460-10103          AL359257.9         46474-48117         c
            10104-10273         AL359257.9         45416-45585         c
            10274-10518         AL359257.9         44462-44706         c
            10519-11194         AF075587.1         10235-10910
            11195-11355         AL359257.9         32136-32296         c
            11356-14240         AF075587.1         11072-13956
            14241-15077         AC001226.1         76066-76902         c
FEATURES             Location/Qualifiers
     source          1..15077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.3"
     gene            1..15077
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /note="MYC binding protein 2"
                     /db_xref="GeneID:23077"
                     /db_xref="HGNC:HGNC:23386"
                     /db_xref="MIM:610392"
     exon            1..621
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..14356
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /EC_number="2.3.2.33"
                     /note="protein associated with Myc; myc-binding protein 2;
                     Highwire; RING-type E3 ubiquitin transferase MYCBP2;
                     PAM/Highwire/RPM-1 protein 1; MYC binding protein 2, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MYCBP2"
                     /protein_id="NP_055872.4"
                     /db_xref="GeneID:23077"
                     /db_xref="HGNC:HGNC:23386"
                     /db_xref="MIM:610392"
                     /translation="MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDG
                     SVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRN
                     KKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLE
                     WQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSH
                     PSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTA
                     LSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGK
                     IQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYS
                     GTVRGHIYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVM
                     LPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHA
                     CGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGP
                     SAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQS
                     KPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHF
                     VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDL
                     EEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGC
                     GSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQ
                     LRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDG
                     SGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQL
                     GHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDV
                     PYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIG
                     LVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRFRPNTRE
                     LWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAA
                     MQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDI
                     LLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFD
                     EPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQ
                     IPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVL
                     GVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKL
                     AECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHS
                     FYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAY
                     DGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVI
                     VVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASAN
                     RFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHA
                     GDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTAN
                     GDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKAN
                     EEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGP
                     VAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTT
                     SSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTV
                     QNSGYGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDK
                     ASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDL
                     EILEEAALQVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVP
                     GSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKV
                     EVKAVPVSQKKMSLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMI
                     VKEARYIAITMMKVYENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGL
                     YTLHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPKSEPQPNKVRKFVAKDSAGLR
                     IRSHPSLQSEQIGIVKVNGTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCL
                     SFNQHLGKSLLVPVDESKTNTDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKT
                     GPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGE
                     AWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNS
                     KGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSASESL
                     ILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLP
                     ANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKKM
                     PLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSSTLKTN
                     SLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPKKE
                     KSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPE
                     LSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKN
                     KVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIK
                     AASQNMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVRPRGNLFGEMAQLAVGG
                     PEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGIG
                     GSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALF
                     LLSLSSAAEPSILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTLARHHHENFVG
                     YQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLETSPITDTD
                     LAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHPSPELSR
                     LISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLC
                     NVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSDIV
                     IAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNV
                     FHHINNILSKSDDGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAM
                     IGSLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTF
                     LTGKAVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGW
                     KDGESTKIAGQISASVAQQRNCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALL
                     SSPEGEEKVYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEW
                     EHAISSKENANSQPNDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSL
                     LHTASPRVQRQVTSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHSTEKGDWNKLG
                     ILDMFLGCIAKALTVQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWW
                     MKGSTPTQISEIIIKLIKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCI
                     ATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVC
                     GNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMK
                     AMVEFREHTGKPTTSSSEACRFCGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCG
                     HPCGGVKNEEHCLPCLHGCDKSATSLKQDADDMCMICFTEALSAAPAIQLDCSHIFHL
                     QCCRRVLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYEDVRRKALMRLE
                     YEGLHKSEAITTPGVRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDAEAGRGDDY
                     DPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDFQR
                     MTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF"
     exon            622..697
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..913
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1067
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1264
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1507
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1579
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1676
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1750
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1889
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1966
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2171
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2336
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2495
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2700
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2846
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2948
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3056
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3176
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3258
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3376
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3581
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3735
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3908
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4034
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4162
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4254
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4389
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4473
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4570
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4763
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..5038
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5260
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5452
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5453..5659
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5660..5791
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5970
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5971..6113
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6114..6214
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6215..6433
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6434..6659
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6660..6778
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6779..6866
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6867..6916
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6917..7089
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7090..7234
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7235..7450
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7451..7506
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7507..7622
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7720
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7721..7837
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7838..7978
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7979..8203
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8204..8336
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8337..8459
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8460..10103
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10104..10273
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10274..10518
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10519..10686
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10687..10844
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10845..11044
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11045..11194
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11195..11355
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11356..11512
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11513..11737
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11738..11803
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11804..12043
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12044..12142
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12143..12223
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12224..12490
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12491..12774
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12775..12871
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12872..12991
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12992..13093
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13094..13222
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13223..13355
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13356..13459
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13460..13648
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13649..13756
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13757..13966
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13967..14074
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14075..14240
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14241..15077
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15038..15043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /note="hexamer: AATAAA"
     polyA_site      15077
                     /gene="MYCBP2"
                     /gene_synonym="Myc-bp2; PAM; Phr; PHR1"
                     /note="major polyA site"
ORIGIN      
        1 agcttcccat tgcgggtagc cccggcggtg gtggcggtgg tagcggtggt ggcggcggca
       61 gtggcggcac cgcctcctcc tcacattccc ggggtggcgg ggttagatga gcggccccag
      121 tagcggcgag ggcggcgcgg gggggaggag gagaagaagg aggaggagaa ggaggtcgct
      181 gtctttgtag tctccctgct gcgggagcca gaggccgccg ccggagccgt cgtcgttgga
      241 aaagggctgt gtgtgcgcgc gcgtgtctgc ccgcccggcc cgcggggacg aggcggcggc
      301 ggcggcggcg gcggcgagga tgatgatgtg cgcagcgact gcctcccccg ccgccgcctc
      361 ctcggggctc ggcggggacg gattctaccc agccgccacc ttctcttcct ccccggcgcc
      421 gggggcgctg ttcatgccgg ttcccgacgg ctccgtggct gctgcggggc tggggctggg
      481 gctacccgcc gcggactccc ggggtcacta ccagctgctg ctgtcaggcc gggccctggc
      541 cgaccgctac cggaggattt ataccgctgc gctcaatgac agggaccagg ggggcggcag
      601 cgctggacac ccagcctcca ggaataagaa aattttaaat aagaagaaat tgaaaagaaa
      661 acagaagagc aaatcaaaag tgaagacaag aagcaagtct gaaaacttag agaatacagt
      721 aatcatacca gatatcaaac tacatagcaa tccttctgct ttcaatattt actgtaatgt
      781 acgccattgc gttctggaat ggcagaaaaa ggaaatatca ttggcagccg catctaagaa
      841 ctctgtgcag agtggagaat cagatagtga tgaagaagag gaatccaaag agccccctat
      901 caagcttcca aagattattg aggttggcct ttgtgaagtt tttgaattga tcaaagagac
      961 acgattttct catccatccc tgtgtctcag gagtctccaa gccctgctca acgtgctgca
     1021 gggccagcag ccagaaggcc tccagtctga gccacctgag gtcctagagt ctctcttcca
     1081 gcttcttttg gaaatcaccg ttcgaagtac tgggatgaat gacagcacag gacagtcctt
     1141 aacagcactt tcctgtgctt gcctctttag tctggtggct tcttggggag aaacaggaag
     1201 gacacttcag gccatctctg ctatcctcac caacaatgga agccatgctt gccaaactat
     1261 tcaggtgcca acaattctaa attcgctaca gagaagtgta caagcagttt tggtgggaaa
     1321 aattcaaatt caggactggt ttagtaatgg cattaagaaa gcagctttaa tgcacaagtg
     1381 gccattaaaa gaaatatctg ttgatgaaga tgaccaatgt ctacttcaga atgatggatt
     1441 ttttctttat ctattatgca aggatggatt atataaaata ggctctggat acagtggaac
     1501 agttaggggc catatataca attctacatc ccgtattaga aacagaaaag aaaaaaagtc
     1561 ttggttaggg tatgctcagg gttatttatt atatagagat gtgaataacc acagcatgac
     1621 agccataagg ataagccctg aaacactgga gcaagatggt actgtgatgt taccagattg
     1681 ccacactgaa ggtcaaaata ttttattcac tgatggagaa tatattaatc agatagctgc
     1741 ttcaagagat gatggctttg ttgtcagaat atttgccaca agcactgaac ctgttctaca
     1801 gcaagaattg caacttaaac tggctagaaa atgcttacat gcctgtggta tctcactatt
     1861 cgatctggaa aaggacttgc atattataag tacaggattt gatgaggagt cagcaattct
     1921 tggtgcagga cgagagtttg cgctaatgaa aacagcaaat ggaaagatat attacactgg
     1981 caaataccag agtcttggaa tcaaacaagg tggtccttca gcaggaaaat gggttgagct
     2041 accaattaca aaatctccaa agatagtaca cttctcagtt ggacacgatg gctctcacgc
     2101 ccttttagtt gcagaagatg ggagcatatt ctttacagga tctgctagta aaggagaaga
     2161 tggagaatca actaagagca gacggcaatc caaaccttat aaacctaaaa agataattaa
     2221 gatggaagga aagattgtgg tatatacagc ctgcaataat ggaagtagtt ctgttatttc
     2281 taaagatgga gaactctaca tgtttggaaa agatgccatt tactctgata gttcaagttt
     2341 ggtaactgat ttgaagggcc attttgtaac tcaggtagct atgggcaaag ctcacacttg
     2401 tgttttaatg aagaatggag aggtgtggac atttggtgta aataataaag gacagtgtgg
     2461 acgagatact ggtgccatga accaaggtgg gaaagggttt ggagttgaaa atatggcaac
     2521 agcaatggat gaagacctgg aagaagaact agatgaaaaa gatgagaagt ctatgatgtg
     2581 ccctccaggc atgcacaaat ggaagctgga gcagtgcatg gtttgcactg tctgtggaga
     2641 ctgtacaggt tatggagcca gctgtgtcag tagtggacgg ccagacagag tccccggagg
     2701 gatctgtggt tgtggttccg gagaatctgg ttgtgctgtg tgtggatgtt gcaaggcctg
     2761 tgcaagagag ttagatggtc aagaggcaag acaaagagga attcttgatg cagtgaaaga
     2821 aatgatacct ttagatcttc ttttagctgt cccagtgccc ggggttaaca ttgaagaaca
     2881 ccttcagtta cgacaagaag aaaaacggca acgtgtaatc agaaggcaca gattagagga
     2941 aggaagaggc ccccttgtat ttgctggtcc tatttttatg aaccatcgag aacaggctct
     3001 agccagactc agatcccatc cagcacagct aaagcataaa cgggacaagc acaaagatgg
     3061 aagtggagaa agaggcgaaa aggatgcaag caaaatcaca acataccctc caggctctgt
     3121 gcgatttgac tgtgagctcc gggcagtcca agtcagctgt ggatttcacc attcagtggt
     3181 tttaatggaa aatggagatg tctatacatt tggttatggg cagcatgggc agctaggaca
     3241 tggagatgtc aactccaggg gatgtcccac tcttgttcaa gcattgccag gccctagcac
     3301 acaagtcact gcaggcagca accatacggc agtactttta atggatggac aggtcttcac
     3361 atttggaagt ttttctaaag gacaactggg cagaccaatt ttggatgtgc catattggaa
     3421 tgcaaagcca gctcccatgc ctaacattgg atcaaaatat ggaagaaaag ctacttggat
     3481 aggtgcaagt ggggaccaaa cttttttacg aattgatgaa gcacttatta attctcatgt
     3541 acttgctaca tcagaaattt ttgccagtaa acacataata ggcttggtac ctgcttctat
     3601 atcagaacct cctccattta aatgccttct gataaataaa gtggatggga gttgtaaaac
     3661 ttttaatgac tcagaacaag aggatctgca aggatttggt gtgtgtcttg atcctgtata
     3721 tgatgtaatt tggaggtttc gaccaaatac tagagagctg tggtgttaca atgcggtggt
     3781 tgctgatgcc aggcttccct ctgcagcaga catgcagtcc agatgtagta tcctaagtcc
     3841 tgaacttgcc ttaccaacag gatcaagggc cctcactacc cgatctcatg cagctttgca
     3901 cattttaggt tgtcttgata ccttggcagc tatgcaggac ttaaaaatgg gtgttgcaag
     3961 tacagaggaa gagactcaag cagtaatgaa ggtttattct aaagaagatt atagtgtggt
     4021 aaacaggttt gaaagtcatg gaggaggctg gggttattct gcccattcag tagaagctat
     4081 acgtttcagt gccgacactg atattttact tggtggtctt ggtctgtttg gaggtagagg
     4141 agaatatact gctaaaatta agctgtttga attgggtcct gatggaggag atcatgaaac
     4201 tgatggtgac cttcttgcag agactgatgt attggcttat gactgtgctg ctagagaaaa
     4261 atatgcaatg atgtttgatg agcctgttct cctgcaagct gggtggtggt atgtggcatg
     4321 ggcccgagtg tcaggaccca gcagtgactg tggatctcat ggacaggcat ctattaccac
     4381 agatgatggg gttgttttcc agttcaagag ttcaaagaaa tcaaataatg gtacagatgt
     4441 taatgcgggt cagatacctc agttattata cagacttcca accagtgatg gcagtgcttc
     4501 aaaaggcaaa cagcaaacca gtgaacctgt acacatttta aagaggtctt ttgcaagaac
     4561 tgtctcagtg gaatgttttg agtcattgtt gagtattctt cactggagct ggaccacctt
     4621 agtcttagga gttgaagaac ttagaggatt aaaaggattc cagttcacag ctacactcct
     4681 agatttagag agactgcgct ttgtgggtac ctgttgtctg aggttattgc gtgtctatac
     4741 ctgtgaaatt tacccagtgt cagctacagg aaaagcagtt gtagaagaaa ctagcaaatt
     4801 agcagagtgt attggaaaaa ccagaacttt gttaagaaaa attttatcag aaggagttga
     4861 tcactgcatg gtgaaattgg ataatgatcc tcaaggatat ctcagtcaac ccttgagtct
     4921 tctagaagct gtccttcagg aatgtcataa tactttcact gcctgctttc attctttcta
     4981 cccaactcct gccttacagt gggcttgcct ttgtgatctg ctgaattgtt tggatcagga
     5041 tatccaagaa gcaaacttca agacatcaag tagccgactc cttgcagctg ttatgtcagc
     5101 tctgtgtcac acgtctgtta agctgacttc catcttcccg attgcgtatg atggagaagt
     5161 attactacga tcaattgtta aacaagttag tacagagaac gactcaacac tagttcatcg
     5221 ttttcccctt ttggtggcac atatggaaaa actcagccag agtgaagaga atatctcagg
     5281 gatgacaagc ttccgtgaag ttctggagaa aatgctggtc attgttgtgc taccagtcag
     5341 gaacagcctg aggagagaaa atgaactctt ctcctcccac ctcgtctcta acacctgtgg
     5401 attactggcc agcattgtca gtgaactgac agcgtcagcc ctgggatctg aggttgatgg
     5461 acttaattct cttcactctg taaaagctag tgctaaccga tttacaaaaa caagtcaggg
     5521 cagaagttgg aacactggga acgggtcccc tgatgcaatc tgtttttcag tagacaaacc
     5581 tggaatagtt gtggttggtt tctctgtcta tggaggaggt ggaattcatg aatatgaatt
     5641 agaggtgttg gttgatgata gtgaacatgc aggagattca actcattccc acagatggac
     5701 atctctggaa ttagtgaaag gaacgtacac aacggatgac tcacccagtg atatagctga
     5761 gatcagactt gacaaagtgg ttcctttaaa ggaaaatgtt aaatatgctg tgcgcttgag
     5821 gaactatgga agccgtacag ccaatggaga tggaggaatg accacagttc agtgccctga
     5881 tggtgtgaca ttcacattca gcacgtgcag cttgagcagt aacggcacaa accaaaccag
     5941 aggacagatc ccacagatac tctactatag gagtgaattt gatggagatt tacaatccca
     6001 acttctgagt aaagccaatg aagaagataa aaactgtagc agagcattgt ctgttgtaag
     6061 cactgtcgtt cgagcctcta aggacctcct gcacagagct cttgctgtgg atgctgatga
     6121 cattccagaa ctgctgagtt cttccagtct gttttccatg ctgctccccc ttattatagc
     6181 ctacatagga ccagtagctg ctgctattcc caaggtggct gtagaagtct ttggccttgt
     6241 ccaacaattg cttccgtcag ttgccatttt gaatcagaag tatgcaccgc ctgccttcaa
     6301 ccctaatcag tcgacagata gcaccacagg aaaccagcct gaacagggcc tctctgcttg
     6361 tacaacctcc agtcactatg ctgtcataga gagtgagcac ccgtataaac ctgcctgtgt
     6421 gatgcattac aaggtgacat tcccagaatg tgtgaggtgg atgacaatcg aatttgaccc
     6481 tcagtgtggt actgcacagt cagaagatgt ccttcgtttg ttgattcctg tcagaactgt
     6541 tcagaattca ggatatggac caaaattgac atctgttcat gaaaatctta attcatggat
     6601 agaattaaag aaattttcag gatcctctgg gtggcctact atggttttgg tgttgccagg
     6661 aaatgaggcc cttttttcat tggagactgc atcagattat gtgaaagatg acaaagcttc
     6721 tttctatggt tttaagtgtt ttgcaattgg atatgaattt agccctggac ctgatgaggg
     6781 agtcatccaa ttggaaaaag aattagccaa tcttggtggg gtttgtgcag cagctctgat
     6841 gaagaaggac ctagcacttc ctattggtaa tgaattagaa gaagaccttg aaattcttga
     6901 ggaggctgca ttgcaggtgt gcaaaaccca ttctggaatt cttggaaagg gtctagctct
     6961 ttctcattca ccaactatat tagaagcact tgagggaaat ttaccactcc aaatccaaag
     7021 caatgaacag tcttttctgg atgattttat tgcctgtgtc ccaggatcaa gtggtggaag
     7081 gcttgcaagg tggcttcagc cagattcata tgcggatcct cagaaaacat ctttgatcct
     7141 gaataaggat gatattcgtt gtggttggcc taccaccata actgttcaaa caaaagacca
     7201 gtatggggat gtggtacatg ttcccaatat gaaggtggaa gtgaaagctg tccctgtttc
     7261 tcagaaaaaa atgtctttac aacaagatca agcaaagaaa cctcaaagga ttcctggcag
     7321 tcctgcagta acagctgcat cttctaatac tgacatgact tatggagggc tggcatcacc
     7381 aaagctagat gtttcatatg aaccaatgat agtgaaggaa gctcgatata ttgccataac
     7441 aatgatgaag gtttatgaaa attattcatt tgaagaacta cgttttgcat caccaactcc
     7501 taagagaccc agtgagaata tgctgatccg tgtcaataat gatgggactt attgtgcaaa
     7561 ttggactcca ggggctattg gactctacac tcttcatgtt accattgatg gcattgaaat
     7621 cgatgctggt ctggaagtaa aagtaaaaga cccaccaaaa gggatgatac caccaggaac
     7681 tcagttggtc aaaccaaagt ctgaacctca gcctaataag gttcgaaaat ttgtggccaa
     7741 ggacagtgcg gggcttcgca tccgtagcca cccttccctt cagagtgagc agataggcat
     7801 agtgaaagtc aatggaacta tcacttttat tgatgagatc cataatgatg atggtgtgtg
     7861 gctgaggctg aatgatgaga caataaagaa gtatgtccct aacatgaatg gttacactga
     7921 agcctggtgc ctctctttta atcaacatct tggcaagagt cttctggtcc ctgttgacga
     7981 atctaaaact aatactgatg actttttcaa agacataaac tcctgctgcc cacaggaagc
     8041 aacaatgcaa gaacaagata tgccattctt gcgaggaggg ccaggcatgt acaaggtagt
     8101 gaagacggga ccttcaggtc acaacatcag aagctgccct aaccttagag gtatcccaat
     8161 tggaatgtta gttctgggaa acaaagtcaa agcagtggga gaggtaacca attctgaagg
     8221 gacatgggtg caactggatc agaacagcat ggtagagttc tgtgagagtg atgaaggaga
     8281 ggcatggtcc ttagctagag acagaggcgg aaaccagtac ctccgacatg aagatgaaca
     8341 agctcttctg gatcagaatt ctcaaactcc tcctccaagc cctttctcag tgcaagcttt
     8401 taataaaggg gcaagttgca gtgcccaagg atttgattat ggactcggaa atagcaaagg
     8461 tgatcgagga aacatctcaa catcttctaa accagcctct acatcaggaa aatcagagct
     8521 gtcctctaaa cacagcagat cgcttaaacc tgatggacgt atgagccgga ctactgctga
     8581 tcagaagaag ccaaggggca cagaaagttt atctgctagt gaatccctca tcttaaaatc
     8641 tgatgctgca aagttgaggt cagattccca cagtaggtca ttatccccca accataacac
     8701 cttgcagaca ttgaaatctg atgggaggat gccttctagc tccagagctg aatccccagg
     8761 accaggttct cggttgtcat ctcctaagcc aaagactctc ccagccaata ggtctagccc
     8821 atcgggtgct agttctccac gctcctcctc accacatgat aaaaatctac ctcaaaaaag
     8881 tactgctcct gttaagacaa agcttgatcc tcctcgggaa cgttctaaat cagactctta
     8941 cacacttgat ccagataccc tccgcaagaa gaaaatgccc ctcacagaac ctttgagagg
     9001 acggtcaacg tcaccaaaac caaaatcagt accaaaggat tctacagatt cccctggatc
     9061 tgaaaataga gctccctctc cccatgtggt acaggaaaac ctccacagtg aggtggtcga
     9121 agtctgcacc tcaagtactt taaaaacaaa tagtctaaca gacagcacct gcgatgacag
     9181 cagtgaattt aagagtgtgg atgaaggttc aaataaagtt cattttagca ttggaaaagc
     9241 accactgaaa gatgaacagg aaatgagagc atctcccaaa ataagtcgaa aatgtgctaa
     9301 tagacacacc aggcccaaaa aagaaaaatc gagttttctt ttcaaaggag atggatccaa
     9361 gcctttagag ccagccaagc aagccatgtc tccttctgtg gccgaatgtg ccagagctgt
     9421 gtttgcttcc ttcctctggc atgaaggcat agtacatgat gcaatggctt gttcttcttt
     9481 cctaaagttt catcctgaac tttccaaaga acatgctcct ataaggagta gtttaaatag
     9541 ccaacaacct acagaggaaa aagaaaccaa gttaaaaaat agacattcat tagaaatatc
     9601 atctgcactg aatatgttta atattgcacc ccatggacca gatatatcta agatgggtag
     9661 catcaacaaa aacaaggtat tgtctatgct taaggaacca cctctgcatg aaaaatgtga
     9721 ggatgggaaa accgagacca cttttgaaat gtccatgcat aacacaatga agtctaagtc
     9781 tcctcttccc ttaactttac aacatttagt ggctttttgg gaagacatct ctttggctac
     9841 tatcaaagct gcttcccaga atatgatttt tccaagtcct ggttcctgtg cagttcttaa
     9901 aaagaaagag tgtgagaaag agaataagaa gtccaaaaag gaaaaaaaga aaaaagaaaa
     9961 ggcagaagtt aggcccaggg gtaatttgtt tggagagatg gcccagctgg cagtaggagg
    10021 accagagaaa gataccatct gtgaactgtg tggggagtca catccatacc cggtgaccta
    10081 tcacatgaga caagctcacc caggttgtgg ccgatatgct ggtggacaag gttacaatag
    10141 cattgggcat ttttgtggag gatgggctgg taactgtggt gatggtggca taggaggaag
    10201 cacttggtat ctggtatgtg atcgctgtag agaaaaatac ctccgcgaaa aacaggctgc
    10261 tgcaagggag aaggtcaaac aatctaggag aaaaccaatg caagtcaaga cccctcgtgc
    10321 cttgcccacc atggaagctc accaggtgat taaagccaat gcactcttcc tgctgtccct
    10381 gagcagtgca gcagaaccga gcattctgtg ttaccatcct gcaaagccat tccaatctca
    10441 gttgcccagt gtaaaagaag gcatttctga ggatcttcct gtgaaaatgc cttgtctcta
    10501 cctgcagaca ttagctaggc atcatcatga aaattttgtg ggctatcaag atgacaatct
    10561 attccaggat gaaatgagat atctacgttc aacatctgta cctgccccgt atatatcagt
    10621 aactcctgat gcaagtccta atgtatttga agagccagag agcaatatga agtctatgcc
    10681 accaagttta gaaaccagtc ccataactga tactgatctt gcaaagagaa ctgtcttcca
    10741 aagatcatac tcagttgttg cttccgaata tgataaacaa cactccattt tacctgcacg
    10801 agttaaagct attcctagaa gaagagttaa cagtggagac actgaagttg gttcttccct
    10861 tttgagacat ccgtctcctg agctttctcg gctaatctca gcccacagct ctctttctaa
    10921 aggagaacga aatttccagt ggccagtttt agcttttgtt atacaacatc atgatctaga
    10981 aggtcttgaa atagcaatga aacaggccct aaggaaatct gcttgtcgag tttttgctat
    11041 ggaggctttc aactggcttc tgtgtaatgt catccaaacc acttctctcc atgatattct
    11101 gtggcatttt gtggcatcac tgactcctgc accagtggaa ccagaggaag aagaggatga
    11161 agaaaataaa acaagcaaag aaaattcaga acaagagaaa gatacaagag tatgtgaaca
    11221 tccactctca gacatagtga ttgccgggga agctgctcat cctttaccac acacctttca
    11281 ccgcttgctg cagaccatct cagaccttat gatgtctctc cccagcggca gttcattaca
    11341 gcaaatggcc ctgaggtgct ggagtctcaa attcaagcaa tctgatcacc agttccttca
    11401 tcagagcaac gtctttcatc acattaacaa tattttgtca aagtcagatg atggcgatag
    11461 tgaagagagt tttagcatca gtatacagtc tggctttgaa gctatgagtc aggaattatg
    11521 catagtaatg tgcttaaagg acttaaccag cattgttgac ataaaaactt caagccgacc
    11581 tgccatgatt ggcagtttga cagacggctc cacagaaacc ttttgggaat caggagatga
    11641 agataaaaac aaaactaaga acatcaccat caactgtgta aaaggaatca atgcccgcta
    11701 tgtgtctgtt cacgtggaca attcccgaga tcttgggaat aaagttacct caatgacctt
    11761 cttaactggc aaagcagtag aagatttgtg cagaataaag caggttgatc tggattccag
    11821 gcacattggc tgggtaacaa gtgaacttcc aggaggggat aatcacatca taaaaattga
    11881 attaaaaggc ccagaaaata cactgagagt tcgacaagtc aaagtcctgg gctggaaaga
    11941 tggtgaaagc acaaaaatag ctggccagat ttcagccagt gtggcccagc agaggaactg
    12001 tgaagctgag actctgcgag tattcagact gattacgtct caagtatttg gaaagctcat
    12061 ctctggagat gctgaaccta caccagaaca agaggaaaaa gcactattgt catcacctga
    12121 aggagaagaa aaagtataca atgcaacatc agatgctgac ctgaaagaac atatggttgg
    12181 aatcatattc agcaggagta agctgactaa cttacaaaaa caggtgtgtg ctcatattgt
    12241 ccaagctatt cgcatggaag ctaccagagt ccgtgaagaa tgggaacatg ctatatcaag
    12301 caaagaaaat gccaattctc agccaaatga tgaagatgcc tcctctgatg cctactgctt
    12361 tgagctgctc tctatggttt tagcactgag tggctctaac gttggccggc aatatctggc
    12421 tcaacagcta accctgcttc aggatctctt ctcgctgctt cacacagcct ctcctagagt
    12481 ccagagacag gtaacctctt tactaagaag agttttgcct gaagtaaccc ctagtcgtct
    12541 ggccagcatc ataggagtga aatccctccc cccagcagat atcagtgata tcattcactc
    12601 aacagagaaa ggagactgga ataagctggg tatcttggac atgtttctag gatgcattgc
    12661 caaagcactc actgtacagc taaaagccaa aggaaccacc atcactggaa cagctggtac
    12721 cactgtgggc aaaggagtta caacagttac tcttccgatg attttcaatt ccagttatct
    12781 ccgacgaggt gaaagtcatt ggtggatgaa gggctcaacc cctacccaga tctcagagat
    12841 catcattaaa cttatcaagg atatggcagc aggtcatctg tcagaagctt ggtcccgagt
    12901 gacaaaaaat gctattgcag aaaccatcat tgccttgacc aagatggaag aagaatttag
    12961 gtctccagtg agatgtattg caacaactag actctggctt gctctcgcat ccctatgtgt
    13021 tcttgatcag gaccacgtag atcgtctctc ctcggggaga tggatgggaa aggatggaca
    13081 acaaaaacaa atgcctatgt gtgataacca tgatgatggt gaaactgcag caatcatttt
    13141 atgcaatgtc tgtggaaatt tatgtacaga ctgtgacaga ttccttcacc ttcatcgaag
    13201 aaccaaaact catcaaagac aggtcttcaa agaagaagaa gaagctataa aggttgacct
    13261 tcatgaaggt tgtggtagaa ccaaattgtt ctggttgatg gcactggcag attctaaaac
    13321 aatgaaggca atggtggaat tccgagaaca cacaggcaaa cccaccacga gtagctcaga
    13381 agcatgtcgc ttctgtggtt ccaggagtgg aacagagtta tctgctgttg gcagtgtttg
    13441 ttctgatgca gattgccagg aatacgctaa gatagcctgt agtaagacgc atccttgtgg
    13501 ccatccatgc gggggtgtta aaaacgaaga gcactgtctg ccctgtctac acggctgtga
    13561 caaaagtgcc acaagcctga agcaagacgc cgatgacatg tgcatgatat gtttcaccga
    13621 agcgctctcg gcagcaccag ccattcagct ggattgtagt cacatattcc acttacagtg
    13681 ctgtcggcga gtattagaaa atcgatggct tggcccaagg ataacatttg gatttatatc
    13741 ttgtcccatt tgcaagaaca aaattaatca catagtacta aaagacctac ttgatccaat
    13801 aaaagaactc tatgaggatg tcagaagaaa agccttaatg agattggaat atgaaggtct
    13861 gcataagagt gaagctatca caactcctgg tgtgaggttt tataatgacc cagctggcta
    13921 tgcaatgaat agatatgcat attatgtgtg ctacaaatgc agaaaggcat attttggtgg
    13981 tgaagctcgc tgcgatgctg aggctggacg gggagatgat tatgatccca gagagctcat
    14041 ttgtggtgcc tgttctgatg tttccagggc tcagatgtgt cccaaacatg gcacagactt
    14101 tttggaatat aaatgtcgct actgctgttc agtggctgtt tttttctgtt ttggaacaac
    14161 acatttttgt aatgcttgtc atgatgattt tcaaagaatg actagcattc ctaaggaaga
    14221 actaccacac tgtcctgcag gtcccaaagg caagcagtta gaaggaactg aatgtccact
    14281 ccatgttgtt catccaccca ctggggaaga gtttgctctg ggatgtggag tgtgcagaaa
    14341 tgcccacact ttttagaaca cgcagatcct ttgtctacag agagaaaaat tgccttcatc
    14401 ccccaagagg atgcggtgaa gtttaaactc tgctcaggat aaggacggga ccatttttac
    14461 atccatgaaa atgaaccatt cacagtgcaa gaaggatacc aaataccatg tacataattc
    14521 ttgctatgaa aagtttcccc attattttgg tttatcttct tttgaacaaa tgacatcaaa
    14581 cttgtgaggt gtttgcatgt ggccattacc gtcattggcc tgtgaagcat tggacattta
    14641 tagataattg atataaaaga atcgccatgc ccatggacta agaacgatgc tggctttcaa
    14701 gcaaaaaaga aaaataatca ttgtttattg tatactgcct ttttgtaatc ctgtacaatt
    14761 gcatcacggg tggggataaa aagaggaata ttctggttta tttcctagac tgttatttaa
    14821 aaaaaaaaaa aacattgtgt taggacagca tataaatgta ataagtatca cactgtatat
    14881 aaacatatca atgtttgtcc tgtataagaa ttactaaatt acaaatgcaa tttcatttaa
    14941 acttctaggt taagtttgag cctgaaattt taatgaagtg caatactgag tgtgcctcat
    15001 tatcttgcag ctgtaaacat attggaatgt acatgtcaat aaaaccactg tacattttta
    15061 tacagtgata aagtcta
//
