LOCUS       NM_012333               2532 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MYC binding protein (MYCBP), transcript variant 1,
            mRNA.
ACCESSION   NM_012333
VERSION     NM_012333.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Zhang,Y., Zhan,Y., Liu,Z., Guo,H., Liu,D. and Chen,C.
  TITLE     Circ_0002669 promotes osteosarcoma tumorigenesis through directly
            binding to MYCBP and sponging miR-889-3p
  JOURNAL   Biol Direct 19 (1), 25 (2024)
   PUBMED   38570856
  REMARK    GeneRIF: Circ_0002669 promotes osteosarcoma tumorigenesis through
            directly binding to MYCBP and sponging miR-889-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2532)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2532)
  AUTHORS   Wang,H., Zhang,S., Zhang,Y., Jia,J., Wang,J., Liu,X., Zhang,J.,
            Song,X., Ribback,S., Cigliano,A., Evert,M., Liang,B., Wu,H.,
            Calvisi,D.F., Zeng,Y. and Chen,X.
  TITLE     TAZ is indispensable for c-MYC-induced hepatocarcinogenesis
  JOURNAL   J Hepatol 76 (1), 123-134 (2022)
   PUBMED   34464659
  REMARK    GeneRIF: TAZ is indispensable for c-MYC-induced
            hepatocarcinogenesis.
            Erratum:[J Hepatol. 2022 Mar;76(3):755-756. doi:
            10.1016/j.jhep.2021.12.006.. PMID: 34965902]
REFERENCE   4  (bases 1 to 2532)
  AUTHORS   Ma,S., Wei,H., Wang,C., Han,J., Chen,X. and Li,Y.
  TITLE     MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP
            in triple-negative breast cancer
  JOURNAL   Cell Mol Biol Lett 26 (1), 52 (2021)
   PUBMED   34895159
  REMARK    GeneRIF: MiR-26b-5p inhibits cell proliferation and EMT by
            targeting MYCBP in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2532)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2532)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 2532)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AAT-1, a novel testis-specific AMY-1-binding protein, forms a
            quaternary complex with AMY-1, A-kinase anchor protein 84, and a
            regulatory subunit of cAMP-dependent protein kinase and is
            phosphorylated by its kinase
  JOURNAL   J Biol Chem 277 (47), 45480-45492 (2002)
   PUBMED   12223483
  REMARK    GeneRIF: identified a novel AMY-1-binding protein, AAT-1, and
            determied its expression profiles, genes, and cellular
            localization; results showed that AAT-1 was specifically expressed
            in the testis throughout spermatogenesis and was also present in
            mature sperm
REFERENCE   8  (bases 1 to 2532)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AMAP-1, a novel testis-specific AMY-1-binding protein, is
            differentially expressed during the course of spermatogenesis
  JOURNAL   Biochim Biophys Acta 1577 (1), 126-132 (2002)
   PUBMED   12151104
REFERENCE   9  (bases 1 to 2532)
  AUTHORS   Furusawa,M., Ohnishi,T., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AMY-1, a c-Myc-binding protein, is localized in the mitochondria of
            sperm by association with S-AKAP84, an anchor protein of
            cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 276 (39), 36647-36651 (2001)
   PUBMED   11483602
  REMARK    GeneRIF: AMY-1 was localized in the mitochondria of HeLa and sperm
            in association with AKAP149 and S-AKAP84, respectively. These
            results suggest that AMY-1 plays a role in spermatogenesis
REFERENCE   10 (bases 1 to 2532)
  AUTHORS   Taira,T., Maeda,J., Onishi,T., Kitaura,H., Yoshida,S., Kato,H.,
            Ikeda,M., Tamai,K., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AMY-1, a novel C-MYC binding protein that stimulates transcription
            activity of C-MYC
  JOURNAL   Genes Cells 3 (8), 549-565 (1998)
   PUBMED   9797456
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU601195.1, BC008686.1,
            AL139260.19 and CN478752.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012333.4.
            
            Summary: The protein encoded by this gene binds to the N-terminus
            of the oncogenic protein C-MYC, enhancing the ability of C-MYC to
            activate E box-dependent transcription. The encoded protein is
            normally found in the cytoplasm, but it translocates to the nucleus
            during S phase of the cell cycle and associates with C-MYC. This
            protein may be involved in spermatogenesis. This gene can be
            silenced by microRNA-22. Two transcript variants, one
            protein-coding and the other probably not protein-coding, have been
            found for this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007191.2, SRR18074967.2605729.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:12665801)
            MANE Ensembl match               :: ENST00000397572.5/
                                                ENSP00000380702.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BU601195.1         33-37
            6-1533              BC008686.1         1-1528
            1534-2494           AL139260.19        78632-79592         c
            2495-2532           CN478752.1         22-59               c
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2532
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="MYC binding protein"
                     /db_xref="GeneID:26292"
                     /db_xref="HGNC:HGNC:7554"
                     /db_xref="MIM:606535"
     exon            1..58
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..355
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="associate of myc-1; c-myc binding protein"
                     /codon_start=1
                     /product="C-Myc-binding protein"
                     /protein_id="NP_036465.2"
                     /db_xref="CCDS:CCDS431.1"
                     /db_xref="GeneID:26292"
                     /db_xref="HGNC:HGNC:7554"
                     /db_xref="MIM:606535"
                     /translation="MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSA
                     LDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQYEPPQEEKRA
                     E"
     exon            59..131
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..180
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..310
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..2532
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      507..512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="hexamer: AATAAA"
     polyA_site      524
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="major polyA site"
     polyA_site      1526
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="major polyA site"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
                     /note="hexamer: AATATA"
     polyA_site      2532
                     /gene="MYCBP"
                     /gene_synonym="AMY-1"
ORIGIN      
        1 agtcgcggtc tccggcgcca gctacgccgc tgccgctgtc actatggccc attacaaagc
       61 cgccgactcg aagcgtgagc agttccggag gtacttggag aagtcggggg tgctggacac
      121 gctgaccaag gtgttggtag ccttatatga agaaccagag aaacctaaca gtgctttgga
      181 ttttttaaag catcacttag gagctgctac tccagaaaat ccagaaatag agctgcttcg
      241 cctagaactg gccgaaatga aagagaagta tgaagctatt gtagaagaaa ataaaaaact
      301 gaaagcaaag cttgctcagt atgaaccacc tcaggaggag aagcgtgctg aataggattc
      361 ttctcagttt gaaagacaat gaaaaatggt tttgtatgac ttgaatagtt tgtatagtat
      421 ataatctttt ctgaacagat gctatagaac tcttttaata tgtttaattc acctatcaca
      481 ctctgttaaa aacacataga atcatcaata aaaactcaat ataactttct ttgggtctta
      541 aagcaggaga atccaaagta aatcctgaac aaaacctaaa cacagccatc taactcatta
      601 ccttaaaaga cattctgttt attagtctga ttaggaatga tggcactggt tgtattttag
      661 ccaagacagt ttagcatgga gctattcctt ggtgcagttc aggatatgaa cacaggtaca
      721 gtcattcttt gaaggtgaca ctgttctgta tattccctat aggcagctgg agagatctgt
      781 gtgacacaag atgcttttgt acgggttccc atgaatcttc tgctcttgtt tgtgtgacat
      841 ggaacaaata acttctttgc caccactttg ccttagataa ctgtgtgtgt gtgtgccagt
      901 ttgaactctg acaccacatt ttccttctat gcaatcatgc ctgtctgata atcttgcatt
      961 gctttcctct gagctttagt gggtcctagt tgcacactgg cctttctgtg ctgtttttca
     1021 atttgcctaa taatagcagt taccctgatt gtaatttatg taactttaaa caggatcaca
     1081 ctgtaccccc tgcctgcctt atttgcttac tgagcacagg acagaggcaa tatacaactc
     1141 tgggttcaca cacaagctga gatgagaaga ggaatgagcc atatattggg gaaaatcata
     1201 gtttgtaggt ataattatat agtgcttttc tccctcaaag tatttttcta gccttgaatt
     1261 cattttatct tcattatccc tgtgaagtag gtgggacaag tataagggga agaggggtgc
     1321 tgaattttta ggccaaagac tgatattaat acaaatcact cactaactgt agagccttgg
     1381 gcattatcag tgaactactc tgagatttac tgtcttcatc tgtttaatga gtagaatgtc
     1441 cgtgatgcct acctcacagg gttgttgtga gggtcaaatg agaatgtatg tgaaagattt
     1501 gtaaatggta aagcactata ttcttgtttg ttagtccttt ttcctttctt tgggtagacc
     1561 tacagtcaga tgttttgttt tatggatcac ttattttcct tactggtaga ctgtcgtttt
     1621 atagacatat tcctatttca tatattctct ccctgttgtt agagaaccta tctttgtttt
     1681 tggtcaaaac acacatagaa aacaaaatga tccaatgaaa actggtttaa ctagcaaaag
     1741 ccttggcacc tgttggagac tatgaccaag ccaataaaaa gggcatttaa atcagccctg
     1801 ttagtaggaa tgtggctatg gctggtgcct cttctagtca caagtttgtt tttggagggg
     1861 gtccagaaga tcattccctt gcatagattt ctcttttacc aatttgagtg cctcctacat
     1921 gggcagcagt ggactaagtg ctgggtgtga taaagaggaa tgacttaatt atgagactgt
     1981 atataatcaa atacagtgtg ggttaggacc tgtggcagac cattataata aagcatggcc
     2041 ccgtgagggt tttgaaagag agagagactt ggcttcctta gttggtatga tagtttcttg
     2101 gtagatacag gttgaaaatt ttttgtggca gccaatcctc atgggctttt tactcatttg
     2161 attagtatta atatttatgt cagtaagcca ggtgactgtg actgtctttg gtaccatcct
     2221 ttttgaacag aaaggcaaca tgtgggttgg ataatcacac ttttaggtga aactgacttg
     2281 cttaaactgt aacagtcagt gctatttaag aattcaggat aagcttagcc tctagaggtc
     2341 ctcttcaaca tttctgtcaa ggatttggat gaatacaaca agatgctcca tggaagagaa
     2401 aatggataaa tggatcccac cagttaagct cctattatgc ttcagctgct ttgtctataa
     2461 aatatcgact tcacatcttg cctatctcac aagttggttg taagaatcaa attaaatata
     2521 atggatgtaa aa
//
