LOCUS       NM_002467               3721 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens MYC proto-oncogene, bHLH transcription factor (MYC),
            transcript variant 1, mRNA.
ACCESSION   NM_002467 XM_001129632
VERSION     NM_002467.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Hu,F., Zhao,L., Wang,J., Li,X., Xue,Z., Ma,Y., Zheng,M., Chen,C.,
            Tong,M., Guo,X., Li,H., Jin,H., Xie,Q., Zhang,X., Huang,C. and
            Huang,H.
  TITLE     TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer
            cell proliferation through the c-Myc/p21 axis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119855 (2024)
   PUBMED   39357549
  REMARK    GeneRIF: TRIM40 interacts with ROCK1 directly and inhibits
            colorectal cancer cell proliferation through the c-Myc/p21 axis.
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J.,
            Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B.
            and Cao,J.
  TITLE     WDR20 prevents hepatocellular carcinoma senescence by orchestrating
            the simultaneous USP12/46-mediated deubiquitination of c-Myc
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2407904121 (2024)
   PUBMED   39432777
  REMARK    GeneRIF: WDR20 prevents hepatocellular carcinoma senescence by
            orchestrating the simultaneous USP12/46-mediated deubiquitination
            of c-Myc.
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Zhai,W., Yang,W., Ge,J., Xiao,X., Wu,K., She,K., Zhou,Y., Kong,Y.,
            Wu,L., Luo,S. and Pu,X.
  TITLE     ADAMTS4 exacerbates lung cancer progression via regulating c-Myc
            protein stability and activating MAPK signaling pathway
  JOURNAL   Biol Direct 19 (1), 94 (2024)
   PUBMED   39415271
  REMARK    GeneRIF: ADAMTS4 exacerbates lung cancer progression via regulating
            c-Myc protein stability and activating MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Ma,Y., Shi,H. and Zheng,W.
  TITLE     METTL3 Regulates the Translation of Oncogene Myc through m6A
            Modification and Promotes the Occurrence and Development of
            Cervical Cancer
  JOURNAL   Discov Med 36 (188), 1902-1910 (2024)
   PUBMED   39327253
  REMARK    GeneRIF: METTL3 Regulates the Translation of Oncogene Myc through
            m[6]A Modification and Promotes the Occurrence and Development of
            Cervical Cancer.
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Chatterjee,S., Prashanth,P., Rawat,V. and Ghosh Roy,S.
  TITLE     Regulation of lipid and serine metabolism by the oncogene c-Myc
  JOURNAL   Int Rev Cell Mol Biol 389, 236-256 (2024)
   PUBMED   39396848
  REMARK    GeneRIF: Regulation of lipid and serine metabolism by the oncogene
            c-Myc.
            Review article
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Iijima,S., Teraoka,H., Date,T. and Tsukada,K.
  TITLE     DNA-activated protein kinase in Raji Burkitt's lymphoma cells.
            Phosphorylation of c-Myc oncoprotein
  JOURNAL   Eur J Biochem 206 (2), 595-603 (1992)
   PUBMED   1597196
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Astrin,S.M. and Laurence,J.
  TITLE     Human immunodeficiency virus activates c-myc and Epstein-Barr virus
            in human B lymphocytes
  JOURNAL   Ann N Y Acad Sci 651, 422-432 (1992)
   PUBMED   1318011
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Bernstein,P.L., Herrick,D.J., Prokipcak,R.D. and Ross,J.
  TITLE     Control of c-myc mRNA half-life in vitro by a protein capable of
            binding to a coding region stability determinant
  JOURNAL   Genes Dev 6 (4), 642-654 (1992)
   PUBMED   1559612
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Seth,A., Alvarez,E., Gupta,S. and Davis,R.J.
  TITLE     A phosphorylation site located in the NH2-terminal domain of c-Myc
            increases transactivation of gene expression
  JOURNAL   J Biol Chem 266 (35), 23521-23524 (1991)
   PUBMED   1748630
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Hann,S.R., King,M.W., Bentley,D.L., Anderson,C.W. and Eisenman,R.N.
  TITLE     A non-AUG translational initiation in c-myc exon 1 generates an
            N-terminally distinct protein whose synthesis is disrupted in
            Burkitt's lymphomas
  JOURNAL   Cell 52 (2), 185-195 (1988)
   PUBMED   3277717
  REMARK    GeneRIF: Alternative translation initiation from an upstream,
            in-frame non-AUG (CUG) and a downstream AUG start site results in
            the production of two isoforms with distinct N-termini.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103819.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 11, 2019 this sequence version replaced NM_002467.5.
            
            Summary: This gene is a proto-oncogene and encodes a nuclear
            phosphoprotein that plays a role in cell cycle progression,
            apoptosis and cellular transformation. The encoded protein forms a
            heterodimer with the related transcription factor MAX. This complex
            binds to the E box DNA consensus sequence and regulates the
            transcription of specific target genes. Amplification of this gene
            is frequently observed in numerous human cancers. Translocations
            involving this gene are associated with Burkitt lymphoma and
            multiple myeloma in human patients. There is evidence to show that
            translation initiates both from an upstream, in-frame non-AUG (CUG)
            and a downstream AUG start site, resulting in the production of two
            isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.55018.1,
                                           SRR7346977.1160260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000621592.8/ ENSP00000478887.2
            non-AUG initiation codon :: PMID: 3277717
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression, longest
                                        protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AC103819.3         87815-88207
            394-1165            AC103819.3         89832-90603
            1166-3721           AC103819.3         91980-94535
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..3721
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="MYC proto-oncogene, bHLH transcription factor"
                     /db_xref="GeneID:4609"
                     /db_xref="HGNC:HGNC:7553"
                     /db_xref="MIM:190080"
     exon            1..393
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1728
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; avian
                     myelocytomatosis viral oncogene homolog; myc
                     proto-oncogene protein; myc-related
                     translation/localization regulatory factor; proto-oncogene
                     c-Myc; transcription factor p64; class E basic
                     helix-loop-helix protein 39; v-myc avian myelocytomatosis
                     viral oncogene homolog; v-myc myelocytomatosis viral
                     oncogene homolog"
                     /codon_start=1
                     /product="myc proto-oncogene protein isoform 1"
                     /protein_id="NP_002458.2"
                     /db_xref="CCDS:CCDS6359.2"
                     /db_xref="GeneID:4609"
                     /db_xref="HGNC:HGNC:7553"
                     /db_xref="MIM:190080"
                     /translation="MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEE
                     NFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDND
                     GGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLV
                     SEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSS
                     SPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEE
                     IDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDY
                     PAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFAL
                     RDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLR
                     NSCA"
     exon            394..1165
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..3721
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="hexamer: AATAAA"
     regulatory      2180..2185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="hexamer: AATATA"
     polyA_site      2192
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="major polyA site"
     polyA_site      2204
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="major polyA site"
     regulatory      3398..3403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="hexamer: AATAAA"
     polyA_site      3418
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
                     /note="hexamer: AATAAA"
     polyA_site      3721
                     /gene="MYC"
                     /gene_synonym="bHLHe39; c-Myc; MRTL; MYCC"
ORIGIN      
        1 aactcgctgt agtaattcca gcgagaggca gagggagcga gcgggcggcc ggctagggtg
       61 gaagagccgg gcgagcagag ctgcgctgcg ggcgtcctgg gaagggagat ccggagcgaa
      121 tagggggctt cgcctctggc ccagccctcc cgctgatccc ccagccagcg gtccgcaacc
      181 cttgccgcat ccacgaaact ttgcccatag cagcgggcgg gcactttgca ctggaactta
      241 caacacccga gcaaggacgc gactctcccg acgcggggag gctattctgc ccatttgggg
      301 acacttcccc gccgctgcca ggacccgctt ctctgaaagg ctctccttgc agctgcttag
      361 acgctggatt tttttcgggt agtggaaaac cagcagcctc ccgcgacgat gcccctcaac
      421 gttagcttca ccaacaggaa ctatgacctc gactacgact cggtgcagcc gtatttctac
      481 tgcgacgagg aggagaactt ctaccagcag cagcagcaga gcgagctgca gcccccggcg
      541 cccagcgagg atatctggaa gaaattcgag ctgctgccca ccccgcccct gtcccctagc
      601 cgccgctccg ggctctgctc gccctcctac gttgcggtca cacccttctc ccttcgggga
      661 gacaacgacg gcggtggcgg gagcttctcc acggccgacc agctggagat ggtgaccgag
      721 ctgctgggag gagacatggt gaaccagagt ttcatctgcg acccggacga cgagaccttc
      781 atcaaaaaca tcatcatcca ggactgtatg tggagcggct tctcggccgc cgccaagctc
      841 gtctcagaga agctggcctc ctaccaggct gcgcgcaaag acagcggcag cccgaacccc
      901 gcccgcggcc acagcgtctg ctccacctcc agcttgtacc tgcaggatct gagcgccgcc
      961 gcctcagagt gcatcgaccc ctcggtggtc ttcccctacc ctctcaacga cagcagctcg
     1021 cccaagtcct gcgcctcgca agactccagc gccttctctc cgtcctcgga ttctctgctc
     1081 tcctcgacgg agtcctcccc gcagggcagc cccgagcccc tggtgctcca tgaggagaca
     1141 ccgcccacca ccagcagcga ctctgaggag gaacaagaag atgaggaaga aatcgatgtt
     1201 gtttctgtgg aaaagaggca ggctcctggc aaaaggtcag agtctggatc accttctgct
     1261 ggaggccaca gcaaacctcc tcacagccca ctggtcctca agaggtgcca cgtctccaca
     1321 catcagcaca actacgcagc gcctccctcc actcggaagg actatcctgc tgccaagagg
     1381 gtcaagttgg acagtgtcag agtcctgaga cagatcagca acaaccgaaa atgcaccagc
     1441 cccaggtcct cggacaccga ggagaatgtc aagaggcgaa cacacaacgt cttggagcgc
     1501 cagaggagga acgagctaaa acggagcttt tttgccctgc gtgaccagat cccggagttg
     1561 gaaaacaatg aaaaggcccc caaggtagtt atccttaaaa aagccacagc atacatcctg
     1621 tccgtccaag cagaggagca aaagctcatt tctgaagagg acttgttgcg gaaacgacga
     1681 gaacagttga aacacaaact tgaacagcta cggaactctt gtgcgtaagg aaaagtaagg
     1741 aaaacgattc cttctaacag aaatgtcctg agcaatcacc tatgaacttg tttcaaatgc
     1801 atgatcaaat gcaacctcac aaccttggct gagtcttgag actgaaagat ttagccataa
     1861 tgtaaactgc ctcaaattgg actttgggca taaaagaact tttttatgct taccatcttt
     1921 tttttttctt taacagattt gtatttaaga attgttttta aaaaatttta agatttacac
     1981 aatgtttctc tgtaaatatt gccattaaat gtaaataact ttaataaaac gtttatagca
     2041 gttacacaga atttcaatcc tagtatatag tacctagtat tataggtact ataaacccta
     2101 atttttttta tttaagtaca ttttgctttt taaagttgat ttttttctat tgtttttaga
     2161 aaaaataaaa taactggcaa atatatcatt gagccaaatc ttaagttgtg aatgttttgt
     2221 ttcgtttctt ccccctccca accaccacca tccctgtttg ttttcatcaa ttgccccttc
     2281 agagggtggt cttaagaaag gcaagagttt tcctctgttg aaatgggtct gggggcctta
     2341 aggtctttaa gttcttggag gttctaagat gcttcctgga gactatgata acagccagag
     2401 ttgacagtta gaaggaatgg cagaaggcag gtgagaaggt gagaggtagg caaaggagat
     2461 acaagaggtc aaaggtagca gttaagtaca caaagaggca taaggactgg ggagttggga
     2521 ggaaggtgag gaagaaactc ctgttacttt agttaaccag tgccagtccc ctgctcactc
     2581 caaacccagg aattctgccc agttgatggg gacacggtgg gaaccagctt ctgctgcctt
     2641 cacaaccagg cgccagtcct gtccatgggt tatctcgcaa accccagagg atctctggga
     2701 ggaatgctac tattaaccct atttcacaaa caaggaaata gaagagctca aagaggttat
     2761 gtaacttatc tgtagccacg cagataatac aaagcagcaa tctggaccca ttctgttcaa
     2821 aacacttaac ccttcgctat catgccttgg ttcatctggg tctaatgtgc tgagatcaag
     2881 aaggtttagg acctaatgga cagactcaag tcataacaat gctaagctct atttgtgtcc
     2941 caagcactcc taagcatttt atccctaact ctacatcaac cccatgaagg agatactgtt
     3001 gatttcccca tattagaagt agagagggaa gctgaggcac acaaagactc atccacatgc
     3061 ccaagattca ctgataggga aaagtggaag cgagatttga acccaggctg tttactccta
     3121 acctgtccaa gccacctctc agacgacggt aggaatcagc tggctgcttg tgagtacagg
     3181 agttacagtc cagtgggtta tgttttttaa gtctcaacat ctaagcctgg tcaggcatca
     3241 gttccccttt ttttgtgatt tattttgttt ttattttgtt gttcattgtt taatttttcc
     3301 ttttacaatg agaaggtcac catcttgact cctaccttag ccatttgttg aatcagactc
     3361 atgacggctc ctgggaagaa gccagttcag atcataaaat aaaacatatt tattctttgt
     3421 catgggagtc attattttag aaactacaaa ctctccttgc ttccatcctt ttttacatac
     3481 tcatgacaca tgctcatcct gagtccttga aaaggtattt ttgaacatgt gtattaatta
     3541 taagcctctg aaaacctatg gcccaaacca gaaatgatgt tgattatata ggtaaatgaa
     3601 ggatgctatt gctgttctaa ttacctcatt gtctcagtct caaagtaggt cttcagctcc
     3661 ctgtactttg ggattttaat ctaccaccac ccataaatca ataaataatt actttctttg
     3721 a
//
