LOCUS       NM_000256               4217 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens myosin binding protein C3 (MYBPC3), mRNA.
ACCESSION   NM_000256
VERSION     NM_000256.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4217)
  AUTHORS   Kampourakis,T., Ponnam,S., Campbell,K.S., Wellette-Hunsucker,A. and
            Koch,D.
  TITLE     Cardiac myosin binding protein-C phosphorylation as a function of
            multiple protein kinase and phosphatase activities
  JOURNAL   Nat Commun 15 (1), 5111 (2024)
   PUBMED   38877002
  REMARK    GeneRIF: Cardiac myosin binding protein-C phosphorylation as a
            function of multiple protein kinase and phosphatase activities.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4217)
  AUTHORS   Armanious,G.P., Lemieux,M.J., Espinoza-Fonseca,L.M. and Young,H.S.
  TITLE     Missense variants in phospholamban and cardiac myosin binding
            protein identified in patients with a family history and clinical
            diagnosis of dilated cardiomyopathy
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (4), 119699 (2024)
   PUBMED   38387507
  REMARK    GeneRIF: Missense variants in phospholamban and cardiac myosin
            binding protein identified in patients with a family history and
            clinical diagnosis of dilated cardiomyopathy.
            Review article
REFERENCE   3  (bases 1 to 4217)
  AUTHORS   Earle,N.J., Winbo,A., Crawford,J., Wheeler,M., Stiles,R.,
            Donoghue,T., Stiles,M.K., Hayes,I., Marcondes,L., Martin,A. and
            Skinner,J.R.
  TITLE     Genetic Testing Yield and Clinical Characteristics of Hypertrophic
            Cardiomyopathy in Understudied Ethnic Groups: Insights From a New
            Zealand National Registry
  JOURNAL   Circ Heart Fail 17 (3), e010970 (2024)
   PUBMED   38456273
  REMARK    GeneRIF: Genetic Testing Yield and Clinical Characteristics of
            Hypertrophic Cardiomyopathy in Understudied Ethnic Groups: Insights
            From a New Zealand National Registry.
REFERENCE   4  (bases 1 to 4217)
  AUTHORS   Hayesmoore,J.B.G., Bowman,M., Shannon,N., Blair,E., Watkins,H. and
            Thomson,K.L.
  TITLE     A Promoter Deletion Confirms That MYBPC3 Haploinsufficiency Is
            Sufficient to Cause Hypertrophic Cardiomyopathy in Humans
  JOURNAL   Circ Genom Precis Med 17 (1), e004134 (2024)
   PUBMED   38258577
  REMARK    GeneRIF: A Promoter Deletion Confirms That MYBPC3
            Haploinsufficiency Is Sufficient to Cause Hypertrophic
            Cardiomyopathy in Humans.
REFERENCE   5  (bases 1 to 4217)
  AUTHORS   Bonne,G., Carrier,L., Bercovici,J., Cruaud,C., Richard,P.,
            Hainque,B., Gautel,M., Labeit,S., James,M., Beckmann,J.,
            Weissenbach,J., Vosberg,H.P., Fiszman,M., Komajda,M. and
            Schwartz,K.
  TITLE     Cardiac myosin binding protein-C gene splice acceptor site mutation
            is associated with familial hypertrophic cardiomyopathy
  JOURNAL   Nat Genet 11 (4), 438-440 (1995)
   PUBMED   7493026
REFERENCE   6  (bases 1 to 4217)
  AUTHORS   Watkins,H., Conner,D., Thierfelder,L., Jarcho,J.A., MacRae,C.,
            McKenna,W.J., Maron,B.J., Seidman,J.G. and Seidman,C.E.
  TITLE     Mutations in the cardiac myosin binding protein-C gene on
            chromosome 11 cause familial hypertrophic cardiomyopathy
  JOURNAL   Nat Genet 11 (4), 434-437 (1995)
   PUBMED   7493025
REFERENCE   7  (bases 1 to 4217)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   8  (bases 1 to 4217)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   9  (bases 1 to 4217)
  AUTHORS   Moos,C. and Feng,I.N.
  TITLE     Effect of C-protein on actomyosin ATPase
  JOURNAL   Biochim Biophys Acta 632 (2), 141-149 (1980)
   PUBMED   6448079
REFERENCE   10 (bases 1 to 4217)
  AUTHORS   Starr,R. and Offer,G.
  TITLE     The interaction of C-protein with heavy meromyosin and
            subfragment-2
  JOURNAL   Biochem J 171 (3), 813-816 (1978)
   PUBMED   352343
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EF560722.1, AU140784.1,
            AJ708511.1, AL691822.1, DA563514.1 and AJ708699.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 5, 2007 this sequence version replaced NM_000256.2.
            
            Summary: MYBPC3 encodes the cardiac isoform of myosin-binding
            protein C. Myosin-binding protein C is a myosin-associated protein
            found in the cross-bridge-bearing zone (C region) of A bands in
            striated muscle. MYBPC3 is expressed exclusively in heart muscle
            and is a key regulator of cardiac contraction. Mutations in this
            gene are a frequent cause of familial hypertrophic cardiomyopathy.
            [provided by RefSeq, May 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU747719.1, EU747718.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000545968.6/ ENSP00000442795.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               EF560722.1         2-254
            254-603             AU140784.1         254-603
            604-1025            EF560722.1         605-1026
            1026-1145           AJ708511.1         174-293
            1146-1249           EF560722.1         1147-1250
            1250-1327           AL691822.1         110-187
            1328-2879           EF560722.1         1329-2880
            2880-3275           DA563514.1         49-444
            3276-4045           EF560722.1         3277-4046
            4046-4217           AJ708699.1         293-464
FEATURES             Location/Qualifiers
     source          1..4217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..4217
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /note="myosin binding protein C3"
                     /db_xref="GeneID:4607"
                     /db_xref="HGNC:HGNC:7551"
                     /db_xref="MIM:600958"
     exon            1..80
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..3880
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /note="myosin binding protein C, cardiac"
                     /codon_start=1
                     /product="myosin-binding protein C, cardiac-type"
                     /protein_id="NP_000247.2"
                     /db_xref="CCDS:CCDS53621.1"
                     /db_xref="GeneID:4607"
                     /db_xref="HGNC:HGNC:7551"
                     /db_xref="MIM:600958"
                     /translation="MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQR
                     GGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEP
                     MLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMR
                     PQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASK
                     VYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSL
                     AGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYE
                     RIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDA
                     EVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVK
                     EPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQ
                     RHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKC
                     EVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACN
                     LSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVI
                     WQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEG
                     AEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYD
                     GGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSR
                     PSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCS
                     EWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPR
                     LQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTIL
                     FIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKP
                     PQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVG
                     FSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAV
                     RGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEA
                     RCECRLEVRVPQ"
     exon            81..347
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            348..461
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            462..560
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            561..709
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            710..827
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            828..876
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            877..906
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            907..960
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            961..963
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            964..981
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1145
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1278
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1281
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1406
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1512
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1679
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1845
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1952
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..1982
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2122
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2203
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2363
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2468
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2657
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2792
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2960
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3049
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3245
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3385
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3545
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3682
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3869
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..3906
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4217
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4186..4191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /note="hexamer: AATAAA"
     polyA_site      4217
                     /gene="MYBPC3"
                     /gene_synonym="CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C"
                     /note="major polyA site"
ORIGIN      
        1 agtccctctt tgggtgacct gtgcctgctt cgtgcctggt gtgacgtctc tcaggatgcc
       61 tgagccgggg aagaagccag tctcagcttt tagcaagaag ccacggtcag tggaagtggc
      121 cgcaggcagc cctgccgtgt tcgaggccga gacagagcgg gcaggagtga aggtgcgctg
      181 gcagcgcgga ggcagtgaca tcagcgccag caacaagtac ggcctggcca cagagggcac
      241 acggcatacg ctgacagtgc gggaagtggg ccctgccgac cagggatctt acgcagtcat
      301 tgctggctcc tccaaggtca agttcgacct caaggtcata gaggcagaga aggcagagcc
      361 catgctggcc cctgcccctg cccctgctga ggccactgga gcccctggag aagccccggc
      421 cccagccgct gagctgggag aaagtgcccc aagtcccaaa gggtcaagct cagcagctct
      481 caatggtcct acccctggag cccccgatga ccccattggc ctcttcgtga tgcggccaca
      541 ggatggcgag gtgaccgtgg gtggcagcat caccttctca gcccgcgtgg ccggcgccag
      601 cctcctgaag ccgcctgtgg tcaagtggtt caagggcaaa tgggtggacc tgagcagcaa
      661 ggtgggccag cacctgcagc tgcacgacag ctacgaccgc gccagcaagg tctatctgtt
      721 cgagctgcac atcaccgatg cccagcctgc cttcactggc agctaccgct gtgaggtgtc
      781 caccaaggac aaatttgact gctccaactt caatctcact gtccacgagg ccatgggcac
      841 cggagacctg gacctcctat cagccttccg ccgcacgagc ctggctggag gtggtcggcg
      901 gatcagtgat agccatgagg acactgggat tctggacttc agctcactgc tgaaaaagag
      961 agacagtttc cggaccccga gggactcgaa gctggaggca ccagcagagg aggacgtgtg
     1021 ggagatccta cggcaggcac ccccatctga gtacgagcgc atcgccttcc agtacggcgt
     1081 cactgacctg cgcggcatgc taaagaggct caagggcatg aggcgcgatg agaagaagag
     1141 cacagccttt cagaagaagc tggagccggc ctaccaggtg agcaaaggcc acaagatccg
     1201 gctgaccgtg gaactggctg accatgacgc tgaggtcaaa tggctcaaga atggccagga
     1261 gatccagatg agcggcagca agtacatctt tgagtccatc ggtgccaagc gtaccctgac
     1321 catcagccag tgctcattgg cggacgacgc agcctaccag tgcgtggtgg gtggcgagaa
     1381 gtgtagcacg gagctctttg tgaaagagcc ccctgtgctc atcacgcgcc ccttggagga
     1441 ccagctggtg atggtggggc agcgggtgga gtttgagtgt gaagtatcgg aggagggggc
     1501 gcaagtcaaa tggctgaagg acggggtgga gctgacccgg gaggagacct tcaaataccg
     1561 gttcaagaag gacgggcaga gacaccacct gatcatcaac gaggccatgc tggaggacgc
     1621 ggggcactat gcactgtgca ctagcggggg ccaggcgctg gctgagctca ttgtgcagga
     1681 aaagaagctg gaggtgtacc agagcatcgc agacctgatg gtgggcgcaa aggaccaggc
     1741 ggtgttcaaa tgtgaggtct cagatgagaa tgttcggggt gtgtggctga agaatgggaa
     1801 ggagctggtg cccgacagcc gcataaaggt gtcccacatc gggcgggtcc acaaactgac
     1861 cattgacgac gtcacacctg ccgacgaggc tgactacagc tttgtgcccg agggcttcgc
     1921 ctgcaacctg tcagccaagc tccacttcat ggaggtcaag attgacttcg tacccaggca
     1981 ggaacctccc aagatccacc tggactgccc aggccgcata ccagacacca ttgtggttgt
     2041 agctggaaat aagctacgtc tggacgtccc tatctctggg gaccctgctc ccactgtgat
     2101 ctggcagaag gctatcacgc aggggaataa ggccccagcc aggccagccc cagatgcccc
     2161 agaggacaca ggtgacagcg atgagtgggt gtttgacaag aagctgctgt gtgagaccga
     2221 gggccgggtc cgcgtggaga ccaccaagga ccgcagcatc ttcacggtcg agggggcaga
     2281 gaaggaagat gagggcgtct acacggtcac agtgaagaac cctgtgggcg aggaccaggt
     2341 caacctcaca gtcaaggtca tcgacgtgcc agacgcacct gcggccccca agatcagcaa
     2401 cgtgggagag gactcctgca cagtacagtg ggagccgcct gcctacgatg gcgggcagcc
     2461 catcctgggc tacatcctgg agcgcaagaa gaagaagagc taccggtgga tgcggctgaa
     2521 cttcgacctg attcaggagc tgagtcatga agcgcggcgc atgatcgagg gcgtggtgta
     2581 cgagatgcgc gtctacgcgg tcaacgccat cggcatgtcc aggcccagcc ctgcctccca
     2641 gcccttcatg cctatcggtc cccccagcga acccacccac ctggcagtag aggacgtctc
     2701 tgacaccacg gtctccctca agtggcggcc cccagagcgc gtgggagcag gaggcctgga
     2761 tggctacagc gtggagtact gcccagaggg ctgctcagag tgggtggctg ccctgcaggg
     2821 gctgacagag cacacatcga tactggtgaa ggacctgccc acgggggccc ggctgctttt
     2881 ccgagtgcgg gcacacaata tggcagggcc tggagcccct gttaccacca cggagccggt
     2941 gacagtgcag gagatcctgc aacggccacg gcttcagctg cccaggcacc tgcgccagac
     3001 cattcagaag aaggtcgggg agcctgtgaa ccttctcatc cctttccagg gcaagccccg
     3061 gcctcaggtg acctggacca aagaggggca gcccctggca ggcgaggagg tgagcatccg
     3121 caacagcccc acagacacca tcctgttcat ccgggccgct cgccgcgtgc attcaggcac
     3181 ttaccaggtg acggtgcgca ttgagaacat ggaggacaag gccacgctgg tgctgcaggt
     3241 tgttgacaag ccaagtcctc cccaggatct ccgggtgact gacgcctggg gtcttaatgt
     3301 ggctctggag tggaagccac cccaggatgt cggcaacacg gagctctggg ggtacacagt
     3361 gcagaaagcc gacaagaaga ccatggagtg gttcaccgtc ttggagcatt accgccgcac
     3421 ccactgcgtg gtgccagagc tcatcattgg caatggctac tacttccgcg tcttcagcca
     3481 gaatatggtt ggctttagtg acagagcggc caccaccaag gagcccgtct ttatccccag
     3541 accaggcatc acctatgagc cacccaacta taaggccctg gacttctccg aggccccaag
     3601 cttcacccag cccctggtga accgctcggt catcgcgggc tacactgcta tgctctgctg
     3661 tgctgtccgg ggtagcccca agcccaagat ttcctggttc aagaatggcc tggacctggg
     3721 agaagacgcc cgcttccgca tgttcagcaa gcagggagtg ttgactctgg agattagaaa
     3781 gccctgcccc tttgacgggg gcatctatgt ctgcagggcc accaacttac agggcgaggc
     3841 acggtgtgag tgccgcctgg aggtgcgagt gcctcagtga ccaggctggc tcctggggat
     3901 ggccaggtac aaccggatgc cagccccgtg ccaggagcct ggagggaagt tggggaaacc
     3961 cctccctact gttggatgta tgtgtgacaa gtgtgtctcc tgtgctgcga tgggggatca
     4021 gcagggcagt tgtcgggcag tcctgagtgg gtgttgcaca gactggtcca cagggctcct
     4081 gaaggaagcc cctggatctt tggggtaaaa ggagggtggc ctcaagaaac aatgtctggg
     4141 gacaggcctt tctggcctgc tatgtcttcc caatgtttat tgggcaataa aagataagtg
     4201 cagtcacaga gaactca
//
