LOCUS       NM_002465               4082 bp    mRNA    linear   PRI 18-JUL-2024
DEFINITION  Homo sapiens myosin binding protein C1 (MYBPC1), transcript variant
            1, mRNA.
ACCESSION   NM_002465
VERSION     NM_002465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4082)
  AUTHORS   Leduc-Pessah,H., Smith,I.C., Kernohan,K.D., Sampaio,M., Melkus,G.,
            Strasser,L., Chisholm,C., Huang,L., Hanes,I., Tran,M.A.,
            Venkateswaran,S., Muir,K., Charlesworth,L. and Warman-Chardon,J.
  TITLE     Congenital tremor and myopathy secondary to novel MYBPC1 variant
  JOURNAL   J Neurol Sci 457, 122864 (2024)
   PUBMED   38185014
  REMARK    GeneRIF: Congenital tremor and myopathy secondary to novel MYBPC1
            variant.
REFERENCE   2  (bases 1 to 4082)
  AUTHORS   Uneoka,S., Kobayashi,T., Numata-Uematsu,Y., Oikawa,Y., Katata,Y.,
            Okubo,Y., Abe,Y., Kikuchi,A., Takayama,J., Tamiya,G., Kure,S.,
            Saito,K. and Uematsu,M.
  TITLE     A Case Series of Patients With MYBPC1 Gene Variants Featuring
            Undulating Tongue Movements as Myogenic Tremor
  JOURNAL   Pediatr Neurol 146, 16-20 (2023)
   PUBMED   37392669
  REMARK    GeneRIF: A Case Series of Patients With MYBPC1 Gene Variants
            Featuring Undulating Tongue Movements as Myogenic Tremor.
REFERENCE   3  (bases 1 to 4082)
  AUTHORS   Liu,J., Song,J. and Li,C.
  TITLE     MYBPC1 is a key regulator for laryngeal carcinoma formation
  JOURNAL   Anticancer Drugs 34 (1), 1-8 (2023)
   PUBMED   36539363
  REMARK    GeneRIF: MYBPC1 is a key regulator for laryngeal carcinoma
            formation.
REFERENCE   4  (bases 1 to 4082)
  AUTHORS   Shashi,V., Geist,J., Lee,Y., Yoo,Y., Shin,U., Schoch,K.,
            Sullivan,J., Stong,N., Smith,E., Jasien,J., Kranz,P., Lee,Y.,
            Shin,Y.B., Wright,N.T., Choi,M. and Kontrogianni-Konstantopoulos,A.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Heterozygous variants in MYBPC1 are associated with an expanded
            neuromuscular phenotype beyond arthrogryposis
  JOURNAL   Hum Mutat 40 (8), 1115-1126 (2019)
   PUBMED   31264822
  REMARK    GeneRIF: Data substantiate that damaging variants in MYBPC1 are
            associated with a new form of an early-onset myopathy with tremor,
            which is a defining and consistent characteristic in all affected
            individuals, with no contractures. Recognition of this expanded
            myopathic phenotype can enable identification of individuals with
            MYBPC1 variants without arthrogryposis.
REFERENCE   5  (bases 1 to 4082)
  AUTHORS   Gurnett,C.A., Desruisseau,D.M., McCall,K., Choi,R., Meyer,Z.I.,
            Talerico,M., Miller,S.E., Ju,J.S., Pestronk,A., Connolly,A.M.,
            Druley,T.E., Weihl,C.C. and Dobbs,M.B.
  TITLE     Myosin binding protein C1: a novel gene for autosomal dominant
            distal arthrogryposis type 1
  JOURNAL   Hum Mol Genet 19 (7), 1165-1173 (2010)
   PUBMED   20045868
  REMARK    GeneRIF: These findings reveal that the MYBPC1 is a novel gene
            responsible for DA1, though the mechanism of disease may differ
            from how some cardiac MYBPC3 mutations cause hypertrophic
            cardiomyopathy.
REFERENCE   6  (bases 1 to 4082)
  AUTHORS   Welikson,R.E. and Fischman,D.A.
  TITLE     The C-terminal IgI domains of myosin-binding proteins C and H
            (MyBP-C and MyBP-H) are both necessary and sufficient for the
            intracellular crosslinking of sarcomeric myosin in transfected
            non-muscle cells
  JOURNAL   J Cell Sci 115 (Pt 17), 3517-3526 (2002)
   PUBMED   12154082
REFERENCE   7  (bases 1 to 4082)
  AUTHORS   Alyonycheva,T.N., Mikawa,T., Reinach,F.C. and Fischman,D.A.
  TITLE     Isoform-specific interaction of the myosin-binding proteins (MyBPs)
            with skeletal and cardiac myosin is a property of the C-terminal
            immunoglobulin domain
  JOURNAL   J Biol Chem 272 (33), 20866-20872 (1997)
   PUBMED   9252413
REFERENCE   8  (bases 1 to 4082)
  AUTHORS   Weber,F.E., Vaughan,K.T., Reinach,F.C. and Fischman,D.A.
  TITLE     Complete sequence of human fast-type and slow-type muscle
            myosin-binding-protein C (MyBP-C). Differential expression,
            conserved domain structure and chromosome assignment
  JOURNAL   Eur J Biochem 216 (2), 661-669 (1993)
   PUBMED   8375400
REFERENCE   9  (bases 1 to 4082)
  AUTHORS   Furst,D.O., Vinkemeier,U. and Weber,K.
  TITLE     Mammalian skeletal muscle C-protein: purification from bovine
            muscle, binding to titin and the characterization of a full-length
            human cDNA
  JOURNAL   J Cell Sci 102 (Pt 4), 769-778 (1992)
   PUBMED   1429890
REFERENCE   10 (bases 1 to 4082)
  AUTHORS   Johnston,L.H., Barker,D.G. and Nurse,P.
  TITLE     Cloning and characterization of the Schizosaccharomyces pombe DNA
            ligase gene CDC17
  JOURNAL   Gene 41 (2-3), 321-325 (1986)
   PUBMED   3011605
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA433791.1, AL832456.2,
            AL831993.2, AK295727.1, BC030980.1 and AC010205.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002465.3.
            
            Summary: This gene encodes a member of the myosin-binding protein C
            family. Myosin-binding protein C family members are
            myosin-associated proteins found in the cross-bridge-bearing zone
            (C region) of A bands in striated muscle. The encoded protein is
            the slow skeletal muscle isoform of myosin-binding protein C and
            plays an important role in muscle contraction by recruiting
            muscle-type creatine kinase to myosin filaments. Mutations in this
            gene are associated with distal arthrogryposis type I.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832456.2, AL831993.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361466.7/ ENSP00000354849.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA433791.1         5-29
            26-1437             AL832456.2         1-1412
            1438-1438           AL831993.2         1413-1413
            1439-2643           AL832456.2         1414-2618
            2644-3105           AK295727.1         2491-2952
            3106-3919           AL832456.2         3081-3894
            3920-3934           BC030980.1         962-976
            3935-4082           AC010205.6         13386-13533
FEATURES             Location/Qualifiers
     source          1..4082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..4082
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /note="myosin binding protein C1"
                     /db_xref="GeneID:4604"
                     /db_xref="HGNC:HGNC:7549"
                     /db_xref="MIM:160794"
     exon            1..125
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3616
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     skeletal muscle C-protein; slow MyBP-C; myosin binding
                     protein C, slow type; slow skeletal-type muscle
                     myosin-binding-protein C"
                     /codon_start=1
                     /product="myosin-binding protein C, slow-type isoform 1"
                     /protein_id="NP_002456.2"
                     /db_xref="CCDS:CCDS9083.1"
                     /db_xref="GeneID:4604"
                     /db_xref="HGNC:HGNC:7549"
                     /db_xref="MIM:160794"
                     /translation="MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDEEEVSPPSA
                     LPPGLGSRALERKDSDWTLVETPPGEEQAKQNANSQLSILFIEKPQGGTVKVGEDITF
                     IAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEMQIIKAKDN
                     FAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGL
                     LKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKS
                     AAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRIL
                     FINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSE
                     DDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAK
                     LSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVVHKG
                     RIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGN
                     KLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHI
                     NLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIE
                     RKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPL
                     AVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLID
                     KTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTY
                     IRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSG
                     KYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITG
                     YTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKES
                     AVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWM
                     KNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVI
                     YQGVNTPGQPVFLEGQQQSLHNKDF"
     exon            126..161
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            162..203
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            204..242
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            243..278
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            279..389
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            390..538
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            539..656
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            657..708
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            709..765
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            766..932
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1065
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1190
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1296
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1463
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1626
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1733
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1867
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2027
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2132
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2321
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2456
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2624
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2713
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2909
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3049
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3209
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3346
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3533
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3592
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3635
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..4082
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3900..3905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /note="hexamer: ATTAAA"
     regulatory      3913..3918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /note="hexamer: AACAAA"
     polyA_site      3924
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
                     /note="major polyA site"
     polyA_site      3934
                     /gene="MYBPC1"
                     /gene_synonym="CMYO16; CMYP16; LCCS4; MYBPCC; MYBPCS;
                     MYOTREM; ssMyBP-C"
ORIGIN      
        1 gtcacaccga cctgcaccat ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga
       61 gggaaggaga ctctttaaag aataacatct tattgtggcc atgccagaac ccactaagaa
      121 agaggaaaat gaagtgccag ccccagcccc acccccggaa gaaccaagta aagagaagga
      181 ggccggaact acaccagcaa aagatgaaga ggaagtctcc ccgcctagcg ccttgcctcc
      241 aggtttgggt agtcgggccc tggagagaaa agattcagac tggacccttg tcgaaactcc
      301 tcctggggag gaacaagcca agcagaatgc caactcccag ctgtccatct tgttcattga
      361 aaaacctcaa ggaggaacag tgaaagttgg tgaagatatc accttcatag ccaaagtcaa
      421 ggctgaagat cttctgagaa aacccactat caaatggttc aaaggaaaat ggatggacct
      481 ggccagcaaa gccgggaagc accttcagct gaaggaaacc tttgagaggc acagtcgggt
      541 gtacacattt gagatgcaga tcatcaaggc caaagataac tttgcaggaa attacagatg
      601 cgaggtcacc tataaggata agtttgacag ctgttcattt gatcttgaag tgcacgaatc
      661 tactgggact actccaaaca ttgacatcag atctgctttc aagagaagtg gagaaggtca
      721 agaggatgca ggagaacttg actttagtgg tctcctgaaa cgtagggagg tgaagcagca
      781 ggaggaagaa ccccaggtgg acgtatggga gttgctgaag aacgcgaaac ccagtgagta
      841 cgagaagatc gccttccagt atggaatcac cgacctgcgc ggcatgctca agcgactcaa
      901 gcgcatgcgc agagaggaga agaagagcgc agcttttgca aaaattcttg atcctgcata
      961 tcaggttgac aaaggaggca gagtgaggtt tgttgtggag ctggcagatc caaagttgga
     1021 ggtgaaatgg tataaaaatg gtcaagaaat tcgacccagt accaaataca tctttgaaca
     1081 caaaggatgc cagagaatcc tgtttatcaa taactgtcag atgacagatg attcagagta
     1141 ttatgtgaca gccggtgatg agaaatgttc cactgagctc ttcgtaagag agcctccaat
     1201 tatggtgacc aaacagctgg aagatacaac tgcttattgt ggggagagag tggaattaga
     1261 atgtgaggtg tctgaagatg atgccaatgt aaaatggttt aagaatggtg aagagattat
     1321 ccctggtcca aaatcaagat accgaattag agttgagggt aaaaaacaca tcttgatcat
     1381 agagggagca acaaaggctg atgctgcaga atattcagta atgacaacag gaggacaatc
     1441 atctgctaaa cttagtgttg acttgaaacc tctgaagatt ttgacacctc tgactgatca
     1501 gactgtaaat cttggaaaag aaatctgcct gaagtgtgaa atctctgaaa acataccagg
     1561 aaaatggact aaaaatggcc tacctgttca ggagagtgac cgtctaaagg tggttcacaa
     1621 gggaaggatc cacaagttag tgatagccaa tgccctcact gaagatgaag gtgattatgt
     1681 atttgcacct gatgcctaca atgttactct gcctgccaaa gttcatgtta ttgatcctcc
     1741 taagatcatc ctggatggtc ttgatgctga caacacagtg acagtgattg caggaaacaa
     1801 gcttcgtctt gagatcccca tcagcggaga accacctcct aaagccatgt ggagccgggg
     1861 agataaggct attatggaag gcagtggccg gataagaaca gaatcttacc ctgatagcag
     1921 cactctggtc attgatatag ctgaaagaga tgactctggt gtttaccaca tcaatctgaa
     1981 aaacgaagct ggagaggcac atgcaagcat caaggttaaa gttgtggact tccctgatcc
     2041 tccagtggca ccgactgtga cagaggtggg agatgactgg tgtatcatga actgggagcc
     2101 tcctgcctac gacggaggct ctccaatcct aggatatttt attgagagga agaagaaaca
     2161 aagctccagg tggatgaggc tgaattttga tctctgcaaa gaaacaactt ttgagcccaa
     2221 gaagatgatt gaaggtgtgg cctatgaggt ccgcatcttt gcagtcaatg ccattggcat
     2281 ctccaagccc agtatgccct ccaggccttt tgttcctttg gctgtaacaa gccctcctac
     2341 tcttctgact gtggactctg tcactgacac gactgtcacg atgaggtggc gccccccaga
     2401 ccacattggt gcagcaggtt tagatggcta tgtgctagag tattgctttg aaggaactga
     2461 ggactggata gttgcaaaca aagatctgat tgacaagacg aagttcacca tcacaggtct
     2521 gccaacagat gcaaagatct ttgtgcgtgt gaaggctgtt aatgcagctg gtgccagcga
     2581 gcccaagtac tattctcagc ccattctcgt gaaggaaatc atagaacctc caaagattcg
     2641 cattccaaga cacctgaagc aaacctatat ccgcagagtt ggagaagctg tcaatctggt
     2701 tatacctttc cagggaaaac caagaccaga attaacttgg aagaaggatg gtgcagaaat
     2761 tgataagaat caaataaaca ttcgcaactc tgagactgat acaatcatat ttattagaaa
     2821 agcagagagg agccactctg ggaaatatga tctgcaagtc aaagtggaca aattcgtgga
     2881 gaccgcatca attgacatcc agatcattga ccgtccaggt ccaccccaaa ttgtgaagat
     2941 tgaggatgtc tggggagaaa atgtcgctct cacatggact ccaccaaagg atgatggaaa
     3001 tgctgctatc acaggctata ccattcagaa ggctgacaag aagagcatgg aatggtttac
     3061 tgtcattgag cattatcatc gaaccagtgc caccattact gaattggtca tagggaatga
     3121 atattacttc cgggtctttt ctgaaaacat gtgtggcctc agtgaggatg ccaccatgac
     3181 taaagagagt gcagtgatcg ccagggatgg taaaatctac aaaaatccag tgtatgaaga
     3241 ctttgatttc tcagaggcac ccatgtttac tcagcctttg gttaacacct atgccatagc
     3301 tggttacaat gccaccctaa actgcagtgt gagaggaaat cctaagccta aaataacctg
     3361 gatgaaaaac aaagttgcta ttgtggatga tccaagatac aggatgttca gcaaccaggg
     3421 agtctgtacc ctggaaattc gcaagcccag cccctatgat ggaggcactt actgctgcaa
     3481 agcagtcaat gaccttggga cagtggagat tgaatgcaaa ctggaggtga aagtgatata
     3541 tcaaggagta aatacccctg gacaaccagt cttcctggag gggcagcaac agtcattgca
     3601 caataaggat ttttgaatgt ataatatcat ctaaggtggg ctctccttct gcagactcct
     3661 cttgcaaggc gtacctccaa acataattga ttcgtatctg cgagacttac actcaagcaa
     3721 tcctgaggaa tactgaggga gggcctggct actgtctctc tgcactctgc tgctttgaaa
     3781 tctggttgaa atgagaaaaa gcattttctg ttttcccacc aggcccccaa gtgtggtctt
     3841 tttctttcct cctaatgttg aagagaaaaa aaaaaaaaaa agtttgccca gattgcttaa
     3901 ttaaaaattg caaacaaaat ctcatttgaa gtcagcactt tggtcattat tatctctgct
     3961 cactgtatta tactttacaa aaatgcaagt catagaataa gcaaaagcag ttatttttgt
     4021 ttacatagta ggctataaat gctttttttt tcctctcaga gtaaaaaaca taacacaatg
     4081 ca
//
