LOCUS       NM_002466               2668 bp    mRNA    linear   PRI 21-MAR-2025
DEFINITION  Homo sapiens MYB proto-oncogene like 2 (MYBL2), transcript variant
            1, mRNA.
ACCESSION   NM_002466
VERSION     NM_002466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   German,B., Alaiwi,S.A., Ho,K.L., Nanda,J.S., Fonseca,M.A.,
            Burkhart,D.L., Sheahan,A.V., Bergom,H.E., Morel,K.L., Beltran,H.,
            Hwang,J.H., Freedman,M.L., Lawrenson,K. and Ellis,L.
  TITLE     MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its
            Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine
            Prostate Cancer
  JOURNAL   Cancer Res Commun 4 (9), 2295-2307 (2024)
   PUBMED   39113611
  REMARK    GeneRIF: MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its
            Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine
            Prostate Cancer.
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Shao,W., Lin,Z., Xiahou,Z., Zhao,F., Xu,J., Liu,X. and Cai,P.
  TITLE     Single-cell RNA sequencing reveals that MYBL2 in malignant
            epithelial cells is involved in the development and progression of
            ovarian cancer
  JOURNAL   Front Immunol 15, 1438198 (2024)
   PUBMED   39136009
  REMARK    GeneRIF: Single-cell RNA sequencing reveals that MYBL2 in malignant
            epithelial cells is involved in the development and progression of
            ovarian cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Yi,J., Li,B., Yin,X., Liu,L., Song,C., Zhao,Y., Cai,M., Tang,H.,
            Chen,D. and Lyu,N.
  TITLE     CircMYBL2 facilitates hepatocellular carcinoma progression by
            regulating E2F1 expression
  JOURNAL   Oncol Res 32 (6), 1129-1139 (2024)
   PUBMED   38827325
  REMARK    GeneRIF: CircMYBL2 facilitates hepatocellular carcinoma progression
            by regulating E2F1 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Herwig,A., Osterhof,C., Keppner,A., Maric,D., Koay,T.W.,
            Mbemba-Nsungi,A. and Hoogewijs,D.
  TITLE     Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression
  JOURNAL   Cells 13 (10), 826 (2024)
   PUBMED   38786048
  REMARK    GeneRIF: Ectopic MYBL2-Mediated Regulation of Androglobin Gene
            Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Gao,W., Zhou,J., Huang,J., Zhang,Z., Chen,W., Zhang,R., Kang,T.,
            Liao,D. and Zhong,L.
  TITLE     Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer
            stem-like cells population during heterogeneous tumor generation
  JOURNAL   Cancer Lett 586, 216708 (2024)
   PUBMED   38336287
  REMARK    GeneRIF: Up-regulation of RAN by MYBL2 maintains osteosarcoma
            cancer stem-like cells population during heterogeneous tumor
            generation.
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Lam,E.W., Bennett,J.D. and Watson,R.J.
  TITLE     Cell-cycle regulation of human B-myb transcription
  JOURNAL   Gene 160 (2), 277-281 (1995)
   PUBMED   7642110
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Golay,J., Cusmano,G. and Introna,M.
  TITLE     Independent regulation of c-myc, B-myb, and c-myb gene expression
            by inducers and inhibitors of proliferation in human B lymphocytes
  JOURNAL   J Immunol 149 (1), 300-308 (1992)
   PUBMED   1376749
REFERENCE   8  (bases 1 to 2668)
  AUTHORS   Reiss,K., Travali,S., Calabretta,B. and Baserga,R.
  TITLE     Growth regulated expression of B-myb in fibroblasts and
            hematopoietic cells
  JOURNAL   J Cell Physiol 148 (3), 338-343 (1991)
   PUBMED   1717494
REFERENCE   9  (bases 1 to 2668)
  AUTHORS   Golay,J., Capucci,A., Arsura,M., Castellano,M., Rizzo,V. and
            Introna,M.
  TITLE     Expression of c-myb and B-myb, but not A-myb, correlates with
            proliferation in human hematopoietic cells
  JOURNAL   Blood 77 (1), 149-158 (1991)
   PUBMED   1984793
REFERENCE   10 (bases 1 to 2668)
  AUTHORS   Nomura,N., Takahashi,M., Matsui,M., Ishii,S., Date,T., Sasamoto,S.
            and Ishizaki,R.
  TITLE     Isolation of human cDNA clones of myb-related genes, A-myb and
            B-myb
  JOURNAL   Nucleic Acids Res 16 (23), 11075-11089 (1988)
   PUBMED   3060855
  REMARK    Erratum:[Nucleic Acids Res 1989 Feb 11;17(3):1282]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007585.1 and AL121886.22.
            
            On Nov 22, 2018 this sequence version replaced NM_002466.3.
            
            Summary: The protein encoded by this gene, a member of the MYB
            family of transcription factor genes, is a nuclear protein involved
            in cell cycle progression. The encoded protein is phosphorylated by
            cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell
            cycle and possesses both activator and repressor activities. It has
            been shown to activate the cell division cycle 2, cyclin D1, and
            insulin-like growth factor-binding protein 5 genes. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007585.1, BC053555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217026.5/ ENSP00000217026.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1075              BC007585.1         21-1095
            1076-1076           AL121886.22        93173-93173
            1077-2668           BC007585.1         1097-2688
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2668
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /note="MYB proto-oncogene like 2"
                     /db_xref="GeneID:4605"
                     /db_xref="HGNC:HGNC:7548"
                     /db_xref="MIM:601415"
     exon            1..190
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2273
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MYB-related protein B; myb-like protein 2; v-myb
                     myeloblastosis viral oncogene homolog-like 2; v-myb avian
                     myeloblastosis viral oncogene homolog-like 2"
                     /codon_start=1
                     /product="myb-related protein B isoform 1"
                     /protein_id="NP_002457.1"
                     /db_xref="CCDS:CCDS13322.1"
                     /db_xref="GeneID:4605"
                     /db_xref="HGNC:HGNC:7548"
                     /db_xref="MIM:601415"
                     /translation="MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRA
                     LVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYG
                     TKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEI
                     AKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPT
                     EGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKR
                     EDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEP
                     SAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPI
                     SPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLP
                     FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQ
                     KYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPE
                     KQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGI
                     KEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKAR
                     QLLGRLKPSHTSRTLILS"
     exon            191..284
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            285..356
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            357..449
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            450..670
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            671..833
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1121
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1535
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1675
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1775
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1889
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1994
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2144
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2668
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /note="hexamer: AATAAA"
     polyA_site      2668
                     /gene="MYBL2"
                     /gene_synonym="B-MYB; BMYB"
                     /note="major polyA site"
ORIGIN      
        1 gactgcagtt cctgcgagcg aggagcgcgg gacctgctga cacgctgacg ccttcgagcg
       61 cggcccgggg cccggagcgg ccggagcagc ccgggtcctg accccggccc ggctcccgct
      121 ccgggctctg ccggcgggcg ggcgagcgcg gcgcggtccg ggccgggggg atgtctcggc
      181 ggacgcgctg cgaggatctg gatgagctgc actaccagga cacagattca gatgtgccgg
      241 agcagaggga tagcaagtgc aaggtcaaat ggacccatga ggaggacgag cagctgaggg
      301 ccctggtgag gcagtttgga cagcaggact ggaagttcct ggccagccac ttccctaacc
      361 gcactgacca gcaatgccag tacaggtggc tgagagtttt gaatccagac cttgtcaagg
      421 ggccatggac caaagaggaa gaccaaaaag tcatcgagct ggttaagaag tatggcacaa
      481 agcagtggac actgattgcc aagcacctga agggccggct ggggaagcag tgccgtgaac
      541 gctggcacaa ccacctcaac cctgaggtga agaagtcttg ctggaccgag gaggaggacc
      601 gcatcatctg cgaggcccac aaggtgctgg gcaaccgctg ggccgagatc gccaagatgt
      661 tgccagggag gacagacaat gctgtgaaga atcactggaa ctctaccatc aaaaggaagg
      721 tggacacagg aggcttcttg agcgagtcca aagactgcaa gcccccagtg tacttgctgc
      781 tggagctcga ggacaaggac ggcctccaga gtgcccagcc cacggaaggc cagggaagtc
      841 ttctgaccaa ctggccctcc gtccctccta ccataaagga ggaggaaaac agtgaggagg
      901 aacttgcagc agccaccaca tcgaaggaac aggagcccat cggtacagat ctggacgcag
      961 tgcgaacacc agagcccttg gaggaattcc cgaagcgtga ggaccaggaa ggctccccac
     1021 cagaaacgag cctgccttac aagtgggtgg tggaggcagc taacctcctc atccctgctg
     1081 tgggttctag cctctctgaa gccctggact tgatcgagtc ggaccctgat gcttggtgtg
     1141 acctgagtaa atttgacctc cctgaggaac catctgcaga ggacagtatc aacaacagcc
     1201 tagtgcagct gcaagcgtca catcagcagc aagtcctgcc accccgccag ccttccgccc
     1261 tggtgcccag tgtgaccgag taccgcctgg atggccacac catctcagac ctgagccgga
     1321 gcagccgggg cgagctgatc cccatctccc ccagcactga agtcgggggc tctggcattg
     1381 gcacaccgcc ctctgtgctc aagcggcaga ggaagaggcg tgtggctctg tcccctgtca
     1441 ctgagaatag caccagtctg tccttcctgg attcctgtaa cagcctcacg cccaagagca
     1501 cacctgttaa gaccctgccc ttctcgccct cccagtttct gaacttctgg aacaaacagg
     1561 acacattgga gctggagagc ccctcgctga catccacccc agtgtgcagc cagaaggtgg
     1621 tggtcaccac accactgcac cgggacaaga cacccctgca ccagaaacat gctgcgtttg
     1681 taaccccaga tcagaagtac tccatggaca acactcccca cacgccaacc ccgttcaaga
     1741 acgccctgga gaagtacgga cccctgaagc ccctgccaca gaccccgcac ctggaggagg
     1801 acttgaagga ggtgctgcgt tctgaggctg gcatcgaact catcatcgag gacgacatca
     1861 ggcccgagaa gcagaagagg aagcctgggc tgcggcggag ccccatcaag aaagtccgga
     1921 agtctctggc tcttgacatt gtggatgagg atgtgaagct gatgatgtcc acactgccca
     1981 agtctctatc cttgccgaca actgcccctt caaactcttc cagcctcacc ctgtcaggta
     2041 tcaaagaaga caacagcttg ctcaaccagg gcttcttgca ggccaagccc gagaaggcag
     2101 cagtggccca gaagccccga agccacttca cgacacctgc ccctatgtcc agtgcctgga
     2161 agacggtggc ctgcgggggg accagggacc agcttttcat gcaggagaaa gcccggcagc
     2221 tcctgggccg cctgaagccc agccacacat ctcggaccct catcttgtcc tgaggtgttg
     2281 agggtgtcac gagcccattc tcatgtttac aggggttgtg ggggcagagg gggtctgtga
     2341 atctgagagt cattcaggtg acctcctgca gggagccttc tgccaccagc ccctccccag
     2401 actctcaggt ggaggcaaca gggccatgtg ctgccctgtt gccgagccca gctgtgggcg
     2461 gctcctggtg ctaacaacaa agttccactt ccaggtctgc ctggttccct ccccaaggcc
     2521 acagggagct ccgtcagctt ctcccaagcc cacgtcaggc ctggcctcat ctcagaccct
     2581 gcttaggatg ggggatgtgg ccaggggtgc tcctgtgctc accctctctt ggtgcatttt
     2641 tttggaagaa taaaattgcc tctctctt
//
