LOCUS       NM_001080416            5161 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens MYB proto-oncogene like 1 (MYBL1), transcript variant
            1, mRNA.
ACCESSION   NM_001080416 XM_034274
VERSION     NM_001080416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5161)
  AUTHORS   Feinberg,J., Da Cruz Paula,A., da Silva,E.M., Pareja,F., Patel,J.,
            Zhu,Y., Selenica,P., Leitao,M.M. Jr., Abu-Rustum,N.R.,
            Reis-Filho,J.S., Joehlin-Price,A. and Weigelt,B.
  TITLE     Adenoid cystic carcinoma of the Bartholin's gland is underpinned by
            MYB- and MYBL1- rearrangements
  JOURNAL   Gynecol Oncol 185, 58-67 (2024)
   PUBMED   38368814
  REMARK    GeneRIF: Adenoid cystic carcinoma of the Bartholin's gland is
            underpinned by MYB- and MYBL1- rearrangements.
REFERENCE   2  (bases 1 to 5161)
  AUTHORS   Ding,S.A., Liu,H., Zheng,R., Ge,Y., Fu,Z., Mei,J. and Tang,M.
  TITLE     Downregulation of MYBL1 in endothelial cells contributes to
            atherosclerosis by repressing PLEKHM1-inducing autophagy
  JOURNAL   Cell Biol Toxicol 40 (1), 40 (2024)
   PUBMED   38797732
  REMARK    GeneRIF: Downregulation of MYBL1 in endothelial cells contributes
            to atherosclerosis by repressing PLEKHM1-inducing autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5161)
  AUTHORS   Player,A., Cunningham,S., Philio,D., Roy,R., Haynes,C., Dixon,C.,
            Thirston,L., Ibikunle,F., Boswell,T.A., Alnakhalah,A.,
            Contreras,J., Bell,M., McGuffery,T., Bryant,S., Nganya,C. and
            Kanu,S.
  TITLE     Characterization of MYBL1 Gene in Triple-Negative Breast Cancers
            and the Genes' Relationship to Alterations Identified at the
            Chromosome 8q Loci
  JOURNAL   Int J Mol Sci 25 (5), 2539 (2024)
   PUBMED   38473786
  REMARK    GeneRIF: Characterization of MYBL1 Gene in Triple-Negative Breast
            Cancers and the Genes' Relationship to Alterations Identified at
            the Chromosome 8q Loci.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5161)
  AUTHORS   Kalelioglu,T., Rama,B., Cho,B.B., Lopes,B.M. and Patel,S.H.
  TITLE     Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration:
            report of 2 cases
  JOURNAL   Neuroradiol J 36 (2), 232-235 (2023)
   PUBMED   36074655
  REMARK    GeneRIF: Pediatric-type diffuse low-grade glioma with MYB/MYBL1
            alteration: report of 2 cases.
REFERENCE   5  (bases 1 to 5161)
  AUTHORS   Wang,T., Jian,W., Xue,W., Meng,Y., Xia,Z., Li,Q., Xu,S., Dong,Y.,
            Mao,A. and Zhang,C.
  TITLE     Integration analysis identifies MYBL1 as a novel immunotherapy
            biomarker affecting the immune microenvironment in clear cell renal
            cell carcinoma: Evidence based on machine learning and experiments
  JOURNAL   Front Immunol 13, 1080403 (2022)
   PUBMED   36591240
  REMARK    GeneRIF: Integration analysis identifies MYBL1 as a novel
            immunotherapy biomarker affecting the immune microenvironment in
            clear cell renal cell carcinoma: Evidence based on machine learning
            and experiments.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5161)
  AUTHORS   Takahashi,T., Nakagoshi,H., Sarai,A., Nomura,N., Yamamoto,T. and
            Ishii,S.
  TITLE     Human A-myb gene encodes a transcriptional activator containing the
            negative regulatory domains
  JOURNAL   FEBS Lett 358 (1), 89-96 (1995)
   PUBMED   7821437
REFERENCE   7  (bases 1 to 5161)
  AUTHORS   Ma,X.P. and Calabretta,B.
  TITLE     DNA binding and transactivation activity of A-myb, a c-myb-related
            gene
  JOURNAL   Cancer Res 54 (24), 6512-6516 (1994)
   PUBMED   7987850
REFERENCE   8  (bases 1 to 5161)
  AUTHORS   Golay,J., Loffarelli,L., Luppi,M., Castellano,M. and Introna,M.
  TITLE     The human A-myb protein is a strong activator of transcription
  JOURNAL   Oncogene 9 (9), 2469-2479 (1994)
   PUBMED   8058310
REFERENCE   9  (bases 1 to 5161)
  AUTHORS   Barletta,C., Druck,T., LaForgia,S., Calabretta,B., Drabkin,H.,
            Patterson,D., Croce,C.M. and Huebner,K.
  TITLE     Chromosome locations of the MYB related genes, AMYB and BMYB
  JOURNAL   Cancer Res 51 (14), 3821-3824 (1991)
   PUBMED   2065336
REFERENCE   10 (bases 1 to 5161)
  AUTHORS   Nomura,N., Takahashi,M., Matsui,M., Ishii,S., Date,T., Sasamoto,S.
            and Ishizaki,R.
  TITLE     Isolation of human cDNA clones of myb-related genes, A-myb and
            B-myb
  JOURNAL   Nucleic Acids Res 16 (23), 11075-11089 (1988)
   PUBMED   3060855
  REMARK    Erratum:[Nucleic Acids Res 1989 Feb 11;17(3):1282]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR003430.1, X13294.1 and AC083928.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001080416.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13294.1, SRR11853565.27551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522677.8/ ENSP00000429633.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               DR003430.1         40-323
            285-2617            X13294.1           9-2341
            2618-5161           AC083928.11        61593-64136
FEATURES             Location/Qualifiers
     source          1..5161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..5161
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /note="MYB proto-oncogene like 1"
                     /db_xref="GeneID:4603"
                     /db_xref="HGNC:HGNC:7547"
                     /db_xref="MIM:159405"
     exon            1..400
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..2639
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myb-related protein A; v-myb avian myeloblastosis viral
                     oncogene homolog-like 1; myb-like protein 1"
                     /codon_start=1
                     /product="myb-related protein A isoform 1"
                     /protein_id="NP_001073885.1"
                     /db_xref="CCDS:CCDS47867.1"
                     /db_xref="GeneID:4603"
                     /db_xref="HGNC:HGNC:7547"
                     /db_xref="MIM:159405"
                     /translation="MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDD
                     KLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV
                     QKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNR
                     WAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHM
                     QTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLM
                     SAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQ
                     NSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTP
                     VKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKK
                     RKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSF
                     TSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQ
                     EKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVR
                     KSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDIN
                     STNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTY
                     TATSSTSRALIL"
     exon            401..506
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            507..578
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            579..671
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            672..892
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1067
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1142
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1247
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1481
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1850
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1993
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2108
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2225
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2330
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2510
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..5161
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /note="hexamer: AATAAA"
     polyA_site      5161
                     /gene="MYBL1"
                     /gene_synonym="A-MYB; AMYB"
                     /note="major polyA site"
ORIGIN      
        1 gcagaactgc tagctgcggg ggagagggca ggggtcgggc gcctgtggcg gagccgggct
       61 ggggccaggg cagggaggct gacaagcggc gggagaagcc ggcggagggc gggatcgcgc
      121 ctcctgacat gttgggggta tccctggccg ggccgggccg gggctaagag cggcgctgcg
      181 ggccggggtc ggggtcgggt cgcggtccgc ccccgctgtc cctccgtcct gccctgtcga
      241 ggacgtgcgt tccgcactcg gccgcctcca gagggagcga gggaagcggc tagaggatcg
      301 gggagaagga gcattcgccg gaggctggag gaggctgacc cgcgtccccg cccagcctgc
      361 tcctatgcgg tacttgaagg atggcgaaga ggtcgcgcag tgaggatgag gatgatgacc
      421 ttcagtatgc cgatcatgat tatgaagtac cacaacaaaa aggactgaag aaactctgga
      481 acagagtaaa atggacaagg gacgaggatg ataaattaaa gaagttggtt gaacaacatg
      541 gaactgatga ttggactcta attgctagtc atcttcaaaa tcgctctgat tttcagtgcc
      601 agcatcgatg gcagaaagtt ttaaatcctg aattgataaa gggtccttgg actaaagaag
      661 aagatcagag ggttattgaa ttagttcaga aatatgggcc aaaaagatgg tctttaattg
      721 caaaacattt aaaaggaaga ataggcaagc agtgtagaga aagatggcat aatcatctga
      781 atcctgaggt aaagaaatct tcctggacag aagaggagga caggatcatc tatgaagcac
      841 ataagcggtt gggaaatcgt tgggcagaaa ttgccaaact acttccagga aggactgata
      901 attctatcaa aaatcattgg aattctacta tgcgaagaaa agtggaacag gagggctatt
      961 tacaagatgg aataaaatca gaacgatctt catctaaact tcaacacaaa ccttgtgcag
     1021 ctatggatca tatgcaaacc cagaatcagt tttacatacc tgttcagatc cctgggtatc
     1081 agtatgtgtc acctgaaggc aattgtatag aacatgttca gcctacttct gcctttattc
     1141 agcaaccctt cattgatgaa gatcctgata aggaaaagaa aataaaggaa cttgagatgc
     1201 ttcttatgtc agctgagaat gaagttagaa gaaagcgaat tccatcacag cctggaagtt
     1261 tttctagctg gtctggtagt ttcctcatgg atgataacat gtctaatact ctaaatagcc
     1321 ttgacgagca cactagtgag ttttacagta tggatgaaaa tcagcctgtg tctgctcagc
     1381 agaattcacc cacaaagttc ctggccgtgg aggcaaacgc tgtgttatcc tctttgcaga
     1441 ccatcccaga atttgcagag actctagaac ttattgaatc tgatcctgta gcatggagtg
     1501 acgttaccag ttttgatatt tctgatgctg ctgcttctcc tatcaaatcc accccagtta
     1561 aattaatgag aattcagcac aatgaaggag ccatggaatg ccaatttaac gtcagtcttg
     1621 tacttgaagg gaaaaaaaac acttgtaatg gtggcaacag tgaagctgtt cctttaacat
     1681 ccccaaatat agccaagttt agcactccac cagccatcct cagaaagaag agaaaaatgc
     1741 gagtgggtca ttccccaggc agcgaactta gggatggctc attgaacgat ggtggtaata
     1801 tggcgctaaa acatacacca ctgaaaacac taccattttc tccttcacag tttttcaaca
     1861 catgtcctgg taatgaacaa cttaatatag aaaatccttc atttacatca acccctattt
     1921 gtgggcagaa agctctcatt acaactcctc ttcataagga aacaactccc aaagatcaaa
     1981 aggaaaatgt agggtttaga acacctacta ttagaagatc tatactgggt accacaccaa
     2041 gaactcctac tccttttaag aatgcgcttg ctgctcagga gaaaaaatat ggacctctta
     2101 aaattgtgtc ccagccactt gctttcttgg aagaagatat tcgggaagtt ttaaaagaag
     2161 aaactggaac agacctattc ctcaaagagg aagatgaacc tgcttacaaa agctgcaaac
     2221 aagagaatac cgcttctggg aagaaagtca gaaaatcact agtcttagat aattgggaaa
     2281 aagaagaatc aggcactcaa ctgttgactg aagacatttc agacatgcag tcagaaaata
     2341 gatttactac atccttatta atgataccat tattggaaat acatgacaat aggtgcaact
     2401 tgattcctga aaaacaagat ataaattcaa ccaacaaaac atatacactt actaaaaaga
     2461 aaccaaaccc taacacttcc aaagttgtca aattggaaaa gaatcttcag tcaaattgtg
     2521 aatgggaaac agtggtttat gggaagacag aagaccaact tattatgact gaacaagcaa
     2581 gaagatatct gagtacttac acagctacca gtagtacttc aagagctctc atactgtaat
     2641 tgttattaaa attgatgaaa tgccccactc ccttactgca gtctctacta aattaggttg
     2701 cagtgaaatt tttctcaatt agttgttttt aaagttgtaa gatagccctt ttaatacagc
     2761 atcttttttc tattctatat agtaggcaga aagctagtaa gtcacttaag gggtagatag
     2821 tttcatagtt tattttttaa gagatgagat ttttaaaaat tgtttttaaa gaacaagatg
     2881 ggaaaataat agaatgttca tggatttcta aaagtaaatt ctcatatatt ttcttcacaa
     2941 gatatatgtt gctactctct tgatgctgca gttttgttat agataggtgt atgagtatat
     3001 atgatttctg aaattagtct atgtatggaa agcacacatg attttatgaa gtacttttgc
     3061 ccatgtgctg atttacttag gctaccattt acaaagaaac acattgaaaa ggaatttaaa
     3121 ggaaggatag aaagttgcac tactaatttt ttgttttttt tttcagaagc agtaaaatta
     3181 actacagtgt taaatgtatt tatttgagca tagtactgaa aacaaaaagc attcaaaaaa
     3241 gagttttttc tttattagta aatagtattt tcttaatctc agaggagctg agagttttgt
     3301 tgaatgtatt gtacagtatg taggagcagg agaactttgt aaattggaaa gaagtctgtt
     3361 tttataattt atttttattt ttaaagctta aatgtagata tttatacgta tacagggtgc
     3421 ctagaagcca atgttgtttc ctgttattac agctaacaca gtaaagaata attttgactt
     3481 taagtatgaa acagtagtaa gttatagctg caaagaatac aatatctata ctgtatgtca
     3541 catctaccta aatgttgcac tatgcccttt aaatcatgct ggttataaag tagttctaaa
     3601 aatgtactaa ataataattt aatattttct ttttaaatta tatcgggggt ggtcatatac
     3661 attaatctgg tgatttgtat atgtgtttga aatttttgca ttttgtttaa aaaataatat
     3721 ggtaccttgg tccctaaaaa cagtctgcac ttagaagttt atatttactc agtgtttcag
     3781 aagtggagaa cattatcttt tatttataaa aatattttgt ccttttttaa atgttttgtg
     3841 tttctctaca ggttacaaca gttgcttcag ttgcctgttt taggtgtttg cacttatttt
     3901 atttcttctt gaaagaattt ttatttgctt ttgtggtaga gattatatgt aatttttttt
     3961 cagtcatata atggtgtgct gtcaacttaa acactgacag gtaaatagaa ttgtacactg
     4021 tagtttgaat tatttataat tgacacactc tctccctctc cactcctgaa gtatgctgct
     4081 atagaaaata gcagaatcgg cttgctgcta cgagagaagg aaagagcgac caccacttgc
     4141 actgtgtgaa aagataaaaa acaaatgatg gcaagttctc aagttaacta aatggaatca
     4201 accattacca ggcaaattct tgcaaatacc aaaatactac tatgccttat aaaacaaaat
     4261 gaaagcaggt taagattttc tgctctgttt gtatgttaat agaaatggaa atactaagta
     4321 ttttaatgct tagctcttga acagtagacc taaaagggtt ttaagctatt taaatctact
     4381 tgctagtttt tgcatatttt atatatatat atatttatat atatatatag tgagaagtga
     4441 agaaaatgta tggtactaag attatgcctt attgataaat agataaacca atttgaatcc
     4501 tcttagcatg tttaagtatg ttgattgctt tctaattaat gaacttctca cagaaatttc
     4561 acttagtgaa accaatgatt gtagcaaact catactggat catttcagtt accttgaact
     4621 aatagcacat aatggttttt tgttgttgtt gtttttaatg tagcccttac ctggatatac
     4681 atagtctgca atcaccaaag tataatatct tgtaaggcta tattttttaa agcatatttt
     4741 ttcttgagca ttaaattatc ctaaatggta atatattgtg gataagtctg ggcttattgg
     4801 acataataca tatttgggtt ggtactggtt gaatccttca gttaactgct ttgttgcttt
     4861 ttgcaagatt ttttatctta aacatgtcag gcatcttaag tcacctttat actgttttgt
     4921 tcctctgagt ttctttcagt atgttataca aatgccagac ataacatgta gcagccatac
     4981 ttgcatggaa actgactaca catacataat actgcatttt attgtaaggt tttcacatta
     5041 atacagcaat taccctgact aaattgagtt ttgtgatata tggaaaactt cattgtaaga
     5101 gaatcttgca tacaatgttg acatattaac atccaaaata aagcatctgt gtacaagctg
     5161 a
//
