LOCUS       NM_014520               4558 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens MYB binding protein 1a (MYBBP1A), transcript variant
            2, mRNA.
ACCESSION   NM_014520
VERSION     NM_014520.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4558)
  AUTHORS   Pimenta,R., Mioshi,C.M., Goncalves,G.L., Candido,P., Camargo,J.A.,
            Guimaraes,V.R., Chiovatto,C., Ghazarian,V., Romao,P., da
            Silva,K.S., Dos Santos,G.A., Silva,I.A., Srougi,M., Nahas,W.C.,
            Leite,K.R., Viana,N.I. and Reis,S.T.
  TITLE     Intratumoral Restoration of miR-137 Plus Cholesterol Favors
            Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively
            Modulates Tumor Progression in Advanced Prostate Cancer
  JOURNAL   Int J Mol Sci 24 (11), 9633 (2023)
   PUBMED   37298588
  REMARK    GeneRIF: Intratumoral Restoration of miR-137 Plus Cholesterol
            Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and
            Negatively Modulates Tumor Progression in Advanced Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4558)
  AUTHORS   Abaji,R., Roux,V., Yssaad,I.R., Kalegari,P., Gagne,V., Gioia,R.,
            Ferbeyre,G., Beausejour,C. and Krajinovic,M.
  TITLE     Characterization of the impact of the MYBBP1A gene and rs3809849 on
            asparaginase sensitivity and cellular functions
  JOURNAL   Pharmacogenomics 23 (7), 415-430 (2022)
   PUBMED   35485735
  REMARK    GeneRIF: Characterization of the impact of the MYBBP1A gene and
            rs3809849 on asparaginase sensitivity and cellular functions.
REFERENCE   3  (bases 1 to 4558)
  AUTHORS   Felipe-Abrio,B., Verdugo-Sivianes,E.M. and Carnero,A.
  TITLE     c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss
            in renal cancer
  JOURNAL   Mol Oncol 13 (7), 1519-1533 (2019)
   PUBMED   31066170
  REMARK    GeneRIF: This study shows the capability of MYBBP1A to regulate
            glucose metabolism through c-MYB and PGC1alpha in human tumors.
REFERENCE   4  (bases 1 to 4558)
  AUTHORS   Kumazawa,T., Nishimura,K., Katagiri,N., Hashimoto,S., Hayashi,Y.
            and Kimura,K.
  TITLE     Gradual reduction in rRNA transcription triggers p53 acetylation
            and apoptosis via MYBBP1A
  JOURNAL   Sci Rep 5, 10854 (2015)
   PUBMED   26044764
  REMARK    GeneRIF: We propose that the nucleolus functions as a stress sensor
            to modulate p53 protein levels and its acetylation status,
            determining cell fate between cell cycle arrest and apoptosis by
            regulating MYBBP1A translocation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4558)
  AUTHORS   Akaogi,K., Ono,W., Hayashi,Y., Kishimoto,H. and Yanagisawa,J.
  TITLE     MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53
            dependent anoikis
  JOURNAL   BMC Cancer 13, 65 (2013)
   PUBMED   23388179
  REMARK    GeneRIF: Suggest that MYBBP1A is required for p53 activation during
            anoikis; therefore, it is involved in suppressing colony formation
            and the tumorigenesis of breast cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4558)
  AUTHORS   He,B., Minges,J.T., Lee,L.W. and Wilson,E.M.
  TITLE     The FXXLF motif mediates androgen receptor-specific interactions
            with coregulators
  JOURNAL   J Biol Chem 277 (12), 10226-10235 (2002)
   PUBMED   11779876
REFERENCE   7  (bases 1 to 4558)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 4558)
  AUTHORS   Keough,R., Woollatt,E., Crawford,J., Sutherland,G.R., Plummer,S.,
            Casey,G. and Gonda,T.J.
  TITLE     Molecular cloning and chromosomal mapping of the human homologue of
            MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3
  JOURNAL   Genomics 62 (3), 483-489 (1999)
   PUBMED   10644447
REFERENCE   9  (bases 1 to 4558)
  AUTHORS   Tavner,F.J., Simpson,R., Tashiro,S., Favier,D., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G., Macmillan,E.M., Lutwyche,J.,
            Keough,R.A., Ishii,S. and Gonda,T.J.
  TITLE     Molecular cloning reveals that the p160 Myb-binding protein is a
            novel, predominantly nucleolar protein which may play a role in
            transactivation by Myb
  JOURNAL   Mol Cell Biol 18 (2), 989-1002 (1998)
   PUBMED   9447996
REFERENCE   10 (bases 1 to 4558)
  AUTHORS   Favier,D. and Gonda,T.J.
  TITLE     Detection of proteins that bind to the leucine zipper motif of
            c-Myb
  JOURNAL   Oncogene 9 (1), 305-311 (1994)
   PUBMED   8302594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC346952.1, BC050546.1,
            AC118754.6, BC000641.2, BF111023.1 and CB243989.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_014520.3.
            
            Summary: This gene encodes a nucleolar transcriptional regulator
            that was first identified by its ability to bind specifically to
            the Myb proto-oncogene protein. The encoded protein is thought to
            play a role in many cellular processes including response to
            nucleolar stress, tumor suppression and synthesis of ribosomal DNA.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) differs in the 3' structure
            resulting in a novel 3' coding region and 3' UTR compared to
            variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050546.1, SRR18074968.2060247.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254718.9/ ENSP00000254718.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC346952.1         3-57
            56-884              BC050546.1         1-829
            885-885             AC118754.6         108937-108937
            886-3142            BC050546.1         831-3087
            3143-4116           BC000641.2         797-1770
            4117-4524           BF111023.1         4-411
            4525-4558           CB243989.1         26-59               c
FEATURES             Location/Qualifiers
     source          1..4558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..4558
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /note="MYB binding protein 1a"
                     /db_xref="GeneID:10514"
                     /db_xref="HGNC:HGNC:7546"
                     /db_xref="MIM:604885"
     exon            1..258
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..4047
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     p53-activated protein-2; myb-binding protein 1A; MYB
                     binding protein (P160) 1a"
                     /codon_start=1
                     /product="myb-binding protein 1A isoform 2"
                     /protein_id="NP_055335.2"
                     /db_xref="CCDS:CCDS11046.1"
                     /db_xref="GeneID:10514"
                     /db_xref="HGNC:HGNC:7546"
                     /db_xref="MIM:604885"
                     /translation="MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAK
                     PEQETRLAATEKLLEYLRGRPKGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQS
                     FEDLPLCSILQQIQEKYDLHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSV
                     KLLQALAQYQNHLQEQPRKALVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELF
                     LLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLAL
                     KEDKFPRFWKEVVEQGLLKMQFWPASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYG
                     EHVCTAKLPKQFKFAPEMDDYVGTFLEGCQDDPERQLAVLVAFSSVTNQGLPVTPTFW
                     RVVRFLSPPALQGYVAWLRAMFLQPDLDSLVDFSTNNQKKAQDSSLHMPERAVFRLRK
                     WIIFRLVSIVDSLHLEMEEALTEQVARFCLFHSFFVTKKPTSQIPETKHPFSFPLENQ
                     AREAVSSAFFSLLQTLSTQFKQAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFT
                     AQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCI
                     RKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLT
                     PRALQLILDVLNPETSEDENDRVVVTDDSDERRLKGAEDKSEEGEDNRSSESEEESEG
                     EESEEEERDGDVDQGFREQLMTVLQAGKALGGEDSENEEELGDEAMMALDQSLASLFA
                     EQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSII
                     RRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQ
                     PDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLN
                     LVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQA
                     CLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLEL
                     LNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQR
                     PKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQ
                     PPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVN
                     GAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKA
                     QVRKAGKP"
     exon            259..354
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            355..438
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..513
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            514..621
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            622..797
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            798..965
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1083
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1379
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1490
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1616
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1784
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1884
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1981
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2133
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2220
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2370
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2541
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2699
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2952
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3078
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3147
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3255
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3357
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3494
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..4558
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4518..4523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /note="hexamer: AATAAA"
     polyA_site      4558
                     /gene="MYBBP1A"
                     /gene_synonym="P160; PAP2; Pol5"
                     /note="major polyA site"
ORIGIN      
        1 gacctggaag cggctggggc cggagcacac gtgtttcgtg tttcggtgag tgtggcggag
       61 atggagagcc gggatcccgc ccagccgatg tcgcctggag aagcgacgca gagtggcgcc
      121 cggcctgccg accgctatgg cctattgaag cacagtcgcg agttcttgga cttcttctgg
      181 gacattgcga agcctgagca ggagacgcga cttgcggcca cggagaagct gctggagtat
      241 ctgcgtggca ggccgaaggg gtccgagatg aaatatgccc tgaagcgtct aatcacggga
      301 ctcggggtcg ggcgagaaac agcccggccc tgctacagtt tggccctggc acagctgtta
      361 cagtcttttg aagacctccc cttgtgcagc atcctgcagc agatacaaga aaaatatgac
      421 ctgcatcagg tgaagaaggc aatgctgaga cctgctctct ttgcaaacct gtttggagtg
      481 ctcgccctct ttcagtcagg tcggctggtg aaggaccagg aggcactgat gaagtcggtg
      541 aagctgctgc aggccctggc ccagtaccaa aaccacttgc aggagcagcc ccggaaggcc
      601 ctggtggaca tcctctccga ggtctcgaag gccacattgc aggagatcct gccggaggtc
      661 ctcaaagccg acttgaatat aatactcagc tcccctgaac agctagagct cttcctcctg
      721 gcccagcaga aggtgccctc caagctcaag aagctggtgg gatccgtgaa cctattctca
      781 gatgagaatg tccccaggct ggtgaatgtg ctgaagatgg ccgcctcctc tgtgaagaag
      841 gaccgcaagc tgcccgccat tgctctggac ctgctccgcc tggcactcaa ggaagacaag
      901 ttcccacggt tctggaagga ggtggtggaa caagggctgc tgaagatgca gttctggcca
      961 gccagctacc tgtgtttccg cctgctgggc gcggccctgc ccctgctgac caaggagcag
     1021 ctgcacctgg tgatgcaggg agacgtgatc cgccattacg gggagcacgt gtgcactgct
     1081 aagctcccaa agcagttcaa gtttgcccca gagatggacg attacgtggg caccttccta
     1141 gaggggtgcc aggatgaccc tgagcggcag ctggccgtgc tagtggcctt ctcatctgtc
     1201 accaaccaag gcctccctgt cacgcctact ttctggcggg tcgtgcggtt cctgagccct
     1261 ccggccctgc agggctatgt ggcctggctg cgggccatgt ttctccagcc agacctggac
     1321 tccttggttg acttcagcac caacaaccag aagaaagccc aggattcatc gctccacatg
     1381 cctgagcgag ctgtgttccg gctgaggaaa tggatcatct ttcgattggt gagcattgtg
     1441 gacagcctgc acctggagat ggaggaggcc ttgactgagc aggtggccag gttttgtttg
     1501 ttccactcgt tctttgtcac aaagaagccc acatcccaga tccctgagac aaagcacccg
     1561 ttctccttcc ctttggaaaa ccaggcccga gaggctgtca gcagtgcctt cttcagtctg
     1621 ttgcagaccc tcagcacgca gttcaagcag gcaccgggcc agacccaggg tgggcagccc
     1681 tggacctacc acctggtgca gttcgcagac ctcctgttga atcacagcca caacgtgacc
     1741 accgtgacac ccttcactgc gcagcagcgc caggcctggg accggatgct gcagactctg
     1801 aaggagctgg aggcccactc cgcagaggcc agggctgctg ccttccagca ccttctgctc
     1861 ctcgtgggca tccacctcct caagtcccct gcagagagct gtgacctgct gggtgacatc
     1921 cagacctgca tcaggaaaag tctgggagag aagccccgcc ggagccgcac caagaccatc
     1981 gacccccagg aacccccgtg ggtagaggtg ctggtggaga tcttgctggc cctgttggcc
     2041 cagcccagcc acctcatgcg ccaggtggcc cggagcgtgt ttggccacat ctgctcccac
     2101 ctgaccccgc gtgccctgca gctaattctg gatgtgctga accccgagac cagtgaggat
     2161 gagaatgacc gtgtggtggt gacggacgat tctgatgagc ggcggctgaa gggtgcagag
     2221 gacaagagcg aggaaggtga ggacaacaga agctcagaga gtgaagagga gagcgagggg
     2281 gaggagagcg aggaggagga gcgcgacggg gacgtggatc agggcttccg ggaacagctg
     2341 atgaccgtgc tgcaggctgg gaaggcgctg ggtggagagg acagtgagaa cgaggaggag
     2401 ctgggggatg aggccatgat ggccctggac cagagcctcg ccagcctctt tgccgagcag
     2461 aagctgcgta tccaggcccg gcgagacgag aagaacaagc tgcagaagga gaaggctctg
     2521 cggcgcgact tccagatccg ggtgctggac ctggtggagg tgctagtgac caagcagccc
     2581 gagaatgccc tggtcctgga gctgctggag ccgctgctga gcatcatccg gcgcagcctg
     2641 cgcagcagca gctccaaaca ggagcaggac cttctgcaca agacggcgcg catcttcacg
     2701 caccacctgt gccgtgcccg gcgctactgc cacgacttgg gtgagcgcgc aggggccctg
     2761 cacgcccagg tggagcggtt ggtgcagcag gctggccgcc agcccgactc ccccaccgcc
     2821 ctctaccact tcaacgcctc tctctacctg ctccgggtct tgaagggcaa cactgctgag
     2881 ggctgcgtgc atgagacaca ggagaagcag aaagctggca ctgaccccag ccacatgccc
     2941 acgggcccgc aggctgccag ctgcttggac ttgaacctgg tgacccgggt gtactcgaca
     3001 gcactgagct ccttcctgac caagcgcaac agccccctca cagttcccat gttcctcagc
     3061 ctcttctccc ggcacccggt gctctgtcag agcctgctcc ccatcctggt ccagcatatc
     3121 acgggcccgg tgcggccccg tcatcaggcc tgcctgctgc tccagaagac cctgtccatg
     3181 cgggaggtga ggtcgtgctt tgaggacccc gagtggaagc agctgatggg ccaggtccta
     3241 gcaaaggtca ccgagaactt gcgcgtgctg ggggaggcgc agaccaaggc gcagcatcag
     3301 caggcactgt cctccctgga gctgctcaac gttctcttca ggacctgcaa acatgagaag
     3361 ctgaccttgg acctgacggt gctcctgggt gtgctgcagg ggcaacagca gagcctacag
     3421 cagggggcac actccaccgg ctccagccgc ctgcacgacc tctactggca ggccatgaaa
     3481 accctgggag tccagcgccc caagttggag aagaaggatg ccaaggagat ccccagtgcc
     3541 acccagagcc ccatcagtaa gaagcggaag aaaaagggat tcttgccaga gacgaagaag
     3601 cgcaagaaac gcaagtcaga ggatggcacg ccagcggagg atggcacacc tgcagccacc
     3661 ggcgggagcc agccccccag catgggcagg aagaagagga acaggacaaa ggctaaggtc
     3721 ccagcccagg caaacgggac gccaaccacc aagagtccag cccctggcgc ccccacccgg
     3781 agccccagca cccctgccaa atccccaaaa ctgcagaaga aaaaccagaa gccgtcccag
     3841 gtgaatggag ctcccgggtc ccccacggaa cctgcaggcc aaaagcagca tcagaaggct
     3901 cttcccaaaa agggggtctt gggcaaatca ccactgtccg cgctggcacg gaaaaaggca
     3961 aggctgtctt tggtcatcag gagtcccagc ctgcttcaga gtggggccaa gaagaaagca
     4021 caggtgagga aggcagggaa gccctgagca caggtacggg cccccctcag cccctgcctc
     4081 catctgcctg agacgcctat tttttttttt tttttttaaa ccatgatttt aatacgcaag
     4141 ctgtttctaa ggcgctgcca ctggggaggg tggctgttgc cgcctgcccg ggcatcctgc
     4201 tctggcaagc acagcctgag ccattcctgc aggggtccca gggtgcagag acctccccac
     4261 ccccggttct gggctgggac cctggctcca gggccatgtc cagggctctg gtgtttgcct
     4321 gggttggtgc aggttgatgt gctggctgca ggcaggtgtg accatctctc gtgcctgcca
     4381 cctctttgcc cccaggcttt tttgctgtga gggagccacc agggggtgat ttaaataggt
     4441 ttatttcttc atttacaaga ggaatatatt tggcttctct cttaagactc tgagattcac
     4501 aatcagcagc tctaaaaaat aaaggagcag tttggcttcc ggaaggaaga ggaggcaa
//
