LOCUS       NM_005375               3321 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens MYB proto-oncogene, transcription factor (MYB),
            transcript variant 2, mRNA.
ACCESSION   NM_005375
VERSION     NM_005375.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Liu,C., Wang,Y., Shi,M., Tao,X., Man,D., Zhang,J. and Han,B.
  TITLE     hnRNPA0 promotes MYB expression by interacting with enhancer lncRNA
            MY34UE-AS in human leukemia cells
  JOURNAL   Biochem Biophys Res Commun 724, 150221 (2024)
   PUBMED   38865811
  REMARK    GeneRIF: hnRNPA0 promotes MYB expression by interacting with
            enhancer lncRNA MY34UE-AS in human leukemia cells.
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Zhang,X.Y., Zhu,B.C., He,M. and Dong,S.S.
  TITLE     Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian
            cancer cells by downregulating lncRNA NKILA and modulating cancer
            stemness and LIN28A-let7 axis
  JOURNAL   J Ovarian Res 17 (1), 102 (2024)
   PUBMED   38745302
  REMARK    GeneRIF: Proto-oncogene c-Myb potentiates cisplatin resistance of
            ovarian cancer cells by downregulating lncRNA NKILA and modulating
            cancer stemness and LIN28A-let7 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Li,S.Q., Lv,F., Xu,W.T., Yin,Y.X., Wei,H.T., Li,K.Z. and Hu,B.L.
  TITLE     lncRNA SNHG4 inhibits ferroptosis by orchestrating miR-150-5p/c-Myb
            axis in colorectal cancer
  JOURNAL   Int J Biol Macromol 268 (Pt 2), 131961 (2024)
   PUBMED   38692535
  REMARK    GeneRIF: lncRNA SNHG4 inhibits ferroptosis by orchestrating
            miR-150-5p/c-Myb axis in colorectal cancer.
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Zhou,Y.E., O'Rourke,J.P., Edwards,J.S. and Ness,S.A.
  TITLE     Single molecule analysis of c-myb alternative splicing reveals
            novel classifiers for precursor B-ALL
  JOURNAL   PLoS One 6 (8), e22880 (2011)
   PUBMED   21853052
  REMARK    GeneRIF: c-myb alternative RNA splicing was elevated and much more
            complex in leukemia samples.
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   O'Rourke,J.P. and Ness,S.A.
  TITLE     Alternative RNA splicing produces multiple forms of c-Myb with
            unique transcriptional activities
  JOURNAL   Mol Cell Biol 28 (6), 2091-2101 (2008)
   PUBMED   18195038
  REMARK    GeneRIF: An array of variant transcripts, expressed in highly
            regulated, lineage-specific patterns were formed from alternate
            exons 8A, 9A, 9B, 10A, 13A, & 14A. They encoded c-Myb proteins with
            identical DNA binding domains but unique C-terminal domains.
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Nicolaides,N.C., Gualdi,R., Casadevall,C., Manzella,L. and
            Calabretta,B.
  TITLE     Positive autoregulation of c-myb expression via Myb binding sites
            in the 5' flanking region of the human c-myb gene
  JOURNAL   Mol Cell Biol 11 (12), 6166-6176 (1991)
   PUBMED   1944282
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Westin,E.H., Gorse,K.M. and Clarke,M.F.
  TITLE     Alternative splicing of the human c-myb gene
  JOURNAL   Oncogene 5 (8), 1117-1124 (1990)
   PUBMED   2202948
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Kalkbrenner,F., Guehmann,S. and Moelling,K.
  TITLE     Transcriptional activation by human c-myb and v-myb genes
  JOURNAL   Oncogene 5 (5), 657-661 (1990)
   PUBMED   2189102
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Dasgupta,P. and Reddy,E.P.
  TITLE     Identification of alternatively spliced transcripts for human
            c-myb: molecular cloning and sequence analysis of human c-myb exon
            9A sequences
  JOURNAL   Oncogene 4 (12), 1419-1423 (1989)
   PUBMED   2687764
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Majello,B., Kenyon,L.C. and Dalla-Favera,R.
  TITLE     Human c-myb protooncogene: nucleotide sequence of cDNA and
            organization of the genomic locus
  JOURNAL   Proc Natl Acad Sci U S A 83 (24), 9636-9640 (1986)
   PUBMED   3540945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL023693.25, X52125.1,
            BC064955.1 and D25774.1.
            
            On May 31, 2019 this sequence version replaced NM_005375.3.
            
            Summary: This gene encodes a protein with three HTH DNA-binding
            domains that functions as a transcription regulator. This protein
            plays an essential role in the regulation of hematopoiesis. This
            gene may be aberrently expressed or rearranged or undergo
            translocation in leukemias and lymphomas, and is considered to be
            an oncogene. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2, also known as M15024) lacks an
            alternate in-frame exon compared to variant 1. The resulting
            isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064955.1, AJ616235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL023693.25        68622-68628
            8-92                X52125.1           1-85
            93-3317             BC064955.1         38-3262
            3318-3321           D25774.1           154-157
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..3321
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="MYB proto-oncogene, transcription factor"
                     /db_xref="GeneID:4602"
                     /db_xref="HGNC:HGNC:7545"
                     /db_xref="MIM:189990"
     exon            1..229
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2129
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcriptional activator Myb; proto-oncogene c-Myb;
                     oncogene AMV; v-myb avian myeloblastosis viral oncogene
                     homolog; MYB-GATA1 fusion protein"
                     /codon_start=1
                     /product="transcriptional activator Myb isoform 2"
                     /protein_id="NP_005366.2"
                     /db_xref="CCDS:CCDS5174.1"
                     /db_xref="GeneID:4602"
                     /db_xref="HGNC:HGNC:7545"
                     /db_xref="MIM:189990"
                     /translation="MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWT
                     REEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQR
                     VIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHK
                     RLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNS
                     HLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPA
                     AAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIAD
                     HTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEF
                     AETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVF
                     RTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDE
                     SGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAP
                     NILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQMTSSS
                     QARKYVNAFSARTLVM"
     exon            230..347
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            348..419
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            420..512
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            513..733
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            734..968
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1049
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1154
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1409
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1552
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1667
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1793
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1904
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2012
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3321
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="major polyA site"
ORIGIN      
        1 acactttaat atcaacctgt ttcctcctcc tccttctcct cctcctccgt gacctcctcc
       61 tcctctttct cctgagaaac ttcgccccag cggtgcggag cgccgctgcg cagccgggga
      121 gggacgcagg caggcggcgg gcagcgggag gcggcagccc ggtgcggtcc ccgcggctct
      181 cggcggagcc ccgcgcccgc cgcgccatgg cccgaagacc ccggcacagc atatatagca
      241 gtgacgagga tgatgaggac tttgagatgt gtgaccatga ctatgatggg ctgcttccca
      301 agtctggaaa gcgtcacttg gggaaaacaa ggtggacccg ggaagaggat gaaaaactga
      361 agaagctggt ggaacagaat ggaacagatg actggaaagt tattgccaat tatctcccga
      421 atcgaacaga tgtgcagtgc cagcaccgat ggcagaaagt actaaaccct gagctcatca
      481 agggtccttg gaccaaagaa gaagatcaga gagtgataga gcttgtacag aaatacggtc
      541 cgaaacgttg gtctgttatt gccaagcact taaaggggag aattggaaaa caatgtaggg
      601 agaggtggca taaccacttg aatccagaag ttaagaaaac ctcctggaca gaagaggaag
      661 acagaattat ttaccaggca cacaagagac tggggaacag atgggcagaa atcgcaaagc
      721 tactgcctgg acgaactgat aatgctatca agaaccactg gaattctaca atgcgtcgga
      781 aggtcgaaca ggaaggttat ctgcaggagt cttcaaaagc cagccagcca gcagtggcca
      841 caagcttcca gaagaacagt catttgatgg gttttgctca ggctccgcct acagctcaac
      901 tccctgccac tggccagccc actgttaaca acgactattc ctattaccac atttctgaag
      961 cacaaaatgt ctccagtcat gttccatacc ctgtagcgtt acatgtaaat atagtcaatg
     1021 tccctcagcc agctgccgca gccattcaga gacactataa tgatgaagac cctgagaagg
     1081 aaaagcgaat aaaggaatta gaattgctcc taatgtcaac cgagaatgag ctaaaaggac
     1141 agcaggtgct accaacacag aaccacacat gcagctaccc cgggtggcac agcaccacca
     1201 ttgccgacca caccagacct catggagaca gtgcacctgt ttcctgtttg ggagaacacc
     1261 actccactcc atctctgcca gcggatcctg gctccctacc tgaagaaagc gcctcgccag
     1321 caaggtgcat gatcgtccac cagggcacca ttctggataa tgttaagaac ctcttagaat
     1381 ttgcagaaac actccaattt atagattctt tcttaaacac ttccagtaac catgaaaact
     1441 cagacttgga aatgccttct ttaacttcca cccccctcat tggtcacaaa ttgactgtta
     1501 caacaccatt tcatagagac cagactgtga aaactcaaaa ggaaaatact gtttttagaa
     1561 ccccagctat caaaaggtca atcttagaaa gctctccaag aactcctaca ccattcaaac
     1621 atgcacttgc agctcaagaa attaaatacg gtcccctgaa gatgctacct cagacaccct
     1681 ctcatctagt agaagatctg caggatgtga tcaaacagga atctgatgaa tctggaattg
     1741 ttgctgagtt tcaagaaaat ggaccaccct tactgaagaa aatcaaacaa gaggtggaat
     1801 ctccaactga taaatcagga aacttcttct gctcacacca ctgggaaggg gacagtctga
     1861 atacccaact gttcacgcag acctcgcctg tggcagatgc accgaatatt cttacaagct
     1921 ccgttttaat ggcaccagca tcagaagatg aagacaatgt tctcaaagca tttacagtac
     1981 ctaaaaacag gtccctggcg agccccttgc agccttgtag cagtacctgg gaacctgcat
     2041 cctgtggaaa gatggaggag cagatgacat cttccagtca agctcgtaaa tacgtgaatg
     2101 cattctcagc ccggacgctg gtcatgtgag acatttccag aaaagcatta tggttttcag
     2161 aacacttcaa gttgacttgg gatatatcat tcctcaacat gaaacttttc atgaatggga
     2221 gaagaaccta tttttgttgt ggtacaacag ttgagagcag caccaagtgc atttagttga
     2281 atgaagtctt cttggatttc acccaactaa aaggattttt aaaaataaat aacagtctta
     2341 cctaaattat taggtaatga attgtagcca gttgttaata tcttaatgca gattttttta
     2401 aaaaaaacat aaaatgattt atctgtattt taaaggatcc aacagatcag tattttttcc
     2461 tgtgatgggt tttttgaaat ttgacacatt aaaaggtact ccagtatttc acttttctcg
     2521 atcactaaac atatgcatat atttttaaaa atcagtaaaa gcattactct aagtgtagac
     2581 ttaataccat gtgacattta atccagattg taaatgctca tttatggtta atgacattga
     2641 aggtacattt attgtaccaa accattttat gagttttctg ttagcttgct ttaaaaatta
     2701 ttactgtaag aaatagtttt ataaaaaatt atatttttat tcagtaattt aattttgtaa
     2761 atgccaaatg aaaaacgttt tttgctgcta tggtcttagc ctgtagacat gctgctagta
     2821 tcagaggggc agtagagctt ggacagaaag aaaagaaact tggtgttagg taattgacta
     2881 tgcactagta tttcagactt tttaatttta tatatatata catttttttt ccttctgcaa
     2941 tacatttgaa aacttgtttg ggagactctg cattttttat tgtggttttt ttgttattgt
     3001 tggtttatac aagcatgcgt tgcacttctt ttttgggaga tgtgtgttgt tgatgttcta
     3061 tgttttgttt tgagtgtagc ctgactgttt tataatttgg gagttctgca tttgatccgc
     3121 atcccctgtg gtttctaagt gtatggtctc agaactgttg catggatcct gtgtttgcaa
     3181 ctggggagac agaaactgtg gttgatagcc agtcactgcc ttaagaacat ttgatgcaag
     3241 atggccagca ctgaactttt gagatatgac ggtgtactta ctgccttgta gcaaaataaa
     3301 gatgtgccct tattttacct a
//
