LOCUS       NM_001130173            3684 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens MYB proto-oncogene, transcription factor (MYB),
            transcript variant 1, mRNA.
ACCESSION   NM_001130173
VERSION     NM_001130173.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Liu,C., Wang,Y., Shi,M., Tao,X., Man,D., Zhang,J. and Han,B.
  TITLE     hnRNPA0 promotes MYB expression by interacting with enhancer lncRNA
            MY34UE-AS in human leukemia cells
  JOURNAL   Biochem Biophys Res Commun 724, 150221 (2024)
   PUBMED   38865811
  REMARK    GeneRIF: hnRNPA0 promotes MYB expression by interacting with
            enhancer lncRNA MY34UE-AS in human leukemia cells.
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Zhang,X.Y., Zhu,B.C., He,M. and Dong,S.S.
  TITLE     Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian
            cancer cells by downregulating lncRNA NKILA and modulating cancer
            stemness and LIN28A-let7 axis
  JOURNAL   J Ovarian Res 17 (1), 102 (2024)
   PUBMED   38745302
  REMARK    GeneRIF: Proto-oncogene c-Myb potentiates cisplatin resistance of
            ovarian cancer cells by downregulating lncRNA NKILA and modulating
            cancer stemness and LIN28A-let7 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Li,S.Q., Lv,F., Xu,W.T., Yin,Y.X., Wei,H.T., Li,K.Z. and Hu,B.L.
  TITLE     lncRNA SNHG4 inhibits ferroptosis by orchestrating miR-150-5p/c-Myb
            axis in colorectal cancer
  JOURNAL   Int J Biol Macromol 268 (Pt 2), 131961 (2024)
   PUBMED   38692535
  REMARK    GeneRIF: lncRNA SNHG4 inhibits ferroptosis by orchestrating
            miR-150-5p/c-Myb axis in colorectal cancer.
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Zhou,Y.E., O'Rourke,J.P., Edwards,J.S. and Ness,S.A.
  TITLE     Single molecule analysis of c-myb alternative splicing reveals
            novel classifiers for precursor B-ALL
  JOURNAL   PLoS One 6 (8), e22880 (2011)
   PUBMED   21853052
  REMARK    GeneRIF: c-myb alternative RNA splicing was elevated and much more
            complex in leukemia samples.
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   O'Rourke,J.P. and Ness,S.A.
  TITLE     Alternative RNA splicing produces multiple forms of c-Myb with
            unique transcriptional activities
  JOURNAL   Mol Cell Biol 28 (6), 2091-2101 (2008)
   PUBMED   18195038
  REMARK    GeneRIF: An array of variant transcripts, expressed in highly
            regulated, lineage-specific patterns were formed from alternate
            exons 8A, 9A, 9B, 10A, 13A, & 14A. They encoded c-Myb proteins with
            identical DNA binding domains but unique C-terminal domains.
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Nicolaides,N.C., Gualdi,R., Casadevall,C., Manzella,L. and
            Calabretta,B.
  TITLE     Positive autoregulation of c-myb expression via Myb binding sites
            in the 5' flanking region of the human c-myb gene
  JOURNAL   Mol Cell Biol 11 (12), 6166-6176 (1991)
   PUBMED   1944282
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Westin,E.H., Gorse,K.M. and Clarke,M.F.
  TITLE     Alternative splicing of the human c-myb gene
  JOURNAL   Oncogene 5 (8), 1117-1124 (1990)
   PUBMED   2202948
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Kalkbrenner,F., Guehmann,S. and Moelling,K.
  TITLE     Transcriptional activation by human c-myb and v-myb genes
  JOURNAL   Oncogene 5 (5), 657-661 (1990)
   PUBMED   2189102
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Dasgupta,P. and Reddy,E.P.
  TITLE     Identification of alternatively spliced transcripts for human
            c-myb: molecular cloning and sequence analysis of human c-myb exon
            9A sequences
  JOURNAL   Oncogene 4 (12), 1419-1423 (1989)
   PUBMED   2687764
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Majello,B., Kenyon,L.C. and Dalla-Favera,R.
  TITLE     Human c-myb protooncogene: nucleotide sequence of cDNA and
            organization of the genomic locus
  JOURNAL   Proc Natl Acad Sci U S A 83 (24), 9636-9640 (1986)
   PUBMED   3540945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL023693.25, AJ606319.1 and
            D25774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001130173.1.
            
            Summary: This gene encodes a protein with three HTH DNA-binding
            domains that functions as a transcription regulator. This protein
            plays an essential role in the regulation of hematopoiesis. This
            gene may be aberrently expressed or rearranged or undergo
            translocation in leukemias and lymphomas, and is considered to be
            an oncogene. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1, also known as 9Aii) represents
            the longest transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ606319.1, AY787467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341911.10/ ENSP00000339992.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL023693.25        68622-68628
            8-3679              AJ606319.1         1-3672
            3680-3684           D25774.1           153-157
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..3684
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="MYB proto-oncogene, transcription factor"
                     /db_xref="GeneID:4602"
                     /db_xref="HGNC:HGNC:7545"
                     /db_xref="MIM:189990"
     exon            1..229
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2492
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcriptional activator Myb; proto-oncogene c-Myb;
                     oncogene AMV; v-myb avian myeloblastosis viral oncogene
                     homolog; MYB-GATA1 fusion protein"
                     /codon_start=1
                     /product="transcriptional activator Myb isoform 1"
                     /protein_id="NP_001123645.1"
                     /db_xref="CCDS:CCDS47481.1"
                     /db_xref="GeneID:4602"
                     /db_xref="HGNC:HGNC:7545"
                     /db_xref="MIM:189990"
                     /translation="MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWT
                     REEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQR
                     VIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHK
                     RLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNS
                     HLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPA
                     AAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIAD
                     HTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEF
                     AETLQFIDSDSSSWCDLSSFEFFEEADFSPSQHHTGKALQLQQREGNGTKPAGEPSPR
                     VNKRMLSESSLDPPKVLPPARHSTIPLVILRKKRGQASPLATGDCSSFIFADVSSSTP
                     KRSPVKSLPFSPSQFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQK
                     ENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIK
                     QESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSP
                     VADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQ
                     MTSSSQARKYVNAFSARTLVM"
     exon            230..347
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            348..419
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            420..512
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            513..733
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            734..968
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1049
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1154
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1409
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1772
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1915
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2030
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2156
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2267
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2375
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..3684
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="hexamer: AATAAA"
     polyA_site      3684
                     /gene="MYB"
                     /gene_synonym="c-myb; c-myb_CDS; Cmyb; efg"
                     /note="major polyA site"
ORIGIN      
        1 acactttaat atcaacctgt ttcctcctcc tccttctcct cctcctccgt gacctcctcc
       61 tcctctttct cctgagaaac ttcgccccag cggtgcggag cgccgctgcg cagccgggga
      121 gggacgcagg caggcggcgg gcagcgggag gcggcagccc ggtgcggtcc ccgcggctct
      181 cggcggagcc ccgcgcccgc cgcgccatgg cccgaagacc ccggcacagc atatatagca
      241 gtgacgagga tgatgaggac tttgagatgt gtgaccatga ctatgatggg ctgcttccca
      301 agtctggaaa gcgtcacttg gggaaaacaa ggtggacccg ggaagaggat gaaaaactga
      361 agaagctggt ggaacagaat ggaacagatg actggaaagt tattgccaat tatctcccga
      421 atcgaacaga tgtgcagtgc cagcaccgat ggcagaaagt actaaaccct gagctcatca
      481 agggtccttg gaccaaagaa gaagatcaga gagtgataga gcttgtacag aaatacggtc
      541 cgaaacgttg gtctgttatt gccaagcact taaaggggag aattggaaaa caatgtaggg
      601 agaggtggca taaccacttg aatccagaag ttaagaaaac ctcctggaca gaagaggaag
      661 acagaattat ttaccaggca cacaagagac tggggaacag atgggcagaa atcgcaaagc
      721 tactgcctgg acgaactgat aatgctatca agaaccactg gaattctaca atgcgtcgga
      781 aggtcgaaca ggaaggttat ctgcaggagt cttcaaaagc cagccagcca gcagtggcca
      841 caagcttcca gaagaacagt catttgatgg gttttgctca ggctccgcct acagctcaac
      901 tccctgccac tggccagccc actgttaaca acgactattc ctattaccac atttctgaag
      961 cacaaaatgt ctccagtcat gttccatacc ctgtagcgtt acatgtaaat atagtcaatg
     1021 tccctcagcc agctgccgca gccattcaga gacactataa tgatgaagac cctgagaagg
     1081 aaaagcgaat aaaggaatta gaattgctcc taatgtcaac cgagaatgag ctaaaaggac
     1141 agcaggtgct accaacacag aaccacacat gcagctaccc cgggtggcac agcaccacca
     1201 ttgccgacca caccagacct catggagaca gtgcacctgt ttcctgtttg ggagaacacc
     1261 actccactcc atctctgcca gcggatcctg gctccctacc tgaagaaagc gcctcgccag
     1321 caaggtgcat gatcgtccac cagggcacca ttctggataa tgttaagaac ctcttagaat
     1381 ttgcagaaac actccaattt atagattctg attcttcatc atggtgtgat ctcagcagtt
     1441 ttgaattctt tgaagaagca gatttttcac ctagccaaca tcacacaggc aaagccctac
     1501 agcttcagca aagagagggc aatgggacta aacctgcagg agaacctagc ccaagggtga
     1561 acaaacgtat gttgagtgag agttcacttg acccacccaa ggtcttacct cctgcaaggc
     1621 acagcacaat tccactggtc atccttcgaa aaaaacgggg ccaggccagc cccttagcca
     1681 ctggagactg tagctccttc atatttgctg acgtcagcag ttcaactccc aagcgttccc
     1741 ctgtcaaaag cctacccttc tctccctcgc agttcttaaa cacttccagt aaccatgaaa
     1801 actcagactt ggaaatgcct tctttaactt ccacccccct cattggtcac aaattgactg
     1861 ttacaacacc atttcataga gaccagactg tgaaaactca aaaggaaaat actgttttta
     1921 gaaccccagc tatcaaaagg tcaatcttag aaagctctcc aagaactcct acaccattca
     1981 aacatgcact tgcagctcaa gaaattaaat acggtcccct gaagatgcta cctcagacac
     2041 cctctcatct agtagaagat ctgcaggatg tgatcaaaca ggaatctgat gaatctggaa
     2101 ttgttgctga gtttcaagaa aatggaccac ccttactgaa gaaaatcaaa caagaggtgg
     2161 aatctccaac tgataaatca ggaaacttct tctgctcaca ccactgggaa ggggacagtc
     2221 tgaataccca actgttcacg cagacctcgc ctgtggcaga tgcaccgaat attcttacaa
     2281 gctccgtttt aatggcacca gcatcagaag atgaagacaa tgttctcaaa gcatttacag
     2341 tacctaaaaa caggtccctg gcgagcccct tgcagccttg tagcagtacc tgggaacctg
     2401 catcctgtgg aaagatggag gagcagatga catcttccag tcaagctcgt aaatacgtga
     2461 atgcattctc agcccggacg ctggtcatgt gagacatttc cagaaaagca ttatggtttt
     2521 cagaacactt caagttgact tgggatatat cattcctcaa catgaaactt ttcatgaatg
     2581 ggagaagaac ctatttttgt tgtggtacaa cagttgagag cagcaccaag tgcatttagt
     2641 tgaatgaagt cttcttggat ttcacccaac taaaaggatt tttaaaaata aataacagtc
     2701 ttacctaaat tattaggtaa tgaattgtag ccagttgtta atatcttaat gcagattttt
     2761 ttaaaaaaaa cataaaatga tttatctgta ttttaaagga tccaacagat cagtattttt
     2821 tcctgtgatg ggttttttga aatttgacac attaaaaggt actccagtat ttcacttttc
     2881 tcgatcacta aacatatgca tatattttta aaaatcagta aaagcattac tctaagtgta
     2941 gacttaatac catgtgacat ttaatccaga ttgtaaatgc tcatttatgg ttaatgacat
     3001 tgaaggtaca tttattgtac caaaccattt tatgagtttt ctgttagctt gctttaaaaa
     3061 ttattactgt aagaaatagt tttataaaaa attatatttt tattcagtaa tttaattttg
     3121 taaatgccaa atgaaaaacg ttttttgctg ctatggtctt agcctgtaga catgctgcta
     3181 gtatcagagg ggcagtagag cttggacaga aagaaaagaa acttggtgtt aggtaattga
     3241 ctatgcacta gtatttcaga ctttttaatt ttatatatat atacattttt tttccttctg
     3301 caatacattt gaaaacttgt ttgggagact ctgcattttt tattgtggtt tttttgttat
     3361 tgttggttta tacaagcatg cgttgcactt cttttttggg agatgtgtgt tgttgatgtt
     3421 ctatgttttg ttttgagtgt agcctgactg ttttataatt tgggagttct gcatttgatc
     3481 cgcatcccct gtggtttcta agtgtatggt ctcagaactg ttgcatggat cctgtgtttg
     3541 caactgggga gacagaaact gtggttgata gccagtcact gccttaagaa catttgatgc
     3601 aagatggcca gcactgaact tttgagatat gacggtgtac ttactgcctt gtagcaaaat
     3661 aaagatgtgc ccttatttta ccta
//
