LOCUS       NM_138373               3054 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens myeloid associated differentiation marker (MYADM),
            transcript variant 2, mRNA.
ACCESSION   NM_138373
VERSION     NM_138373.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Wang,J., Shen,Y., Zhang,Y., Lin,D., Wang,Q., Sun,X., Wei,D.,
            Shen,B., Chen,J., Ji,Y., Fulton,D., Yu,Y., Chen,F. and Hu,L.
  TITLE     Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular
            Remodeling by Regulating Myadm Transcript Stability
  JOURNAL   Hypertension 81 (8), 1785-1798 (2024)
   PUBMED   38832511
  REMARK    GeneRIF: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary
            Vascular Remodeling by Regulating Myadm Transcript Stability.
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Qiao,W., Richards,C.M., Kim,Y., Zengel,J.R., Ding,S.,
            Greenberg,H.B. and Carette,J.E.
  TITLE     MYADM binds human parechovirus 1 and is essential for viral entry
  JOURNAL   Nat Commun 15 (1), 3469 (2024)
   PUBMED   38658526
  REMARK    GeneRIF: MYADM binds human parechovirus 1 and is essential for
            viral entry.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Watanabe,K., Oka,T., Takagi,H., Anisimov,S., Yamashita,S.I.,
            Katsuragi,Y., Takahashi,M., Higuchi,M., Kanki,T., Saitoh,A. and
            Fujii,M.
  TITLE     Myeloid-associated differentiation marker is an essential host
            factor for human parechovirus PeV-A3 entry
  JOURNAL   Nat Commun 14 (1), 1817 (2023)
   PUBMED   37002207
  REMARK    GeneRIF: Myeloid-associated differentiation marker is an essential
            host factor for human parechovirus PeV-A3 entry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Dy,A.B.C., Langlais,P.R., Barker,N.K., Addison,K.J.,
            Tanyaratsrisakul,S., Boitano,S., Christenson,S.A., Kraft,M.,
            Meyers,D., Bleecker,E.R., Li,X. and Ledford,J.G.
  TITLE     Myeloid-associated differentiation marker is a novel
            SP-A-associated transmembrane protein whose expression on airway
            epithelial cells correlates with asthma severity
  JOURNAL   Sci Rep 11 (1), 23392 (2021)
   PUBMED   34862427
  REMARK    GeneRIF: Myeloid-associated differentiation marker is a novel
            SP-A-associated transmembrane protein whose expression on airway
            epithelial cells correlates with asthma severity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Aranda,J.F., Reglero-Real,N., Kremer,L., Marcos-Ramiro,B.,
            Ruiz-Saenz,A., Calvo,M., Enrich,C., Correas,I., Millan,J. and
            Alonso,M.A.
  TITLE     MYADM regulates Rac1 targeting to ordered membranes required for
            cell spreading and migration
  JOURNAL   Mol Biol Cell 22 (8), 1252-1262 (2011)
   PUBMED   21325632
  REMARK    GeneRIF: Myeloid-associated differentiation marker (MYADM)
            regulates Rac1 targeting to ordered membranes required for cell
            spreading and migration.
REFERENCE   7  (bases 1 to 3054)
  AUTHORS   Wang,Q., Li,N., Wang,X., Shen,J., Hong,X., Yu,H., Zhang,Y., Wan,T.,
            Zhang,L., Wang,J. and Cao,X.
  TITLE     Membrane protein hMYADM preferentially expressed in myeloid cells
            is up-regulated during differentiation of stem cells and myeloid
            leukemia cells
  JOURNAL   Life Sci 80 (5), 420-429 (2007)
   PUBMED   17097684
REFERENCE   8  (bases 1 to 3054)
  AUTHORS   de Wit,N.J., Rijntjes,J., Diepstra,J.H., van Kuppevelt,T.H.,
            Weidle,U.H., Ruiter,D.J. and van Muijen,G.N.
  TITLE     Analysis of differential gene expression in human melanocytic
            tumour lesions by custom made oligonucleotide arrays
  JOURNAL   Br J Cancer 92 (12), 2249-2261 (2005)
   PUBMED   15900300
REFERENCE   9  (bases 1 to 3054)
  AUTHORS   Cui,W., Yu,L., He,H., Chu,Y., Gao,J., Wan,B., Tang,L. and Zhao,S.
  TITLE     Cloning of human myeloid-associated differentiation marker (MYADM)
            gene whose expression was up-regulated in NB4 cells induced by
            all-trans retinoic acid
  JOURNAL   Mol Biol Rep 28 (3), 123-138 (2001)
   PUBMED   12075932
  REMARK    GeneRIF: Cloning and characterization of human MYADM gene whose
            expression was up-regulated in NB4 cells induced by all-trans
            retinoic acid.
REFERENCE   10 (bases 1 to 3054)
  AUTHORS   Pettersson,M., Dannaeus,K., Nilsson,K. and Jonsson,J.I.
  TITLE     Isolation of MYADM, a novel hematopoietic-associated marker gene
            expressed in multipotent progenitor cells and up-regulated during
            myeloid differentiation
  JOURNAL   J Leukoc Biol 67 (3), 423-431 (2000)
   PUBMED   10733104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA948116.1, AC008440.9 and AF087882.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138373.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 6. All twelve variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095412.1, AY358582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391770.9/ ENSP00000375650.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               DA948116.1         19-127
            110-110             AC008440.9         14166-14166
            111-537             DA948116.1         129-555
            538-2938            AC008440.9         18283-20683
            2939-3054           AF087882.1         3054-3169
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3054
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="myeloid associated differentiation marker"
                     /db_xref="GeneID:91663"
                     /db_xref="HGNC:HGNC:7544"
                     /db_xref="MIM:609959"
     exon            1..61
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     exon            62..146
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     exon            147..3054
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1117
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="myeloid upregulated protein"
                     /codon_start=1
                     /product="myeloid-associated differentiation marker"
                     /protein_id="NP_612382.1"
                     /db_xref="CCDS:CCDS12866.1"
                     /db_xref="GeneID:91663"
                     /db_xref="HGNC:HGNC:7544"
                     /db_xref="MIM:609959"
                     /translation="MPVTVTRTTITTTTTSSSGLGSPMIVGSPRALTQPLGLLRLLQL
                     VSTCVAFSLVASVGAWTGSMGNWSMFTWCFCFSVTLIILIVELCGLQARFPLSWRNFP
                     ITFACYAALFCLSASIIYPTTYVQFLSHGRSRDHAIAATFFSCIACVAYATEVAWTRA
                     RPGEITGYMATVPGLLKVLETFVACIIFAFISDPNLYQHQPALEWCVAVYAICFILAA
                     IAILLNLGECTNVLPIPFPSFLSGLALLSVLLYATALVLWPLYQFDEKYGGQPRRSRD
                     VSCSRSHAYYVCAWDRRLAVAILTAINLLAYVADLVHSAHLVFVKV"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="hexamer: TATAAA"
     polyA_site      3051
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="major polyA site"
     polyA_site      3054
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="major polyA site"
ORIGIN      
        1 agacccttcc agctgccgct gtcgtctttg cttcagccgc agtcgccact ggctgcctga
       61 ggtgctctta cagcctgttc caagtgtggc ttaatccgtc tccaccacca gatctttctc
      121 cgtggattcc tctgctaaga ccgctgccat gccagtgacg gtaacccgca ccaccatcac
      181 aaccaccacg acgtcatctt cgggcctggg gtcccccatg atcgtggggt cccctcgggc
      241 cctgacacag cccctgggtc tccttcgcct gctgcagctg gtgtctacct gcgtggcctt
      301 ctcgctggtg gctagcgtgg gcgcctggac ggggtccatg ggcaactggt ccatgttcac
      361 ctggtgcttc tgcttctccg tgaccctgat catcctcatc gtggagctgt gcgggctcca
      421 ggcccgcttc cccctgtctt ggcgcaactt ccccatcacc ttcgcctgct atgcggccct
      481 cttctgcctc tcggcctcca tcatctaccc caccacctat gtccagttcc tgtcccacgg
      541 ccgttcgcgg gaccacgcca tcgccgccac cttcttctcc tgcatcgcgt gtgtggctta
      601 cgccaccgaa gtggcctgga cccgggcccg gcccggcgag atcactggct atatggccac
      661 cgtacccggg ctgctgaagg tgctggagac cttcgttgcc tgcatcatct tcgcgttcat
      721 cagcgacccc aacctgtacc agcaccagcc ggccctggag tggtgcgtgg cggtgtacgc
      781 catctgcttc atcctagcgg ccatcgccat cctgctgaac ctgggggagt gcaccaacgt
      841 gctacccatc cccttcccca gcttcctgtc ggggctggcc ttgctgtctg tcctcctcta
      901 tgccaccgcc cttgttctct ggcccctcta ccagttcgat gagaagtatg gcggccagcc
      961 tcggcgctcg agagatgtaa gctgcagccg cagccatgcc tactacgtgt gtgcctggga
     1021 ccgccgactg gctgtggcca tcctgacggc catcaaccta ctggcgtatg tggctgacct
     1081 ggtgcactct gcccacctgg tttttgtcaa ggtctaagac tctcccaaga ggctcccgtt
     1141 ccctctccaa cctctttgtt cttcttgccc gagttttctt tatggagtac ttctttcctc
     1201 cgcctttcct ctgttttcct cttcctgtct cccctccctc ccaccttttt ctttccttcc
     1261 caattccttg cactctaacc agttcttgga tgcatcttct tccttccctt tcctcttgct
     1321 gtttccttcc tgtgttgttt tgttgcccac atcctgtttt cacccctgag ctgtttctct
     1381 ttttcttttc tttttttttt tttttttttt ttaagacgga ttctcactct gtggcccagg
     1441 ctggagtgca gtggtgcgat ctcgactcac tgcaaccccc gcctcctggg ttcaagcgat
     1501 tctcctgccc cagcctccca agtagctggg aggacaggtg tgagctgccg cacccagcct
     1561 gtttctcttt ttccactctt cttttttctc atctcttttc tgggttgcct gtcggctttc
     1621 ttatctgcct gttttgcaag caccttctcc tgtgtccttg ggagccctga gacttctttc
     1681 tctccttgcc tccacccacc tccaaaggtg ctgagctcac atccacaccc cttgcagccg
     1741 tccatgccac agccccccaa ggggccccat tgccaaagca tgcctgccca ccctcgctgt
     1801 gccttagtca gtgtgtacgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ttggggggtg
     1861 gggggtgggt agctggggat tgggccctct ttctcccagt ggaggaaggt gtgcagtgta
     1921 cttccccttt aaattaaaaa acatatatat atatatattt ggaggtcagt aatttccaat
     1981 gggcgggagg ctttaagcac cgaccctggg tccctaggcc ccgcctggca ctcagccttg
     2041 ccagagattg gctccagaat ttttgccagg cttacagaac acccactgcc tagaggccat
     2101 cttaaaggaa gcaggggctg gatgcctttc atcccaacta ttctctgtgg tatcaaaaag
     2161 aaaaaaaaaa aaaaagaagg agtcggggcc gggcgtggtg gctcacgcct gtaatcccag
     2221 cactttggga gaccaagtca ggcaatcatc tgaagtcagg agttcaagac cagcctggcc
     2281 aacatggtga aagcatgtct ctattaaaaa tacaaaaatt agccgggcgt ggtggcgggc
     2341 gcctgtaatc ccaggtattt ggggggactg agacaggaga atcccttcaa cccgggaggt
     2401 ggaggttgca gtaagtcaag atggcaccac tgtgctccag cctgggggac agagcgagac
     2461 tccatctcaa aaaaaaaaag gaatcggacg aagaaccaca ggatgttgaa gacaactgtc
     2521 tgaagtattt gtgagggaca gcgatgtggc cctctgtgtt aagaataacg tgtcctgctt
     2581 tggcagagag aagaaaatag ccactgcccg ctttcaaggc aagatcgacc ttttctgttt
     2641 tgttttgttt ttctttcttt ttcctggcca tgaggacaaa aattactgag tggcccttaa
     2701 agagggaagt ttgttttcag ctgttctctt ttgcccgtag gtgggagggt ggggattgct
     2761 gcgtcctagc tagaggaatg gctttgcttg aatgtgtagt gcacacgcac gggtgtttct
     2821 gtgtgctagt tgcttcttgc tgctgcttcc tgcttgtctg ggactcacat acataacgtg
     2881 atatatatat atatatatat aaatgtataa atatatattt tatttttttt taaatccctg
     2941 gagcttctgg ttcctatcag ttcctgttgt taatcgtaga accgttgtcc cttcccccat
     3001 tcccgtatcc atcatgttct ttttctttta aatatcaata taaaggtaaa agaa
//
