LOCUS       NM_001290191            3042 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens myeloid associated differentiation marker (MYADM),
            transcript variant 9, mRNA.
ACCESSION   NM_001290191
VERSION     NM_001290191.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Wang,J., Shen,Y., Zhang,Y., Lin,D., Wang,Q., Sun,X., Wei,D.,
            Shen,B., Chen,J., Ji,Y., Fulton,D., Yu,Y., Chen,F. and Hu,L.
  TITLE     Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular
            Remodeling by Regulating Myadm Transcript Stability
  JOURNAL   Hypertension 81 (8), 1785-1798 (2024)
   PUBMED   38832511
  REMARK    GeneRIF: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary
            Vascular Remodeling by Regulating Myadm Transcript Stability.
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Qiao,W., Richards,C.M., Kim,Y., Zengel,J.R., Ding,S.,
            Greenberg,H.B. and Carette,J.E.
  TITLE     MYADM binds human parechovirus 1 and is essential for viral entry
  JOURNAL   Nat Commun 15 (1), 3469 (2024)
   PUBMED   38658526
  REMARK    GeneRIF: MYADM binds human parechovirus 1 and is essential for
            viral entry.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Watanabe,K., Oka,T., Takagi,H., Anisimov,S., Yamashita,S.I.,
            Katsuragi,Y., Takahashi,M., Higuchi,M., Kanki,T., Saitoh,A. and
            Fujii,M.
  TITLE     Myeloid-associated differentiation marker is an essential host
            factor for human parechovirus PeV-A3 entry
  JOURNAL   Nat Commun 14 (1), 1817 (2023)
   PUBMED   37002207
  REMARK    GeneRIF: Myeloid-associated differentiation marker is an essential
            host factor for human parechovirus PeV-A3 entry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Dy,A.B.C., Langlais,P.R., Barker,N.K., Addison,K.J.,
            Tanyaratsrisakul,S., Boitano,S., Christenson,S.A., Kraft,M.,
            Meyers,D., Bleecker,E.R., Li,X. and Ledford,J.G.
  TITLE     Myeloid-associated differentiation marker is a novel
            SP-A-associated transmembrane protein whose expression on airway
            epithelial cells correlates with asthma severity
  JOURNAL   Sci Rep 11 (1), 23392 (2021)
   PUBMED   34862427
  REMARK    GeneRIF: Myeloid-associated differentiation marker is a novel
            SP-A-associated transmembrane protein whose expression on airway
            epithelial cells correlates with asthma severity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Aranda,J.F., Reglero-Real,N., Kremer,L., Marcos-Ramiro,B.,
            Ruiz-Saenz,A., Calvo,M., Enrich,C., Correas,I., Millan,J. and
            Alonso,M.A.
  TITLE     MYADM regulates Rac1 targeting to ordered membranes required for
            cell spreading and migration
  JOURNAL   Mol Biol Cell 22 (8), 1252-1262 (2011)
   PUBMED   21325632
  REMARK    GeneRIF: Myeloid-associated differentiation marker (MYADM)
            regulates Rac1 targeting to ordered membranes required for cell
            spreading and migration.
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Wang,Q., Li,N., Wang,X., Shen,J., Hong,X., Yu,H., Zhang,Y., Wan,T.,
            Zhang,L., Wang,J. and Cao,X.
  TITLE     Membrane protein hMYADM preferentially expressed in myeloid cells
            is up-regulated during differentiation of stem cells and myeloid
            leukemia cells
  JOURNAL   Life Sci 80 (5), 420-429 (2007)
   PUBMED   17097684
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   de Wit,N.J., Rijntjes,J., Diepstra,J.H., van Kuppevelt,T.H.,
            Weidle,U.H., Ruiter,D.J. and van Muijen,G.N.
  TITLE     Analysis of differential gene expression in human melanocytic
            tumour lesions by custom made oligonucleotide arrays
  JOURNAL   Br J Cancer 92 (12), 2249-2261 (2005)
   PUBMED   15900300
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Cui,W., Yu,L., He,H., Chu,Y., Gao,J., Wan,B., Tang,L. and Zhao,S.
  TITLE     Cloning of human myeloid-associated differentiation marker (MYADM)
            gene whose expression was up-regulated in NB4 cells induced by
            all-trans retinoic acid
  JOURNAL   Mol Biol Rep 28 (3), 123-138 (2001)
   PUBMED   12075932
  REMARK    GeneRIF: Cloning and characterization of human MYADM gene whose
            expression was up-regulated in NB4 cells induced by all-trans
            retinoic acid.
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Pettersson,M., Dannaeus,K., Nilsson,K. and Jonsson,J.I.
  TITLE     Isolation of MYADM, a novel hematopoietic-associated marker gene
            expressed in multipotent progenitor cells and up-regulated during
            myeloid differentiation
  JOURNAL   J Leukoc Biol 67 (3), 423-431 (2000)
   PUBMED   10733104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA472260.1, AC008440.9 and AF087882.1.
            
            On May 31, 2019 this sequence version replaced NM_001290191.1.
            
            Transcript Variant: This variant (9) differs in the 5' UTR compared
            to variant 6. All twelve variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.7627681.1,
                                           SRR14038195.765316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               DA472260.1         1-528
            529-2926            AC008440.9         18286-20683
            2927-3042           AF087882.1         3054-3169
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3042
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="myeloid associated differentiation marker"
                     /db_xref="GeneID:91663"
                     /db_xref="HGNC:HGNC:7544"
                     /db_xref="MIM:609959"
     exon            1..61
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     exon            62..134
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     exon            135..3042
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1105
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="myeloid upregulated protein"
                     /codon_start=1
                     /product="myeloid-associated differentiation marker"
                     /protein_id="NP_001277120.1"
                     /db_xref="CCDS:CCDS12866.1"
                     /db_xref="GeneID:91663"
                     /db_xref="HGNC:HGNC:7544"
                     /db_xref="MIM:609959"
                     /translation="MPVTVTRTTITTTTTSSSGLGSPMIVGSPRALTQPLGLLRLLQL
                     VSTCVAFSLVASVGAWTGSMGNWSMFTWCFCFSVTLIILIVELCGLQARFPLSWRNFP
                     ITFACYAALFCLSASIIYPTTYVQFLSHGRSRDHAIAATFFSCIACVAYATEVAWTRA
                     RPGEITGYMATVPGLLKVLETFVACIIFAFISDPNLYQHQPALEWCVAVYAICFILAA
                     IAILLNLGECTNVLPIPFPSFLSGLALLSVLLYATALVLWPLYQFDEKYGGQPRRSRD
                     VSCSRSHAYYVCAWDRRLAVAILTAINLLAYVADLVHSAHLVFVKV"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="hexamer: TATAAA"
     polyA_site      3039
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="major polyA site"
     polyA_site      3042
                     /gene="MYADM"
                     /gene_synonym="SB135"
                     /note="major polyA site"
ORIGIN      
        1 agacccttcc agctgccgct gtcgtctttg cttcagccgc agtcgccact ggctgcctga
       61 gcctgttcca agtgtggctt aatccgtctc caccaccaga tctttctccg tggattcctc
      121 tgctaagacc gctgccatgc cagtgacggt aacccgcacc accatcacaa ccaccacgac
      181 gtcatcttcg ggcctggggt cccccatgat cgtggggtcc cctcgggccc tgacacagcc
      241 cctgggtctc cttcgcctgc tgcagctggt gtctacctgc gtggccttct cgctggtggc
      301 tagcgtgggc gcctggacgg ggtccatggg caactggtcc atgttcacct ggtgcttctg
      361 cttctccgtg accctgatca tcctcatcgt ggagctgtgc gggctccagg cccgcttccc
      421 cctgtcttgg cgcaacttcc ccatcacctt cgcctgctat gcggccctct tctgcctctc
      481 ggcctccatc atctacccca ccacctatgt ccagttcctg tcccacggcc gttcgcggga
      541 ccacgccatc gccgccacct tcttctcctg catcgcgtgt gtggcttacg ccaccgaagt
      601 ggcctggacc cgggcccggc ccggcgagat cactggctat atggccaccg tacccgggct
      661 gctgaaggtg ctggagacct tcgttgcctg catcatcttc gcgttcatca gcgaccccaa
      721 cctgtaccag caccagccgg ccctggagtg gtgcgtggcg gtgtacgcca tctgcttcat
      781 cctagcggcc atcgccatcc tgctgaacct gggggagtgc accaacgtgc tacccatccc
      841 cttccccagc ttcctgtcgg ggctggcctt gctgtctgtc ctcctctatg ccaccgccct
      901 tgttctctgg cccctctacc agttcgatga gaagtatggc ggccagcctc ggcgctcgag
      961 agatgtaagc tgcagccgca gccatgccta ctacgtgtgt gcctgggacc gccgactggc
     1021 tgtggccatc ctgacggcca tcaacctact ggcgtatgtg gctgacctgg tgcactctgc
     1081 ccacctggtt tttgtcaagg tctaagactc tcccaagagg ctcccgttcc ctctccaacc
     1141 tctttgttct tcttgcccga gttttcttta tggagtactt ctttcctccg cctttcctct
     1201 gttttcctct tcctgtctcc cctccctccc acctttttct ttccttccca attccttgca
     1261 ctctaaccag ttcttggatg catcttcttc cttccctttc ctcttgctgt ttccttcctg
     1321 tgttgttttg ttgcccacat cctgttttca cccctgagct gtttctcttt ttcttttctt
     1381 tttttttttt tttttttttt aagacggatt ctcactctgt ggcccaggct ggagtgcagt
     1441 ggtgcgatct cgactcactg caacccccgc ctcctgggtt caagcgattc tcctgcccca
     1501 gcctcccaag tagctgggag gacaggtgtg agctgccgca cccagcctgt ttctcttttt
     1561 ccactcttct tttttctcat ctcttttctg ggttgcctgt cggctttctt atctgcctgt
     1621 tttgcaagca ccttctcctg tgtccttggg agccctgaga cttctttctc tccttgcctc
     1681 cacccacctc caaaggtgct gagctcacat ccacacccct tgcagccgtc catgccacag
     1741 ccccccaagg ggccccattg ccaaagcatg cctgcccacc ctcgctgtgc cttagtcagt
     1801 gtgtacgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt ggggggtggg gggtgggtag
     1861 ctggggattg ggccctcttt ctcccagtgg aggaaggtgt gcagtgtact tcccctttaa
     1921 attaaaaaac atatatatat atatatttgg aggtcagtaa tttccaatgg gcgggaggct
     1981 ttaagcaccg accctgggtc cctaggcccc gcctggcact cagccttgcc agagattggc
     2041 tccagaattt ttgccaggct tacagaacac ccactgccta gaggccatct taaaggaagc
     2101 aggggctgga tgcctttcat cccaactatt ctctgtggta tcaaaaagaa aaaaaaaaaa
     2161 aaagaaggag tcggggccgg gcgtggtggc tcacgcctgt aatcccagca ctttgggaga
     2221 ccaagtcagg caatcatctg aagtcaggag ttcaagacca gcctggccaa catggtgaaa
     2281 gcatgtctct attaaaaata caaaaattag ccgggcgtgg tggcgggcgc ctgtaatccc
     2341 aggtatttgg ggggactgag acaggagaat cccttcaacc cgggaggtgg aggttgcagt
     2401 aagtcaagat ggcaccactg tgctccagcc tgggggacag agcgagactc catctcaaaa
     2461 aaaaaaagga atcggacgaa gaaccacagg atgttgaaga caactgtctg aagtatttgt
     2521 gagggacagc gatgtggccc tctgtgttaa gaataacgtg tcctgctttg gcagagagaa
     2581 gaaaatagcc actgcccgct ttcaaggcaa gatcgacctt ttctgttttg ttttgttttt
     2641 ctttcttttt cctggccatg aggacaaaaa ttactgagtg gcccttaaag agggaagttt
     2701 gttttcagct gttctctttt gcccgtaggt gggagggtgg ggattgctgc gtcctagcta
     2761 gaggaatggc tttgcttgaa tgtgtagtgc acacgcacgg gtgtttctgt gtgctagttg
     2821 cttcttgctg ctgcttcctg cttgtctggg actcacatac ataacgtgat atatatatat
     2881 atatatataa atgtataaat atatatttta ttttttttta aatccctgga gcttctggtt
     2941 cctatcagtt cctgttgtta atcgtagaac cgttgtccct tcccccattc ccgtatccat
     3001 catgttcttt ttcttttaaa tatcaatata aaggtaaaag aa
//
