LOCUS       NM_032348               2293 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens matrix remodeling associated 8 (MXRA8), transcript
            variant 2, mRNA.
ACCESSION   NM_032348
VERSION     NM_032348.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Miao,M., Song,Y., Jin,M., Du,Y., Xin,P., Jiang,Y. and Zhang,H.
  TITLE     Single-cell RNA combined with bulk RNA analysis to explore
            oxidative stress and energy metabolism factors and found a new
            prostate cancer oncogene MXRA8
  JOURNAL   Aging (Albany NY) 16 (5), 4469-4502 (2024)
   PUBMED   38441550
  REMARK    GeneRIF: Single-cell RNA combined with bulk RNA analysis to explore
            oxidative stress and energy metabolism factors and found a new
            prostate cancer oncogene MXRA8.
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Simpson,K.E., Staikos,C.A., Watson,K.L. and Moorehead,R.A.
  TITLE     Loss of MXRA8 Delays Mammary Tumor Development and Impairs
            Metastasis
  JOURNAL   Int J Mol Sci 24 (18), 13730 (2023)
   PUBMED   37762032
  REMARK    GeneRIF: Loss of MXRA8 Delays Mammary Tumor Development and Impairs
            Metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Simpson,K.E., Watson,K.L. and Moorehead,R.A.
  TITLE     Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses
            MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In
            Vivo
  JOURNAL   Genes (Basel) 13 (4), 691 (2022)
   PUBMED   35456497
  REMARK    GeneRIF: Elevated Expression of miR-200c/141 in MDA-MB-231 Cells
            Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and
            Metastasis In Vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Song,H., Zhao,Z., Chai,Y., Jin,X., Li,C., Yuan,F., Liu,S., Gao,Z.,
            Wang,H., Song,J., Vazquez,L., Zhang,Y., Tan,S., Morel,C.M., Yan,J.,
            Shi,Y., Qi,J., Gao,F. and Gao,G.F.
  TITLE     Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding
            to Chikungunya Virus Envelope Protein
  JOURNAL   Cell 177 (7), 1714-1724 (2019)
   PUBMED   31080063
  REMARK    GeneRIF: the stalk region of MXRA8 is critical for CHIKV virus
            entry.
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Basore,K., Kim,A.S., Nelson,C.A., Zhang,R., Smith,B.K., Uranga,C.,
            Vang,L., Cheng,M., Gross,M.L., Smith,J., Diamond,M.S. and
            Fremont,D.H.
  TITLE     Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8
            Receptor
  JOURNAL   Cell 177 (7), 1725-1737 (2019)
   PUBMED   31080061
  REMARK    GeneRIF: studies provide insight into how Mxra8 binds CHIKV and
            creates a path for developing alphavirus entry inhibitors.
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Han,S.W., Jung,Y.K., Lee,E.J., Park,H.R., Kim,G.W., Jeong,J.H.,
            Han,M.S. and Choi,J.Y.
  TITLE     DICAM inhibits angiogenesis via suppression of AKT and p38 MAP
            kinase signalling
  JOURNAL   Cardiovasc Res 98 (1), 73-82 (2013)
   PUBMED   23386276
  REMARK    GeneRIF: exogenous expression of DICAM in human umbilical vein
            endothelial cells suppressed angiogenesis in vitro Matrigel and in
            vivo plug assays, and conversely, DICAM knockdown enhanced
            angiogenesis
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Yonezawa,T., Ohtsuka,A., Yoshitaka,T., Hirano,S., Nomoto,H.,
            Yamamoto,K. and Ninomiya,Y.
  TITLE     Limitrin, a novel immunoglobulin superfamily protein localized to
            glia limitans formed by astrocyte endfeet
  JOURNAL   Glia 44 (3), 190-204 (2003)
   PUBMED   14603461
  REMARK    GeneRIF: new member of the transmembrane-type immunoglobulin
            superfamily and designated limitrin, localizing selectively to glia
            limitans in mouse brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139287.24.
            
            On Jun 2, 2019 this sequence version replaced NM_032348.3.
            
            Transcript Variant: This variant (2) differs in both UTRs and uses
            two alternate splice sites in the 3' coding region compared to
            variant 1. The encoded isoform (2) is shorter and has a distinct
            C-terminus compared to isoform 1. Variants 2 and 5 encode the same
            isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006213.2, SRR11853560.45.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309212.11/ ENSP00000307887.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL139287.24        58409-58508         c
            101-124             AL139287.24        56634-56657         c
            125-427             AL139287.24        55403-55705         c
            428-529             AL139287.24        55197-55298         c
            530-1000            AL139287.24        54635-55105         c
            1001-1156           AL139287.24        54307-54462         c
            1157-1196           AL139287.24        54146-54185         c
            1197-1273           AL139287.24        53983-54059         c
            1274-1354           AL139287.24        53801-53881         c
            1355-2293           AL139287.24        52644-53582         c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2293
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /note="matrix remodeling associated 8"
                     /db_xref="GeneID:54587"
                     /db_xref="HGNC:HGNC:7542"
                     /db_xref="MIM:617293"
     exon            1..100
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1380
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; limitrin; matrix-remodeling-associated protein
                     8; matrix-remodelling associated 8"
                     /codon_start=1
                     /product="matrix remodeling-associated protein 8 isoform 2
                     precursor"
                     /protein_id="NP_115724.1"
                     /db_xref="CCDS:CCDS24.1"
                     /db_xref="GeneID:54587"
                     /db_xref="HGNC:HGNC:7542"
                     /db_xref="MIM:617293"
                     /translation="MALPSRILLWKLVLLQSSAVLLHSGSSVPAAAGSSVVSESAVSW
                     EAGARAVLRCQSPRMVWTQDRLHDRQRVLHWDLRGPGGGPARRLLDLYSAGEQRVYEA
                     RDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTCNLHHHYCHLYESLAVRLEVTDGP
                     PATPAYWDGEKEVLAVARGAPALLTCVNRGHVWTDRHVEEAQQVVHWDRQPPGVPHDR
                     ADRLLDLYASGERRAYGPLFLRDRVAVGADAFERGDFSLRIEPLEVADEGTYSCHLHH
                     HYCGLHERRVFHLTVAEPHAEPPPRGSPGNGSSHSGAPGPDPTLARGHNVINVIVPES
                     RAHFFQQLGYVLATLLLFILLLVTVLLAARRRRGGYEYSDQKSGKSKGKDVNLAEFAV
                     AAGDQMLYRSEDIQLDYKNNILKERAELAHSPLPAKYIDLDKGFRKENCK"
     exon            101..124
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            125..427
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..529
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            530..1000
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1156
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1196
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1273
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1354
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..2293
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="MXRA8"
                     /gene_synonym="ASP3"
                     /note="major polyA site"
ORIGIN      
        1 ggagagagac ttagagccga gtgggacaaa gcctggggct gggcgggggc catggcgctg
       61 ccatcccgaa tcctgctttg gaaacttgtg cttctgcaga gctctgctgt tctcctgcac
      121 tcagggtcct cggtacccgc cgctgctggc agctccgtgg tgtccgagtc cgcggtgagc
      181 tgggaggcgg gcgcccgggc ggtgctgcgc tgccagagcc cgcgcatggt gtggacccag
      241 gaccggctgc acgaccgcca gcgcgtgctc cactgggacc tgcgcggccc cgggggtggc
      301 cccgcgcggc gcctgctgga cttgtactcg gcgggcgagc agcgcgtgta cgaggcgcgg
      361 gaccgcggcc gcctggagct ctcggcctcg gccttcgacg acggcaactt ctcgctgctc
      421 atccgcgcgg tggaggagac ggacgcgggg ctgtacacct gcaacctgca ccatcactac
      481 tgccacctct acgagagcct ggccgtccgc ctggaggtca ccgacggccc cccggccacc
      541 cccgcctact gggacggcga gaaggaggtg ctggcggtgg cgcgcggcgc acccgcgctt
      601 ctgacctgcg tgaaccgcgg gcacgtgtgg accgaccggc acgtggagga ggctcaacag
      661 gtggtgcact gggaccggca gccgcccggg gtcccgcacg accgcgcgga ccgcctgctg
      721 gacctctacg cgtcgggcga gcgccgcgcc tacgggcccc tttttctgcg cgaccgcgtg
      781 gctgtgggcg cggatgcctt tgagcgcggt gacttctcac tgcgtatcga gccgctggag
      841 gtcgccgacg agggcaccta ctcctgccac ctgcaccacc attactgtgg cctgcacgaa
      901 cgccgcgtct tccacctgac ggtcgccgaa ccccacgcgg agccgccccc ccggggctct
      961 ccgggcaacg gctccagcca cagcggcgcc ccaggcccag accccacact ggcgcgcggc
     1021 cacaacgtca tcaatgtcat cgtccccgag agccgagccc acttcttcca gcagctgggc
     1081 tacgtgctgg ccacgctgct gctcttcatc ctgctactgg tcactgtcct cctggccgcc
     1141 cgcaggcgcc gcggaggcta cgaatactcg gaccagaagt cgggaaagtc aaaggggaag
     1201 gatgttaact tggcggagtt cgctgtggct gcaggggacc agatgcttta caggagtgag
     1261 gacatccagc tagattacaa aaacaacatc ctgaaggaga gggcggagct ggcccacagc
     1321 cccctgcctg ccaagtacat cgacctagac aaagggttcc ggaaggagaa ctgcaaatag
     1381 ggaggccctg ggctcctggc tgggccagca gctgcacctc tcctgtctgt gctcctcggg
     1441 gcatctcctg atgctccggg gctcaccccc cttccagcgg ctggtcccgc tttcctggaa
     1501 tttggcctgg gcgtatgcag aggccgcctc cacacccctc tcccaggggc ttggtggcag
     1561 catagccccc acccctgcgg cctttgctca cgggtggccc tgcccacccc tggcacaacc
     1621 aaaatcccac tgatgcccat catgccctca gacccttctg ggctctgccc gctgggggcc
     1681 tgaagacatt cctggaggac actcccatca gaacctggca gccccaaaac tggggtcagc
     1741 ctcagggcag gagtcccact cctccagggc tctgctcgtc gggggctggg agatgttcct
     1801 ggaggaggac actcccatca gaacttggca gccttgaagt tggggtcagc ctcggcagga
     1861 gtcccactcc tcctggggtg ctgcctgcca ccgagagctc ccccacctgt accaccatgt
     1921 gggactccag gcaccatctg ttctccccag ggacctgctg acttgaatgc cagcccttgc
     1981 tcctctgtgt tgctttgggc cacctggggc tgcacccctt gccctttctc tgccccatcc
     2041 ctaccctagc cttgctctca gccaccttga tagtcactgg gctccctgtg acttctgacc
     2101 ctgacacccc tcccttggac tctgcctggg ctggagtcta gggctggggc tacatttggc
     2161 ttctgtactg gctgaggaca ggggagggag tgaagttggt ttggggtggc ctgtgttgcc
     2221 actctcagca ccccacattt gcatctgctg gtggacctgc caccatcaca ataaagtccc
     2281 catctgattt tta
//
