LOCUS       NM_198530               1833 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens matrix remodeling associated 7 (MXRA7), transcript
            variant 3, mRNA.
ACCESSION   NM_198530 XM_353151
VERSION     NM_198530.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Sun,Z., Ke,P., Shen,Y., Ma,K., Wang,B., Lin,D. and Wang,Y.
  TITLE     MXRA7 is involved in monocyte-to-macrophage differentiation
  JOURNAL   Mol Immunol 171, 12-21 (2024)
   PUBMED   38735126
  REMARK    GeneRIF: MXRA7 is involved in monocyte-to-macrophage
            differentiation.
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Sun,Z., Lin,D., Shen,Y., Ma,K., Wang,B., Liu,H., Chen,S., Wu,D. and
            Wang,Y.
  TITLE     Critical role of MXRA7 in differentiation blockade in human acute
            promyelocytic leukemia cells
  JOURNAL   Exp Hematol 125-126, 45-54 (2023)
   PUBMED   37419299
  REMARK    GeneRIF: Critical role of MXRA7 in differentiation blockade in
            human acute promyelocytic leukemia cells.
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Ma,K.P., Sun,Z.J., Shen,Y., Wang,Y.Q. and Lin,D.D.
  TITLE     [Effect of MXRA7 on the Biological Functions of Acute B
            Lymphoblastic Leukemia Cell Line REH]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 31 (1), 50-56 (2023)
   PUBMED   36765476
  REMARK    GeneRIF: [Effect of MXRA7 on the Biological Functions of Acute B
            Lymphoblastic Leukemia Cell Line REH].
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Ning,J., Shen,Y., Wang,T., Wang,M., Liu,W., Sun,Y., Zhang,F.,
            Chen,L. and Wang,Y.
  TITLE     Altered expression of matrix remodelling associated 7 (MXRA7) in
            psoriatic epidermis: Evidence for a protective role in the
            psoriasis imiquimod mouse model
  JOURNAL   Exp Dermatol 27 (9), 1038-1042 (2018)
   PUBMED   29781547
  REMARK    GeneRIF: MXRA7 gene might function as a negative modulator in
            psoriasis development when propsoriatic factors attack, presumably
            via expression alteration or redistribution of MXRA7 proteins in
            keratinocytes.
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Sim,X., Jensen,R.A., Ikram,M.K., Cotch,M.F., Li,X., MacGregor,S.,
            Xie,J., Smith,A.V., Boerwinkle,E., Mitchell,P., Klein,R.,
            Klein,B.E., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M., de
            Jong,P.T., Hofman,A., Rivadeneira,F., Uitterlinden,A.G., van
            Duijn,C.M., Aspelund,T., Eiriksdottir,G., Harris,T.B., Jonasson,F.,
            Launer,L.J., Attia,J., Baird,P.N., Harrap,S., Holliday,E.G.,
            Inouye,M., Rochtchina,E., Scott,R.J., Viswanathan,A., Li,G.,
            Smith,N.L., Wiggins,K.L., Kuo,J.Z., Taylor,K.D., Hewitt,A.W.,
            Martin,N.G., Montgomery,G.W., Sun,C., Young,T.L., Mackey,D.A., van
            Zuydam,N.R., Doney,A.S., Palmer,C.N., Morris,A.D., Rotter,J.I.,
            Tai,E.S., Gudnason,V., Vingerling,J.R., Siscovick,D.S., Wang,J.J.
            and Wong,T.Y.
  CONSRTM   Wellcome Trust Case Control Consortium 2; Global BPGen Consortium
  TITLE     Genetic loci for retinal arteriolar microcirculation
  JOURNAL   PLoS One 8 (6), e65804 (2013)
   PUBMED   23776548
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053983.1, AL046940.1 and AC005837.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198530.3.
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon, and it thus differs in the 3' coding region and 3'
            UTR, compared to variant 1. The encoded isoform (3) has a distinct
            C-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.1084516.1, BC053983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449428.7/ ENSP00000391466.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1518              BC053983.1         41-1558
            1519-1830           AL046940.1         310-621
            1831-1833           AC005837.1         83922-83924
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1833
                     /gene="MXRA7"
                     /note="matrix remodeling associated 7"
                     /db_xref="GeneID:439921"
                     /db_xref="HGNC:HGNC:7541"
     exon            1..361
                     /gene="MXRA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..532
                     /gene="MXRA7"
                     /note="isoform 3 is encoded by transcript variant 3;
                     matrix-remodeling-associated protein 7; matrix-remodelling
                     associated 7"
                     /codon_start=1
                     /product="matrix-remodeling-associated protein 7 isoform
                     3"
                     /protein_id="NP_940932.2"
                     /db_xref="CCDS:CCDS45786.1"
                     /db_xref="GeneID:439921"
                     /db_xref="HGNC:HGNC:7541"
                     /translation="MEAPAELLAALPALATALALLLAWLLVRRGAAASPEPARAPPEP
                     APPAEATGAPAPSRPCAPEPAASPAGPEEPGEPAGLGELGEPAGPGEPEGPGDPAAAP
                     AEAEEQAVEARQEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGKLRGNQYKKMMTKE
                     ELEEEQRTEE"
     exon            362..425
                     /gene="MXRA7"
                     /inference="alignment:Splign:2.1.0"
     exon            426..519
                     /gene="MXRA7"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1833
                     /gene="MXRA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      867..872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXRA7"
                     /note="hexamer: GATAAA"
     polyA_site      890
                     /gene="MXRA7"
                     /note="major polyA site"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXRA7"
                     /note="hexamer: AATAAA"
     polyA_site      1833
                     /gene="MXRA7"
                     /note="major polyA site"
ORIGIN      
        1 actcggcggc cgcggcgcga tggaggcgcc ggccgagcta ctggccgcgc tgcctgcgct
       61 ggccaccgcg ctggcccttc tgctcgcctg gctactggtg cggcgtgggg cggccgcgag
      121 cccggagcct gcccgcgcgc ccccggaacc cgcgcccccg gccgaggcca ccggggcccc
      181 ggcgccgtcc cgcccctgcg cccccgagcc ggcggcctcg cccgcggggc cggaggagcc
      241 tggagagccc gcggggctgg gggagctcgg ggagcctgcg ggaccggggg agcccgaagg
      301 gccaggggat cccgcggcgg cgccagcgga ggcggaggag caggcggtgg aggcgaggca
      361 ggaagaggag caggacttgg atggtgagaa ggggccatca tcggaagggc ctgaggagga
      421 ggacggagaa ggcttctcct tcaaatacag ccccgggaag ctgaggggaa accagtacaa
      481 gaagatgatg accaaagagg agctggagga ggagcagaga actgaagaat aacgaagtta
      541 tccttagcgt cctcctaaag gcttttcctt ttggcatctt aaaagcttga gagataaaac
      601 ggaaacccca gagaggagtc tgggcaggct cccagggtgc atgctgcctc cataaatctg
      661 ctgagctcta gaccctcaat caggacttgt cccttggcta gcaggatcct gggaacacct
      721 ttggccctgc cctgtgtaga gatgttcatg tctgttcctg tgggtcactt tgttaagctg
      781 aagagtttta agaggtagag ctcagaccct ggactgggat ttttcttacc actcaaactt
      841 gctatccaca caccctgcac accttagata aaaagaacat tttaaaagca gagttcactt
      901 tcactccagt ctcccctctt ttgccctcac tgaagccaaa ccacagaaga ctttgaggaa
      961 tgagagacaa atgaggtaga gctcacctgt gctcaccagc tccgtcaggg tggtcagccg
     1021 acccctttcc ctgggaaccc cacttctctc tgtggctggc ttggttgtcg ggggtgagat
     1081 gccatattga ttacagggca gcaaagaacc agtaccagga atttacttga ccattcccct
     1141 tatttttcat ctagaggaat ctcggattca gccctttcat tgctaagaca ccttttcact
     1201 gaggttctta ccagctcagc caaatctcca ctctgctata gcagaagcaa taatgtttgc
     1261 tttaaaaaga tttcttgacc tatgcctttt cttagaaagt ttgatagatt agttagaact
     1321 tcagatcatc agatcagtct caaatgggtt tcttggaatt ttatatttga caatatttat
     1381 actataccaa actcatttgc agttcttagg tttgttggtt aaaacatttt tttaaagcag
     1441 taagtttata gaaaatgttt tcatttaatg gaaggctggg gaatgtccag catcaacccc
     1501 tatggcatgc attcccaggg gccttctcat ctgggcctgg aacctttggt tcagggctta
     1561 ggggagaaca ggccacatgg caacagccac acagtcattg ccttcaacac agagccacgt
     1621 gtccccaaac agcaatagtc atgcccttgt ccaggctggg atctaattga cacaataggt
     1681 cgttgactcc ctcctagtag agctatctag gtttgtctgg aaagtttccg accctggctt
     1741 ataggcacca cacctcatgt actcctcatg gcttggatct ctgtattcag cctttgttca
     1801 gtccaataaa ctttgagtag atgatctcaa tta
//
