LOCUS       NM_015419               9804 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens matrix remodeling associated 5 (MXRA5), mRNA.
ACCESSION   NM_015419
VERSION     NM_015419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9804)
  AUTHORS   Nie,L., Huang,L., Zhu,Q., Yao,Q., Wu,Y., Zhao,L., Yu,L. and Fu,F.
  TITLE     HIF-1alpha Activates Hypoxia-Induced MXRA5 Expression in the
            Progression of Ovarian Cancer
  JOURNAL   J Environ Pathol Toxicol Oncol 44 (1), 47-55 (2025)
   PUBMED   39462449
  REMARK    GeneRIF: HIF-1alpha Activates Hypoxia-Induced MXRA5 Expression in
            the Progression of Ovarian Cancer.
REFERENCE   2  (bases 1 to 9804)
  AUTHORS   Sun,Y., Yang,H., Guo,J., Du,J., Han,S. and Yang,X.
  TITLE     Identification of HTRA1, DPT and MXRA5 as potential biomarkers
            associated with osteoarthritis progression and immune infiltration
  JOURNAL   BMC Musculoskelet Disord 25 (1), 647 (2024)
   PUBMED   39148085
  REMARK    GeneRIF: Identification of HTRA1, DPT and MXRA5 as potential
            biomarkers associated with osteoarthritis progression and immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9804)
  AUTHORS   Yoshida,K., Suzuki,S., Yuan,H., Sato,A., Hirata-Tsuchiya,S.,
            Saito,M., Yamada,S. and Shiba,H.
  TITLE     Public RNA-seq data-based identification and functional analyses
            reveal that MXRA5 retains proliferative and migratory abilities of
            dental pulp stem cells
  JOURNAL   Sci Rep 13 (1), 15574 (2023)
   PUBMED   37730838
  REMARK    GeneRIF: Public RNA-seq data-based identification and functional
            analyses reveal that MXRA5 retains proliferative and migratory
            abilities of dental pulp stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9804)
  AUTHORS   Sun,J.Z., Zhang,J.H., Li,J.B., Yuan,F., Tong,L.Q., Wang,X.Y.,
            Chen,L.L., Fan,X.G., Zhang,Y.M., Ren,X., Zhang,C., Yu,S.P. and
            Yang,X.J.
  TITLE     MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor
            Prognosis in Glioma
  JOURNAL   Dis Markers 2021, 6680883 (2021)
   PUBMED   34211612
  REMARK    GeneRIF: MXRA5 Is a Novel Immune-Related Biomarker That Predicts
            Poor Prognosis in Glioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9804)
  AUTHORS   Xiao,H., Jiang,Y., He,W., Xu,D., Chen,P., Liu,D., Liu,J., Wang,X.,
            DiSanto,M.E. and Zhang,X.
  TITLE     Identification and functional activity of matrix-remodeling
            associated 5 (MXRA5) in benign hyperplastic prostate
  JOURNAL   Aging (Albany NY) 12 (9), 8605-8621 (2020)
   PUBMED   32392178
  REMARK    GeneRIF: Identification and functional activity of
            matrix-remodeling associated 5 (MXRA5) in benign hyperplastic
            prostate.
REFERENCE   6  (bases 1 to 9804)
  AUTHORS   He,Y., Chen,X., Liu,H., Xiao,H., Kwapong,W.R. and Mei,J.
  TITLE     Matrix-remodeling associated 5 as a novel tissue biomarker predicts
            poor prognosis in non-small cell lung cancers
  JOURNAL   Cancer Biomark 15 (5), 645-651 (2015)
   PUBMED   26406953
  REMARK    GeneRIF: These results indicated the potential value of MXRA5 as a
            novel therapeutic target for the treatment of non-small cell lung
            cancer.
REFERENCE   7  (bases 1 to 9804)
  AUTHORS   Xiong,D., Li,G., Li,K., Xu,Q., Pan,Z., Ding,F., Vedell,P., Liu,P.,
            Cui,P., Hua,X., Jiang,H., Yin,Y., Zhu,Z., Li,X., Zhang,B., Ma,D.,
            Wang,Y. and You,M.
  TITLE     Exome sequencing identifies MXRA5 as a novel cancer gene frequently
            mutated in non-small cell lung carcinoma from Chinese patients
  JOURNAL   Carcinogenesis 33 (9), 1797-1805 (2012)
   PUBMED   22696596
  REMARK    GeneRIF: screened one most frequently mutated novel gene,
            matrix-remodeling associated 5 (MXRA5), in an additional larger
            Chinese sample set of 52 patients with NSCLC and confirmed its high
            somatic mutation frequency
REFERENCE   8  (bases 1 to 9804)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   9  (bases 1 to 9804)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 9804)
  AUTHORS   Chondrogianni,N., de C M Simoes,D., Franceschi,C. and Gonos,E.S.
  TITLE     Cloning of differentially expressed genes in skin fibroblasts from
            centenarians
  JOURNAL   Biogerontology 5 (6), 401-409 (2004)
   PUBMED   15609104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004616.1, CD626974.1,
            BC064986.1 and AF245505.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015419.3.
            
            Summary: This gene encodes one of the matrix-remodelling associated
            proteins. This protein contains 7 leucine-rich repeats and 12
            immunoglobulin-like C2-type domains related to perlecan. This gene
            has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments. An in-frame AUG is located 25
            codons upstream of the annotated translation start site but is not
            being annotated as a start site since it is poorly conserved, is in
            a weak Kozak sequence context, and is predicted to disrupt an
            N-terminal signal peptide sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF245505.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000217939.7/
                                                ENSP00000217939.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC004616.1         88460-88468         c
            10-12               CD626974.1         13-15
            13-2379             BC064986.1         1-2367
            2380-5725           AC004616.1         61942-65287         c
            5726-6163           AF245505.1         5560-5997
            6164-6164           AC004616.1         59499-59499         c
            6165-7420           AF245505.1         5999-7254
            7421-9191           AC004616.1         50994-52764         c
            9192-9804           AF245505.1         9028-9640
FEATURES             Location/Qualifiers
     source          1..9804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.33"
     gene            1..9804
                     /gene="MXRA5"
                     /note="matrix remodeling associated 5"
                     /db_xref="GeneID:25878"
                     /db_xref="HGNC:HGNC:7539"
                     /db_xref="MIM:300938"
     exon            1..138
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     exon            139..354
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..8653
                     /gene="MXRA5"
                     /note="adlican; adhesion protein with leucine-rich repeats
                     and Immunoglobulin domains related to perlecan;
                     matrix-remodelling associated 5"
                     /codon_start=1
                     /product="matrix-remodeling-associated protein 5
                     precursor"
                     /protein_id="NP_056234.2"
                     /db_xref="CCDS:CCDS14124.1"
                     /db_xref="GeneID:25878"
                     /db_xref="HGNC:HGNC:7539"
                     /db_xref="MIM:300938"
                     /translation="MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFR
                     SLASVPAGIAKHVERINLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDL
                     SSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEG
                     NLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNP
                     WTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCL
                     KPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVC
                     DIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKLWKLIAYYSEVPVKLH
                     RELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSIDIQLNRRQSTAKK
                     VLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASES
                     PSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRM
                     VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLAN
                     TSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRR
                     PGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQEVFLKTKDDAINGDKKAKKG
                     RRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINPERWADILAKVRGKNLPKG
                     TEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEESSADVPLLGEEEHVLG
                     TISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLI
                     SEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAES
                     EPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFEDSTIGEPGVPG
                     QSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHSRSSESEGQ
                     ESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSSTMSTHP
                     SRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSLVPTA
                     WVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPSPE
                     NKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT
                     SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTP
                     TWNPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEE
                     AGSSTTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASS
                     SPSTILMSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHM
                     SGPNELSTPSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPA
                     KPILPTATVRLPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLS
                     STTIPLPLHMSKPSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYS
                     NGRLPFFTNKTLSFPQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGP
                     PAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPP
                     ASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNT
                     RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ
                     DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEAS
                     FSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAA
                     PLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSAR
                     RTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDA
                     LFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHK
                     EENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN
                     GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVV
                     TVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRN
                     SAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAF
                     PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP
                     MEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHK
                     ADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGET
                     LKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCR
                     METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELP
                     DKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF
                     "
     exon            355..484
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..875
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     exon            876..5843
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     exon            5844..6744
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     exon            6745..9804
                     /gene="MXRA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9786..9791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXRA5"
                     /note="hexamer: AATAAT"
     polyA_site      9804
                     /gene="MXRA5"
                     /note="major polyA site"
ORIGIN      
        1 gctgggaagc cgagctgcct cacccccggc cccgggaagg gcatggcccc ggcaaactcc
       61 cggccgtgac tcgcgcgccc cggctcggtg gatgctcccg gcgcaccgct cccgtgtgcg
      121 gcggcttccc aaggacaggt atccgagaat caggcacccc gacaagatgc ccaagcgcgc
      181 gcactggggg gccctctccg tggtgctgat cctgctttgg ggccatccgc gagtggcgct
      241 ggcctgcccg catccttgtg cctgctacgt ccccagcgag gtccactgca cgttccgatc
      301 cctggcttcc gtgcccgctg gcattgctaa acacgtggaa agaatcaatt tggggtttaa
      361 tagcatacag gccctgtcag aaacctcatt tgcaggactg accaagttgg agctacttat
      421 gattcacggc aatgagatcc caagcatccc cgatggagct ttaagagacc tcagctctct
      481 tcaggttttc aagttcagct acaacaagct gagagtgatc acaggacaga ccctccaggg
      541 tctctctaac ttaatgaggc tgcacattga ccacaacaag atcgagttta tccaccctca
      601 agctttcaac ggcttaacgt ctctgaggct actccatttg gaaggaaatc tcctccacca
      661 gctgcacccc agcaccttct ccacgttcac atttttggat tatttcagac tctccaccat
      721 aaggcacctc tacttagcag agaacatggt tagaactctt cctgccagca tgcttcggaa
      781 catgccgctt ctggagaatc tttacttgca gggaaatccg tggacctgcg attgtgagat
      841 gagatggttt ttggaatggg atgcaaaatc cagaggaatt ctgaagtgta aaaaggacaa
      901 agcttatgaa ggcggtcagt tgtgtgcaat gtgcttcagt ccaaagaagt tgtacaaaca
      961 tgagatacac aagctgaagg acatgacttg tctgaagcct tcaatagagt cccctctgag
     1021 acagaacagg agcaggagta ttgaggagga gcaagaacag gaagaggatg gtggcagcca
     1081 gctcatcctg gagaaattcc aactgcccca gtggagcatc tctttgaata tgaccgacga
     1141 gcacgggaac atggtgaact tggtctgtga catcaagaaa ccaatggatg tgtacaagat
     1201 tcacttgaac caaacggatc ctccagatat tgacataaat gcaacagttg ccttggactt
     1261 tgagtgtcca atgacccgag aaaactatga aaagctatgg aaattgatag catactacag
     1321 tgaagttccc gtgaagctac acagagagct catgctcagc aaagacccca gagtcagcta
     1381 ccagtacagg caggatgctg atgaggaagc tctttactac acaggtgtga gagcccagat
     1441 tcttgcagaa ccagaatggg tcatgcagcc atccatagat atccagctga accgacgtca
     1501 gagtacggcc aagaaggtgc tactttccta ctacacccag tattctcaaa caatatccac
     1561 caaagataca aggcaggctc ggggcagaag ctgggtaatg attgagccta gtggagctgt
     1621 gcaaagagat cagactgtcc tggaaggggg tccatgccag ttgagctgca acgtgaaagc
     1681 ttctgagagt ccatctatct tctgggtgct tccagatggc tccatcctga aagcgcccat
     1741 ggatgaccca gacagcaagt tctccattct cagcagtggc tggctgagga tcaagtccat
     1801 ggagccatct gactcaggct tgtaccagtg cattgctcaa gtgagggatg aaatggaccg
     1861 catggtatat agggtacttg tgcagtctcc ctccactcag ccagccgaga aagacacagt
     1921 gacaattggc aagaacccag gggagtcggt gacattgcct tgcaatgctt tagcaatacc
     1981 cgaagcccac cttagctgga ttcttccaaa cagaaggata attaatgatt tggctaacac
     2041 atcacatgta tacatgttgc caaatggaac tctttccatc ccaaaggtcc aagtcagtga
     2101 cagtggttac tacagatgtg tggctgtcaa ccagcaaggg gcagaccatt ttacggtggg
     2161 aatcacagtg accaagaaag ggtctggctt gccatccaaa agaggcagac gcccaggtgc
     2221 aaaggctctt tccagagtca gagaagacat cgtggaggat gaagggggct cgggcatggg
     2281 agatgaagag aacacttcaa ggagacttct gcatccaaag gaccaagagg tgttcctcaa
     2341 aacaaaggat gatgccatca atggagacaa gaaagccaag aaagggagaa gaaagctgaa
     2401 actctggaag cattcggaaa aagaaccaga gaccaatgtt gcagaaggtc gcagagtgtt
     2461 tgaatctaga cgaaggataa acatggcaaa caaacagatt aatccggagc gctgggctga
     2521 tattttagcc aaagtccgtg ggaaaaatct ccctaagggc acagaagtac ccccattgat
     2581 taaaaccaca agtcctccat ccttgagtct agaagtcaca ccaccttttc ctgctatttc
     2641 tcccccctca gcatctcctg tgcagacagt aaccagtgct gaagaatcct cagcagatgt
     2701 acctctactt ggtgaagaag agcacgtttt gggtaccatt tcctcagcca gcatggggct
     2761 agaacacaac cacaatggag ttattcttgt tgaacctgaa gtaacaagca cacctctgga
     2821 ggaagttgtt gatgaccttt ccgagaagac tgaggagata acttccactg aaggagacct
     2881 gaaggggaca gcagccccta cacttatatc tgagccttat gaaccatctc ctactctgca
     2941 cacattagac acagtctatg aaaagcccac ccatgaagag acggcaacag agggttggtc
     3001 tgcagcagat gttggatcgt caccagagcc cacatccagt gagtatgagc ctccattgga
     3061 tgctgtctcc ttggctgagt ctgagcccat gcaatacttt gacccagatt tggagactaa
     3121 gtcacaacca gatgaggata agatgaaaga agacaccttt gcacacctta ctccaacccc
     3181 caccatctgg gttaatgact ccagtacatc acagttattt gaggattcta ctatagggga
     3241 accaggtgtc ccaggccaat cacatctaca aggactgaca gacaacatcc accttgtgaa
     3301 aagtagtcta agcactcaag acaccttact gattaaaaag ggtatgaaag agatgtctca
     3361 gacactacag ggaggaaata tgctagaggg agaccccaca cactccagaa gttctgagag
     3421 tgagggccaa gagagcaaat ccatcacttt gcctgactcc acactgggta taatgagcag
     3481 tatgtctcca gttaagaagc ctgcggaaac cacagttggt accctcctag acaaagacac
     3541 cacaacagca acaacaacac caaggcaaaa agttgctccg tcatccacca tgagcactca
     3601 cccttctcga aggagaccca acgggagaag gagattacgc cccaacaaat tccgccaccg
     3661 gcacaagcaa accccaccca caacttttgc cccatcagag actttttcta ctcaaccaac
     3721 tcaagcacct gacattaaga tttcaagtca agtggagagt tctctggttc ctacagcttg
     3781 ggtggataac acagttaata cccccaaaca gttggaaatg gagaagaatg cagaacccac
     3841 atccaaggga acaccacgga gaaaacacgg gaagaggcca aacaaacatc gatatacccc
     3901 ttctacagtg agctcaagag cgtccggatc caagcccagc ccttctccag aaaataaaca
     3961 tagaaacatt gttactccca gttcagaaac tatacttttg cctagaactg tttctctgaa
     4021 aactgagggc ccttatgatt ccttagatta catgacaacc accagaaaaa tatattcatc
     4081 ttaccctaaa gtccaagaga cacttccagt cacatataaa cccacatcag atggaaaaga
     4141 aattaaggat gatgttgcca caaatgttga caaacataaa agtgacattt tagtcactgg
     4201 tgaatcaatt actaatgcca taccaacttc tcgctccttg gtctccacta tgggagaatt
     4261 taaggaagaa tcctctcctg taggctttcc aggaactcca acctggaatc cctcaaggac
     4321 ggcccagcct gggaggctac agacaggcat acctgttacc acttctgggg aaaatcttac
     4381 agaccctccc cttcttaaag agcttgagga tgtggatttc acttccgagt ttttgtcctc
     4441 tttgacagtc tccacaccat ttcaccagga agaagctggt tcttccacaa ctctctcaag
     4501 cataaaagtg gaggtggctt caagtcaggc agaaaccacc acccttgatc aagatcatct
     4561 tgaaaccact gtggctattc tcctttctga aactagacca cagaatcaca cccctactgc
     4621 tgcccggatg aaggagccag catcctcgtc cccatccaca attctcatgt ctttgggaca
     4681 aaccaccacc actaagccag cacttcccag tccaagaata tctcaagcat ctagagattc
     4741 caaggaaaat gttttcttga attatgtggg gaatccagaa acagaagcaa ccccagtgaa
     4801 caatgaagga acacagcata tgtcagggcc aaatgaatta tcaacaccct cttccgacca
     4861 ggatgcattt aacttgtcta caaagctgga attggaaaag caagtatttg gtagtaggag
     4921 tctaccacgt ggcccagata gccaacgcca ggatggaaga gttcatgctt ctcatcaact
     4981 aaccagagtc cctgccaaac ccatcctacc aacagcaaca gtgaggctgc ctgaaatgtc
     5041 cacacaaagc gcttccagat actttgtaac ttcccagtca cctcgtcact ggaccaacaa
     5101 accggaaata actacatatc cttctggggc tttgccagag aacaaacagt ttacaactcc
     5161 aagattatca agtacaacaa ttcctctccc attgcacatg tccaaaccca gcattcctag
     5221 taagtttact gaccgaagaa ctgaccaatt caatggctac tccaaagtgt ttggaaataa
     5281 caacatccct gaggcaagaa acccagttgg aaagcctccc agtccaagaa ttcctcatta
     5341 ttccaatgga agactccctt tctttaccaa caagactctt tcttttccac agttgggagt
     5401 cacccggaga ccccagatac ccacttctcc tgccccagta atgagagaga gaaaagttat
     5461 tccaggttcc tacaacagga tacattccca tagcaccttc catctggact ttggccctcc
     5521 ggcacctccg ttgttgcaca ctccgcagac cacgggatca ccctcaacta acttacagaa
     5581 tatccctatg gtctcttcca cccagagttc tatctccttt ataacatctt ctgtccagtc
     5641 ctcaggaagc ttccaccaga gcagctcaaa gttctttgca ggaggacctc ctgcatccaa
     5701 attctggtct cttggggaaa agccacaaat cctcaccaag tccccacaga ctgtgtccgt
     5761 caccgctgag acagacactg tgttcccctg tgaggcaaca ggaaaaccaa agcctttcgt
     5821 tacttggaca aaggtttcca caggagctct tatgactccg aataccagga tacaacggtt
     5881 tgaggttctc aagaacggta ccttagtgat acggaaggtt caagtacaag atcgaggcca
     5941 gtatatgtgc accgccagca acctgcacgg cctggacagg atggtggtct tgctttcggt
     6001 caccgtgcag caacctcaaa tcctagcctc ccactaccag gacgtcactg tctacctggg
     6061 agacaccatt gcaatggagt gtctggccaa agggacccca gccccccaaa tttcctggat
     6121 cttccctgac aggagggtgt ggcaaactgt gtcccccgtg gagggccgca tcaccctgca
     6181 cgaaaaccgg accctttcca tcaaggaggc gtccttctca gacagaggcg tctataagtg
     6241 cgtggccagc aatgcagccg gggcggacag cctggccatc cgcctgcacg tggcggcact
     6301 gccccccgtt atccaccagg agaagctgga gaacatctcg ctgcccccgg ggctcagcat
     6361 tcacattcac tgcactgcca aggctgcgcc cctgcccagc gtgcgctggg tgctcgggga
     6421 cggtacccag atccgcccct cgcagttcct ccacgggaac ttgtttgttt tccccaacgg
     6481 gacgctctac atccgcaacc tcgcgcccaa ggacagcggg cgctatgagt gcgtggccgc
     6541 caacctggta ggctccgcgc gcaggacggt gcagctgaac gtgcagcgtg cagcagccaa
     6601 cgcgcgcatc acgggcacct ccccgcggag gacggacgtc aggtacggag gaaccctcaa
     6661 gctggactgc agcgcctcgg gggacccctg gccgcgcatc ctctggaggc tgccgtccaa
     6721 gaggatgatc gacgcgctct tcagttttga tagcagaatc aaggtgtttg ccaatgggac
     6781 cctggtggtg aaatcagtga cggacaaaga tgccggagat tacctgtgcg tagctcgaaa
     6841 taaggttggt gatgactacg tggtgctcaa agtggatgtg gtgatgaaac cggccaagat
     6901 tgaacacaag gaggagaacg accacaaagt cttctacggg ggtgacctga aagtggactg
     6961 tgtggccacc gggcttccca atcccgagat ctcctggagc ctcccagacg ggagtctggt
     7021 gaactccttc atgcagtcgg atgacagcgg tggacgcacc aagcgctatg tcgtcttcaa
     7081 caatgggaca ctctacttta acgaagtggg gatgagggag gaaggagact acacctgctt
     7141 tgctgaaaat caggtcggga aggacgagat gagagtcaga gtcaaggtgg tgacagcgcc
     7201 cgccaccatc cggaacaaga cttacttggc ggttcaggtg ccctatggag acgtggtcac
     7261 tgtagcctgt gaggccaaag gagaacccat gcccaaggtg acttggttgt ccccaaccaa
     7321 caaggtgatc cccacctcct ctgagaagta tcagatatac caagatggca ctctccttat
     7381 tcagaaagcc cagcgttctg acagcggcaa ctacacctgc ttggtcagga acagcgcggg
     7441 agaggatagg aagacggtgt ggattcacgt caacgtccag ccacccaaga tcaacggtaa
     7501 ccccaacccc atcaccactg tgcgggagat agcagccggg ggcagtcgga aactgattga
     7561 ctgcaaagct gaaggcatcc ccaccccgag ggtgttatgg gcttttcccg agggtgtggt
     7621 tctgccagct ccatactatg gaaaccggat cactgtccat ggcaacggtt ccctggacat
     7681 caggagtttg aggaagagcg actccgtcca gctggtatgc atggcacgca acgagggagg
     7741 ggaggccagg ttgatcctgc agctcactgt cctggagccc atggagaaac ccatcttcca
     7801 cgacccgatc agcgagaaga tcacggccat ggcgggccac accatcagcc tcaactgctc
     7861 tgccgcgggg accccgacac ccagcctggt gtgggtcctt cccaatggca ccgatctgca
     7921 gagtggacag cagctgcagc gcttctacca caaggctgac ggcatgctac acattagcgg
     7981 tctctcctcg gtggacgccg gggcctaccg ctgcgtggcc cgcaatgccg ctggccacac
     8041 ggagaggctg gtctccctga aggtgggact gaagccagaa gcaaacaagc agtatcataa
     8101 cctggtcagc atcatcaatg gtgagaccct gaagctcccc tgcacccctc ccggggctgg
     8161 gcagggacgt ttctcctgga cgctccccaa tggcatgcat ctggagggcc cccaaaccct
     8221 gggacgcgtt tctcttctgg acaatggcac cctcacggtt cgtgaggcct cggtgtttga
     8281 caggggtacc tatgtatgca ggatggagac ggagtacggc ccttcggtca ccagcatccc
     8341 cgtgattgtg atcgcctatc ctccccggat caccagcgag cccaccccgg tcatctacac
     8401 ccggcccggg aacaccgtga aactgaactg catggctatg gggattccca aagctgacat
     8461 cacgtgggag ttaccggata agtcgcatct gaaggcaggg gttcaggctc gtctgtatgg
     8521 aaacagattt cttcaccccc agggatcact gaccatccag catgccacac agagagatgc
     8581 cggcttctac aagtgcatgg caaaaaacat tctcggcagt gactccaaaa caacttacat
     8641 ccacgtcttc tgaaatgtgg attccagaat gattgcttag gaactgacaa caaagcgggg
     8701 tttgtaaggg aagccaggtt ggggaatagg agctcttaaa taatgtgtca cagtgcatgg
     8761 tggcctctgg tgggtttcaa gttgaggttg atcttgatct acaattgttg ggaaaaggaa
     8821 gcaatgcaga cacgagaagg agggctcagc cttgctgaga cactttcttt tgtgtttaca
     8881 tcatgccagg ggcttcattc agggtgtctg tgctctgact gcaatttttc tttttttgca
     8941 aatgccactc gactgccttc ataagcgtcc ataggatatc tgaggaacat tcatcaaaaa
     9001 taagccatag acatgaacaa cacctcacta ccccattgaa gacgcatcac ctagttaacc
     9061 tgctgcagtt tttacatgat agactttgtt ccagattgac aagtcatctt tcagttattt
     9121 cctctgtcac ttcaaaactc cagcttgccc aataaggatt tagaaccaga gtgactgata
     9181 tatatatata ttttaattca gagttacata catacagcta ccattttata tgaaaaaaga
     9241 aaaacatttc ttcctggaac tcacttttta tataatgttt tatatatata ttttttcctt
     9301 tcaaatcaga cgatgagact agaaggagaa atactttctg tcttattaaa attaataaat
     9361 tattggtctt tacaagactt ggatacatta cagcagacat ggaaatataa ttttaaaaaa
     9421 tttctctcca acctccttca aattcagtca ccactgttat attaccttct ccaggaaccc
     9481 tccagtgggg aaggctgcga tattagattt ccttgtatgc aaagtttttg ttgaaagctg
     9541 tgctcagagg aggtgagagg agaggaagga gaaaactgca tcataacttt acagaattga
     9601 atctagagtc ttccccgaaa agcccagaaa cttctctgca gtatctggct tgtccatctg
     9661 gtctaaggtg gctgcttctt ccccagccat gagtcagttt gtgcccatga ataatacacg
     9721 acctgttatt tccatgactg ctttactgta tttttaaggt caatatactg tacatttgat
     9781 aataaaataa tattctccca aaaa
//
