LOCUS       NM_130439               3470 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens MAX interactor 1, dimerization protein (MXI1),
            transcript variant 2, mRNA.
ACCESSION   NM_130439
VERSION     NM_130439.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Lei,Y., Huang,Y., Lin,J., Sun,S., Che,K., Shen,J., Liao,J.,
            Chen,Y., Chen,K., Lin,Z. and Lin,X.
  TITLE     Mxi1 participates in the progression of lung cancer via the
            microRNA-300/KLF9/GADD34 Axis
  JOURNAL   Cell Death Dis 13 (5), 425 (2022)
   PUBMED   35501353
  REMARK    GeneRIF: Mxi1 participates in the progression of lung cancer via
            the microRNA-300/KLF9/GADD34 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   Huang,Y., Yang,X., Lu,Y., Zhao,Y., Meng,R., Zhang,S., Dong,X.,
            Xu,S. and Wu,G.
  TITLE     UBE2O targets Mxi1 for ubiquitination and degradation to promote
            lung cancer progression and radioresistance
  JOURNAL   Cell Death Differ 28 (2), 671-684 (2021)
   PUBMED   32901121
  REMARK    GeneRIF: UBE2O targets Mxi1 for ubiquitination and degradation to
            promote lung cancer progression and radioresistance.
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Hu,Z., Wang,F., Wu,Z., Gu,H., Dong,N., Jiang,X., Xu,J., Wu,Z.,
            Wechsler,D.S. and Zheng,D.
  TITLE     FOXO3a-dependent up-regulation of Mxi1-0 promotes hypoxia-induced
            apoptosis in endothelial cells
  JOURNAL   Cell Signal 51, 233-242 (2018)
   PUBMED   30118760
  REMARK    GeneRIF: HIF-1alpha-induced FOXO3a promotes apoptosis of hypoxic
            endothelial cells by directly inducing Mxi1- 0, which leads to the
            activation of caspase-8 apoptotic pathway.
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Albarosa,R., DiDonato,S. and Finocchiaro,G.
  TITLE     Redefinition of the coding sequence of the MXI1 gene and
            identification of a polymorphic repeat in the 3' non-coding region
            that allows the detection of loss of heterozygosity of chromosome
            10q25 in glioblastomas
  JOURNAL   Hum Genet 95 (6), 709-711 (1995)
   PUBMED   7789959
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Zervos,A.S., Gyuris,J. and Brent,R.
  TITLE     Mxi1, a protein that specifically interacts with Max to bind
            Myc-Max recognition sites
  JOURNAL   Cell 79 (2), following388 (1994)
   PUBMED   7954804
  REMARK    Correction to:[Cell. 1993 Jan 29;72(2):223-32. doi:
            10.1016/0092-8674(93)90662-a.. PMID: 8425219]
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Wechsler,D.S., Hawkins,A.L., Li,X., Jabs,E.W., Griffin,C.A. and
            Dang,C.V.
  TITLE     Localization of the human Mxi1 transcription factor gene (MXI1) to
            chromosome 10q24-q25
  JOURNAL   Genomics 21 (3), 669-672 (1994)
   PUBMED   7959753
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Edelhoff,S., Ayer,D.E., Zervos,A.S., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Eisenman,R.N., Brent,R. and
            Disteche,C.M.
  TITLE     Mapping of two genes encoding members of a distinct subfamily of
            MAX interacting proteins: MAD to human chromosome 2 and mouse
            chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome
            19
  JOURNAL   Oncogene 9 (2), 665-668 (1994)
   PUBMED   8290278
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   Zervos,A.S., Gyuris,J. and Brent,R.
  TITLE     Mxi1, a protein that specifically interacts with Max to bind
            Myc-Max recognition sites
  JOURNAL   Cell 72 (2), 223-232 (1993)
   PUBMED   8425219
  REMARK    Erratum:[Cell. 1994 Oct 21;79(2):following 388.. PMID: 7954804]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035128.1, BQ924073.1,
            BC016678.1, AA854855.1, BM668806.1 and AW291670.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 7, 2005 this sequence version replaced NM_130439.2.
            
            Summary: Expression of the c-myc gene, which produces an oncogenic
            transcription factor, is tightly regulated in normal cells but is
            frequently deregulated in human cancers. The protein encoded by
            this gene is a transcriptional repressor thought to negatively
            regulate MYC function, and is therefore a potential tumor
            suppressor. This protein inhibits the transcriptional activity of
            MYC by competing for MAX, another basic helix-loop-helix protein
            that binds to MYC and is required for its function. Defects in this
            gene are frequently found in patients with prostate tumors. Three
            alternatively spliced transcripts encoding different isoforms have
            been described. Additional alternatively spliced transcripts may
            exist but the products of these transcripts have not been verified
            experimentally. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2), also referred to as SRalpha,
            differs in the 5' UTR and coding region, compared to variant 1. The
            resulting protein (isoform b) is longer and has a distinct
            N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.36057.1,
                                           SRR1660805.184233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332674.9/ ENSP00000331152.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               BC035128.1         7-165
            160-611             BQ924073.1         105-556
            612-641             BC016678.1         680-709
            642-2611            BC016678.1         786-2755
            2612-2736           BC035128.1         2616-2740
            2737-2973           AA854855.1         1-237               c
            2974-3253           BM668806.1         231-510             c
            3254-3467           AW291670.1         16-229              c
            3468-3470           BM668806.1         14-16               c
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..3470
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="MAX interactor 1, dimerization protein"
                     /db_xref="GeneID:4601"
                     /db_xref="HGNC:HGNC:7534"
                     /db_xref="MIM:600020"
     exon            1..478
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1092
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="isoform b is encoded by transcript variant 2; MAX
                     dimerization protein 2; MAX-interacting protein 1;
                     Max-related transcription factor; class C basic
                     helix-loop-helix protein 11"
                     /codon_start=1
                     /product="max-interacting protein 1 isoform b"
                     /protein_id="NP_569157.2"
                     /db_xref="CCDS:CCDS7563.1"
                     /db_xref="GeneID:4601"
                     /db_xref="HGNC:HGNC:7534"
                     /db_xref="MIM:600020"
                     /translation="MGKRGRPRKEARCEGAGLAPAAPPAVPPAVAAPQPPALPEDPAG
                     AKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIEKENKKCEHGYASSFP
                     SMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVL
                     IPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQ
                     EMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLP
                     SIGSDEGYSSASVKLSFTS"
     exon            479..611
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     exon            612..641
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     exon            642..756
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     exon            757..928
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     exon            929..3470
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="hexamer: AATAAA"
     polyA_site      2740
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="major polyA site"
     regulatory      3163..3168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="hexamer: AATGAA"
     polyA_site      3181
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
                     /note="hexamer: AATAAA"
     polyA_site      3470
                     /gene="MXI1"
                     /gene_synonym="bHLHc11; MAD2; MXD2; MXI"
ORIGIN      
        1 atacacacag actcacagcg agaccgacac acactcccat acactcacac acacaactgc
       61 aggcagcgag gctcgggaag tcaggccggc ttttcgcccc ggcgccttct ctgctccagc
      121 cggccgggtc tccctggggg cccggagctc ggccgggccg cgcagccccg ttagaggacg
      181 agctcggcgg acccccgctc ctccatgggc aaacgcgggc ggccgcgcaa ggaggcgcgc
      241 tgcgagggcg cggggctggc ccccgccgcg cccccggctg tgccccccgc cgtggccgcg
      301 ccccagcccc cggccctgcc cgaggacccc gctggggcca agcccaggtg ccccttctca
      361 gacattttca acaccagcga gaactcgatg gagaagcaca tcaacacttt tctgcagaac
      421 gtgcagattc tgctcgaggc cgccagctac ctggagcaga tcgagaaaga aaacaaaaag
      481 tgtgaacatg gctacgcctc ttcattcccg tccatgccga gcccccgact gcagcattca
      541 aagcccccac ggaggttgag ccgggcacag aaacacagca gcgggagcag caacaccagc
      601 actgccaaca gatctacaca caatgagctg gaaaagaatc gacgagctca tctgcgcctt
      661 tgtttagaac gcttaaaagt tctgattcca ctaggaccag actgcacccg gcacacaaca
      721 cttggtttgc tcaacaaagc caaagcacac atcaagaaac ttgaagaagc tgaaagaaaa
      781 agccagcacc agctcgagaa tttggaacga gaacagagat ttttaaagtg gcgactggaa
      841 cagctgcagg gtcctcagga gatggaacga atacgaatgg acagcattgg atcaactatt
      901 tcttcagatc gttctgattc agagcgagag gagattgaag tggatgttga aagcacagag
      961 ttctcccatg gagaagtgga caatataagt accaccagca tcagtgacat tgatgaccac
     1021 agcagcctgc cgagtattgg gagtgacgag ggttactcca gtgccagtgt caaactttca
     1081 ttcacttcat agaacccagc atgacataac agtgcagggc aaaatattca ctgggccaat
     1141 tcaatacaaa caatctctta aattgggttc atgatgcagt ctcctcttta aaacaaaaca
     1201 aaacaaaaca aaactatact tgaacaaaag ggtcagagga cctgtattta agcaaatact
     1261 tagcaaaaag tggggcagag cctcccaagg agaacaaata ttcagaatat tcatattgga
     1321 aaaatcacaa tttttaatgg cagcagaaaa cttgtgtgaa attttcttga tttgagttga
     1381 ttgagaagag gacattggag atgccatcct ctttctcttt tctagtttgc tcatactaca
     1441 ttgagtagac acatttaagg atggggttat gaacccttcc tgagctttat ggtcctaaaa
     1501 gcaaaataaa aactattcga atgaaaagac aagaaaatca ggtattaatc ttggatagct
     1561 aataatgagc tattaaaact cagcctggga cagtttatca tgaagcctgt ggatgatcaa
     1621 tcctttatta ttattttttt tttttgaaaa aagctcattt catgctctgc aaaaggagag
     1681 actcccatga agccttttga aagggatcat catgcagctc aactttctgt tggattccat
     1741 gctaagcaag ctaaccttat cctgcattgt tagcactagg cacccagctg ccacctctcc
     1801 atcctgctgc ccttaggcca catgggagca gtccatgcat gacagcctct atcctacaag
     1861 gcctatgagt atggattggg ggggccaaaa ggaaaaagct ccatgtgcct ctttgtctgc
     1921 gtgggtcaga agagttgtgc acgcagatta gcaggccaag gtctgagcca cagcagcatt
     1981 tttatttcag attttgataa ctgtttatat gtgttgaaaa ccaaaatgac atctttttaa
     2041 agcttatcca taaaaaaaaa tagatgtctt ttatagtgga aaaacacatg gggaaaaaaa
     2101 tcatctattt tgatgcagca tttgataatg ataaaacacc tcacacctca ctctttatag
     2161 tgcacaaaat gaatgaggtc tgggctaggt agaaaaaggg tcaatgctat ttttgttttt
     2221 agaatcatta ccttttacca gcttttaacc atctgatatc tatagtagac acactatcat
     2281 agttaacata gtaagttcag cacttgtctc attttaatgt aaagatttgc ttccattttc
     2341 ctacaggcag tctctctctt cctcacagtc ccactgtgca ggtgctattg ttactcttac
     2401 gaatattttc agtaatgtta ttttcttcta agtgaaattt ctagcctgca ctttgatgtc
     2461 atgtgttccc tttgtctttc aaactccaag gttcccttgt ggccctctcc cttaccctgg
     2521 gaaggcctct tggagacctt acccctggct gtttggactt tgtatacttt aaataattta
     2581 actaccctta attacttaaa aaaaaaaaaa agctttatga ttttcataac ttattgctga
     2641 ttttaatgga ttgttaattt cagtcctgta gttttatttt atgtttagat agggctgggc
     2701 aaggaaaaag aaaataaaga caaccatatt tagcagtgca gttgagttgt gtgttaatgt
     2761 tagactatcc ctttgtgagt gacactttaa cagcattcac tgcttctata tatagtgtac
     2821 catcttggtc atacattacg cctcaacata tacttgtgct cttcctttgc ctccagaaga
     2881 agtttttcct tgattgtgct atgtttcagt ggaagaaatt ctttgaagta gatgtgagtg
     2941 aaaaactgca tgcctttaga agcccagtat cagaacttgc tacgtttcag gtgctaggga
     3001 cttaatgaaa aacaggacaa aacaattcct ttttgtggcc caggtaaatt atttctggtt
     3061 tcacttataa ttactaatgg ctgagtcaag atgttgtctc tgtgtttgct tactcttgat
     3121 caagtgtgag acagtttgaa gactgtgcta ccatacaaag tgaatgaagc cagtgactaa
     3181 gcttctgttt gttttgttat tctcatggcc ttcgcttgca ttatttgggc cttcattcag
     3241 atgaacttga ggtgccattt tgttgcatat gtacaggatt atgggctgga aagcatttgt
     3301 tataaaccta tagtgcacat tttaactgcc ccctaaatta cccttccctg ggtttgtttt
     3361 ccttggggtg gtgtagattg tatgagtaag aagtattaat tttttaaaag acaaatcaac
     3421 tttgaagaca caaaagttaa ttggaagaaa taaaaactgt gaacgaagaa
//
