LOCUS       NM_006454               3871 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MAX dimerization protein 4 (MXD4), mRNA.
ACCESSION   NM_006454
VERSION     NM_006454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Coutier,J., Auvre,F., Lemaitre,G., Lataillade,J.J., Deleuze,J.F.,
            Romeo,P.H., Martin,M.T. and Fortunel,N.O.
  TITLE     MXD4/MAD4 Regulates Human Keratinocyte Precursor Fate
  JOURNAL   J Invest Dermatol 143 (1), 105-114 (2023)
   PUBMED   36007550
  REMARK    GeneRIF: MXD4/MAD4 Regulates Human Keratinocyte Precursor Fate.
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Hu,C.L., Chen,B.Y., Li,Z., Yang,T., Xu,C.H., Yang,R., Yu,P.C.,
            Zhao,J., Liu,T., Liu,N., Shan,B., Zhang,Q., Song,J., Fei,M.Y.,
            Zong,L.J., Zhang,J.Y., Wu,J.C., Chen,S.B., Wang,Y., Chang,B.,
            Hou,D., Liu,P., Jiang,Y., Li,X., Chen,X., Deng,C.H., Ren,Y.Y.,
            Wang,R., Jin,J., Xue,K., Zhang,Y., Du,M., Shi,J., Wu,L.Y.,
            Chang,C.K., Shen,S., Chen,Z., Chen,S.J., Liu,X., Sun,X.J., Zheng,M.
            and Wang,L.
  TITLE     Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell
            eradication in myeloid leukemia
  JOURNAL   Cell Res 32 (12), 1105-1123 (2022)
   PUBMED   36302855
  REMARK    GeneRIF: Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating
            cell eradication in myeloid leukemia.
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Van Treeck,B.J., Thangaiah,J.J., Torres-Mora,J., Stevens,T.M.,
            Rothermundt,C., Fassan,M., Loupakis,F., Diebold,J., Hornick,J.L.,
            Halling,K.C. and Folpe,A.L.
  TITLE     NUTM1-rearranged colorectal sarcoma: a clinicopathologically and
            genetically distinctive malignant neoplasm with a poor prognosis
  JOURNAL   Mod Pathol 34 (8), 1547-1557 (2021)
   PUBMED   33714983
  REMARK    GeneRIF: NUTM1-rearranged colorectal sarcoma: a
            clinicopathologically and genetically distinctive malignant
            neoplasm with a poor prognosis.
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Yang,W., Yang,X., David,G. and Dorsey,J.F.
  TITLE     Dissecting the complex regulation of Mad4 in glioblastoma
            multiforme cells
  JOURNAL   Cancer Biol Ther 13 (13), 1339-1348 (2012)
   PUBMED   22895069
  REMARK    GeneRIF: The E3 ligase activity of c-IAP1 was not required for
            downregulation of Mad4 expression.
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3871)
  AUTHORS   Jiang,D.J., Yu,H.X., Hexige,S.Y., Guo,Z.K., Wang,X., Ma,L.J.,
            Chen,Z., Zhao,S.Y. and Yu,L.
  TITLE     Human liver specific transcriptional factor TCP10L binds to MAD4
  JOURNAL   J Biochem Mol Biol 37 (4), 402-407 (2004)
   PUBMED   15469726
  REMARK    GeneRIF: Data suggest that the biological function of the
            interaction between T-complex protein 10-like and MAD4 may be to
            maintain the differentiation state in liver cells.
REFERENCE   7  (bases 1 to 3871)
  AUTHORS   Kime,L. and Wright,S.C.
  TITLE     Mad4 is regulated by a transcriptional repressor complex that
            contains Miz-1 and c-Myc
  JOURNAL   Biochem J 370 (Pt 1), 291-298 (2003)
   PUBMED   12418961
  REMARK    GeneRIF: regulation by a transcriptional repressor complex that
            contains Miz-1 and c-Myc
REFERENCE   8  (bases 1 to 3871)
  AUTHORS   Cairo,S., Merla,G., Urbinati,F., Ballabio,A. and Reymond,A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   9  (bases 1 to 3871)
  AUTHORS   Billin,A.N., Eilers,A.L., Queva,C. and Ayer,D.E.
  TITLE     Mlx, a novel Max-like BHLHZip protein that interacts with the Max
            network of transcription factors
  JOURNAL   J Biol Chem 274 (51), 36344-36350 (1999)
   PUBMED   10593926
REFERENCE   10 (bases 1 to 3871)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158068.18.
            
            On May 17, 2019 this sequence version replaced NM_006454.2.
            
            Summary: This gene is a member of the MAD gene family . The MAD
            genes encode basic helix-loop-helix-leucine zipper proteins that
            heterodimerize with MAX protein, forming a transcriptional
            repression complex. The MAD proteins compete for MAX binding with
            MYC, which heterodimerizes with MAX forming a transcriptional
            activation complex. Studies in rodents suggest that the MAD genes
            are tumor suppressors and contribute to the regulation of cell
            growth in differentiating tissues. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.215519.1, AF082740.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337190.7/ ENSP00000337889.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AL158068.18        87899-88091
            194-293             AL158068.18        88184-88283
            294-323             AL158068.18        91997-92026
            324-438             AL158068.18        97486-97600
            439-601             AL158068.18        98762-98924
            602-3871            AL158068.18        99307-102576
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..3871
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="MAX dimerization protein 4"
                     /db_xref="GeneID:10608"
                     /db_xref="HGNC:HGNC:13906"
                     /db_xref="MIM:620016"
     exon            1..193
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..759
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="Mad4 homolog; max dimerizer 4; max-associated
                     protein 4; class C basic helix-loop-helix protein 12;
                     max-interacting transcriptional repressor MAD4"
                     /codon_start=1
                     /product="max dimerization protein 4"
                     /protein_id="NP_006445.1"
                     /db_xref="CCDS:CCDS3361.1"
                     /db_xref="GeneID:10608"
                     /db_xref="HGNC:HGNC:13906"
                     /db_xref="MIM:620016"
                     /translation="MELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFAREKTKA
                     AGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKVHI
                     KKLEEQDRRALSIKEQLQQEHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVD
                     IEGMEFGPGELDSVGSSSDADDHYSLQSGTGGDSGFGPHCRRLGRPALS"
     exon            194..293
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     exon            294..323
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     exon            324..438
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     exon            439..601
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     exon            602..3871
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1057..1062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="hexamer: ATTAAA"
     polyA_site      1077
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="major polyA site"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="hexamer: AATACA"
     polyA_site      3871
                     /gene="MXD4"
                     /gene_synonym="bHLHc12; MAD4; MST149; MSTP149"
                     /note="major polyA site"
ORIGIN      
        1 gagcgccgga gtccgcggag tctggaagtg cggcggccgg gcgcgcgggg tgggcggcga
       61 gcggagccgg ccggagcggg ccgggcagcg gccgccgccg tcccggggcg gacgggcgcg
      121 ggcgggagga tggagctgaa ctccctgctg atcctgctgg aggcggccga gtacctggag
      181 cgcagggatc gagaggccga gcacggctac gcctcggtgc tgcccttcga cggcgacttc
      241 gccagggaga aaacaaaggc ggccggcctg gtgcgcaagg ccccgaacaa caggtcttca
      301 cacaacgagc tagaaaagca cagacgagcc aaactcaggc tgtaccttga gcagctcaag
      361 caactggtgc ccctgggccc cgacagcacc cgccacacca cgctgagcct cctgaagcgg
      421 gccaaggtgc acatcaagaa actggaggag caggaccgcc gggcactgag catcaaggag
      481 cagctgcagc aggagcatcg tttcctgaag cggcgcctgg agcagctgtc ggtgcagagc
      541 gtggagcgcg tgcgcacaga tagcacgggc tctgctgtct ccacggacga ctcagagcaa
      601 gaagtggaca tagagggcat ggagtttggc cctggtgagc tggacagtgt tggcagcagc
      661 agtgacgcgg acgaccacta cagcctgcag agtggcaccg gcggcgacag tggcttcggg
      721 ccccactgcc ggcggctggg ccgccccgcc ctctcgtagg cccgtgccct ctgctccttg
      781 gcctgcctgc ccgccagcca cgcgtgtcag ccctccagtt ctccttcagt tgacgccagc
      841 ctctccacag gcccactgct gtgccattct ggaagctcca gctgctgctg ggctgcctgg
      901 cactgcccgc ttgccggtca gggcctgccg agctgcctgc cccttccagc tgggcagagt
      961 cccctgcaag gaggcagggc ccagcttcca catccggagc cctggtcagc atagccgccc
     1021 acggtctgtt ctcagattcc taatcattcc agaagtatta aacgtcattg ctgcaaacct
     1081 cggcaggtgc cgtgtgaggg gcttaatgac caccacaggg agctcagacc ccaaccctgg
     1141 atcccaggag aaaggagtgg accgaggaag gaaggaaggc aaggctgtct gtccatccgt
     1201 ccgtctgtcc acctacctgt cagtccacat aggctcctgg cgtggacaag gggtctgtga
     1261 agggcgggaa ctgggtgagc acctggggca ggtgggtggt taaggtcctt cccacttcgc
     1321 aggtgtcaga acctagggct gggctctcgg ggccaggcag gccagcccag cccacgccga
     1381 gctgggcagc gtctgctctg gtaggactgt cagacgcaca cgcgcacgca cctagacaca
     1441 cccactcatg tacatgctca cacatgcaga cacacctggg cgtcccgagg tcacatgttc
     1501 tggggatgat ggccttcagg ggtcatctgg caaacagccc ctgggctgtg cctggatccc
     1561 cctctagctc ctgctcaccc acgcccaccc agtagtcctg cctgtctgca caggagaggg
     1621 gcttctcttc ctggctgggg ctggggtgaa ctggaggctg gttaagttgc agccgctggg
     1681 tcctcggggg cttactcatc tccctttttt aaacaaaaag caaaaaagta aaatgctgca
     1741 ctgcccagca gcccggttag ggctcctgga gccaccttag gaaagggctt ctcatgagct
     1801 ctgctgcggc agcttcagct ggcagagagg ctttcccaga aaaaaaaaaa aaaccatttt
     1861 taaaaagaag aaagcctaaa gactctcggc ctagggacgt ccgtgtgtgc cgcctctgtt
     1921 tcctgtacca gatttttgta ttctattttc ctagctgttg ttgcgtcctt gtttgctgag
     1981 gggtgggagc cacccagcgt ctcagggacc tgtccctccg tcacgtcgtc aaagtgtgcc
     2041 ttgtgtcttg tgtcaggcct tgcccttccc accagcatgt ccctcgtggc tcagggtgcc
     2101 ccaggcctgc ccagctagtg ctgtcctccc atctcctgtg ggcagcccct cccggcagcc
     2161 agggcttcct ggaggcgatg cagccaggcc cctgtgggtg gcacggaggg gctgtgacct
     2221 ggtccccagt gttgccctcc ccagtggctg gcaggggcct gcttgctcac tagagagatg
     2281 gattctcacc tgtcacctga ctcgagcccc ctgcttcctg gcctaggcga gggttccagg
     2341 tttcagacac tggcagccaa tgaagactgt gctcgctggg tggtgcaggc ctggcaccag
     2401 gaggcttgca cccgcctttc cttcctgacg tcctctgtcc ttggggctgg cccatagcag
     2461 tgcctgccgt gcctctggta catctgtagc caattcccat atcatgggga aaattcgtgt
     2521 ctattttcag tcgtacgcat agacgcccca ggatgggggg cccactgtgg cggaaggggg
     2581 tccctggaaa caactctggc acagaacctg ccctgcaggc tgtagggggc atggtgcctg
     2641 gagctgaggg gcatccgaac gcgttgcggg tggttgtgag gaggcctgtc tgcatctcct
     2701 tccggcccca ctggggtcca ggggtgccca gaaaggagct tcccctgcct gcctgagtct
     2761 gtccccccag gcttcatttc aaacaccgtg gcacctccga gcaaggcggg ccgtgtgtaa
     2821 aagcttgctt ccccagccag cactgcaggg ccctgaggtg gtcgtgtccc tgccctcaat
     2881 tcttgaagca ccagctccct gccccaccct ccagtgcctg aggcagctag gggcttctgc
     2941 tctcatctct gaccagcaga atccacccgg tgaccagtgg tggcccctca gcccaccctc
     3001 ccggcagctc agcctgtggc tcttgaggcc gtggttccca cgtggactgg gaggcagtct
     3061 cagccacccg gggtgctgtt cagctgcccc tccctgccat cagcaggtgg gtgaggggtt
     3121 gcccactggg tgggggcccg tgctaggagt caccacatgc tccaacctcc cactgctccc
     3181 tgtcaggggc ccaggctgcc atcactggag gctgcaggga ccaagaggcc atcaccgtgt
     3241 ctatagagag cagacagaag cagaacagag cccggggctc ctgagcctct gcgtgtgccc
     3301 tcccagccca caccagtgct ctcggccact gagcacccag actcaggctt gggttcccca
     3361 gccttattgg aaggcagctc ccgcatacca ggataacccc cgcaaaccac atagcagacc
     3421 cccgccatcc tcgcagagtg ggagaggctg cagcaaggct ttgcctctgc agaccccatc
     3481 ttagtggcac ggtgcttggg cctgtgtccc cgggtggtgg aaccctgtac cggtctgtgg
     3541 ccctagggtc cctgctctgt ctgccccggc ccgtgctgtc cgctgggtga ggcaggctcc
     3601 cccgtgccct gcctccctct gtcagggaac ctgggacccc ctccccactg cctgcacaga
     3661 ggaccctgac cctcggccag cagggtggcc ccaggtccat gttgggcact agggcaggtt
     3721 ccgtgccaga gtcgggggcc acacgagggc ctggtgccgg tgaggggggc gtgcgctaga
     3781 gggggaaagg ggcccccggc cacctgtcca ccgtgtgggc cgtgctgtgt ccttatgtca
     3841 ttgtaatata aatacagatt tttatatctc a
//
