LOCUS       NM_031300               1067 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAX dimerization protein 3 (MXD3), transcript variant
            1, mRNA.
ACCESSION   NM_031300
VERSION     NM_031300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1067)
  AUTHORS   Tsai,Y.W., Jeng,K.S., He,M.K., Hsieh,Y.W., Lai,H.H., Lai,C.Y.,
            Huang,C.C., Chang,C.F., Huang,C.T. and Her,G.M.
  TITLE     MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway
            in Gender-Disparity Hepatocarcinogenesis
  JOURNAL   Cells 10 (12), 3434 (2021)
   PUBMED   34943942
  REMARK    GeneRIF: MXD3 Promotes Obesity and the Androgen Receptor Signaling
            Pathway in Gender-Disparity Hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1067)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1067)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1067)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1067)
  AUTHORS   Duong,C., Yoshida,S., Chen,C., Barisone,G., Diaz,E., Li,Y.,
            Beckett,L., Chung,J., Antony,R., Nolta,J., Nitin,N. and Satake,N.
  TITLE     Novel targeted therapy for neuroblastoma: silencing the MXD3 gene
            using siRNA
  JOURNAL   Pediatr Res 82 (3), 527-535 (2017)
   PUBMED   28419087
  REMARK    GeneRIF: results indicate that MXD3 is a potential new target and
            that the use of MXD3 siRNA nanocomplexes is a novel therapeutic
            approach for neuroblastoma
REFERENCE   6  (bases 1 to 1067)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1067)
  AUTHORS   Barisone,G.A., Yun,J.S. and Diaz,E.
  TITLE     From cerebellar proliferation to tumorigenesis: new insights into
            the role of Mad3
  JOURNAL   Cell Cycle 7 (4), 423-427 (2008)
   PUBMED   18235219
  REMARK    Review article
REFERENCE   8  (bases 1 to 1067)
  AUTHORS   Yun,J.S., Rust,J.M., Ishimaru,T. and Diaz,E.
  TITLE     A novel role of the Mad family member Mad3 in cerebellar granule
            neuron precursor proliferation
  JOURNAL   Mol Cell Biol 27 (23), 8178-8189 (2007)
   PUBMED   17893326
REFERENCE   9  (bases 1 to 1067)
  AUTHORS   Hurlin,P.J. and Huang,J.
  TITLE     The MAX-interacting transcription factor network
  JOURNAL   Semin Cancer Biol 16 (4), 265-274 (2006)
   PUBMED   16908182
  REMARK    Review article
REFERENCE   10 (bases 1 to 1067)
  AUTHORS   Sommer,A., Bousset,K., Kremmer,E., Austen,M. and Luscher,B.
  TITLE     Identification and characterization of specific DNA-binding
            complexes containing members of the Myc/Max/Mad network of
            transcriptional regulators
  JOURNAL   J Biol Chem 273 (12), 6632-6642 (1998)
   PUBMED   9506959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM849150.1 and BC000745.2.
            
            On Jun 2, 2019 this sequence version replaced NM_031300.3.
            
            Summary: This gene encodes a member of the Myc superfamily of basic
            helix-loop-helix leucine zipper transcriptional regulators. The
            encoded protein forms a heterodimer with the cofactor MAX which
            binds specific E-box DNA motifs in the promoters of target genes
            and regulates their transcription. Disruption of the MAX-MXD3
            complex is associated with uncontrolled cell proliferation and
            tumorigenesis. Transcript variants of this gene encoding different
            isoforms have been described.[provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 3 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000745.2, AK222579.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439742.7/ ENSP00000401867.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BM849150.1         373-390
            19-1067             BC000745.2         1-1049
FEATURES             Location/Qualifiers
     source          1..1067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1067
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /note="MAX dimerization protein 3"
                     /db_xref="GeneID:83463"
                     /db_xref="HGNC:HGNC:14008"
                     /db_xref="MIM:609450"
     exon            1..138
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..689
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /note="isoform a is encoded by transcript variant 1;
                     Max-interacting transcriptional repressor MAD3;
                     Max-associated protein 3; max dimerizer 3; class C basic
                     helix-loop-helix protein 13"
                     /codon_start=1
                     /product="max dimerization protein 3 isoform a"
                     /protein_id="NP_112590.1"
                     /db_xref="CCDS:CCDS4416.1"
                     /db_xref="GeneID:83463"
                     /db_xref="HGNC:HGNC:14008"
                     /db_xref="MIM:609450"
                     /translation="MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRR
                     KKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRA
                     RMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLS
                     SERSDSDQEELEVDVESLVFGGEAELLRGFVAGQEHSYSHGGGAWL"
     exon            139..244
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     exon            245..274
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     exon            275..389
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     exon            390..573
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1067
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1048..1053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /note="hexamer: ATTAAA"
     polyA_site      1067
                     /gene="MXD3"
                     /gene_synonym="BHLHC13; MAD3; MYX"
                     /note="major polyA site"
ORIGIN      
        1 aacaaaagtg ctgcagccgc ttgctccggc cggcacccta ggccggcccg ccgccagctg
       61 tcgccgacat ggaacccttg gccagcaaca tccaggtcct gctgcaggcg gccgagttcc
      121 tggagcgccg tgagagagag gccgagcatg gttatgcgtc cctgtgcccg catcgcagtc
      181 caggccccat ccacaggagg aagaagcgac ccccccaggc tcctggcgcg caggacagcg
      241 ggcggtcagt gcacaatgaa ctggagaagc gcaggagggc ccagttgaag cggtgcctgg
      301 agcggctgaa gcagcagatg cccctggggg ccgactgtgc ccggtacacc acgctgagcc
      361 tgctgcgccg tgccaggatg cacatccaga agctggagga tcaggagcag cgggcccgac
      421 agctcaagga gaggctgcgc agcaagcagc agagcctgca gcggcagctg gagcagctcc
      481 gggggctggc aggggcggcc gagcgggagc ggctgcgggc ggacagtctg gactcctcag
      541 gcctctcctc tgagcgctca gactcagacc aagaggagct ggaggtggat gtggagagcc
      601 tggtgtttgg gggtgaggcc gagctgctgc ggggcttcgt cgccggccag gagcacagct
      661 actcgcacgg cggcggcgcc tggctatgat gttcctcacc cagggcgggc ctctgccctc
      721 tactcgtgcc aggcccactt gccaggcagg agccctcccc aagccttcag ggctgctcgg
      781 agtcacctgt tggaatggac taaaaggacc cttgtgtggg aacaggtgct ccccaaacac
      841 cctgctgctg gctgccaggc aggccctctg gaagggaagg ggcaggactc atcaggacct
      901 ccctggaccc ctgcagggca ggcagcttgg gcccgagccc aagcatttgg ctctgctgcc
      961 cccaagggga caggaagcct cttgggcctc ttcccttcct ggacaaggcc ccctgccttt
     1021 gcctcacata aactgtacag tattttcatt aaaagcctct ttcataa
//
