LOCUS       NM_002357               5549 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAX dimerization protein 1 (MXD1), transcript variant
            1, mRNA.
ACCESSION   NM_002357
VERSION     NM_002357.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5549)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5549)
  AUTHORS   Li,S., He,X., Gan,Y., Zhang,J., Gao,F., Lin,L., Qiu,X., Yu,T.,
            Zhang,X., Chen,P., Tong,J., Qian,W. and Xu,Y.
  TITLE     Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the
            growth of B cell lymphoma
  JOURNAL   Theranostics 11 (7), 3439-3451 (2021)
   PUBMED   33537096
  REMARK    GeneRIF: Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and
            inhibits the growth of B cell lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5549)
  AUTHORS   Du,F., Dong,D., Zhang,X. and Jia,J.
  TITLE     MXD1 is a Potential Prognostic Biomarker and Correlated With
            Specific Molecular Change and Tumor Microenvironment Feature in
            Esophageal Squamous Cell Carcinoma
  JOURNAL   Technol Cancer Res Treat 20, 15330338211052142 (2021)
   PUBMED   34761715
  REMARK    GeneRIF: MXD1 is a Potential Prognostic Biomarker and Correlated
            With Specific Molecular Change and Tumor Microenvironment Feature
            in Esophageal Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 5549)
  AUTHORS   Jiang,K., Hein,N., Eckert,K., Luscher-Firzlaff,J. and Luscher,B.
  TITLE     Regulation of the MAD1 promoter by G-CSF
  JOURNAL   Nucleic Acids Res 36 (5), 1517-1531 (2008)
   PUBMED   18203738
  REMARK    GeneRIF: Results suggest STAT3 functions as a C/EBPbeta cofactor in
            the regulation of the MAD1 gene.
REFERENCE   5  (bases 1 to 5549)
  AUTHORS   Guo,X.L., Pan,L., Zhang,X.J., Suo,X.H., Niu,Z.Y., Zhang,J.Y.,
            Wang,F., Dong,Z.R., Da,W. and Ohno,R.
  TITLE     Expression and mutation analysis of genes that encode the Myc
            antagonists Mad1, Mxi1 and Rox in acute leukaemia
  JOURNAL   Leuk Lymphoma 48 (6), 1200-1207 (2007)
   PUBMED   17577784
  REMARK    GeneRIF: Mad1, Mxi1 and Rox genes were expressed and displayed
            mutations in haematological malignancies.
REFERENCE   6  (bases 1 to 5549)
  AUTHORS   Hassig,C.A., Fleischer,T.C., Billin,A.N., Schreiber,S.L. and
            Ayer,D.E.
  TITLE     Histone deacetylase activity is required for full transcriptional
            repression by mSin3A
  JOURNAL   Cell 89 (3), 341-347 (1997)
   PUBMED   9150133
REFERENCE   7  (bases 1 to 5549)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
REFERENCE   8  (bases 1 to 5549)
  AUTHORS   Shapiro,D.N., Valentine,V., Eagle,L., Yin,X., Morris,S.W. and
            Prochownik,E.V.
  TITLE     Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13
            and 10q24-q25
  JOURNAL   Genomics 23 (1), 282-285 (1994)
   PUBMED   7829091
REFERENCE   9  (bases 1 to 5549)
  AUTHORS   Edelhoff,S., Ayer,D.E., Zervos,A.S., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Eisenman,R.N., Brent,R. and
            Disteche,C.M.
  TITLE     Mapping of two genes encoding members of a distinct subfamily of
            MAX interacting proteins: MAD to human chromosome 2 and mouse
            chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome
            19
  JOURNAL   Oncogene 9 (2), 665-668 (1994)
   PUBMED   8290278
REFERENCE   10 (bases 1 to 5549)
  AUTHORS   Ayer,D.E., Kretzner,L. and Eisenman,R.N.
  TITLE     Mad: a heterodimeric partner for Max that antagonizes Myc
            transcriptional activity
  JOURNAL   Cell 72 (2), 211-222 (1993)
   PUBMED   8425218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC098396.1 and AC019206.4.
            
            On Nov 22, 2018 this sequence version replaced NM_002357.3.
            
            Summary: This gene encodes a member of the MYC/MAX/MAD network of
            basic helix-loop-helix leucine zipper transcription factors. The
            MYC/MAX/MAD transcription factors mediate cellular proliferation,
            differentiation and apoptosis. The encoded protein antagonizes
            MYC-mediated transcriptional activation of target genes by
            competing for the binding partner MAX and recruiting repressor
            complexes containing histone deacetylases. Mutations in this gene
            may play a role in acute leukemia, and the encoded protein is a
            potential tumor suppressor. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098396.1, SRR1803611.16788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264444.7/ ENSP00000264444.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1963              BC098396.1         39-2001
            1964-2770           AC019206.4         190143-190949
            2771-5549           BC098396.1         2811-5589
FEATURES             Location/Qualifiers
     source          1..5549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..5549
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /note="MAX dimerization protein 1"
                     /db_xref="GeneID:4084"
                     /db_xref="HGNC:HGNC:6761"
                     /db_xref="MIM:600021"
     exon            1..295
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..888
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAX-binding protein; antagonizer of myc transcriptional
                     activity; max dimerizer 1"
                     /codon_start=1
                     /product="max dimerization protein 1 isoform 1"
                     /protein_id="NP_002348.1"
                     /db_xref="CCDS:CCDS1896.1"
                     /db_xref="GeneID:4084"
                     /db_xref="HGNC:HGNC:6761"
                     /db_xref="MIM:600021"
                     /translation="MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDAL
                     KRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAK
                     LHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDRE
                     EIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKAC
                     LGL"
     exon            296..395
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..425
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..540
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..700
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..5549
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3225..3230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /note="hexamer: TATAAA"
     polyA_site      3245
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
     regulatory      5524..5529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /note="hexamer: AATAAA"
     polyA_site      5549
                     /gene="MXD1"
                     /gene_synonym="BHLHC58; MAD; MAD1"
                     /note="major polyA site"
ORIGIN      
        1 gctctgctcc gggttctgtc actgtgtcgg cggtgcccag ctcactggcc ccctccctct
       61 cttgtcgagc gtggttgcca gagaggctcc ctcagccctg ctccgcgggg tccacagcgg
      121 gctccacagc gggctccata gcgggctcca cagcggtccg gcggcggcag cgagcccgtg
      181 ggcagtgggg gttggtcccg tggctccggc ccccggtgca gaatggcggc ggcggttcgg
      241 atgaacatcc agatgctgct ggaggcggcc gactatctgg agcggcggga gagagaagct
      301 gaacatggtt atgcctccat gttaccatac aataacaagg acagagatgc cttaaaacgg
      361 aggaacaaat ccaaaaagaa taacagcagt agcagatcaa ctcacaatga aatggagaag
      421 aatagacggg ctcatcttcg cttgtgcctg gagaagttga aggggctggt gccacttgga
      481 cccgaatcaa gtcgacacac tacgttgagt ttattaacaa aagccaaatt gcacataaag
      541 aaacttgaag attgtgacag aaaagccgtt caccaaatcg accagcttca gcgagagcag
      601 cgacacctga agaggcagct ggagaagctg ggcattgaga ggatccggat ggacagcatc
      661 ggctccaccg tctcctcgga gcgctccgac tccgacaggg aagaaatcga cgttgacgtg
      721 gagagcacgg actatctcac aggtgatctg gactggagca gcagcagtgt gagcgactct
      781 gacgagcggg gcagcatgca gagcctcggc agtgatgagg gctattccag caccagcatc
      841 aagagaataa agctgcagga cagtcacaag gcgtgtcttg gtctctaaga gagtgggcac
      901 tgcggctgtc tccttgaagg ttctccctgt tggttctgat taggtaacgt attggacctg
      961 cccacaactc ccttgcacgt aaacttcagt gtcccacctt gaccaaaatc agctttgtaa
     1021 ctgttttcaa ggaggtgctt aggattgtgg gtttctgatt gcatccacta gcttctcttt
     1081 ttctcgccat aaaaatttgt ctctgagaga ctatacattc caatcaattt gaagcatcca
     1141 agaattctta gaccgaataa gcaatgtcca catctcagca atccccctct ttgctctcct
     1201 cgtgtcctct cccagacctt tcttccagtt ttctggctta ctgtgttact tgcctaggag
     1261 gaatgtccaa gtgtgtcttg tacttaggaa actgaaggaa acaaactttt gaaattgaga
     1321 tcctgatctc agaactccaa agtaagcttt gaaagcagca tttaagagca cttaaccatg
     1381 gacctcacca ccagtgagga agtcaggaat acctctagaa aacacgccct tcacaccgcg
     1441 catgctcatt cccccgacgc gccgcgtgtg gatgggagca gtatttctca ctttaaaatg
     1501 gacaccttga tagtgtgtct ctggggttgc acagctcatc aaagttccaa attgtttgtt
     1561 ctcacaaaca aaacggtaca atctattttt gtgcgatgtt cttgggacct cgctgtgttc
     1621 tgctatctcg aggcacattc tcccctccaa ctttgttaat gctacttgtc tctggaacat
     1681 ttttttttcc tacctcagag ataaatgaga tctccatttc ccacttaaca cagtgattat
     1741 ccttttttcc ccccccaaaa tagtgacatt tggtccaatt ataatctatt ttcctattga
     1801 actttcagca ataactgagc tgtggcacta gcagagctag tagccattat cagtgaaaga
     1861 aaaagtccac atttctactc tctgttgcag gtgaacagga gaggatggta cactgttact
     1921 agaactcctc tccttattga ttatttttgg acacacccag aaacttcttt atggaggctt
     1981 ttgggttgat agtttaaaag gctgattttt ctttttggtt atgatttctc ccttaagtgg
     2041 tctccgactt tgtagcattt ttatttaagc taaaacagag cacatgtata tgtacataag
     2101 acacattaaa tctataaata ctatttattc attttatata aactaatgta atggaaaaca
     2161 aattcttatg actttgtggt tttatagatg ttctagaaac tttgtatgta ggtatctaca
     2221 aaattagttc attcccctga atatttttgc attcatattt ttgaggtctt gatgttttca
     2281 gcctctggcg aatctttttc attgaatttg aaccatttgt aaaatctgtg atgctgaagc
     2341 agagtgtgtc acaaagtgat gagaacatta ctaaaatcca cggacgcact gcgacctaag
     2401 ggctcaacgg ctgactcggc agcgggcagc caccccacgc tcccctgcgg tcactcgcac
     2461 accacagcct gaagctcccc cagcgcctgc acctcgcaca cagctaaggt caaagttcaa
     2521 acgcactcca cacggaagct cattctatac ccgaagagca gtctcagaaa gcaagattac
     2581 ttttgtgttt tttaaaaaat gattctttaa tgtatttttc taaacattct gattggaagt
     2641 agtggattcc taaatgattc caaagtcacc tgtaattctt ctgtttttgt tttgttctgt
     2701 cttttcttca ttttggcttt gggtgggggg aggggcaggt gacacaaagg attttttttt
     2761 ttttttttta atttttggaa tcttttccaa taaccagcta aagatttgca ctgaaataca
     2821 acttgtatgc cttttgcatt tttaaagcct gcttcctgga tttaagcaga gtgatagtgt
     2881 tcaaagagcc agttcagcct gtaacatatt tgaaaaagat atgtctgcac tttgaggtcc
     2941 cttttgaatg ccattcacta gacctctcaa gcattttgtt tcattgctac atccaagcgc
     3001 ctcacaagtc cacaatgcgg gacagcatca aaagctcaag actttggaaa aagcttgtgg
     3061 gcttgcactg ggggagggaa gggaacaaaa tttgtgtact tctttgttta atttagaaat
     3121 aaggcatcca agagatgcca ttattttctg tgtttcaatt gttgtgcctt tgagttaaac
     3181 tgcatttttg tcttttggtt gaaatctgaa atgtactgtc ccaatataaa acagtaatta
     3241 tttgaccttt gcactgtttg tctggtcctt ttcagtttga ttgcatataa atgtggaact
     3301 tgatagatct ctatattttt aatgcacttg tgataaactg gcagcagggt tagacattac
     3361 tttcaaagct tgaggtagac cgagtcagca tgctagacag gcttctctct ctaaccaaaa
     3421 ctgtaatctt caggaccagc aaactcagcc caaggcagct aatcccccca accccatcct
     3481 ccgcgccccg tgcggctgat cggcagccct gattcgccaa tttgtcctct ctcattcact
     3541 gatccaccag cctgactgct aagagctata gtctttttag ttgttttgtc tttttaagca
     3601 agatgaaaac ctttctatta gggattttgg ggttgggagg ggatgggcag agatataaac
     3661 cccagccttt aagactttga caattgtacg taaatacaga tgtgtataaa tataggcaca
     3721 tgcatatttt tatgtgaaag ttgattttaa aaaactaaaa aaatctaaac tgcactctta
     3781 ttgataccat cataacgcaa gtgggaaaaa taagagtacg cagtctaatt taatttcatg
     3841 cagtgggaaa atatatatgt gtgcttctgt aacatcctga aaacatagct ttccatcccc
     3901 tgttggcttt gaatggtggg ccgagcaccc aggtcgtctg tattttggtt ttcttttgct
     3961 aagcagagat cttgaattct tcaaggtgct gatagcaact gctggctcct ttctgtagtc
     4021 acacacctaa tgctagttta gtgattcaaa atgcatcaca tttttaggca ggacctagat
     4081 tttccctgtc aacctaagat gaaaataatt tcagtgttga ttcagaactg aacattaagt
     4141 aggccctcgt cctgcagttg gccacttgag tgttttgttt tgtttttatt ttttaaggtg
     4201 ggcattttcc tttaacctct actttttcaa aagcaacaaa ggggcctcaa cctgagtttc
     4261 ctatgggcct ctcttctgca tccccaaagc ggccaagagc aaatcctggg ggataagaaa
     4321 aaagtgtaaa ctaggtagga ttgtgatgct caaaataacc atctagcaat atcttggagc
     4381 ttgagaatag attttgtggg cttatttctt cttgcctctt ccccatcctt tcaagagaga
     4441 acttattttt gaaaagtatc tatatataca cacacacaca cacacacaca tattattatt
     4501 taggttttta taccatactg tattggcgag aataccacta tcattgtcct ttacagtcta
     4561 tttcttcccc caagtcttgg tcttttttta ttttctattt tttcatgaac cacacaggag
     4621 actttaacat cctggtcttt tctgtttctt ctttgtttcc ccaagtttgt ctgtccccct
     4681 ttgccttccc tgagtgttga acatcaggta gtaaaaggct aaacgcaatt tcttgcatgt
     4741 caatctattc tttttctatg tttgactctg atgcagtgtg tttagcgtgt ctagtagctg
     4801 gctactccta tttaaaaact cttcctggta gaagacaacc caaagaccct tttcgatgag
     4861 gtggtttctc attctacatc ctctgatctc tatagactgt aggatgcttt gctttcaaag
     4921 ataactgggt tagagggtgg ggtgtgcaat aggtgattta tcatggtttt tttcattatc
     4981 aatattacat ggatgatttt ctcagattct tctgaaagaa gaaattgaca ggcactgcta
     5041 gattcagcta ttgaatggct gaagagattg agtatttgac cttctctcaa aatcataaag
     5101 tgagaattca taaggcaccc aatgttaaga tttatccaga tttttacatt ttgatttctt
     5161 ctctctgtgg ggtggcaagt tgagggagca ttcttcattt tagcttttac ctgacaacca
     5221 aacttgcctt taccccatcc ctagaattgg tgctcttgga atattgctgt taccatcatt
     5281 tttggggggc catcttccta atgctacaca cagcctgaca ggggagcagc agatgaaagg
     5341 gtatgctatt ctgtttccag atgtttcttt atgtaaatat gacgccaatg taaatcctgt
     5401 gtcaagatca tagagaatgg tgctttttac tacagttagc acatgcattt ttagaaacta
     5461 ctacatgttt tagagaatct ttgctgtgta tatgtaaact gtattgttca actgttaaca
     5521 aataataaat tatttcatta ttaaagaaa
//
