LOCUS       NM_002463               3408 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens MX dynamin like GTPase 2 (MX2), mRNA.
ACCESSION   NM_002463
VERSION     NM_002463.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Bayer,A., Child,S.J., Malik,H.S. and Geballe,A.P.
  TITLE     A single polymorphic residue in humans underlies species-specific
            restriction of HSV-1 by the antiviral protein MxB
  JOURNAL   J Virol 97 (10), e0083023 (2023)
   PUBMED   37796130
  REMARK    GeneRIF: A single polymorphic residue in humans underlies
            species-specific restriction of HSV-1 by the antiviral protein MxB.
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   He,M., Liu,M., Geng,J., Liu,L., Huang,P., Yue,M., Xia,X. and
            Zhang,A.M.
  TITLE     Polymorphisms of the MxA and MxB genes are associated with
            biochemical indices and viral subtypes in Yunnan HCV patients
  JOURNAL   Front Cell Infect Microbiol 13, 1119805 (2023)
   PUBMED   36743306
  REMARK    GeneRIF: Polymorphisms of the MxA and MxB genes are associated with
            biochemical indices and viral subtypes in Yunnan HCV patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3408)
  AUTHORS   Meng,X.W., Cheng,Z.L., Lu,Z.Y., Tan,Y.N., Jia,X.Y. and Zhang,M.
  TITLE     MX2: Identification and systematic mechanistic analysis of a novel
            immune-related biomarker for systemic lupus erythematosus
  JOURNAL   Front Immunol 13, 978851 (2022)
   PUBMED   36059547
  REMARK    GeneRIF: MX2: Identification and systematic mechanistic analysis of
            a novel immune-related biomarker for systemic lupus erythematosus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3408)
  AUTHORS   Zheng,K., Shen,Y., Xia,X., Song,Y. and Zhang,A.M.
  TITLE     Genetic polymorphisms in the IFNL4, MxA, and MxB genes were
            associated with biochemical index of chronic HBV patients from
            Yunnan, China
  JOURNAL   PeerJ 10, e13353 (2022)
   PUBMED   35505682
  REMARK    GeneRIF: Genetic polymorphisms in the IFNL4, MxA, and MxB genes
            were associated with biochemical index of chronic HBV patients from
            Yunnan, China.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3408)
  AUTHORS   Ren,Y., Chen,M., Wu,G., Ji,D., Zhou,G.G., Ren,P.G. and Fu,W.
  TITLE     High accumulation of Mx2 renders limited multiplication of
            oncolytic herpes simplex virus-1 in human tumor cells
  JOURNAL   Sci Rep 11 (1), 21227 (2021)
   PUBMED   34707174
  REMARK    GeneRIF: High accumulation of Mx2 renders limited multiplication of
            oncolytic herpes simplex virus-1 in human tumor cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3408)
  AUTHORS   al-Masri,A.N., Werfel,T., Jakschies,D. and von Wussow,P.
  TITLE     Intracellular staining of Mx proteins in cells from peripheral
            blood, bone marrow and skin
  JOURNAL   Mol Pathol 50 (1), 9-14 (1997)
   PUBMED   9208807
REFERENCE   7  (bases 1 to 3408)
  AUTHORS   Melen,K., Keskinen,P., Ronni,T., Sareneva,T., Lounatmaa,K. and
            Julkunen,I.
  TITLE     Human MxB protein, an interferon-alpha-inducible GTPase, contains a
            nuclear targeting signal and is localized in the heterochromatin
            region beneath the nuclear envelope
  JOURNAL   J Biol Chem 271 (38), 23478-23486 (1996)
   PUBMED   8798556
REFERENCE   8  (bases 1 to 3408)
  AUTHORS   Horisberger,M.A., McMaster,G.K., Zeller,H., Wathelet,M.G.,
            Dellis,J. and Content,J.
  TITLE     Cloning and sequence analyses of cDNAs for interferon- and
            virus-induced human Mx proteins reveal that they contain putative
            guanine nucleotide-binding sites: functional study of the
            corresponding gene promoter
  JOURNAL   J Virol 64 (3), 1171-1181 (1990)
   PUBMED   2154602
REFERENCE   9  (bases 1 to 3408)
  AUTHORS   Aebi,M., Fah,J., Hurt,N., Samuel,C.E., Thomis,D., Bazzigher,L.,
            Pavlovic,J., Haller,O. and Staeheli,P.
  TITLE     cDNA structures and regulation of two interferon-induced human Mx
            proteins
  JOURNAL   Mol Cell Biol 9 (11), 5062-5072 (1989)
   PUBMED   2481229
REFERENCE   10 (bases 1 to 3408)
  AUTHORS   Horisberger,M.A., Wathelet,M., Szpirer,J., Szpirer,C., Islam,Q.,
            Levan,G., Huez,G. and Content,J.
  TITLE     cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the
            human equivalent of murine Mx gene
  JOURNAL   Somat Cell Mol Genet 14 (2), 123-131 (1988)
   PUBMED   3162334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M30818.1 and AL773578.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002463.1.
            
            Summary: The protein encoded by this gene has a nuclear and a
            cytoplasmic form and is a member of both the dynamin family and the
            family of large GTPases. The nuclear form is localized in a
            granular pattern in the heterochromatin region beneath the nuclear
            envelope. A nuclear localization signal (NLS) is present at the
            amino terminal end of the nuclear form but is lacking in the
            cytoplasmic form due to use of an alternate translation start
            codon. This protein is upregulated by interferon-alpha but does not
            contain the antiviral activity of a similar myxovirus resistance
            protein 1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M30818.1, SRR1660805.77533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330714.8/ ENSP00000333657.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2957              M30818.1           5-2961
            2958-3408           AL773578.1         143426-143876
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..3408
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="MX dynamin like GTPase 2"
                     /db_xref="GeneID:4600"
                     /db_xref="HGNC:HGNC:7533"
                     /db_xref="MIM:147890"
     exon            1..29
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            30..349
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2248
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="interferon-regulated resistance GTP-binding protein
                     MXB; second interferon-induced protein p78; p78-related
                     protein; myxovirus (influenza virus) resistance 2;
                     myxovirus resistance protein 2"
                     /codon_start=1
                     /product="interferon-induced GTP-binding protein Mx2"
                     /protein_id="NP_002454.1"
                     /db_xref="CCDS:CCDS13672.1"
                     /db_xref="GeneID:4600"
                     /db_xref="HGNC:HGNC:7533"
                     /db_xref="MIM:147890"
                     /translation="MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMM
                     FPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCID
                     LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLK
                     KQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEV
                     PDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEAL
                     SMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEIT
                     NRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQ
                     IRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRL
                     YNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQY
                     IQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAEN
                     MIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFT
                     EIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQ
                     SETATKRRILKERIYRLTQARHALCQFSSKEIH"
     exon            350..542
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            543..677
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            678..832
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            833..971
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1170
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1249
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1372
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1514
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1673
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1750
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..2005
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..3408
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="hexamer: AATAAA"
     polyA_site      2675
                     /gene="MX2"
                     /gene_synonym="MXB"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="hexamer: AAGAAA"
     polyA_site      2958
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="major polyA site"
     regulatory      3387..3392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MX2"
                     /gene_synonym="MXB"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="MX2"
                     /gene_synonym="MXB"
ORIGIN      
        1 gatgatttct ccatcctgaa cgtgcagcga gcttgtcagg aagatcggag gtgccaagta
       61 gcagagaaag catcccccag ctctgacagg gagacagcac atgtctaagg cccacaagcc
      121 ttggccctac cggaggagaa gtcaattttc ttctcgaaaa tacctgaaaa aagaaatgaa
      181 ttccttccag caacagccac cgccattcgg cacagtgcca ccacaaatga tgtttcctcc
      241 aaactggcag ggggcagaga aggacgctgc tttcctcgcc aaggacttca actttctcac
      301 tttgaacaat cagccaccac caggaaacag gagccaacca agggcaatgg ggcccgagaa
      361 caacctgtac agccagtacg agcagaaggt gcgcccctgc attgacctca tcgactccct
      421 gcgggctctg ggtgtggagc aggacctggc cctgccagcc atcgccgtca tcggggacca
      481 gagctcgggc aagagctctg tgctggaggc actgtcagga gtcgcgcttc ccagaggcag
      541 cggaatcgta accaggtgtc cgctggtgct gaaactgaaa aagcagccct gtgaggcatg
      601 ggccggaagg atcagctacc ggaacaccga gctagagctt caggaccctg gccaggtgga
      661 gaaagagata cacaaagccc agaacgtcat ggccgggaat ggccggggca tcagccatga
      721 gctcatcagc ctggagatca cctcccctga ggttccagac ctgaccatca ttgaccttcc
      781 cggcatcacc agggtggctg tggacaacca gccccgagac atcggactgc agatcaaggc
      841 tctcatcaag aagtacatcc agaggcagca gacgatcaac ttggtggtgg ttccctgtaa
      901 cgtggacatt gccaccacgg aggcgctgag catggcccat gaggtggacc cggaagggga
      961 caggaccatc ggtatcctga ccaaaccaga tctaatggac aggggcactg agaaaagcgt
     1021 catgaatgtg gtgcggaacc tcacgtaccc cctcaagaag ggctacatga ttgtgaagtg
     1081 ccggggccag caggagatca caaacaggct gagcttggca gaggcaacca agaaagaaat
     1141 tacattcttt caaacacatc catatttcag agttctcctg gaggaggggt cagccacggt
     1201 tccccgactg gcagaaagac ttaccactga actcatcatg catatccaaa aatcgctccc
     1261 gttgttagaa ggacaaataa gggagagcca ccagaaggcg accgaggagc tgcggcgttg
     1321 cggggctgac atccccagcc aggaggccga caagatgttc tttctaattg agaaaatcaa
     1381 gatgtttaat caggacatcg aaaagttagt agaaggagaa gaagttgtaa gggagaatga
     1441 gacccgttta tacaacaaaa tcagagagga ttttaaaaac tgggtaggca tacttgcaac
     1501 taatacccaa aaagttaaaa atattatcca cgaagaagtt gaaaaatatg aaaagcagta
     1561 tcgaggcaag gagcttctgg gatttgtcaa ctacaagaca tttgagatca tcgtgcatca
     1621 gtacatccag cagctggtgg agcccgccct tagcatgctc cagaaagcca tggaaattat
     1681 ccagcaagct ttcattaacg tggccaaaaa acattttggc gaatttttca accttaacca
     1741 aactgttcag agcacgattg aagacataaa agtgaaacac acagcaaagg cagaaaacat
     1801 gatccaactt cagttcagaa tggagcagat ggttttttgt caagatcaga tttacagtgt
     1861 tgttctgaag aaagtccgag aagagatttt taaccctctg gggacgcctt cacagaatat
     1921 gaagttgaac tctcattttc ccagtaatga gtcttcggtt tcctccttta ctgaaatagg
     1981 catccacctg aatgcctact tcttggaaac cagcaaacgt ctcgccaacc agatcccatt
     2041 tataattcag tattttatgc tccgagagaa tggtgactcc ttgcagaaag ccatgatgca
     2101 gatactacag gaaaaaaatc gctattcctg gctgcttcaa gagcagagtg agaccgctac
     2161 caagagaaga atccttaagg agagaattta ccggctcact caggcgcgac acgcactctg
     2221 tcaattctcc agcaaagaga tccactgaag ggcggcgatg cctgtggttg ttttcttgtg
     2281 cgtactcatt cattctaagg ggagtcggtg caggatgccg cttctgcttt ggggccaaac
     2341 tcttctgtca ctatcagtgt ccatctctac tgtactccct cagcatcaga gcatgcatca
     2401 ggggtccaca caggctcagc tctctccacc acccagctct tccctgacct tcacgaaggg
     2461 atggctctcc agtccttggg tcccgtagca cacagttaca gtgtcctaag atactgctat
     2521 cattcttcgc taatttgtat ttgtattccc ttccccctac aagattatga gaccccagag
     2581 ggggaaggtc tgggtcaaat tcttcttttg tatgtccagt ctcctgcaca gcacctgcag
     2641 cattgtaact gcttaataaa tgacatctca ctgaacgaat gagtgctgtg taagtgatgg
     2701 agatacctga ggctattgct caagcccagg ccttggacat ttagtgactg ttagccggtc
     2761 cctttcagat ccagtggcca tgccccctgc ttcccatggt tcactgtcat tgtgtttccc
     2821 agcctctcca ctcccccgcc agaaaggagc ctgagtgatt ctcttttctt cttgtttccc
     2881 tgattatgat gagcttccat tgttctgtta agtcttgaag aggaatttaa taaagcaaag
     2941 aaacttttta aaaacgtagc caggttcagt gactcatacc tgtaatccca gtgactctgg
     3001 agactgaagc agaaggatca cttgagccca ggagttcaag accagactgg gcaacacagg
     3061 gagaccctgt ctctaaaaaa atttgtttgt aagtagccag acatggtggt gcacacctgt
     3121 agtcccagcc actcaggtgg ctggagcagg aggatccctt gagcccagga ttttgaggct
     3181 gcagtgagcc atgactgcac catgtactac agcctgggtg acagagtgag agtgagactc
     3241 tgtctctgaa tacacacaca cacacacaca cacatacaca gagagagaga gagagaactt
     3301 cacaccagtg atcatcatta tgggtaattt tcttttcttc ttcatgtttt cctgtatgtt
     3361 tcaaatgatg aacatataga ttccttaata aaaaggcaat agaataaa
//
