LOCUS       NM_002462               2776 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens MX dynamin like GTPase 1 (MX1), transcript variant 2,
            mRNA.
ACCESSION   NM_002462
VERSION     NM_002462.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2776)
  AUTHORS   Sehgal,P.B., Yuan,H., Centone,A. and DiSenso-Browne,S.V.
  TITLE     Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity
            Dynamically Regulate Formation of Membraneless Biomolecular
            Condensates of Antiviral Human MxA in Oral Epithelial Cells
  JOURNAL   Cells 13 (7), 590 (2024)
   PUBMED   38607029
  REMARK    GeneRIF: Oral Antiviral Defense: Saliva- and Beverage-like
            Hypotonicity Dynamically Regulate Formation of Membraneless
            Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2776)
  AUTHORS   Zhang,F., Zhou,P., Wang,L., Liao,X., Liu,X., Ke,C., Wen,S. and
            Shu,Y.
  TITLE     Polymorphisms of IFN signaling genes and FOXP4 influence the
            severity of COVID-19
  JOURNAL   BMC Infect Dis 24 (1), 270 (2024)
   PUBMED   38429664
  REMARK    GeneRIF: Polymorphisms of IFN signaling genes and FOXP4 influence
            the severity of COVID-19.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2776)
  AUTHORS   Noguchi,S., Hijikata,M., Hamano,E., Matsushita,I., Ito,H.,
            Ohashi,J., Nagase,T. and Keicho,N.
  TITLE     MxA transcripts with distinct first exons and modulation of gene
            expression levels by single-nucleotide polymorphisms in human
            bronchial epithelial cells
  JOURNAL   Immunogenetics 65 (2), 107-114 (2013)
   PUBMED   23160781
  REMARK    GeneRIF: Our results suggest that MxA observed in respiratory viral
            infections is possibly dominated by the MxA transcript and partly
            influenced by relevant 5' SNPs.
REFERENCE   4  (bases 1 to 2776)
  AUTHORS   Ku,C.C., Che,X.B., Reichelt,M., Rajamani,J., Schaap-Nutt,A.,
            Huang,K.J., Sommer,M.H., Chen,Y.S., Chen,Y.Y. and Arvin,A.M.
  TITLE     Herpes simplex virus-1 induces expression of a novel MxA isoform
            that enhances viral replication
  JOURNAL   Immunol Cell Biol 89 (2), 173-182 (2011)
   PUBMED   20603636
  REMARK    GeneRIF: human MxA gene encodes two MxA isoforms, which are
            expressed differentially depending on whether the stimulus is
            IFN-alpha or HSV-1.
REFERENCE   5  (bases 1 to 2776)
  AUTHORS   Haller,O. and Kochs,G.
  TITLE     Human MxA protein: an interferon-induced dynamin-like GTPase with
            broad antiviral activity
  JOURNAL   J Interferon Cytokine Res 31 (1), 79-87 (2011)
   PUBMED   21166595
  REMARK    GeneRIF: The structural and functional data suggest that MxA
            targets the nucleoprotein of MxA-sensitive viruses. [Review]
            Review article
REFERENCE   6  (bases 1 to 2776)
  AUTHORS   Tazi-Ahnini,R., di Giovine,F.S., McDonagh,A.J., Messenger,A.G.,
            Amadou,C., Cox,A., Duff,G.W. and Cork,M.J.
  TITLE     Structure and polymorphism of the human gene for the
            interferon-induced p78 protein (MX1): evidence of association with
            alopecia areata in the Down syndrome region
  JOURNAL   Hum Genet 106 (6), 639-645 (2000)
   PUBMED   10942113
REFERENCE   7  (bases 1 to 2776)
  AUTHORS   Pavlovic,J., Haller,O. and Staeheli,P.
  TITLE     Human and mouse Mx proteins inhibit different steps of the
            influenza virus multiplication cycle
  JOURNAL   J Virol 66 (4), 2564-2569 (1992)
   PUBMED   1548781
REFERENCE   8  (bases 1 to 2776)
  AUTHORS   Horisberger,M.A., McMaster,G.K., Zeller,H., Wathelet,M.G.,
            Dellis,J. and Content,J.
  TITLE     Cloning and sequence analyses of cDNAs for interferon- and
            virus-induced human Mx proteins reveal that they contain putative
            guanine nucleotide-binding sites: functional study of the
            corresponding gene promoter
  JOURNAL   J Virol 64 (3), 1171-1181 (1990)
   PUBMED   2154602
REFERENCE   9  (bases 1 to 2776)
  AUTHORS   Aebi,M., Fah,J., Hurt,N., Samuel,C.E., Thomis,D., Bazzigher,L.,
            Pavlovic,J., Haller,O. and Staeheli,P.
  TITLE     cDNA structures and regulation of two interferon-induced human Mx
            proteins
  JOURNAL   Mol Cell Biol 9 (11), 5062-5072 (1989)
   PUBMED   2481229
REFERENCE   10 (bases 1 to 2776)
  AUTHORS   Horisberger,M.A., Wathelet,M., Szpirer,J., Szpirer,C., Islam,Q.,
            Levan,G., Huez,G. and Content,J.
  TITLE     cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the
            human equivalent of murine Mx gene
  JOURNAL   Somat Cell Mol Genet 14 (2), 123-131 (1988)
   PUBMED   3162334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M33882.1, EB388095.1 and
            BC032602.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002462.4.
            
            Summary: This gene encodes a guanosine triphosphate
            (GTP)-metabolizing protein that participates in the cellular
            antiviral response. The encoded protein is induced by type I and
            type II interferons and antagonizes the replication process of
            several different RNA and DNA viruses. There is a related gene
            located adjacent to this gene on chromosome 21, and there are
            multiple pseudogenes located in a cluster on chromosome 4.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2, also known as T1) lacks three
            exons and contains an alternate terminal exon in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M33882.1, SRR1660809.8607.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398598.8/ ENSP00000381599.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1467              M33882.1           13-1479
            1468-1811           EB388095.1         475-818
            1812-2730           M33882.1           1824-2742
            2731-2776           BC032602.1         2689-2734
FEATURES             Location/Qualifiers
     source          1..2776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2776
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /note="MX dynamin like GTPase 1"
                     /db_xref="GeneID:4599"
                     /db_xref="HGNC:HGNC:7532"
                     /db_xref="MIM:147150"
     exon            1..25
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            26..124
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            125..236
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            237..312
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            313..438
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2322
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /note="isoform a is encoded by transcript variant 2;
                     interferon-induced GTP-binding protein Mx1;
                     interferon-induced protein p78; myxovirus (influenza
                     virus) resistance 1, interferon-inducible protein p78;
                     interferon-regulated resistance GTP-binding protein MxA;
                     myxoma resistance protein 1"
                     /codon_start=1
                     /product="interferon-induced GTP-binding protein Mx1
                     isoform a"
                     /protein_id="NP_002453.2"
                     /db_xref="CCDS:CCDS13673.1"
                     /db_xref="GeneID:4599"
                     /db_xref="HGNC:HGNC:7532"
                     /db_xref="MIM:147150"
                     /translation="MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQ
                     YEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIV
                     TRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHE
                     LITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVP
                     SNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYM
                     IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITH
                     ICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQG
                     EETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVN
                     YRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIED
                     IRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQS
                     SSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKD
                     TYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG"
     exon            439..631
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            632..769
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            770..924
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1063
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1262
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1341
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1464
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1606
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1765
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1842
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2091
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2776
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2756..2761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /note="hexamer: AATAAA"
     polyA_site      2776
                     /gene="MX1"
                     /gene_synonym="IFI-78K; IFI78; lncMX1-215; MX; MxA"
                     /note="major polyA site"
ORIGIN      
        1 gcactccagc actgcgcagg gaccgccttg gaccgcagtt gccggccagg aatcccagtg
       61 tcacggtgga cacgcctccc tcgcgccctt gccgcccacc tgctcaccca gctcaggggc
      121 tttggaattc tgtggccaca ctgcgaggag atcggttctg ggtcggaggc tacaggaaga
      181 ctcccactcc ctgaaatctg gagtgaagaa cgccgccatc cagccaccat tccaaggagg
      241 tgcaggagaa cagctctgtg ataccattta acttgttgac attactttta tttgaaggaa
      301 cgtatattag agcttacttt gcaaagaagg aagatggttg tttccgaagt ggacatcgca
      361 aaagctgatc cagctgctgc atcccaccct ctattactga atggagatgc tactgtggcc
      421 cagaaaaatc caggctcggt ggctgagaac aacctgtgca gccagtatga ggagaaggtg
      481 cgcccctgca tcgacctcat tgactccctg cgggctctag gtgtggagca ggacctggcc
      541 ctgccagcca tcgccgtcat cggggaccag agctcgggca agagctccgt gttggaggca
      601 ctgtcaggag ttgcccttcc cagaggcagc gggatcgtga ccagatgccc gctggtgctg
      661 aaactgaaga aacttgtgaa cgaagataag tggagaggca aggtcagtta ccaggactac
      721 gagattgaga tttcggatgc ttcagaggta gaaaaggaaa ttaataaagc ccagaatgcc
      781 atcgccgggg aaggaatggg aatcagtcat gagctaatca ccctggagat cagctcccga
      841 gatgtcccgg atctgactct aatagacctt cctggcataa ccagagtggc tgtgggcaat
      901 cagcctgctg acattgggta taagatcaag acactcatca agaagtacat ccagaggcag
      961 gagacaatca gcctggtggt ggtccccagt aatgtggaca tcgccaccac agaggctctc
     1021 agcatggccc aggaggtgga ccccgaggga gacaggacca tcggaatctt gacgaagcct
     1081 gatctggtgg acaaaggaac tgaagacaag gttgtggacg tggtgcggaa cctcgtgttc
     1141 cacctgaaga agggttacat gattgtcaag tgccggggcc agcaggagat ccaggaccag
     1201 ctgagcctgt ccgaagccct gcagagagag aagatcttct ttgagaacca cccatatttc
     1261 agggatctgc tggaggaagg aaaggccacg gttccctgcc tggcagaaaa acttaccagc
     1321 gagctcatca cacatatctg taaatctctg cccctgttag aaaatcaaat caaggagact
     1381 caccagagaa taacagagga gctacaaaag tatggtgtcg acataccgga agacgaaaat
     1441 gaaaaaatgt tcttcctgat agataaagtt aatgccttta atcaggacat cactgctctc
     1501 atgcaaggag aggaaactgt aggggaggaa gacattcggc tgtttaccag actccgacac
     1561 gagttccaca aatggagtac aataattgaa aacaattttc aagaaggcca taaaattttg
     1621 agtagaaaaa tccagaaatt tgaaaatcag tatcgtggta gagagctgcc aggctttgtg
     1681 aattacagga catttgagac aatcgtgaaa cagcaaatca aggcactgga agagccggct
     1741 gtggatatgc tacacaccgt gacggatatg gtccggcttg ctttcacaga tgtttcgata
     1801 aaaaattttg aagagttttt taacctccac agaaccgcca agtccaaaat tgaagacatt
     1861 agagcagaac aagagagaga aggtgagaag ctgatccgcc tccacttcca gatggaacag
     1921 attgtctact gccaggacca ggtatacagg ggtgcattgc agaaggtcag agagaaggag
     1981 ctggaagaag aaaagaagaa gaaatcctgg gattttgggg ctttccagtc cagctcggca
     2041 acagactctt ccatggagga gatctttcag cacctgatgg cctatcacca ggaggccagc
     2101 aagcgcatct ccagccacat ccctttgatc atccagttct tcatgctcca gacgtacggc
     2161 cagcagcttc agaaggccat gctgcagctc ctgcaggaca aggacaccta cagctggctc
     2221 ctgaaggagc ggagcgacac cagcgacaag cggaagttcc tgaaggagcg gcttgcacgg
     2281 ctgacgcagg ctcggcgccg gcttgcccag ttccccggtt aaccacactc tgtccagccc
     2341 cgtagacgtg cacgcacact gtctgccccc gttcccgggt agccactgga ctgacgactt
     2401 gagtgctcag tagtcagact ggatagtccg tctctgctta tccgttagcc gtggtgattt
     2461 agcaggaagc tgtgagagca gtttggtttc tagcatgaag acagagcccc accctcagat
     2521 gcacatgagc tggcgggatt gaaggatgct gtcttcgtac tgggaaaggg attttcagcc
     2581 ctcagaatcg ctccaccttg cagctctccc cttctctgta ttcctagaaa ctgacacatg
     2641 ctgaacatca cagcttattt cctcattttt ataatgtccc ttcacaaacc cagtgtttta
     2701 ggagcatgag tgccgtgtgt gtgcgtcctg tcggagccct gtctcctctc tctgtaataa
     2761 actcatttct agcaga
//
