LOCUS       NM_005115               2798 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens major vault protein (MVP), transcript variant 2, mRNA.
ACCESSION   NM_005115
VERSION     NM_005115.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Li,C., Gao,M., Zha,N. and Guo,G.
  TITLE     The prognostic value and immunological role of MVP in pan-cancer
            study
  JOURNAL   Aging (Albany NY) 16 (10), 8497-8510 (2024)
   PUBMED   38713157
  REMARK    GeneRIF: The prognostic value and immunological role of MVP in
            pan-cancer study.
REFERENCE   2  (bases 1 to 2798)
  AUTHORS   Yu,C., Zhu,Q., Ma,C., Luo,C., Nie,L., Cai,H., Wang,Q., Wang,F.,
            Ren,H., Yan,H., Xu,K., Zhou,L., Zhang,C., Lu,G., Lu,Z., Zhu,Y. and
            Liu,S.
  TITLE     Major vault protein regulates tumor-associated macrophage
            polarization through interaction with signal transducer and
            activator of transcription 6
  JOURNAL   Front Immunol 14, 1289795 (2024)
   PUBMED   38264642
  REMARK    GeneRIF: Major vault protein regulates tumor-associated macrophage
            polarization through interaction with signal transducer and
            activator of transcription 6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2798)
  AUTHORS   Pietras,P., Lesniczak-Staszak,M., Kasprzak,A., Andrzejewska,M.,
            Jopek,K., Sowinski,M., Rucinski,M., Lyons,S.M., Ivanov,P. and
            Szaflarski,W.
  TITLE     MVP Expression Facilitates Tumor Cell Proliferation and Migration
            Supporting the Metastasis of Colorectal Cancer Cells
  JOURNAL   Int J Mol Sci 22 (22), 12121 (2021)
   PUBMED   34829999
  REMARK    GeneRIF: MVP Expression Facilitates Tumor Cell Proliferation and
            Migration Supporting the Metastasis of Colorectal Cancer Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2798)
  AUTHORS   Wang,W., Yan,T., Guo,W., Niu,J., Zhao,Z., Sun,K., Zhang,H., Yu,Y.
            and Ren,T.
  TITLE     Constitutive GLI1 expression in chondrosarcoma is regulated by
            major vault protein via mTOR/S6K1 signaling cascade
  JOURNAL   Cell Death Differ 28 (7), 2221-2237 (2021)
   PUBMED   33637972
  REMARK    GeneRIF: Constitutive GLI1 expression in chondrosarcoma is
            regulated by major vault protein via mTOR/S6K1 signaling cascade.
REFERENCE   5  (bases 1 to 2798)
  AUTHORS   Holzmann,K., Ambrosch,I., Elbling,L., Micksche,M. and Berger,W.
  TITLE     A small upstream open reading frame causes inhibition of human
            major vault protein expression from a ubiquitous mRNA splice
            variant
  JOURNAL   FEBS Lett 494 (1-2), 99-104 (2001)
   PUBMED   11297743
  REMARK    GeneRIF: MVP gene expression regulated by alternative splicing due
            to generation of an upstream open reading frame
REFERENCE   6  (bases 1 to 2798)
  AUTHORS   Dingemans,A.M., van Ark-Otte,J., van der Valk,P., Apolinario,R.M.,
            Scheper,R.J., Postmus,P.E. and Giaccone,G.
  TITLE     Expression of the human major vault protein LRP in human lung
            cancer samples and normal lung tissues
  JOURNAL   Ann Oncol 7 (6), 625-630 (1996)
   PUBMED   8879378
REFERENCE   7  (bases 1 to 2798)
  AUTHORS   Izquierdo,M.A., Scheffer,G.L., Flens,M.J., Schroeijers,A.B., van
            der Valk,P. and Scheper,R.J.
  TITLE     Major vault protein LRP-related multidrug resistance
  JOURNAL   Eur J Cancer 32A (6), 979-984 (1996)
   PUBMED   8763338
  REMARK    Review article
REFERENCE   8  (bases 1 to 2798)
  AUTHORS   Izquierdo,M.A., Scheffer,G.L., Flens,M.J., Giaccone,G.,
            Broxterman,H.J., Meijer,C.J., van der Valk,P. and Scheper,R.J.
  TITLE     Broad distribution of the multidrug resistance-related vault lung
            resistance protein in normal human tissues and tumors
  JOURNAL   Am J Pathol 148 (3), 877-887 (1996)
   PUBMED   8774142
REFERENCE   9  (bases 1 to 2798)
  AUTHORS   Slovak,M.L., Ho,J.P., Cole,S.P., Deeley,R.G., Greenberger,L., de
            Vries,E.G., Broxterman,H.J., Scheffer,G.L. and Scheper,R.J.
  TITLE     The LRP gene encoding a major vault protein associated with drug
            resistance maps proximal to MRP on chromosome 16: evidence that
            chromosome breakage plays a key role in MRP or LRP gene
            amplification
  JOURNAL   Cancer Res 55 (19), 4214-4219 (1995)
   PUBMED   7671223
REFERENCE   10 (bases 1 to 2798)
  AUTHORS   Scheffer,G.L., Wijngaard,P.L., Flens,M.J., Izquierdo,M.A.,
            Slovak,M.L., Pinedo,H.M., Meijer,C.J., Clevers,H.C. and
            Scheper,R.J.
  TITLE     The drug resistance-related protein LRP is the human major vault
            protein
  JOURNAL   Nat Med 1 (6), 578-582 (1995)
   PUBMED   7585126
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA940597.1, BQ932800.1,
            BC015623.2 and BM999583.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005115.4.
            
            Summary: This gene encodes the major component of the vault
            complex. Vaults are multi-subunit ribonucleoprotein structures that
            may be involved in nucleo-cytoplasmic transport. The encoded
            protein may play a role in multiple cellular processes by
            regulating the MAP kinase, JAK/STAT and phosphoinositide
            3-kinase/Akt signaling pathways. The encoded protein also plays a
            role in multidrug resistance, and expression of this gene may be a
            prognostic marker for several types of cancer. Alternatively
            spliced transcript variants have been observed for this gene.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (2, also known as S-MVP) uses a
            different splice site in the 5' UTR, compared to variant 1.
            Variants 1 and 2 encode the same isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005570.1, SRR1803617.77162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357402.10/ ENSP00000349977.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA940597.1         69-71
            4-716               BQ932800.1         1-713
            717-2797            BC015623.2         693-2773
            2798-2798           BM999583.1         37-37               c
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2798
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /note="major vault protein"
                     /db_xref="GeneID:9961"
                     /db_xref="HGNC:HGNC:7531"
                     /db_xref="MIM:605088"
     exon            1..49
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..209
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2766
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /note="isoform 1 is encoded by transcript variant 2; lung
                     resistance-related protein; testicular secretory protein
                     Li 30"
                     /codon_start=1
                     /product="major vault protein isoform 1"
                     /protein_id="NP_005106.2"
                     /db_xref="CCDS:CCDS10656.1"
                     /db_xref="GeneID:9961"
                     /db_xref="HGNC:HGNC:7531"
                     /db_xref="MIM:605088"
                     /translation="MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVL
                     FAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPG
                     EVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVV
                     EIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDA
                     VILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTL
                     GPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLL
                     RALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQD
                     VKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLA
                     PRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRP
                     HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPD
                     FVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
                     QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQ
                     EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGS
                     VLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQM
                     TEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQ
                     PLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR"
     exon            210..405
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..529
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..661
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..756
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..993
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1275
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1520
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1718
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2105
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2222
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2349
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2538
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2798
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /note="hexamer: AATACA"
     polyA_site      2798
                     /gene="MVP"
                     /gene_synonym="LRP; VAULT1"
                     /note="major polyA site"
ORIGIN      
        1 gagagttccc catctgaggc gtttgttgca gctacctgca cttctagatt catcttcttg
       61 tgagccctgg gcttaggagt caccatggca actgaagagt tcatcatccg catcccccca
      121 taccactata tccatgtgct ggaccagaac agcaacgtgt cccgtgtgga ggtcgggcca
      181 aagacctaca tccggcagga caatgagagg gtactgtttg cccccatgcg catggtgacc
      241 gtccccccac gtcactactg cacagtggcc aaccctgtgt ctcgggatgc ccagggcttg
      301 gtgctgtttg atgtcacagg gcaagttcgg cttcgccacg ctgacctcga gatccggctg
      361 gcccaggacc ccttccccct gtacccaggg gaggtgctgg aaaaggacat cacacccctg
      421 caggtggttc tgcccaacac tgccctccat ctaaaggcgc tgcttgattt tgaggataaa
      481 gatggagaca aggtggtggc aggagatgag tggcttttcg agggacctgg cacgtacatc
      541 ccccggaagg aagtggaggt cgtggagatc attcaggcca ccatcatcag gcagaaccag
      601 gctctgcggc tcagggcccg caaggagtgc tgggaccggg acggcaagga gagggtgaca
      661 ggggaagaat ggctggtcac cacagtaggg gcgtacctcc cagcggtgtt tgaggaggtt
      721 ctggatttgg tggacgccgt catccttacg gaaaagacag ccctgcacct ccgggctcgg
      781 cggaacttcc gggacttcag gggagtgtcc cgccgcactg gggaggagtg gctggtaaca
      841 gtgcaggaca cagaggccca cgtgccagat gtccacgagg aggtgctggg ggttgtgccc
      901 atcaccaccc tgggccccca caactactgc gtgattctcg accctgtcgg accggatggc
      961 aagaatcagc tggggcagaa gcgcgtggtc aagggagaga agtctttttt cctccagcca
     1021 ggagagcagc tggaacaagg catccaggat gtgtatgtgc tgtcggagca gcaggggctg
     1081 ctgctgaggg ccctgcagcc cctggaggag ggggaggatg aggagaaggt ctcacaccag
     1141 gctggggacc actggctcat ccgcggaccc ctggagtatg tgccatctgc caaagtggag
     1201 gtggtggagg agcgccaggc catccctcta gacgagaacg agggcatcta tgtgcaggat
     1261 gtcaagaccg gaaaggtgcg cgctgtgatt ggaagcacct acatgctgac ccaggacgaa
     1321 gtcctgtggg agaaagagct gcctcccggg gtggaggagc tgctgaacaa ggggcaggac
     1381 cctctggcag acaggggtga gaaggacaca gctaagagcc tccagccctt ggcgccccgg
     1441 aacaagaccc gtgtggtcag ctaccgcgtg ccccacaacg ctgcggtgca ggtgtacgac
     1501 taccgagaga agcgagcccg cgtggtcttc gggcctgagc tggtgtcgct gggtcctgag
     1561 gagcagttca cagtgttgtc cctctcagct gggcggccca agcgtcccca tgcccgccgt
     1621 gcgctctgcc tgctgctggg gcctgacttc ttcacagacg tcatcaccat cgaaacggcg
     1681 gatcatgcca ggctgcaact gcagctggcc tacaactggc actttgaggt gaatgaccgg
     1741 aaggaccccc aagagacggc caagctcttt tcagtgccag actttgtagg tgatgcctgc
     1801 aaagccatcg catcccgggt gcggggggcc gtggcctctg tcactttcga tgacttccat
     1861 aagaactcag cccgcatcat tcgcactgct gtctttggct ttgagacctc ggaagcgaag
     1921 ggccccgatg gcatggccct gcccaggccc cgggaccagg ctgtcttccc ccaaaacggg
     1981 ctggtggtca gcagtgtgga cgtgcagtca gtggagcctg tggatcagag gacccgggac
     2041 gccctgcaac gcagcgtcca gctggccatc gagatcacca ccaactccca ggaagcggcg
     2101 gccaagcatg aggctcagag actggagcag gaagcccgcg gccggcttga gcggcagaag
     2161 atcctggacc agtcagaagc cgagaaagct cgcaaggaac ttttggagct ggaggctctg
     2221 agcatggccg tggagagcac cgggactgcc aaggcggagg ccgagtcccg tgcggaggca
     2281 gcccggattg agggagaagg gtccgtgctg caggccaagc taaaagcaca ggccttggcc
     2341 attgaaacgg aggctgagct ccagagggtc cagaaggtcc gagagctgga actggtctat
     2401 gcccgggccc agctggagct ggaggtgagc aaggctcagc agctggctga ggtggaggtg
     2461 aagaagttca agcagatgac agaggccata ggccccagca ccatcaggga ccttgctgtg
     2521 gctgggcctg agatgcaggt aaaactgctc cagtccctgg gcctgaaatc aaccctcatc
     2581 accgatggct ccactcccat caacctcttc aacacagcct ttgggctgct ggggatgggg
     2641 cccgagggtc agcccctggg cagaagggtg gccagtgggc ccagccctgg ggaggggata
     2701 tccccccagt ctgctcaggc ccctcaagct cctggagaca accacgtggt gcctgtactg
     2761 cgctaactcc tgattaatac aatggaagtt tctgggca
//
