LOCUS       NM_024544               2428 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial E3 ubiquitin protein ligase 1 (MUL1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024544
VERSION     NM_024544.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Liu,L., Zou,C., Shen,J., Huang,R., Zhang,F., Du,Y., Luo,X.,
            Yang,A., Zhang,J., Guan,Y. and Yan,X.
  TITLE     MUL1 identified as mitochondria-linked biomarker promoting
            cisplatin resistance in OC cells
  JOURNAL   Gene 930, 148841 (2024)
   PUBMED   39134101
  REMARK    GeneRIF: MUL1 identified as mitochondria-linked biomarker promoting
            cisplatin resistance in OC cells.
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Mohanty,A., Zunino,R., Soubannier,V. and Dilipkumar,S.
  TITLE     A new functional role of mitochondria-anchored protein ligase in
            peroxisome morphology in mammalian cells
  JOURNAL   J Cell Biochem 122 (11), 1686-1700 (2021)
   PUBMED   34322908
  REMARK    GeneRIF: A new functional role of mitochondria-anchored protein
            ligase in peroxisome morphology in mammalian cells.
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Lin,J.Z. and Lin,N.
  TITLE     A risk signature of three autophagy-related genes for predicting
            lower grade glioma survival is associated with tumor immune
            microenvironment
  JOURNAL   Genomics 113 (1 Pt 2), 767-777 (2021)
   PUBMED   33069830
  REMARK    GeneRIF: A risk signature of three autophagy-related genes for
            predicting lower grade glioma survival is associated with tumor
            immune microenvironment.
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Zhang,B., Huang,J., Li,H.L., Liu,T., Wang,Y.Y., Waterman,P.,
            Mao,A.P., Xu,L.G., Zhai,Z., Liu,D., Marrack,P. and Shu,H.B.
  TITLE     GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis
            and slows growth
  JOURNAL   Cell Res 18 (9), 900-910 (2008)
   PUBMED   18591963
  REMARK    GeneRIF: The identification of GIDE, a mitochondrially located E3
            ubiquitin ligase, is reported.
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Zhang,H., Denhard,L.A., Zhou,H., Liu,L.H. and Lan,Z.J.
  TITLE     0610009K11Rik, a testis-specific and germ cell nuclear
            receptor-interacting protein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 898-904 (2008)
   PUBMED   18082624
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Neuspiel,M., Schauss,A.C., Braschi,E., Zunino,R., Rippstein,P.,
            Rachubinski,R.A., Andrade-Navarro,M.A. and McBride,H.M.
  TITLE     Cargo-selected transport from the mitochondria to peroxisomes is
            mediated by vesicular carriers
  JOURNAL   Curr Biol 18 (2), 102-108 (2008)
   PUBMED   18207745
  REMARK    GeneRIF: incorporated within unique, DRP1-independent, 70-100 nm
            diameter mitochondria-derived vesicles which fuse with a subset of
            peroxisomes
            GeneRIF: Confocal- and electron-microscopy studies of MAPL-YFP led
            to the observation that mitochondria-anchored protein ligase (MAPL)
            is incorporated within unique, DRP1-independent, 70-100 nm diameter
            mitochondria-derived vesicles (MDVs).
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391357.20 and BC014010.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024544.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.345141.1, AK022937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000264198.5/
                                                  ENSP00000264198.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL391357.20        29889-29958         c
            71-2428             BC014010.1         1-2358
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..2428
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /note="mitochondrial E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:79594"
                     /db_xref="HGNC:HGNC:25762"
                     /db_xref="MIM:612037"
     exon            1..247
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1186
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /EC_number="2.3.2.27"
                     /note="mitochondrial ubiquitin ligase activator of NF-kB;
                     ring finger protein 218; growth inhibition and death E3
                     ligase; mitochondrial E3 ubiquitin ligase 1;
                     mitochondria-anchored protein ligase; E3 ubiquitin-protein
                     ligase MUL1; mitochondrial-anchored protein ligase;
                     putative NF-kappa-B-activating protein 266; E3
                     SUMO-protein ligase MUL1; RING-type E3 ubiquitin
                     transferase NFKB 1; protein Hades"
                     /codon_start=1
                     /product="mitochondrial ubiquitin ligase activator of NFKB
                     1"
                     /protein_id="NP_078820.2"
                     /db_xref="CCDS:CCDS208.1"
                     /db_xref="GeneID:79594"
                     /db_xref="HGNC:HGNC:25762"
                     /db_xref="MIM:612037"
                     /translation="MESGGRPSLCQFILLGTTSVVTAALYSVYRQKARVSQELKGAKK
                     VHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMV
                     WNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLETVYEKFH
                     PSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQ
                     YYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQ
                     EEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPK
                     KCPICRQAITRVIPLYNS"
     exon            248..335
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /inference="alignment:Splign:2.1.0"
     exon            336..456
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /inference="alignment:Splign:2.1.0"
     exon            457..2428
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /note="hexamer: ATTAAA"
     polyA_site      2428
                     /gene="MUL1"
                     /gene_synonym="C1orf166; GIDE; MAPL; MULAN; RNF218"
                     /note="major polyA site"
ORIGIN      
        1 gactgatttc gagtttccgg tcaggttagg ccgggggggt gcggtcctgg tcggaaggag
       61 gtggagagtc gggggtcacc aggcctatcc ttggcgccac agtcggccac cggggctcgc
      121 cgccgtcatg gagagcggag ggcggccctc gctgtgccag ttcatcctcc tgggcaccac
      181 ctctgtggtc accgccgccc tgtactccgt gtaccggcag aaggcccggg tctcccaaga
      241 gctcaaggga gctaaaaaag ttcatttggg tgaagattta aagagtattc tttcagaagc
      301 tccaggaaaa tgcgtgcctt atgctgttat agaaggagct gtgcggtctg ttaaagaaac
      361 gcttaacagc cagtttgtgg aaaactgcaa gggggtaatt cagcggctga cacttcagga
      421 gcacaagatg gtgtggaatc gaaccaccca cctttggaat gattgctcaa agatcattca
      481 tcagaggacc aacacagtgc cctttgacct ggtgccccac gaggatggcg tggatgtggc
      541 tgtgcgagtg ctgaagcccc tggactcagt ggatctgggt ctagagactg tgtatgagaa
      601 gttccacccc tcgattcagt ccttcaccga tgtcatcggc cactacatca gcggtgagcg
      661 gcccaaaggc atccaagaga ccgaggagat gctgaaggtg ggggccaccc tcacaggggt
      721 tggcgaactg gtcctggaca acaactctgt ccgcctgcag ccgcccaaac aaggcatgca
      781 gtactatcta agcagccagg acttcgacag cctgctgcag aggcaggagt cgagcgtcag
      841 gctctggaag gtgctggcgc tggtttttgg ctttgccaca tgtgccaccc tcttcttcat
      901 tctccggaag cagtatctgc agcggcagga gcgcctgcgc ctcaagcaga tgcaggagga
      961 gttccaggag catgaggccc agctgctgag ccgagccaag cctgaggaca gggagagtct
     1021 gaagagcgcc tgtgtagtgt gtctgagcag cttcaagtcc tgcgtctttc tggagtgtgg
     1081 gcacgtttgt tcctgcaccg agtgctaccg cgccttgcca gagcccaaga agtgccctat
     1141 ctgcagacag gcgatcaccc gggtgatacc cctgtacaac agctaatagt ttggaagccg
     1201 cacagcttga cctggaagca cccctgcccc cttttcaggg atttttatct cgaggccttt
     1261 ggaggagcag tggtgggggt agctgtcacc tccaggtatg attgagggag gaattgggta
     1321 gaaactctcc agacccatgc ctccaatggc aggatgctgc ctttcccacc tgagagggga
     1381 ccctgtccat gtgcagcctc atcagagcct caccctggga ggatgccgtg gcgtctcctc
     1441 ccaggagcca gatcagtgcg agtgtgactg aaaatgcctc atcacttaag caccaaagcc
     1501 agtgatcagc agctcttctg ttcctgtgtc ttctgttttt ttctggtgaa tcgttgcttg
     1561 ctgtggactt ggtggaggac tcagagggga ggaaaggctg ggccccgagt acaacggatg
     1621 ccttgggtgc tgcctccgaa gagactctgc cgcagctttt cttctttttc ctcatgcccc
     1681 gggaaacagt ctttcttcag aattgtcagg ctgggcaggt caacttgtgt tcctttcccc
     1741 tcacctgctt gcctccttaa cgcctgcacg tgtgtgtaga ggacaaaaga aagtgaagtc
     1801 agcacatccg cttctgccca gatggtcggg gccccgggca acagattgaa gagagatcat
     1861 gtgaagggca gttggtcagg caggcctcct ggtttcgcca ctggccctga tttgaactcc
     1921 tgccacttgg gagagctcgg ggtggtccct ggttttccct cctggagaat gaggcgcaga
     1981 ggcctcgcct cctgaaggac gcagtgtgga tgccactggc ctagtgtcct ggcctcacag
     2041 cttccttgca aggctgtcac aaggaaaagc agccggctgg caccctgagc atatgccctc
     2101 ttggggctcc ctcatccagc ccgtcgcagc tttgacatct tggtgtactc atgtcgcttc
     2161 tccttgtgtt accccctccc agtattacca tttgcccctc acctgccctt ggtgagcctt
     2221 ttagtgcaag acagatgggg ctgttttccc ccacctctga gtagttggag gtcacataca
     2281 cagctctttt tttattgccc ttttctgcct ctgaatgttc atctctcgtc ctcctttgtg
     2341 caggcgagga aggggtgccc tcaggggccg acactagtat gatgcagtgt ccagtgtgaa
     2401 cagcagaaat taaacatgtt gcaaccaa
//
