LOCUS       NM_058173                485 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens mucin like 1 (MUCL1), mRNA.
ACCESSION   NM_058173
VERSION     NM_058173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Hao,H., Wang,B., Yang,L., Sang,Y., Xu,W., Liu,W., Zhang,L. and
            Jiang,D.
  TITLE     miRNA-186-5p inhibits migration, invasion and proliferation of
            breast cancer cells by targeting SBEM
  JOURNAL   Aging (Albany NY) 15 (14), 6993-7007 (2023)
   PUBMED   37477531
  REMARK    GeneRIF: miRNA-186-5p inhibits migration, invasion and
            proliferation of breast cancer cells by targeting SBEM.
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Abdulla,M., Traiki,T.B., Vaali-Mohammed,M.A., El-Wetidy,M.S.,
            Alhassan,N., Al-Khayal,K., Zubaidi,A., Al-Obeed,O. and Ahmad,R.
  TITLE     Targeting MUCL1 protein inhibits cell proliferation and EMT by
            deregulating beta-catenin and increases irinotecan sensitivity in
            colorectal cancer
  JOURNAL   Int J Oncol 60 (3) (2022)
   PUBMED   35059735
  REMARK    GeneRIF: Targeting MUCL1 protein inhibits cell proliferation and
            EMT by deregulating betacatenin and increases irinotecan
            sensitivity in colorectal cancer.
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Kim,J. and Choi,H.
  TITLE     The mucin protein MUCL1 regulates melanogenesis and melanoma genes
            in a manner dependent on threonine content
  JOURNAL   Br J Dermatol 186 (3), 532-543 (2022)
   PUBMED   34545566
  REMARK    GeneRIF: The mucin protein MUCL1 regulates melanogenesis and
            melanoma genes in a manner dependent on threonine content.
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Li,Q.H., Liu,Z.Z., Ge,Y.Nu., Liu,X., Xie,X.D., Zheng,Z.D., Ma,Y.H.
            and Liu,B.
  TITLE     Small breast epithelial mucin promotes the invasion and metastasis
            of breast cancer cells via promoting epithelial-to-mesenchymal
            transition
  JOURNAL   Oncol Rep 44 (2), 509-518 (2020)
   PUBMED   32627029
  REMARK    GeneRIF: Small breast epithelial mucin promotes the invasion and
            metastasis of breast cancer cells via promoting
            epithelialtomesenchymal transition.
REFERENCE   5  (bases 1 to 485)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 485)
  AUTHORS   Hube,F., Chooniedass-Kothari,S., Hamedani,M.K., Miksicek,R.J.,
            Leygue,E. and Myal,Y.
  TITLE     Identification of an octamer-binding site controlling the activity
            of the small breast epithelial mucin gene promoter
  JOURNAL   Front Biosci 11, 2483-2495 (2006)
   PUBMED   16720387
  REMARK    GeneRIF: octamer-binding transcription factors participate in the
            strong expression of SBEM gene in breast tissues
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 485)
  AUTHORS   Wadle,A., Mischo,A., Imig,J., Wullner,B., Hensel,D., Watzig,K.,
            Neumann,F., Kubuschok,B., Schmidt,W., Old,L.J., Pfreundschuh,M. and
            Renner,C.
  TITLE     Serological identification of breast cancer-related antigens from a
            Saccharomyces cerevisiae surface display library
  JOURNAL   Int J Cancer 117 (1), 104-113 (2005)
   PUBMED   15880534
REFERENCE   8  (bases 1 to 485)
  AUTHORS   Hube,F., Mutawe,M., Leygue,E. and Myal,Y.
  TITLE     Human small breast epithelial mucin: the promise of a new breast
            tumor biomarker
  JOURNAL   DNA Cell Biol 23 (12), 842-849 (2004)
   PUBMED   15684711
  REMARK    GeneRIF: identification as possible new breast tumor biomarker
REFERENCE   9  (bases 1 to 485)
  AUTHORS   Koga,T., Horio,Y., Mitsudomi,T., Takahashi,T. and Yatabe,Y.
  TITLE     Identification of MGB1 as a marker in the differential diagnosis of
            lung tumors in patients with a history of breast cancer by analysis
            of publicly available SAGE data
  JOURNAL   J Mol Diagn 6 (2), 90-95 (2004)
   PUBMED   15096563
REFERENCE   10 (bases 1 to 485)
  AUTHORS   Miksicek,R.J., Myal,Y., Watson,P.H., Walker,C., Murphy,L.C. and
            Leygue,E.
  TITLE     Identification of a novel breast- and salivary gland-specific,
            mucin-like gene strongly expressed in normal and tumor human
            mammary epithelium
  JOURNAL   Cancer Res 62 (10), 2736-2740 (2002)
   PUBMED   12019145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI905624.1, AY359062.1 and AC117496.5.
            
            On Nov 23, 2018 this sequence version replaced NM_058173.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP314595.1, BP391606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308796.11/ ENSP00000311364.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AI905624.1         2-29
            29-225              AY359062.1         1-197
            226-226             AC117496.5         1851-1851           c
            227-485             AY359062.1         199-457
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..485
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /note="mucin like 1"
                     /db_xref="GeneID:118430"
                     /db_xref="HGNC:HGNC:30588"
                     /db_xref="MIM:610857"
     exon            1..125
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..340
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /note="mucin-like protein 1; small breast epithelial
                     mucin"
                     /codon_start=1
                     /product="mucin-like protein 1 precursor"
                     /protein_id="NP_477521.1"
                     /db_xref="CCDS:CCDS8885.1"
                     /db_xref="GeneID:118430"
                     /db_xref="HGNC:HGNC:30588"
                     /db_xref="MIM:610857"
                     /translation="MKFLAVLVLLGVSIFLVSAQNPTTAAPADTYPATGPADDEAPDA
                     ETTAAATTATTAAPTTATTAASTTARKDIPVLPKWVGDLPNGRVCP"
     exon            126..167
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /inference="alignment:Splign:2.1.0"
     exon            168..290
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /inference="alignment:Splign:2.1.0"
     exon            291..485
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      462..467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /note="hexamer: AATAAA"
     polyA_site      485
                     /gene="MUCL1"
                     /gene_synonym="SBEM"
                     /note="major polyA site"
ORIGIN      
        1 agcgccttgc cttctcttag gctttgaagc atttttgtct gtgctccctg atcttcaggt
       61 caccaccatg aagttcttag cagtcctggt actcttggga gtttccatct ttctggtctc
      121 tgcccagaat ccgacaacag ctgctccagc tgacacgtat ccagctactg gtcctgctga
      181 tgatgaagcc cctgatgctg aaaccactgc tgctgcaacc actgcaacca ctgctgctcc
      241 taccactgca accaccgctg cttctaccac tgctcgtaaa gacattccag ttttacccaa
      301 atgggttggg gatctcccga atggtagagt gtgtccctga gatggaatca gcttgagtct
      361 tctgcaattg gtcacaacta ttcatgcttc ctgtgatttc atccaactac ttaccttgcc
      421 tacgatatcc cctttatctc taatcagttt attttctttc aaataaaaaa taactatgag
      481 caaca
//
